I have been suffering from generalized anxiety disorder from the age of 14 since 2002. My father suffered a heart attack and was admitted to icu. I was in a movie theatre watching a movie and was brought to hospital to see him. That incident triggered my anxiety disorder. The burning sensation / butterflies in the stomach will not go away. That makes my mood worse and impair cognitive functions. Studies and exams became nightmare for me due to this problem. I was treated by a clinical psychologist initially. He trained me progressive muscle relaxation and guided imagery. I did that with some success but my problem worsened and another clinical psychologist trained me deep relaxation with jpmr and diaphragmatic breathing. But my problem never went away and I continued with my studies somehow. Completed 12th and joined b.tech. But I could not pass b.tech papers. The doctor I was seeing was against psychiatric medications and my parents were also not interested in that. In 2011 due to some personal issues my problem worsened and I decided to see a psychiatrist. He prescribed me escitalopram and when it started working I saw a huge improvement. I cleared all my back papers. Then I joined a job and I did pg in mechanical engineering. When I tried to stop medication, the problems came back with a vengeance also the same medicine will not work. Doctors tried different medicines to find the one that works. Also psychiatrists did not advise any psychological therapy. escitalopram worked again and I felt better again. I got married and was leading a good family life. But the medicine stops working sometimes and I am helpless when they do and the symptoms return. Psychiatrists have tried ssri like escitalopram, sertraline, fluoxetine, fluvoxamine, snris like venlafaxine, desvenlafaxine, duloxetine, then other meds like benzodiazepines, buspirone, propranolol, quetiapine, amisurplide etc. I tried even ketamine infusion and that made me feel worse. The only medicines that worked for me are escitalopram and duloxetine. But in those duloxetine stops working very soon and escitalopram stops working in 2-3 years. Now I am in a situation where escitalopram has stopped working. Is there any way to make it work again or any better medicines out there? I have heard stories of people who are on antidepressants on for a very long time. But I am not able to go past 3 year with relapse. I need serious help to live without this problem affecting my life. What should I do to go on antidepressants for a long time with out relapse? I have not tried therapies like cbt, mindfulness, act etc will I be able to manage my problem with psychological interventions like those? All my bad feelings come from my gut area. Is there any underlying biological reason for my disorder? I am willing to spend all my money to recover from this problem. I am inviting suggestions from all the experts in Lybrate who could help me recover from this debilitating problem.