An inherited disorder in which prolonged secretion(or overproduction) of aldosterone by ACTH takes place is known as Glucocorticoid-remediable Aldosteronism. Another name for this condition is aldosterone synthase hyperactivity. Although no specific symptoms are noticed in the affected person, there are several conditions which can be linked with it, like- fatigue, headache, high blood pressure, intermittent or temporary paralysis, muscle spasms, muscle weakness and numbness. Conditions like Conn's syndrome or over activity of both the adrenal glands can lead to Glucocorticoid-remediable Aldosteronism. In order to treat GRA, Dexamethasone, spironolactone and eplerenone can be applied.
HOW IS GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM DIAGNOSED?