The Rubella infection occur after 15 week of pregnancy. If Foetus not infected then rubella IgM TITRE increases or decreases? How many days after Rubella IgM TITRE diminished? If Foetus infected then rubella IgM TITRE increases or decreases? How many days after Rubella IgM TITRE diminished? Pls give answer of above questions separately.
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Fetal infection is acquired hematogenously, and the rate of transmission varies with the gestational age at which maternal infection occurs. After infecting the placenta, the rubella virus spreads through the vascular system of the developing fetus, causing cytopathic damage to blood vessels and ischemia in developing organs.16 When maternal infection/exposure occurs in the first trimester, fetal infection rates are near 80%, dropping to 25% in the late second trimester and increasing again in the third trimester from 35% at 27?30 weeks? gestation to nearly 100% beyond 36 weeks? gestation. The risk of congenital defects has been reported to be 90% when maternal infection occurs before 11 weeks of gestation, 33% at 11?12 weeks, 11% at 13?14 weeks, 24% at 15?16 weeks, and 0% after 16 weeks.7 Therefore, the risk of congenital defects after maternal infection is essentially limited to the first 16 weeks of gestation. Little, if any, risk of CRS is associated with infection beyond 20 weeks, and FGR seems to be the only sequela of third trimester infection
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