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Synovial Mr 250 Mg/50 Mg/325 Mg Tablet

Manufacturer: Synokem Pharmaceuticals Ltd
Medicine composition: Chlorzoxazone, Diclofenac, Paracetamol
Prescription vs.OTC: Prescription by Doctor required

Synovial Mr 250 Mg/50 Mg/325 Mg Tablet act as a muscle relaxer. It works by blocking pain sensations or nerve impulses that are sent to the brain. Synovial Mr 250 Mg/50 Mg/325 Mg Tablet when used together with rest and physical therapy can treat skeletal muscle conditions such as injury or pain.

Avoid using this medicine if you are allergic to it or if you are taking sodium oxybate. Inform your doctor if you are pregnant, planning to become pregnant, or are breast-feeding or if you have have liver problems or a blood disease called porphyria. Stop using this medicine and consult your doctor if you experience any serious side effects including black, bloody, or tarry stools, nausea, itching, fainting, upper stomach pain, dark urine, loss of appetite and clay-coloured stools.

Synovial Mr 250 Mg/50 Mg/325 Mg Tablet is to be taken by mouth with or without food. Taking it with food reduces the risk of stomach upset. Do not take in this medicine in larger or smaller amounts or for longer than recommended. Follow your doctor’s prescription carefully to ensure complete safety.

In addition to its intended effect, Synovial Mr 250 Mg/50 Mg/325 Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Is It safe with alcohol?
Acinimide cp 250 mg/50 mg/325 mg tablet may cause excessive drowsiness and calmness with alcohol.
Taking diclofenac with alcohol can increase your risk of stomach bleeding.
Are there any pregnancy warnings?
Acinimide cp 250 mg/50 mg/325 mg tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Are there any breast-feeding warnings?
Unknown. Human and animal studies are not available. Please consult your doctor.
Is it safe to drive while on this medicine?
Patients should not drive or operate machinery if they get affected symptoms like dizziness, drowsiness, fatigue, visual disturbances.
Does this affect kidney function?
This medicine should be used with caution in patients with underlying kidney disease. Please Consult your doctor.
Does this affect liver function?
Use of this medicine should be avoided in patients with underlying liver disease.
Below is the list of medicines, which have the same composition, strength and form as Synovial Mr 250 Mg/50 Mg/325 Mg Tablet, and hence can be used as its substitute.
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Meridian Medicare Ltd
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
What are you using Synovial Mr 250 Mg/50 Mg/325 Mg Tablet for?
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Hello Lybrate Doctors, I am 28 years old working lady. Around from last 1 year my back, knees, shoulders are aching and I am having very much difficulty in sitting & getting up after sitting. I feel like I am getting old & these are symptoms of weak bones due to ageing. I don't need medicines but some home remedies like please suggest some healthy drinks. Will women horlicks work in my case ?Thanks in advance.

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Hello Lybrate Doctors, I am 28 years old working lady. Around from last 1 year my back, knees, shoulders are aching a...
Pain in joints show you have increased vatta in your body the synovial fluid present between he joints has been reduced hence on friction of bones it pains you require massing to all the joints daily and if your wt is also less do massage to complete body 30 mins before bath check calcium and vitamin D add dairy product in your diet ,1 tsf pure ghee in meals daily sunbath for 15 min before 10 am daily is must daily walk of 20-30 mins tab gemcal daily for 2 months liq dashmularist +liq rasnadi kada each 20 ml in 40 ml of water for 1 month.

My left knee makes a click sound while climbers stairs, I have no pain or swelling in my knees what is the reason for this sound? I have no pain while running or walking as well.

Erasmus Mundus Master in Adapted Physical Activity, MPT, BPTh/BPT
Physiotherapist, Chennai
My left knee makes a click sound while climbers stairs, I have no pain or swelling in my knees what is the reason for...
Symptoms of osteoarthritis may include joint pain and progressive stiffness that develops gradually. Symptoms of rheumatoid arthritis may include painful swelling, inflammation, and stiffness in the fingers, arms, legs, and wrists occurring in the same joints on both sides of the body, especially upon awakening. That might be due to knee pain or it might be due to ankle pain. Our suggestion would be to do hot water fermentation along with Cold (ice) therapy. You shall also keep a pillow under the knee while sleeping, next is you can keep ice in the painful area for about 5--10 minutes.

