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Prescription vs.OTC: Prescription by Doctor required

Belonging to a cluster of drugs known as PPIs, Omeprazole is used for reducing the acid content in the stomach. This drug treats duodenal or gastric ulcers, Gastroesophageal Reflux Disease (GERD), inflammation of the esophagus and conditions wherein the stomach secretes excess acid.

Omeprazole is prescribed as the short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment.

Also, it is given in the treatment of heartburn and other symptoms associated with GERD; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; maintenance of healing of erosive esophagitis.

This medicine is approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer. The most common side effects associated with Omeprazole include diarrhea, gas, vomiting, headache, nausea and stomach aches.

Although rare, certain severe adverse reactions are increased possibility of bone fractures, decreased magnesium levels inside the body, seizures, irregular heart-beats, jitteriness, muscle spasms and weakness, feet/hand spasms, voice box spasms, etc.

The likelihood of these severe side effects goes up if you take this medicine for over a period of 3 months. Also, prolonged intake of this medication (usually over a period of three years) can result in your body’s decreased ability to absorb Vitamin B12.

Other possible (albeit rare) side effects include diarrhea, inflammation of the intestine and the stomach lining, damage to the kidneys, allergic reactions, weight loss, and fever.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

Omeprazole is helpful in treating the below provided problems:

  • Gastroesophageal Reflux Disease

    Omeprazole is used in the treatment of GERD (a condition where stomach acid and contents flow back and irritate the food pipe).
  • Zollinger-Ellison Syndrome

    Omeprazole is used in the treatment of Zollinger-Ellison syndrome (a condition where the tumor in the upper part of the small intestine will produce the excess amount of acid in the stomach.)
  • Duodenal Ulcer

    Omeprazole is used in the treatment of Duodenal ulcer (a condition with open sores on the lining of the small intestine).
  • Helicobacter Pylori Infection

    Omeprazole is used in the treatment of H.Pylori infection which is a most common cause of peptic ulcer caused by bacteria called Helicobacter pylori.
  • Erosive Esophagitis

    Omeprazole is used in the treatment of Erosive Esophagitis which is an inflammation of the food pipe (Esophagus).
  • Allergy

    Avoid if you have a known allergy to Omeprazole or any medicine of the same class.

Side effects of Omeprazole are as follows:

  • How long is the duration of effect?

    This medicine is excreted primarily in urine and the effect of this medicine lasts for a duration of 72 hours.
  • What is the onset of action?

    The peak effect of this medicine can be observed within 1 to 2 hours of administration.
  • Are there any pregnancy warnings?

    This medicine can be used during pregnancy only if the benefits outweigh the risks.
  • Is it habit forming?

    No habit forming tendency has been reported.
  • Are there any breast-feeding warnings?

    This medicine is not recommended for breastfeeding women.
  • Is It safe with alcohol?

    Caution must be taken. Avoid consuming alcohol along with this medicine.
  • Is it safe to drive while on this medicine?

    It is unknown whether this medicine alter the ability of patients driving skills. It patient experience any side effects, he must avoid driving.
  • Does this affect kidney function?

    It is safe to use Omeprazole in patients with kidney disease.
  • Does this affect liver function?

    Caution must be taken in patients with liver disease. Adjustment of dose is needed, kindly consult your doctor before taking this medication.
  • Missed Dose instructions

    Take the missed dose as soon as possible. If it is almost time for the next dose, skip the dose and follow the regular schedule.
  • Overdose instructions

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Omeprazole as ingredient

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This medicine belongs to the class of proton pump inhibitor drug and binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test

    Information not available.
  • Interaction with Medicine


    The desired effect of Ketoconazole and other antifungal agents of the same class will not be achieved when taken with Omeprazole. Inform the doctor about the usage of either of these medications so that safer alternatives can be prescribed.


    It is not recommended to take Omeprazole with methotrexate. This combination will increase the concentration of methotrexate in the blood and can produce serious side effects. Inform the doctor if you are taking these medicines simultaneously. An alternate medicine should be considered based on your clinical condition.


    Omeprazole should be used with caution in you are also taking warfarin. If co-administration is needed, then regular monitoring of prothrombin time, unusual bleeding, the presence of blood in urine is necessary. Appropriate dose adjustments are to be made under doctors supervision.


    The desired effect of anti-viral medications like Nelfinavir will not be obtained when taken with Omeprazole. Inform the doctor if you are taking these medicines simultaneously. An alternate medicine should be considered based on your clinical condition.
  • Interaction with Disease


    The risk of bone fractures is more if you are on high doses and long-term therapy. Use with caution if you are at risk of developing bone fractures and lower doses for a short duration of time should be considered.
  • Interaction with Food

    Information not available.

Ques: What is Omeprazole?

Ans: It is an oral capsule used to reduce the amount of acid in your stomach. It’s used to treat gastric or duodenal ulcers, gastroesophageal reflux disease (GERD), erosive esophagitis, hypersecretory conditions, and infections caused by Helicobacter pylori bacteria.

Ques: How long do I need to use Omeprazole before I see improvement in my condition?

Ans: This medication should be consumed, until the complete eradication of the disease. Thus it is advised to use till the time directed by your doctor.

Ques: At what frequency do I need to use Omeprazole?

Ans: The duration of the effect of this medicine is dependent on the severity of the patient’s condition. Therefore the frequency of usage of this medication will vary from person to person.

Ques: Should I use Omeprazole empty stomach, before food or after food?

Ans: This medication is advised to be consumed orally. It is advised to take this medication before a meal (about 30 min prior) so that it can produce its action completely. Please consult the doctor before using it.

Ques: What are the instructions for the storage and disposal of Omeprazole?

Ans: Store the capsules at room temperature between 59°F and 86°F (15°C and 30°C). Keep it away from light. Don’t store this medication in moist or damp areas, such as bathrooms.

Ques: Is there any allergy warning regarding Omeprazole?

Ans: This drug can cause a severe allergic reaction. Symptoms can include rash, face swelling, throat tightness, trouble breathing.

Ques: What should I know before taking Omeprazole?

Ans: You should not take it if you are taking a medicine containing nelfinavir (used for HIV infection). Consult your doctor if you are suffering from any liver problems, persistent diarrhea or vomiting, black stools (blood-stained stools), or any other disease.

Ques: Can I take antacids along with Omeprazole?

Ans: Yes, you can take antacids along with this drug. Take it 2 hours before or after you take this medication.

Ques: Can Omeprazole be used in cardiac patients?

Ans: Patients with cardiac disease can take this drug as prescribed by the doctor. This medication, however, interacts with certain drugs (e.g clopidogrel, digoxin) which might be used by a patient.

Ques: Is Omeprazole safe to use?

Ans: Yes, it is safe to consume. It is advised to be taken as directed by the doctor for maximum benefit.

Ques: Can I take alcohol with Omeprazole?

Ans: No, you must not control alcohol while on this drug. It is advised to take medical help immediately.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
General Physician
Table of Content
About Omeprazole
What are the uses of Omeprazole
What are the contraindications of Omeprazole ?
What are the side effects of Omeprazole ?
Key highlights of Omeprazole
What are the dosage instructions?
Where is the Omeprazole approved?
Medicines containing Omeprazole
How does this medication work?
What are the interactions of Omeprazole ?
FAQs about Omeprazole