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Efavirenz

Prescription vs.OTC: Prescription by Doctor required

Efavirenz is an antiretroviral medication, used for HIV prevention and treatment. Efavirenz belongs to non-nucleoside reverse transcriptase inhibitors (NNRTIs) class of drugs. Efavirenz is prescribed to adults and children that are at least 3 months old.

Tell your doctor before he subscribes you this medicine:

  • If you have any known allergies
  • If you are allergic to Efavirenz or if you have any other known allergies
  • Have a heart condition
  • If you are pregnant, or are planning to become pregnant
  • Have a history of seizures
  • Have a prescription for boceprevir or carbamazepine
  • If you have used or are using street drugs
  • If you consume a lot of alcohol
  • If you have had liver problems, especially hepatitis B

Common side effects of this medicine include rash, nausea, headache, feeling tired, and trouble sleeping. Other side effects include fatigue, headache, vomiting, and anorexia, dizziness and lack of concentration. In case you notice any serious effects after consuming this medicine such as depression, blood in the urine, difficult or painful urination, pain in the lower back or side, thoughts of suicide, liver problems or seizures, then seek immediate medical attention.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a HIV Specialist before using this medicine.

hiv infection

In addition to its intended effect, Efavirenz may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Rash

Headache

Decrease in granulocyte count

Insomnia (difficulty in sleeping)

Abnormal dreams

Increased liver enzymes

Difficulty in paying attention

Increased triglyceride level in blood.

Is It safe with alcohol?

Taking Efavirenz with alcohol may cause liver problems.

Are there any pregnancy warnings?

Efavir 200mg capsule is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.

Are there any breast-feeding warnings?

Efavir 200mg capsule is probably unsafe to use during breastfeeding. Please consult your doctor.

Is it safe to drive while on this medicine?

Should avoid potentially hazardous tasks such as driving or operating machinery.

Does this affect kidney function?

There is no interaction between renal impairment and consuming this drug. So dose alteration is not needed.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.
Below is the list of medicines, which contains Efavirenz as ingredient
Veritaz Healthcare Ltd
Cipla Ltd
Hetero Drugs Ltd
Sun Pharmaceutical Industries Ltd
Sun Pharmaceutical Industries Ltd
MSD Pharmaceuticals Pvt Ltd
Mylan Pharmaceuticals Pvt Ltd
Cipla Ltd
Alkem Laboratories Ltd
Veritaz Healthcare Ltd
Alkem Laboratories Ltd
Emcure Pharmaceuticals Ltd
Alkem Laboratories Ltd
Alkem Laboratories Ltd
Emcure Pharmaceuticals Ltd
Emcure Pharmaceuticals Ltd
Efavirenz is an antiretroviral drug, most commonly used to treat and prevent HIV/AIDS. The drug inhibits the reverse transcriptase enzyme, which is responsible for the transcription of viral RNA into DNA.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Medicine

Rantac 50Mg/2Ml Injection

Peptiran 75Mg/5Ml Syrup

Onabet Powder

What are you using Efavirenz for?
Other
HIV prevention and treatment
How much was the improvement?
Excellent
Average
Poor
How long did it take before seeing improvement?
More than 2 days
Within a day
Within 2 days
Within 6 hours
How frequently did you take this medicine?
Once a day
How did you take this medicine?
Empty stomach
With or without food
What were the side effects of this medicine?
Sleepiness
Insomnia
Headache
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Sir I am hiv positive .and my doctor gave me this tab. Efavirenz 600 mg / lamivudine 300 mg / tenofovir disoproxil fumarate 300 mg tablets ip. What thus it mean. What is the stage.

MBBS, DDV, FCPS, APEX, Diplomat American Board of Sexology
HIV Specialist, Mumbai
Sir I am hiv positive .and my doctor gave me this tab. Efavirenz 600 mg / lamivudine 300 mg / tenofovir disoproxil fu...
Stage can not be decided based on the treatment. You are given ART. It advisable to take a personal consultation. In the meanwhile take a private consult with audio video chat and then I can guide you properly.