Five beneficial exercises for reducing knee pain & increasing synovial fluid supplements.

MBBS, PG-Diploma In Clinical Pathology
General Physician, Sri Ganganagar
Five beneficial exercises for reducing knee pain & increasing synovial fluid supplements.
You can take Glucosamine &calcium D3 (vestige com) it's help to increase your synovial fluid for further improvement need homoeopathic treatment you can consult with me privately if you want, take care. Also try quadriceps exercises- Lie straight, make a towel role and put it under the knee, press the keen against the role, hold it for 20 secs. Repeat 20 times twice a day. This will help relieve some pain. Core Strengthening Exercise- Straight Leg Raised With Toes Turned Outward, repeat 10 times, twice a day. Hams Stretching- lie straight, take the leg up, pull the feet towards yourself, with a elastic tube or normal belt. Repeat 10 times, twice a day. Sports Taping- stretch the tape from both ends and apply on the affected area.

What is the cause of cracking sound and pain of shoulder during rotation the hands.

General Physician, Mumbai
What is the cause of cracking sound and pain of shoulder during rotation the hands.
Cracking sound of joint is due to movement of synovial fluid. Painful joints is due to swelling of joint or injury to ligament.

My knee joints pain esp. The right one. When I fold my knees to sit down on the floor and get up, both knee sound. It is the same sound when you knuckle the joints of your hand.

Bachelor of Ayurveda Medicine and Surgery (BAMS), M.D (Ayu)
My knee joints pain esp. The right one. When I fold my knees to sit down on the floor and get up, both knee sound. It...
This condition is called as Sandhi Vata in Ayurveda. It may be due to many reasons like your work, Obesity, your food habits etc. The synovial fluid which is present in between joints when reduce then this type of condition is occurs. Ayurveda can very effectivly helo you by Massage therapy and other panchkarma related therapies along with some medicines.
1 person found this helpful

Popular Health Tips

Know More About Arthritis

BHMS, Certificate in Sex Education & Parenthood, PG Dip (Preventive & Promotive Healthcare), Dip in LSM (Prescribing Exercises), Dip in LSM (Metabolic Disroders & Nutrition), Dip in Occupational health & industrial hygiene., MBA (Healthcare), Certificate in Good Clinical Practice, Dip in Healthcare Quality, Core Competency In Lifestyle Medicine
Homeopath, Jamshedpur
Know More About Arthritis

    Arthritis Types and Risk Factors

The term arthritis means “joint inflammation,” and the most common types are known as Osteoarthritis (OA) and Rheumatoid arthritis (RA).

Arthritis is a complex family of musculoskeletal disorders consisting of more than 100 different conditions that destroy joints, bones, muscles, cartilage and other connective tissues, hampering or halting physical movement and causing pain.

While arthritis is not a single disease, its symptoms are often universal and are largely experienced as stiffness, soreness, inflammation and pain. Over time, the cartilage between the joints can begin to wear down, exposing the joint to friction. When two bones rub together, inflammation and pain can take place. Redness and swelling of the joints and loss of joint function soon follow.

While the most common form, osteoarthritis, is a result of external factors like physical injury or wear and tear of joints through overuse, this is not the case with rheumatoid arthritis. In fact, despite advances in science, the exact causes of RA are unknown … but certain risk factors have been identified:- genetics, age, weight, injury, occupational hazards, sports, illness or infection, stress, etc.


Now we will go through two most common types of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA).


Osteoarthritis most commonly type of arthritis which is caused by poor lifestyle. It is degeneration of the cartilage that cushions the area where two bones meet to form a joint. When the cushion wears out or cracks, the bones rub together, causing intense pain. In severe cases, the joints can develop calcifications. This means that calcium builds up on the bones and soft tissues, making them stiff and painful to move. The pain of osteoarthritis gradually worsens with use over the course of the day.

This type of arthritis occurs slowly over time and is the type that many runners, martial artists and construction workers begin to feel by middle age due to over-extreme use of joints.

Prevention is always the best medicine. However, reversing damage already done is also essential.

Rheumatoid Arthritis

Rheumatoid arthritis, on the other hand, is a chronic disease of the autoimmune system that causes inflammation of the synovial membrane (joint lining). This causes destruction and deformity of bone, cartilage, ligaments and muscle tissue.

