Plagerine A 150 mg/75 mg Capsule

Plagerine A 150 mg/75 mg Capsule belongs to the group of medications called analgesics (pain relievers), antipyretics (fever reducers), anti-inflammatories (inflammation reducers), and platelet aggregation inhibitors (anticlotting agents).

This medicine is also prescribed for prophylaxis for myocardial infarction and transient ischemic episodes. It works by interfering with the production of compounds in the body that cause pain, fever, inflammation, and blood clots.

Plagerine A 150 mg/75 mg Capsule is used to treat pain, and reduce fever or inflammation. This medicine is also used in the management of rheumatoid arthritis, rheumatic fever, osteoarthritis, and gout (high dose). It is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina).Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.

Stop using this medicine and call your doctor at once if you have:

• ringing in your ears, confusion, hallucinations, rapid breathing, seizure (convulsions)
• severe nausea, vomiting, or stomach pain
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
• fever lasting longer than 3 days
• swelling, or pain lasting longer than 10 days.

Common uses of Plagerine A 150 mg/75 mg Capsule include headaches, period cramps, colds and flu, sprains and strains, and long-term conditions, such as arthritis.For mild to moderate pain, it is used alone. For moderate to severe pain, it is often used along with other opioid analgesic and NSAIDs.

Plagerine A 150 mg/75 mg Capsule should be avoided by the person who have :

• have a peptic ulcer
• Hemophilia or any other bleeding disorder
• a known allergy to aspirin
• an allergy to any NSAID, such as ibuprofen
• are at risk of gastrointestinal bleeding or hemorrhagic stroke
• drink alcohol regularly
• are undergoing dental or surgical treatment

If self-administered, use exactly as directed (do not increase dose or frequency); adverse reactions can occur with overuse. Take with food or milk. Do not use aspirin with strong vinegar-like odor. Do not crush or chew extended release products.

While using this medication, avoid alcohol, excessive amounts of vitamin C, or salicylate-containing foods (curry powder, prunes, raisins, tea, or licorice), other prescription or OTC medications containing aspirin or salicylate, or other NSAIDs without consulting prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake).

In case of overdosage/toxicology, treatment should also be based upon symptomatology. Toxic symptoms and corresponding treatments are as follows:

• Overdose: Induce emesis with ipecac, and/or lavage with saline, followed with activated charcoal.
• Dehydration: I.V. fluids with KCl (no D5W only).
• Metabolic acidosis (must be treated): Sodium bicarbonate.
• Hyperthermia: Cooling blankets or sponge baths.
• Coagulopathy/hemorrhage: Vitamin K I.V.
• Hypoglycemia (with coma, seizures, or change in mental status): Dextrose 25 g I.V.
• Seizures: Diazepam 5-10 mg I.V.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Mild To Moderate Pain

• Inflammation

• Rheumatic Fever

• Fever

• Rheumatoid Arthritis

• Osteoarthritis

• Gout

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Hypersensitivity

• Asthma

• Rhinitis

• Bleeding Disorders

• Pregnancy

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Hypotension

• Edema (Swelling)

• Rash

• Urticaria

• Dehydration

• Nausea

• Vomiting

• Heartburn

• Duodenal Ulcer

• Anemia

• Weakness

• Tinnitus

• Bronchospasm

• Anaphylaxis

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Is It safe with alcohol?

  Taking Aspirin with alcohol increases the associated risk of stomach bleeding.

• Are there any pregnancy warnings?

  Plagerine A 150 mg/75 mg Capsule is unsafe to use during pregnancy.
  There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.

• Are there any breast-feeding warnings?

  Plagerine A 150 mg/75 mg Capsule is probably usafe to use during lactation. \nLimited human data suggests that the drug could represent a significant risk to the baby.

• Is it safe to drive while on this medicine?

  Plagerine A 150 mg/75 mg Capsule may make you feel dizzy, drowsy or affect your vision. Do not drive until your vision is clear.

• Does this affect kidney function?

  Plagerine A 150 mg/75 mg Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Plagerine A 150 mg/75 mg Capsule may not be needed in these patients. Please consult your doctor.

• Does this affect liver function?

  Plagerine A 150 mg/75 mg Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Plagerine A 150 mg/75 mg Capsule may not be needed in these patients. Please consult your doctor.

• How long is the duration of effect?

  The effect of this medicine will last for about 4 to 6 hours.

• What is the onset of action?

  The effect is initiated within 15 - 30 minutes after its administration.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Below is the list of medicines, which have the same composition, strength and form as Plagerine A 150 mg/75 mg Capsule , and hence can be used as its substitute.

• Adgril A Plus 150Mg/75Mg Tablet

  Aretaeus Pharmaceuticals

• Pidlet Plus 150 Mg/75 Mg Tablet

  Orchid Chemicals & Pharmaceuticals Ltd

• Klotfree A -150 Tablet

  Zydus Cadila

• Clasprin 150 Mg/75 Mg Capsule

  Biocon

• Preva-AS 150 Tablet

  Intas Pharmaceuticals Ltd

• Clavix-As 150 Tablet

  Intas Pharmaceuticals Ltd

• Stromix A 150 mg Capsule

  Abbott India Ltd

• Clodrel Forte Capsule

  Unichem Laboratories Ltd

• Clopivas AP 150 Tablet

  Cipla Ltd

• Deplatt A 150 Tablet

  Torrent Pharmaceuticals Ltd

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

• Are there any overdose instructions?

  Seek emergency medical treatment or contact the doctor in case of an overdose.

• Are there any missed dose instructions?