I am on HIV medication. I am taking Forstavier 3. Can I take Viagra occasionally while I am on this medication?

MBBS, Physician, clinical management of HIV
HIV Specialist, Bangalore
I am on HIV medication.
I am taking Forstavier 3. Can I take Viagra occasionally while I am on this medication?
Occasionally yes, you can with low dose as there is a chance of reaction between efavirenz of forstavir 3, so take viagra in afternoon and forstavir 3 in the empty stomach at night.

What is the life time of HIV person. Please explain stage of HIV infected person based on given report TC: 9900 cells/cumm DC polymorph: 60% lymphocytes: 30% eosinophills: 08% HB: 70%(0.2grams) ESR: 21 mm/ 1hr HIV test (TRIDOT): positive HIV 1: positive HIV 2: negative.

MD-PhD, FIPS, Fellow of Academy of General Education (FAGE), DPM, MBBS
Psychiatrist, Bangalore
The aim of HIV treatment HIV is a virus that attacks the body?s defence against infection and illness ? the immune system. you can take drugs to reduce... Talk to your doctor Taking antiretroviral therapy is a long-term commitment. At present, once you start the drugs, you are likely to be on them for the rest of your life.... How anti-HIV drugs are dispensed You will get a prescription for your HIV treatment, when you attend your regular HIV clinic appointment, which you take to either the specialist HIV pharmacy (in... Generic medicines Pharmaceutical drugs are given several names: A research name based on its chemical make-up or manufacturer, e.g. DMP266. A generic name which is the chemical name of the... Types of antiretroviral drugs There are six main types (?classes?) of antiretroviral drugs: Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide reverse transcriptase inhibitors (NtRTIs), which target an HIV protein called reverse transcriptase. These are often... Single-tablet regimens There are now fixed-dose pills that combine three anti-HIV drugs, from more than one class of drug. These allow many people to take their HIV treatment in... Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs) Most people now take these drugs in a fixed-dose pill that combines a number of drugs. These combination pills are listed first and there are also separate... Integrase inhibitors Names: Dolutegravir, Tivicay Dose: One yellow 50mg tablet once a day. Dolutegravir should be taken twice a day if taken with efavirenz, nevirapine or tipranavir, or for HIV... Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Names: Efavirenz, Sustiva Approved dosage: Efavirenz is available as a generic drug, so its appearance will depend on which type your clinic buys. Efavirenz typically comes as 600mg... Protease inhibitors (PIs) Most protease inhibitors are prescribed with another drug (also a protease inhibitor) called ritonavir. Ritonavir is used to boost the effects of the other protease inhibitor in... CCR5 inhibitors Names: Maraviroc, Celsentri Approved dosage: The dose of maraviroc is dependent on the other anti-HIV drugs you take. Your HIV doctor or pharmacist will talk to you... Fusion inhibitors There is currently one drug in the fusion inhibitor class, called enfuvirtide (T-20, Fuzeon). This is now only prescribed in very rare and specific circumstances. Anyone on... Summary Combination HIV treatment prevents HIV from damaging your immune system, and so prevents ill health and prolongs...
19 people found this helpful

Is trioday tablet cipla is a pep medicine which we can use after 24 hrs of unprotected exposure my doctor recommended it for me. Please suggest me.

Doctor of Medicine, Diploma in Family Medicine, KING GEORGE'S MEDICAL UNIVERSITY.LUCKNOW
HIV Specialist, Ghaziabad
Is trioday tablet cipla is a pep medicine which we can use after 24 hrs of unprotected exposure my doctor recommended...
Hello. PEP is best taken within 24 hrs of an suspected exposure but upto 72 hrs of exposure is also recommended. The PEP should be taken for 4 weeks without break if no serious side effects.
2 people found this helpful

I have started ART after getting positive hiv test in March 18. Now 3 months continuously I am taking medicine Tenolam E Tablet for the last 3 months. Shall my viral load will be reduced till now. Initially my index value was 783 after the test. How long I take Tenolam E Tablet for this.

