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I am a 62-year-old male. I am suffering from Polycythemia Rubra Vera (due to JAK 2 mutation) for last 8 years. First 3 years I was put on treatment with low level of aspirin, amlodipine and periodic venesection. Last 5 years I am on Hydroxyurea along with the above mentioned drugs. The dose of hydroxyurea is adjusted periodically based on FBC. My questions are: 1. What are the adverse effects of long term treatment with Hydroxyurea? 2. I get occasional muscle cramp. How do I get relief from it? I would like to know 1. What is the adverse drug effect of long term intake of Hydroxyurea. 2. I suffer from painful muscle cramp occasionally. What I should do to get relief from it?


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