Granexa 1Mg Tablet

Granexa 1Mg Tablet is used as the prophylaxis and treatment of chemotherapy-related emesis; may be prescribed for patients who are refractory to or have severe adverse reactions to standard antiemetic therapy.

This medicine may be prescribed for young patients (ie, <45 years of age who are more likely to develop extrapyramidal reactions to high-dose metoclopramide) who are to receive highly emetogenic chemotherapeutic agents.

Granexa 1Mg Tablet should not be prescribed for chemotherapeutic agents with a low emetogenic potential (eg, bleomycin, busulfan, cyclophosphamide <1000 mg, etoposide, 5-fluorouracil, vinblastine, vincristine).

Granexa 1Mg Tablet, a 5-HT3 receptor antagonist, is used for preventing vomiting and nausea caused by cancer chemotherapy. It works by blocking serotonin in the body that can cause vomiting.

Do not use Granexa 1Mg Tablet if you are allergic to it or if you are taking apomorphine. Some medical conditions that may interfere with the action of this medicine are heart problems, blood electrolyte problems, an abnormal electrocardiogram and stomach or bowel problems.

Common side effects of this medicine are anxiety, constipation, trouble sleeping, diarrhoea, headache, dizziness, drowsiness, nausea, vomiting and weakness. Some serious side effects include severe allergic reactions, fast or irregular heartbeat, chest pain, fainting, fever, chills, stomach pain or swelling, sore throat, severe or persistent skin irritation and unusual muscle movement.

This drug is taken orally before 24 hours of a surgery or chemotherapy. It can also be taken into a vein as directed by your doctor, usually 30 minutes before cancer chemotherapy or surgery. The drug may be directly administered into a vein in 30 seconds, or it may be mixed with IV fluid and administered into a vein in 5 minutes.

This drug will be administered on days when you receive chemotherapy to reduce nausea and vomiting. If outpatient chemotherapy, you may be given oral medication to take after return home; take as directed.

You may experience drowsiness; use caution when driving. For persistent acute headache request analgesic from prescriber. Frequent mouth care, chewing gum, or sucking on lozenges may relieve persistent nausea. Report unrelieved headache, fever, diarrhea, or constipation.

The most common use of this medication is:

• Nausea

• Vomiting

• Hypersensitivity

Below are some of the common side effects of this medicine:

• Headache

• Dizziness

• Insomnia

• Anxiety

• Constipation

• Abdominal Pain

• Diarrhoea

• Weakness

• Arrhythmia

• Agitation

• Hot Flashes

• Is It safe with alcohol?

  Interaction with alcohol is unknown. Please consult your doctor.

• Are there any pregnancy warnings?

  Granexa 1Mg Tablet is probably safe to use during pregnancy. Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

• Are there any breast-feeding warnings?

  Granexa 1Mg Tablet is probably safe to use during breastfeeding. Please consult your doctor.

• Is it safe to drive while on this medicine?

  There is no interaction between driving and consuming this drug. So dose alteration is not needed.

• Does this affect kidney function?

  There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.

• Does this affect liver function?

  Kinetic studies in patients with hepatic impairment showed that total clearance was approximately halved, however, standard doses were very well tolerated. Please consult doctor before consuming the drug.

• How long is the duration of effect?

  The effects generally last no more than 24 hours maximum.

• What is the onset of action?

  This medicine commonly controls emesis within 1-3 minutes of administration.

Below is the list of medicines, which have the same composition, strength and form as Granexa 1Mg Tablet , and hence can be used as its substitute.

• Graniforce 1Mg Tablet

  Mankind Pharma Ltd

• Grandem 1Mg Tablet

  Aristo Pharmaceuticals Pvt Ltd

• Cadigran 1Mg Tablet

  Cadila Pharmaceuticals Ltd

• Graniset 1Mg Tablet

  Sun Pharmaceutical Industries Ltd

• Are there any missed dose instructions?

  If you miss a dose of Granexa 1Mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Granexa 1Mg Tablet is an antiemetic agent working as a selective antagonist of 5-HT3 serotonin receptors centrally as well as peripherally. Inhibition of 5-HT3 receptors directly as well as indirectly inhibits the visceral stimulation of the vomiting center in turn.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

• Interaction with Medicine

  Concomitant use of Granexa 1Mg Tablet along with bleomycin, busulfan, cyclophosphamide <1000 mg, etoposide, 5-fluorouracil, vinblastine, vincristine must be avoided.

• Interaction with Disease

  Use with caution in patients with liver disease or in pregnant patients.