Get Dettol Kit worth Rs. 130 for just Rs. 4
Common Specialities
{{speciality.keyWord}}
Common Issues
{{issue.keyWord}}
Common Treatments
{{treatment.keyWord}}

Infliximab

Prescription vs.OTC: Prescription by Doctor required

Infliximab is administered to reduce inflammation in the body. It is an effective medicine which is prescribed when most other drugs fail to provide relief. It is known to treat rheumatoid arthritis, Crohn’s disease, ulcerative colitis and certain types of spondylitis. This potent drug is also used to treat advanced stages of plaque psoriasis.

The Infliximab drug is known to cause some fatal side effects. This includes the abnormal lowering of white blood cells in the body causing a major threat to the immunity system. This may often give rise to deadly infections and even certain types of cancer such as the rapidly spreading lethal lymphoma. People suffering from autoimmune diseases are at a higher risk of developing lymphoma that involves complete destruction of protective white blood cells in the body. The drug cannot be administered to a child below 6 or 7 years of age. The drug is also known to affect the blood clotting mechanisms and thus make the patient prone to easy bleeding and bruising.

The drug is injected intravenously and the body vitals are monitored closely to detect early signs of any adverse side effects. The medicine is not recommended for pregnant women or breastfeeding mothers.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Internal Medicine Specialist before using this medicine.

In addition to its intended effect, Infliximab may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Headache

Sinus inflammation

Upper respiratory tract infection

Infusion reaction

Is It safe with alcohol?

Interaction with alcohol is unknown. Please consult your doctor.

Are there any pregnancy warnings?

Infimab 100mg injection is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Are there any breast-feeding warnings?

Unknown. Human and animal studies are not available. Please consult your doctor.

Is it safe to drive while on this medicine?

Flixabi may have a minor influence on the ability to drive and use machines.

Does this affect kidney function?

There is no data available. Please consult doctor before consuming the drug.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.

Are there any missed dose instructions?

If you miss a dose of Infliximab, please consult your doctor.
Below is the list of medicines, which contains Infliximab as ingredient
Janssen Pharmaceuticals
Sun Pharmaceutical Industries Ltd
Infliximab is an IgG1κ monoclonal antibody acting as immunosuppressant and anti-cancer agent. It binds to TNF-α with high affinity to inhibit pro-inflammatory signaling pathways. It also reduces formation of tissue degrading enzymes responsible for joint erosions arthritis and allows healing of damaged joints.
What are you using Infliximab for?
Ulcerative Colitis
Ankylosing Spondylitis
Crohn's Disease
How much was the improvement?
Excellent
How long did it take before seeing improvement?
Within 2 hours
How frequently did you take this medicine?
Once a day
How did you take this medicine?
With Food
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I'm suffering from joint pains like knee elbow arms fingers soldiers ankle n back. I'm female aged about 38 years my weight is 50 kgs. please give me good advice.

M.B.S.(HOMEO), MD - Homeopathy
Homeopath, Visakhapatnam
I'm suffering from joint pains like knee elbow arms fingers soldiers ankle n back. I'm female aged about 38 years my ...
Arthritis is a general term for numerous conditions that affect bone joints; scientists do not know exactly what cause arthritis. Some think the disease is genetic-something that is inherited from your parents. Other think arthritis is caused by infection, obesity, bone damage, or another disease. Regardless of the cause or type of arthritis, people with arthritis experience chronic pain and swelling in their joints. Symptoms associated with arthritis Mainly stiffness, redness, swelling, limitation of movements, may also associated with fever, weight loss, carditis in specific medical conditions of arthritis. Treatment of arthritis Drug treatment – includes Anti-Inflammatory agents, ranging from mild and familiar oral medication, such as aspirin, to powerful new medications, such as etanercept and infliximab. Immunosuppressive medicines (drugs that inhibit the immune system) may be prescribed in rheumatoid arthritis, especially when the activity of disease is moderate or severe. Some important remedies are given below for the homeopathic treatment of arthritis: Bryonia Alba. – Pain with inflammation which, is aggravated by movement and relieved by moderate pressure and rest. Ledum pal. – Excellent remedy for gout and rheumatism which is of ascending nature, better by cold application. Rhus Tox. – Pain aggravated by first movement, damp weather and better by continuous motion.
1 person found this helpful

I am 62 years male, have psoriasis only on both hands mainly on sides n undersides of fingers for past 1 year. Small cracks form n heal in a day or two. Hv bn applying skin creams n sorifix cream. Need help.

