My grandmother has breast cancer. The biopsy result is'Invasive duct carcinoma grade 2' And her PET-CT scan result is'Hypermetabolic retroareolar right breast mass FDG avid regional lymph nodes. No FDG avid distant lesions. Her-2 result is negative. ER and PgR result is positive 90%? Strong. Doctor told that tumor is locally advanced. We have started her treatment and doctor suggested below plan - 1- 11 chemotherapy once in a week 5 chemo are already done. Doctor told that if she can't tolerate chemo then we can stop before 11. The reason doctor gave behind chemo treatment is to shrink a tumor and tumor is stick to skin so chemo will make it loose. 2- Surgery 3- 5 chemotherapy every 21 days of interval 4- Radiation 5- Hormonal treatment for 5 years My grandma is physically fit and she doesn't have BP and diabetics and any other health issues except acidity. Last week my grandma fell down and her x-ray report is'Diffuse osteopenia. Anterior wedging of L1, L2 & L3 vertebra, could represent osteoporosis collapse. She has severe pain in the back. Recently I have taken a 2nd opinion and the doctor suggested that she doesn't need chemotherapy as her ER test is positive. She told that only hormones tablet will help to shrink a tumor and she may not need surgery. She told if we give chemo to her at the age of 75, it may create health problems for her later. I'm in dilemma now. Shall we continue with chemo treatment or switch to hormone treatment? If yes then what about its side effects? If we switch to hormone treatment then the chemo which is given will create any problem? Will it be right to switch to hormone treatment after 5 chemo cycle? What are the chances of metastasis in hormone treatment? What if we have to switch to chemo again after hormone treatment? Will cancer cell become drug resistant because of first chemotherapy? Chemo drugs go in an entire body so if there are any cancer cells in initial stage then it will kill it so chances of metastasis will be less. Is it true? Does hormone treatment also help to prevent metastasis? Let me know if you need more details.