  If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Plagerine A 150 mg/75 mg Capsule is a drug very commonly used to treat fever, pain and inflammation. The drug inactivates the cyclooxygenase, which is required for the synthesis of prostaglandins and thromboxane.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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• Interaction with Alcohol

  Combination causes GI irritation, possible bleeding; avoid or limit alcohol. Patients at increased risk include those prone to hypoprothrombinemia, vitamin K deficiency, thrombocytopenia, thrombotic thrombocytopenia purpura, severe hepatic impairment, and those receiving anticoagulants.

• Interaction with Others

  • Folic acid: Hyperexcretion of folate; folic acid deficiency may result, leading to macrocytic anemia. Supplement with folic acid if necessary.
  • Iron: With chronic aspirin use and at doses of 3-4 g/day, iron deficiency anemia may result; supplement with iron if necessary.
  • Sodium: Hypernatremia resulting from buffered aspirin solutions or sodium salicylate containing high sodium content. Avoid or use with caution in CHF or any condition where hypernatremia would be detrimental.
  • Curry powder, paprika, licorice, Benedictine liqueur, prunes, raisins, tea and gherkins: Potential salicylate accumulation. These foods contain 6 mg salicylate/100 g. An ordinarily American diet contains 10-200 mg/day of salicylate. Foods containing salicylates may contribute to aspirin hypersensitivity. Patients at greatest risk for aspirin hypersensitivity include those with asthma, nasal polyposis or chronic urticaria.
  • Fresh fruits containing vitamin C: Displaces drug from binding sites, resulting in increased urinary excretion of aspirin. Educate patients regarding the potential for a decreased analgesic effect of aspirin with consumption of foods high in vitamin C.

• Interaction with Lab Test

  False-negative results for glucose oxidase urinary glucose tests (Clinistix®); false-positives using the cupric sulfate method (Clinitest®); also, interferes with Gerhardt test, VMA determination; 5-HIAA, xylose tolerance test and T3 and T4.

• Interaction with Medicine

  • ACE inhibitors: The effects of ace inhibitors may be blunted by aspirin administration, particularly at higher dosages.
  • Buspirone increases aspirin's free % in vitro.
  • Carbonic anhydrase inhibitors and corticosteroids have been associated with alteration in salicylate serum concentrations.
  • Heparin and low molecular weight heparins: Concurrent use may increase the risk of bleeding.
  • Methotrexate serum levels may be increased; consider discontinuing aspirin 2-3 days before high-dose methotrexate treatment or avoid concurrent use.
  • NSAIDs may increase the risk of gastrointestinal adverse effects and bleeding. Serum concentrations of some NSAIDs may be decreased by aspirin.
  • Platelet inhibitors (IIb/IIa antagonists): Risk of bleeding may be increased.
  • Probenecid effects may be antagonized by aspirin.
  • Sulfonylureas: The effects of older sulfonylurea agents (tolazamide, tolbutamide) may be potentiated due to displacement from plasma proteins. This effect does not appear to be clinically significant for newer sulfonylurea agents (glyburide, glipizide, glimepiride).
  • Valproic acid may be displaced from its binding sites which can result in toxicity.
  • Verapamil may potentiate the prolongation of bleeding time associated with aspirin.
  • Warfarin and oral anticoagulants may increase the risk of bleeding.

• Interaction with Disease

  • Use with caution in patients with platelet and bleeding disorders, renal dysfunction, dehydration, erosive gastritis, or peptic ulcer disease.
  • Avoid use in severe renal failure or in severe hepatic failure.
  • Discontinue use if tinnitus or impaired hearing occurs.
  • Caution in mild-moderate renal failure (only at high dosages).
  • Patients with sensitivity to tartrazine dyes, nasal polyps and asthma may have an increased risk of salicylate sensitivity.
  • Surgical patients should avoid ASA if possible, for 1-2 weeks prior to surgery, to reduce the risk of excessive bleeding.

• Interaction with Food

  May decrease the rate but not the extent of oral absorption. Drug may cause GI upset, bleeding, ulceration, perforation. Take with food or large volume of water or milk to minimize GI upset.

• Ques : What is Plagerine A 150 mg/75 mg Capsule used for?

  Ans : Plagerine A 150 mg/75 mg Capsule is used in the treatment of pain, and to reduce fever or inflammation, It is also sometimes used to treat or prevent cardiovascular health conditions.

• Ques : What is the onset of action of Plagerine A 150 mg/75 mg Capsule?

  Ans : Plagerine A 150 mg/75 mg Capsule takes approximately 5 to 30 minutes to show its effect.

• Ques : How long does the effect of Plagerine A 150 mg/75 mg Capsule last?

  Ans : The effect of Plagerine A 150 mg/75 mg Capsule lasts between 4 to 6 hours.

• Ques : Where is Plagerine A 150 mg/75 mg Capsule approved?

  Ans : Plagerine A 150 mg/75 mg Capsule is approved in India, Micronesia, Japan, and the USA.

• Ques : Should Plagerine A 150 mg/75 mg Capsule be taken with a meal or without a meal?

  Ans : Plagerine A 150 mg/75 mg Capsule can be taken either as its effectiveness does not depend on a meal.

• Ques : Is Plagerine A 150 mg/75 mg Capsule safe for asthma patients?

  Ans : Plagerine A 150 mg/75 mg Capsule is not recommended for usage in asthma patients.

• Ques : Is Plagerine A 150 mg/75 mg Capsule safe for usage in patients with gastrointestinal disorders?

  Ans : Plagerine A 150 mg/75 mg Capsule is not recommended for usage in patients with gastrointestinal disorders as it can worsen their health conditions.