RA commonly called “crippling arthritis” is a “systemic” disease. Besides the tissues around the joints, other areas RA affects include the glands of the eyes and mouth, the lining of the lungs and the pericardium. When inflamed, the tissue lining between the joints becomes red, painful and swollen. The frequency and duration of these “flare-ups” vary widely. After repeated episodes, chronic inflammation begins to cause damage to the surrounding tissue, cartilage and bone. Eventually this damage can lead to loss of cartilage and weakening of bones, resulting in painful and permanent destruction and deformities.

The second study offers even more hope as to the healing power of green tea for RA sufferers. Green tea, supplementation and relaxation techniques are powerful solutions for this disease.

Juvenile Arthritis

The autoimmune trigger of RA also affects children causing Juvenile arthritis (JA). Actually, JA is a term used to group the various autoimmune disorders affecting children 16 and under. While JA affects the joints, it also can affect the eyes, skin and gastrointestinal (GI) tract as well.

JA, while similar to RA, is more easily diagnosed. Again, this autoimmune disease is not precise in how, or whom, it affects, but inherited genes and external factors can trigger it in a child. If you have a family history of RA and your child shows red inflammatory joints.

The natural solutions and plan for JA are the same as for RA. The difference is that usually a parent or adult will have to manage the lifestyle changes in the home and keep the child on course with the plan.


There Is Hope!

People think that because they experience excruciating pain today, they will experience it tomorrow and keep experiencing it for the rest of their life. It is as if the trajectory of arthritis, to them, is inevitable, and therefore there is no hope. This does not have to be the case. Nothing about arthritis is “inevitable” if you understand the condition and take steps to control it.

People suffering with arthritis do not believe anything can be done to help ease their pain. Why? Because the drug-based therapies they have been following are not useful in providing a change to the condition – only symptomatic relief. Yes, immediate relief of pain or stiffness or inflammation is a good thing and drugs are the fastest means for that relief. However, there are two problems with relying on synthetic drug therapies over the long term.

Problem 1: The drugs and cortisone injections are toxic to the system, causing in some cases damage to the liver and stomach lining, weakening of the joint cartilage and the immune system, and GI tract issues.

Problem 2: Drugs do not change the course of the condition and thus, as the arthritis worsens over time, drugs that are more potent are needed, causing more toxicity and potentially damaging side effects.

The good news is that a multi-pronged approach to arthritis can do wonders, and even feel like a miracle to those suffering its nasty symptoms. Because there is no cure, it is extremely important to become proactive in managing, treating and slowing down the condition.

1 person found this helpful

Drugless Treatments for Different types of Arthritis

Bachelor of Naturopathy & Yogic Sciences (BNYS)
Alternative Medicine Specialist, Ernakulam
Drugless Treatments for Different types of Arthritis

Arthritis is a condition affecting millions of people every year.Most of the arthritic conditions fall into one of two categories: degenerative arthritis, such as osteoarthritis or inflammatory arthritis, such as rheumatoid arthritis. Symptoms of most types of arthritis include pain, stiffness, and swelling in the joint. Here is the list of arthritic conditions which will respond well to Acupuncture & Natural Medicine.

  • Ankylosing spondylitis (AS) mainly affects the spine. Pain and stiffness are the primary symptoms and the condition can lead to the bones of the joints being fused together.
  • Bursitis Inflammation of the bursa is not a type of arthritis, rather it shares similar symptoms and may cause arthritis in some cases.
  • Gout is an often painful type of inflammatory arthritis caused by a buildup of uric acid in a joint. Gout commonly affects the big toe, though other joints in the foot, knee, elbow, wrist, and fingertips can become painful as a result of gout.
  • Juvenile arthritis is an umbrella term that encompasses over 100 different childhood inflammatory and autoimmune conditions, including juvenile idiopathic arthritis (JIA), Kawasaki disease, and juvenile fibromyalgia.
  • Osteoarthritis This type of degenerative arthritis is so common; many people referring to "arthritis" mean just osteoarthritis. Osteoarthritis is the break-down of cartilage in a joint from aging or repetitive movements.
  • Pseudogout (CPPD) is a type of inflammatory arthritis that occurs when calcium pyrophosphate crystals accumulate in a joint. Pseudogout can affect any joint in the body, but is found most commonly in the knee.
  • Psoriatic Arthritis is a condition where psoriasis of the skin is linked to joint inflammation, commonly in the outmost joints of the extremities. Skin symptoms generally present before joint problems are detected.
  • Reactive arthritis is type of inflammatory arthritis that occurs as a reaction to an infection. The condition often causes pain and inflammation in the joints and eyes as well as skin problems.
  • Rheumatoid arthritis is an autoimmune disorder where the body attacks the synovial fluid in the joints, leading to stiffness, pain, and possibly deformities in the affected joints.