MBBS, PG Diploma (HIV Medicines)
HIV Specialist, Surat
I have started ART after getting positive hiv test in March 18. Now 3 months continuously I am taking medicine Tenola...
TENOLAM E tablet will last for whole life. Even your viral load is below detectable limit or not detected even then you must have to conrinue your mediccine
1 person found this helpful

Popular Health Tips

How is Hiv Treatment ?

MD - General Medicine
Sexologist, Delhi
How is Hiv  Treatment ?

Hiv treatment is done by antiviral drugs, there are a number of antiviral drugs available in the market, usually HIV is treated with a combination of drugs, usually two to three drugs are used in treating HIV in the initial stage, we can change the combination of drugs according to the requirement of the patient. Drugs can be adjusted or increased if there is the resistance of HIV in the patient.

There are a number of compounds (about 22 in number) which have been formally approved (by us food and drug administration) for the treatment of HIV infections (aids). According to their point of intervention with the HIV replicative cycle, these compounds can be classified into 5 categories: (1) nrtis (nucleoside reverse transcriptase inhibitors): azidothymidine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (2) ntrtis (nucleotide reverse transcriptase inhibitors): tenofovir, administered as its oral prodrug form tdf (tenofovir disoproxil fumarate); (3) nnrtis (non-nucleoside reverse transcriptase inhibitors): nevirapine, delavirdine and efavirenz; (4) pis (hiv protease inhibitors): saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir; and (5) fis (fusion inhibitors): enfuvirtide. Starting from the drugs which are currently available for the treatment of aids, numerous combinations could be envisaged. Drug combinations are, in principle, aimed at obtaining synergism between the compounds (reasonably expected if they act by different mechanisms), while reducing the likelihood of drug resistance development. Such anti-hiv drug combination regimes were initiated about 10 years ago and have been generally referred to as haart (for highly active antiretroviral therapy). While haart originally consisted of a pill burden of twenty (or more) pills per day, this has been gradually diminished over the past few years, and, since July 2006, an all-in-one pill (teevir from myelin and virotrenz from ranbaxy sun pharma) has become available, which contains three anti-hiv drugs (tenofovir disoproxil fumarate 300 mg, emtricitabine200mg and efavirenz 600 mg) to be taken as a single pill only once daily. Given the information that has been acquired for the therapeutic use (efficacy, safety) of tenofovir disoproxil fumarate over the past five years, it would now seem mandatory to further consider the prophylactic use of tdf [and its combination with emtricitabine (truvada) and/or atripla], as a single daily pill to prevent HIV infection. New combinations of drugs are also available which include tenofovir 300 mg lamivudine 150 mg which is very new drugs.


Now a days we can treat patients who had sex with some sex worker or any male transgender or some unknown person and during sexual intercourse condom gets bursted, we can treat them if they come to us within 72 hours of direct contact, these medicines are called post-exposure prophylaxis (pep) drugs for hiv or prophylactic treatment for hiv, by using these drugs we can treat a patient and we can stop transfusion of hiv virus to the person.

Pep involves taking anti hiv drugs as soon as possible after having been exposed to unprotected sex with some sex worker or transgender of with homosexual prep is a new hiv prevention method in which people who do not have hiv infection take pills of medicine daily to reduce the risk of becoming infected with hiv virus, pep should be taken within 72 hours of exposure to unprotected sex before the virus has time to rapidly duplicate in your body, pep consists of 2-3 antiretroviral drugs taken for 28 days.

3 people found this helpful

Hiv Treatment

MD - General Medicine
Sexologist, Delhi
Hiv Treatment

HIV treatment is done by antiviral drugs, there are number of antiviral drugs available in the market, usually HIV is treated with combination of drugs, usually two to three drugs are used in treating HIV in initial stage, we can change the combination of drugs according to requirement of the patient. Drugs can be adjusted or increased if there is resistance of HIV in the patient.