PDDM, MHA, MBBS
General Physician, Nashik
I am 62 years male, have psoriasis only on both hands mainly on sides n undersides of fingers for past 1 year. Small ...
Psoriasis is an inflammatory skin disease characterised by well defined erythematous scaly plaques with silvery white or candle wax type of scaling. Chronic plaque psoriasis is the most common type. It can affect sites like scalp, arms, and legs, (specifically elbows and knees), palms and soles etc. Other types of psoriasis are: Erythrodermic psoriasis, Pustular psoriasis (generalised and localised), Nail psoriasis and Scalp psoriasis. There are various precipitating factors for psoriasis: Infections (sore throat, dental infections etc), drugs (b-blockers used for hypertension), pregnancy, winters (psoriasis becomes worse in winters), stress, alcohol intake and cigarette smoking, topical irritants like coal tar, salicylic acid and withdrawal of oral/ topical steroids etc. The disease has a chronic course and there topical creams/ointments/gels/lotions etc as well as oral and injectable medicines which can treat psoriasis but there is no permanent cure for psoriasis. For limited disease involving < 20% of BSA, Topical treatment alone suffices: -Moisturisers specially those which contain hygroscopic (attract water from the atmosphere and lock it into the skin) and keratoloytic agents like Ammonium lactate (Amylac cream), Urea, Lactic acid etc are especially useful in dry scaly conditions like psoriasis. -For the patches you could use a steroid+salicylic acid ointment, twice daily (clobetasol+3% OR 6% salicylic acid in an ointment base e.g propysalic NF Ointment) over and above the moisturiser for 4 weeks. -Other treatment modalities which can be used for localized plaque psoriasis are: Vitamin D analogues like calcipotriol, calcipotriene alone or in combination with steroid. For extensive psoriasis (involving more than 20% of BSA) oral as well as topical treatment is combined together: -Once weekly oral methotrexate is another option in case of plaque psoriasis but it should always be taken under the supervision of a dermatologist since it can rarely cause serious side effects like bone marrow suppression. -Oral cyclosporine is given for extensive psoriasis involving more than 20% of the body surface area. It is rapidly effective but it requires monitoring of kidney functions and BP. Other commonly used oral treatment modalities are: -Oral Psoralens e.g 8-methoxypsoralen and UV A phototherapy (PUVA) -Narrow-Band phototharapy (NB-UVB) -Biologics response modifiers (Etanercept, Infliximab, Adalimumab etc) To summarize, in limited psoriasis only topical agents are used, whereas if the disease involves >20% body surface area, it is better to combine both topical and oral therapies. I would suggest that you see a dermatologist and have a fair discussion regarding the most appropriate treatment modalities for you.
2 people found this helpful

I have a 10 years history of arthritis, 1 year ago my hip joint flexibility was almost null, now after taking infliximab 5 dose this year it is 30% but not improving much also after taking regular physiotherapy. Is operation my only choice now?

DM - Rheumatology, MD - General Medicine
Rheumatologist, Mumbai
I have a 10 years history of arthritis, 1 year ago my hip joint flexibility was almost null, now after taking inflixi...
It all depends on how bad is your hip. If your hip is irreparably damages, infliximab will not help. Infliximab will only help to reduce the swelling and associated pain, damage already done cannot be reversed, if pain is persistent then operation is the only option. Consult your doctor.

I am unmarried lady of 39 years old suffering from ankylosing spondylitis since 2013. Doctor has told me to take" infliximab" injection coz that is the only option left for me but I want to go to south and consult with doctors out there. So, please suggest me what shall I do.

Diploma in Acupuncture, Pranic Healing, MD - Acupuncture
Acupuncturist, Bangalore
Initially try this. Give pressure the dipping point on the portion between the thumb and the index finger on the back of the palm. Press and release for 15 times where the pain is more. This will solve the problem. Further do some wrist rotation exercise. Consult after 5 days. For further guidance and treatment.

