Belonging to a cluster of drugs known as PPIs, Omeprazole is used for reducing the acid content in the stomach. This drug treats duodenal or gastric ulcers, Gastro oesophagal Reflux Disease (GERD), inflammation of the oesophagus and conditions wherein the stomach secretes excess acid.
Omeprazole is prescribed as the short-term (4-8 weeks) treatment of severe erosive esophagitis (grade 2 or above), diagnosed by endoscopy and short-term treatment of symptomatic gastroesophageal reflux disease (GERD) poorly responsive to customary medical treatment.
Also, it is given in the treatment of heartburn and other symptoms associated with GERD; pathological hypersecretory conditions; peptic ulcer disease; gastric ulcer therapy; maintenance of healing of erosive esophagitis.
This medicine is approved for combination use in the eradication of H. pylori in patients with active duodenal ulcer. The most common side effects associated with Omeprazole include diarrhea, gas, vomiting, headache, nausea and stomach aches.
Although rare, certain severe adverse reactions are increased possibility of bone fractures, decreased magnesium levels inside the body, seizures, irregular heart-beats, jitteriness, muscle spasms and weakness, feet/hand spasms, voice box spasms, etc.
The likelihood of these severe side effects goes up if you take this medicine for over a period of 3 months. Also, prolonged intake of this medication (usually over a period of three years) can result in your body’s decreased ability to absorb Vitamin B12.
Other possible (albeit rare) side effects include diarrhoea, inflammation of the intestine and the stomach lining, damage to the kidneys, allergic reactions, weight loss, fever and heartburn.
Omeprazole is helpful in treating the below provided problems:
Gastroesophageal Reflux DiseaseOmeprazole is used in the treatment of GERD (a condition where stomach acid and contents flow back and irritate the food pipe).
Zollinger-Ellison SyndromeOmeprazole is used in the treatment of Zollinger-Ellison syndrome (a condition where the tumor in the upper part of the small intestine will produce the excess amount of acid in the stomach.)
Duodenal UlcerOmeprazole is used in the treatment of Duodenal ulcer (a condition with open sores on the lining of the small intestine).
Helicobacter Pylori InfectionOmeprazole is used in the treatment of H.Pylori infection which is a most common cause of peptic ulcer caused by bacteria called Helicobacter pylori.
Erosive EsophagitisOmeprazole is used in the treatment of Erosive Esophagitis which is an inflammation of the food pipe (Esophagus).
How long is the duration of effect?This medicine is excreted primarily in urine and the effect of this medicine lasts for a duration of 72 hours.
What is the onset of action?The peak effect of this medicine can be observed within 1 to 2 hours of administration.
Are there any pregnancy warnings?This medicine can be used during pregnancy only if the benefits outweigh the risks.
Is it habit forming?No habit forming tendency has been reported.
Are there any breast-feeding warnings?This medicine is not recommended for breastfeeding women.
Missed Dose instructionsTake the missed dose as soon as possible. If it is almost time for the next dose, skip the dose and follow the regular schedule.
Overdose instructionsSeek emergency medical treatment or contact the doctor in case of an overdose.
Below is the list of medicines, which contains Omeprazole as ingredient
This medicine belongs to the class of proton pump inhibitor drug and binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
OsteoporosisThe risk of bone fractures is more if you are on high doses and long-term therapy. Use with caution if you are at risk of developing bone fractures and lower doses for a short duration of time should be considered.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Food
Interaction with Medicine
KetoconazoleThe desired effect of Ketoconazole and other antifungal agents of the same class will not be achieved when taken with Omeprazole. Inform the doctor about the usage of either of these medications so that safer alternatives can be prescribed.
MethotrexateIt is not recommended to take Omeprazole with methotrexate. This combination will increase the concentration of methotrexate in the blood and can produce serious side effects. Inform the doctor if you are taking these medicines simultaneously. An alternate medicine should be considered based on your clinical condition.
WarfarinOmeprazole should be used with caution in you are also taking warfarin. If co-administration is needed, then regular monitoring of prothrombin time, unusual bleeding, the presence of blood in urine is necessary. Appropriate dose adjustments are to be made under doctors supervision.
NelfinavirThe desired effect of anti-viral medications like Nelfinavir will not be obtained when taken with Omeprazole. Inform the doctor if you are taking these medicines simultaneously. An alternate medicine should be considered based on your clinical condition.
Ques: What is Omeprazole?
Ques: How long do I need to use Omeprazole before I see improvement in my condition?
Ques: At what frequency do I need to use Omeprazole?
Ques: Should I use Omeprazole empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Omeprazole?
Ques: Is there any allergy warning regarding Omeprazole?
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