There are number of compounds (about 22 in number) which have been formally approved (by the US Food and Drug Administration) for the treatment of HIV infections (AIDS). According to their point of intervention with the HIV replicative cycle, these compounds can be classified in 5 categories: (1) NRTIs (nucleoside reverse transcriptase inhibitors): azidothymidine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (2) NtRTIs (nucleotide reverse transcriptase inhibitors): tenofovir, administered as its oral prodrug form TDF (tenofovir disoproxil fumarate); (3) NNRTIs (non-nucleoside reverse transcriptase inhibitors): nevirapine, delavirdine and efavirenz; (4) PIs (HIV protease inhibitors): saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir; and (5) FIs (fusion inhibitors): enfuvirtide. Starting from the drugs which are currently available for the treatment of AIDS, numerous combinations could be envisaged. Drug combinations are, in principle, aimed at obtaining synergism between the compounds (reasonably expected if they act by different mechanisms), while reducing the likelihood for drug resistance development. Such anti-HIV drug combination regimens were initiated about 10 years ago and have been generally referred to as HAART (for highly active antiretroviral therapy). While HAART originally consisted of a pill burden of twenty (or more) pills per day, this has been gradually diminished over the past few years, and, since July 2006, a all-in-one pill (teevir from myelin and virotrenz from Ranbaxy sun pharma) has become available, which contains three anti-HIV drugs (tenofovir disoproxil fumarate 300 mg, emtricitabine200mg and efavirenz 600 mg) to be taken as a single pill only once daily. Given the information that has been acquired on the therapeutic use (efficacy, safety) of tenofovir disoproxil fumarate over the past five years, it would now seem mandatory to further consider the prophylactic use of TDF [and its combination with emtricitabine (Truvada) and/or Atripla], as a single daily pill to prevent HIV infection. New combinations of drugs are also available which include tenofovir 300 mg lamivudine 150 mg which are very new drugs.


Now a days we can treat patients who had sex with some sex worker or any male transgender or some unknown person and during sexual intercourse condom gets bursted , we can treat them if they come to us within 72 hours of direct contact, these medicines are called POST-EXPOSURE PROPHYLAXIS (PEP) drugs for HIV or prophylactic treatment for HIV, by using these drugs we can treat a patient and we can stop transfusion of HIV virus to the person.

PEP involves taking anti HIV drugs as soon as possible after having been exposed to unprotected sex with some sex worker or transgender or with homosexual PrEP is a new HIV prevention method in which people who do not have HIV infection take pills of medicine daily to reduce the risk of becoming infected with HIV virus ,PEP should be taken within 72 hours of exposure to unprotected sex before the virus has time to rapidly duplicate in your body, PEP consists of 2-3 antiretroviral drugs taken for 28 days.

10 people found this helpful

Post Exposure Prophylaxix (PEP) In HIV

MBBS, D.P.H
General Physician, Gurgaon
Post Exposure Prophylaxix (PEP) In HIV

Pep is required for all persons invo5 in providing medical and surgical services 
No environmental transmission reported but pep is pep is required when they are exposed to -

 potentially infectious body fluid e. G. Blood, semen, vaginal secretions, synovial, pleural, pericardial, peritoneal fluid, amniotic fluid. Any bodu fluid contaminated with" visible blood" considered" at risk"
 exposure to body fluid considered" not at risk" e. G. Tears, sweat, urine, faeces, saliva, sputum and vomitus

Management of exp6 site
- do not panic 
- wash wound and surrounding with soap and water 
- rinse well
- do not scrub
- for not use antiseptic or skin washes
- splash of blood 
- irrigate eyes with water or saine
- if using contact lens leave them in place while irrigating. Remove the contact lens and clean them after eyes is cleaned 
- mouth: spit fluid immediately and rinse mouth thoroughly water/saline repeatedly 

Pep is required within 72 hours of exposure 
 conslt nearest art center for selection of pep regime e. G. 