My daughter is 26. She has crohn' s disease for last 8 yrs. She took infliximab last year 3 doses & is quite fit now. She continues medicines like pentasa & azoran. She is married for last 2. 5 yrs. Can she concieve a healthy baby? Please advise.

MD DGO, Laparoscopic Surgery
Gynaecologist, Mumbai
Integrative medicine is possibly the only real solution for conditions like crohn' s. It will help her get off her medications, return to health, and conceive safely.
1 person found this helpful

Popular Health Tips

Spondyloarthritis

MD
General Physician, Secunderabad
Spondyloarthritis

Spondyloarthritis (also known as spondyloarthropathy) is the term which describes the connective tissue diseases. It is the group of inflammatory diseases, including arthritis of the peripheral joints and spine (sacroiliitis or spondylitis); including the area where ligaments and tendons attach to bones (enthesitis or enthesopathy). These diseases cause pain or stiffness in the leg or arm joints, spine, ligaments and tendons become inflamed. Skin rashes, eye, and intestinal problems may also be able to occur.

Epidemiology

  • Spondyloarthritis is a pathology that specifically strikes young people. The symptoms most frequently start before the age of 45. It affects more males than females.
  • Predisposition to spondyloarthritis, especially spa, is determined largely by genetic factors.
  • The incidence rate is higher in populations with a higher prevalence of hla-b27.
  • Psoriatic skin lesions and colitis due to inflammatory bowel disease (ibd) have been considered as both basic, subtype-defining entities with their own genetic background (distinct from hla-b27 genotype), and as manifestations of spondyloarthritis.
  • There is a strong need to diagnose patients with spa in an earlier stage; currently, there is a delay of 5–10 years between onset of the first symptoms and diagnosis.

Types

There are five types of spondyloarthritis

Ankylosing spondylitis or bechterew disease: it is the type of arthritis that affects the spine. Symptoms include pain and stiffness in the lower back and in the neck. Spine bones fuse together and it will become rigid spine and it leads to stoope over posture.

Psoriatic arthritis: psoriatic arthritis is the form of arthritis that affects the people who have psoriasis. Most people diagnosed with psoriasis and later diagnosed with psoriatic arthritis. It may affect any part of the body such as fingertips and spine. The main symptoms are joint pain, stiffness, and swelling.

Psoriatic arthritis

Reactive arthritis: it occurs due to the infection by certain bacteria. Often the bacteria’s from genitals (chlamydia trachomatis) or bowel (campylobacter, salmonella, shigella, and yersinia). It usually targets your knees and joints of ankles or feet.

Reactive arthritis

Undifferentiated arthritis: undifferentiated inflammatory arthritis does not conform to any of the recognized inflammatory arthritis types. It may include monoarthritis of a single joint; oligoarthritis, which is usually when four or fewer joints are involved; or polyarthritis, which usually involves many small joints.

Risk factors

Risk factors may be higher due to following reasons:

  • Family member having the gene which causes spondyloarthritis
  • Positive results for the hla-b27 gene
  • Recurring bacterial infection in your gut
  • Have other inflammatory conditions such as psoriasis or inflammatory bowel disease

Causes

  • The main cause is not known, but researchers pointed out that the hereditary genetics playing an important role in this disease. Since this disease occurs often in family members of patients who have spondyloarthritis.
  • Many genes cause it. Up to 30 genes have been found. But the major gene that causes spondyloarthritis is hla-b27.
  • Bacterial infections can also cause reactive spondyloarthritis known to be triggered by a bacteria chlamydia or food borne infections.

Symptoms and complications of spondyloarthritis

The first and major symptoms of all types of spondyloarthritis are severe low back pain, swelling of arms, stiffness, and fatigue. The different types of spondyloarthritis can be manifested by the following signs and symptoms.