Frozen Shoulder

BHMS, Certificate in Sex Education & Parenthood, PG Dip (Preventive & Promotive Healthcare), Dip in LSM (Prescribing Exercises), Dip in LSM (Metabolic Disroders & Nutrition), Dip in Occupational health & industrial hygiene., MBA (Healthcare), Certificate in Good Clinical Practice, Dip in Healthcare Quality, Core Competency In Lifestyle Medicine
Homeopath, Jamshedpur
Frozen Shoulder

Frozen shoulder is painful inflammatory condition associated with stiffness and loss of motion in shoulder. The pain gradually grows and becomes chronic leading to restricted movement. Due to inflammatory conditions the muscles surrounding the shoulder becomes stiff. Frozen shoulder has vague triggers, which usually surfaces as a complication commonly in people with diabetes, thyroid disorders, heart disease, and Parkinson's disease and people with chronic rheumatism or arthritis. The general approach towards frozen shoulder is prescription of painkillers, anti-inflammatory and physical therapy to restore the ROM.

What is the suffering 
As the chronicity advances the movement of the shoulder is severely restricted, with progressive loss of both active and passive range of motion. The condition is sometimes caused by injury, leading to lack of use due to pain, but can also arise spontaneously with no obvious trigger (idiopathic frozen shoulder). Rheumatic disease progression and recent shoulder surgery can also cause a pattern of pain and limitation similar to frozen shoulder. Intermittent periods of use may cause inflammation.

In frozen shoulder, the synovial fluid becomes scarce resulting in diminished joint lubrication between the head of humerus (Upper arm bone) and the socket of the scapula. Due to friction as precipitating factor, the shoulder capsule swells, thickens and tightens due to stiffness of ligamentous bands of scar tissue. As a result, the joint movement becomes stiff.

How to know 
First sign of a frozen shoulder is that the joint becomes so tight and stiff that it is nearly impossible to carry out simple movements, such as raising the arm. The movement that is most severely inhibited is abduction and external rotation of the shoulder. Lots of tests are done clinically to assess the frozen shoulder. One of the best test is “Scratch Test” and 2nd is the Lateral external rotation.

People complain that the stiffness and pain worsen at night or the pain is worse during morning. Pain due to frozen shoulder is usually dull or aching. It can be worsened with attempted motion. A therapist or practitioner may suspect the patient has a frozen shoulder if a physical examination reveals limited shoulder movement. XRay of rhe shoulder or an MRI scan may confirm the diagnosis, though its mostly diagnosed clinically.

The frozen shoulder, according to the chronicity is categorised into stages.

Stage one:  "freezing" or painful stage, which may last from six weeks to nine months, and in which the patient has a slow onset of pain. As the pain worsens, the shoulder loses range of motion.
Stage two: "frozen" or adhesive stage is marked by a slow improvement in pain but the stiffness increases. This stage generally lasts from four to nine months.
Stage three: "thawing" or recovery, when shoulder motion slowly returns toward normal. This generally lasts from 5 to 26 months.

What to Do

Frozen shoulder makes the person so disable that he cannot work without pain. Management of the frozen shoulder is focused on restoring joint movement and reducing shoulder pain, involving medications, physical therapy and /or surgical intervention. Treatment may continue for months, there is no strong evidence to favour any particular approach. Medications frequently used include NSAIDs and corticosteroids. Alternative medicines like homeopathy, ayurveda also gives great results. Alternative measures like physical therapy, exercise therapy, yoga have good impact in increasing the range of motion.

2 people found this helpful

Hip Replacement Surgery - What To Expect?