1. Basic regime of 2 drug zidovudine 300 mg bd 

2 drug regime is recommended if third drug is required then use nelfinavir
 arv prophylaxix - short term arv drugs is used to reduce hiv transmission from mother to infant
- all hivexposed infants should receive cotrimoxazole at 4-6 weeks of age
 nevirapine prophylaxix 
- mother- nov 200 mg at onset of labour 
- baby- nvp syrup 2 mg / lg of body weight within 72 hours of delivery
 

2 people found this helpful

HIV - How It Affects Drug Resistance?

MBBS, MD - Dermatology
HIV Specialist, Mumbai
HIV - How It Affects Drug Resistance?

HIV infection is the causative factor of the acquired immune deficiency syndrome (AIDS). Worldwide research is being conducted and treatment strategies are being formulated to combat this fatal disease. Fighting HIV is not an easy task, since the disease cannot be completely reversed. However, worldwide use of anti-retroviral therapy has helped in controlling the spread and transmission of disease. Use of medications, regular screening and close contact with caregivers and physicians is necessary for proper management of the disease. Despite, available treatment options, a difficult obstacle that arises before or during the treatment is drug resistance.

Drugs are aimed at targeting the disease-causing pathogens like bacteria and viruses. These pathogens, over a period of time, develop the ability to acquire resistance against the targeted drugs. The pathogens continue multiplying despite the presence of the drug in the system. In today’s scenario, the potent drug combination of anti-retroviral therapy (ARV) has been successful in remarkably reducing HIV-related mortality. However, an increased emergence of resistance to the drug therapy is concerning.

Amongst the various drug classes available in the ARV, no drug is resistance-proof. The drugs belonging to the same class have a similar mechanism of action against the virus. So resistance developed against a particular class of drug inevitably leads to resistance against all the other drugs belonging to that class. An individual with HIV infection may have one or more drug-resistant mutations, which makes the person less sensitive to one or more anti-retroviral drugs. When the replication of virus in the system is not suppressed fully, a resistance towards it develops.

Non-compliance of the ARV results in resistance. Resistant viruses can spread the infection and affect ARV therapy. Drug resistance is usually attributed to inadequate adherence to the regimen. But in some cases, strict adherence to the drug is seen, yet there is a presence of resistance due to poor absorption. This implies that since the drug is not getting adequately absorbed in the body, it is unable to prevent the replication thus leading to drug resistance.

Anti-retroviral treatment is aimed at limiting the replication of HIV in the body. Various drug classes target different steps of replication, which stops further replicating and infecting of the cells. The nucleo-capsid contains viral genome and three enzymes vital to HIV life cycle:

  • Reverse transcriptase - Transcribes viral RNA genome into complementary deoxyribonucleic acid (DNA)
  • Integrase - Facilitates incorporation of pro-viral DNA into host cell genome
  • Protease - Cleaves viral polypeptide into individual functional enzymes

Drugs targeted on these steps are as follows

  • Nucleoside and non-nucleoside reverse transcriptase inhibitors like Nevirapine and Efavirenz act on the reverse transcriptase enzyme.
  • Integrase inhibitor Raltegravir acts on the Integrase enzyme.
  • Protease inhibitors like Ritonavir, Indinavir, Saquinavir act on the Protease enzyme.
  • Fusion inhibitor Enfuvirtide acts to prevent fusion of HIV with cell membranes.
  • CCR5 inhibitor Maraviroc block the CCR5 co-receptor.
  • A viral mutation occurring at any stage of this process can affect the efficacy of the drug therapy.

The emergence of drug resistance can be managed by evaluation of drug absorption and ensure strict adherence to the drug schedule. Genotype tests can be done to look for drug-resistant mutations in genes. Phenotype tests are done for measuring the ability of a virus in an individual to undergo replication in different drug concentrations. A successfully administered and effectively acted first-line drug treatment, preferably a 3-drug combination, reduces the chances of drug resistance in future.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2472 people found this helpful
Table of Content
About Efavirenz
When is Efavirenz prescribed?
What are the side effects of Efavirenz ?
Key highlights of Efavirenz
Medicines containing Efavirenz
How does medicine works?
What are the interactions for Efavirenz ?