Hi, my father had a heart surgery before 8 yrs! In heart he has a stent to avoid sinkage problem! He was advised to take CLAVIX 75 MG, PLEOPIL 40 MG, TENORMIN 50 MG ,HO PIRM 5 MG and he had take these table for past 6 years and he was normal and brisk. Then 6 months he was advised to take ATORFIT CV 20/75 mg instead of CLAVIX 75 MG and PLEOPIL 40 MG .after this changes he had many problems like ESR had rises to 30-65, serum antinuclear antibody (IF method) is positive+ (normal indirect immunofluorescence method) ,and become very tired. Is there any problem on taking thz ATORFIT CV 20/75 mg. I need further solution to avoid these problem to make him normal as usual.