MBBS, MS - Orthopaedics, DNB - Orthopedics
Orthopedist, Pune
Hip Replacement Surgery - What To Expect?

Hip replacement is a common surgical procedure that you may need if your hip has been damaged due to arthritis, a fracture, or other serious conditions. All of these can make common activities like walking or getting in and out of a chair very painful and difficult. If you are facing the same difficulties despite medications, changes in lifestyle and physiotherapy, it is time to go in for a hip replacement.

Causes of Hip Pain
The most common cause of long-term hip pain and disability is arthritis.

  1. Osteoarthritis- This is an age-related problem that causes wear and tear of the hip joint. Usually, older people get this arthritis. What happens in osteoarthritis is that the cartilage cushioning the bones of the hip wears away. The bones then rub against each other leading to hip pain and stiffness.
  2. Rheumatoid arthritis- RA is an autoimmune disease in which the synovial membrane in the hip joint becomes inflamed. This damages the cartilage causing pain and stiffness.
  3. Post-traumatic arthritis- This arthritis follows a hip injury or fracture. In this the cartilage may become damaged leading to hip pain and stiffness.
  4. Avascular necrosis- The lack of blood to the femoral head can cause the surface of the bone to collapse resulting in arthritis.
  5. Childhood hip disease may also require this surgery.

Hip replacement- How it’s done?

Hip replacement surgery is one of the safest operations in medicine. The hip is a ball –and –socket joint and in a total hip replacement the damaged bone and cartilage is removed and replaced with metal or plastic prosthetics. Hip replacement surgery is usually performed in a traditional manner or using a minimally-invasive technique. The main difference between the two lies in the size of the incision for surgery.

During standard hip replacement surgery, a patient is given general anesthesia. This is followed by a cut along the side of the hip after which the surgeon moves the muscles connected to the tip of the thighbone to expose the hip joint. Post this the ball portion of the hip joint is removed by sawing off the thigh bone. After this, the artificial joint is attached to the thighbone by using either cement or a special material. The surgeon then removes any damaged cartilage from the surface of the hipbone and attaches the replacement socket portion to the hip bone. Most hip replacement surgeries today are performed using the standard technique however; the minimally-invasive technique, is getting more and more popular. In this, the surgeon makes one to two cuts from 2 to 5 inches long and then carries out the same steps like in the standard hip replacement surgery. The patient may have to stay in hospital for 3-6 days post a hip replacement surgery and has to undergo long-term physiotherapy to attain normal use of the hip joint.

In case you have a concern or query you can always consult an expert & get answers to your questions!

4250 people found this helpful

Baker Cyst

Senior Registrar/ Research Associate, MS - Orthopaedics, MBBS, MCh. Orthopedics
Orthopedist, Ghaziabad
Baker Cyst

What is Baker Cyst and its causes?
A baker cyst is a swelling in the space behind the knee. It is also known as popliteal cyst. It causes stiffness and knee pain. Baker Cyst is common nowadays and can be caused by virtually any cause of joint swelling. The pain caused by popliteal cyst is more worsens if the patients fully flexes or extends the knee or moves around .The excess joint fluid (synovial fluid) bulges to back of the knee to form the baker cyst. Ostearoarthritis is the most common type of arthritis associated with Baker’s Cyst. And Juvenile arthritis is one of another cause of baker cyst in children. Baker Cysts is more common in females of 40 plus age or above. Baker cysts also can result from cartilage tears which include torn meniscus, rehematoid arthritis and other knee problems.

What are the symptoms of Baker Cyst?
Joint locking, knee pain, swelling and calf pain are some of the symptoms of baker cyst. Swelling or lump behind the knee is more common symptom and this is more evident while standing or performing any activity of knee.


6 people found this helpful

Table of Content

About Synovial Mr 250 Mg/50 Mg/325 Mg Tablet
When is Synovial Mr 250 Mg/50 Mg/325 Mg Tablet prescribed?
What are the side effects of Synovial Mr 250 Mg/50 Mg/325 Mg Tablet?
Key highlights of Synovial Mr 250 Mg/50 Mg/325 Mg Tablet
What are the substitutes for Synovial Mr 250 Mg/50 Mg/325 Mg Tablet?
What are the interactions for Synovial Mr 250 Mg/50 Mg/325 Mg Tablet?