  • Alternative or unilateral buttock pain
  • Arthritis in small joints
  • Arthritis in large joints such as knee joint, ankle joint and elbow joint (peripheral arthritis)
  • Numbness and tingling sensation in arms and legs
  • Spinal fusion may occur in ankylosing spondylitis
  • Inflammation at the interfaces between bone and tendon or ligament of limbs (enthesitis)
  • Inflammation of intestine, urinary tract and aortic heart valves. These can lead to spinal joints inflammation.
  • Inflammation of joints in pelvis and spine (sacroiliitis)
  • Enteropathic arthritis shows symptoms such as diarrhea and abdominal pain
  • Digestive problems
  • Skin disease like psoriasis
  • Osteoporosis
  • Redness of eye (iritis)
  • Swollen fingers and
  • Pain in the heels cause difficult to walk, stand even for small duration

Diagnosis and testing

First a doctor may ask for patient’s medical history, physical exam and may suspects for symptoms of spondyloarthritis. To confirm doctor may perform the following diagnosis and tests.

  • X-rays: x-ray images shows the change of the sacroiliac joints in the pelvis and fusion of spine. If these changes not observed, but symptoms shows spondyloarthritis doctor will suggest mri scan. Mri shows these changes more promptly than the x-ray.
  • Mri scans: it can show a very clear image of enthesitis and also the changes of sacroiliac joints.
  • Ct scans: ct also used for the imaging of bone joints.
  • Hla-b27: most patients with spondyloarthritis have hla-b27 gene, but some people don’t have this gene. So it is necessary to go for a hla-b27 test if the symptoms suspects spondyloarthritis.
  • Complete blood count (cbc): cbc can be useful to find the inflammation.
  • Musculoskeletal ultrasound scanning: ultrasound imaging uses sound waves to produce the images of inflammatory conditions of muscles, ligaments, and tendons.
  • Dual-energy x-ray absorptiometry (dexa) scans: used for measuring the bone mineral density usually the bones of the lower spine and hips. Bone loss is measured through this technique.

Treatment of spondyloarthritis.

  • There is no way to cure this disease condition, but there are treatments to counterparts the symptoms.
  • Nonsteroidal anti-inflammatory drugs: certain nsaid’s like naproxen, ibuprofen, meloxicam, or indomethacin are prescribed by doctors to relief from the pain due to symptoms.
  • Corticosteroid medication: inflammation around the tendons and in the joints can be overcome by taking some corticosteroid drugs. This helps to reduce the swelling in the joints.
  • Antibiotics: antibiotics can be used in the case of reactive spondyloarthritis in which bacteria cause the major problems.
  • Disease-modifying antirheumatic drugs (dmard’s): sulfasalazine (azulfidine) and methotrexate are the best dmard’s to be used for the joint damages in limbs affected by arthritis.
  • Tumor necrosis alpha (tnf-alpha) blockers: fda approved tnab are adalimumab (humira), adalimumab-atto (amjevita), a biosimilar to humira, certolizumab pegol (cimzia), etanercept (enbrel), etanercept-szzs (ereizi), a biosimilar to enbrel, golimumab (simponi), infliximab (remicade), infliximab-dyyb (inflectra), a biosimilar to remicade, and secukinimab (cosentyx). These are biosimilars used to treat arthritis in spine joints.
  • Surgery: patients with over inflammation of pelvis joints needs hip replacement. In the case of heavy damage in the cartilage of joints needs surgery to repair. In some rare cases, spinal surgery also needed.

Prevention and control measures

  • Prevention from spondyloarthritis needed some lifestyle changes as follows.
  • Quit smoking: smoking speeds up the spinal fusion in addition to other bad health effects.
  • Follow good posture: practicing a proper sitting and posture makes your spine to escape from growing into slumped-over position and strain.
  • Daily physical exercise: frequent home exercise and physiotherapy is essential to reduce the stiffening of spine and other joint problems. It also helps to have your heart healthy.
  • Good diet: follow the diets that are rich in calcium. Dairy products are preferred foe calcium rich foods.
Psoriatic arthritis
4 people found this helpful

Uveitis - Do You Know It Can Increase The Risk Of Other Diseases?

MBBS, MS - Ophthalmology
Ophthalmologist, Ghaziabad
Uveitis - Do You Know It Can Increase The Risk Of Other Diseases?

Uveitis is a set of inflammatory diseases that results in the swelling and damaging of the eye tissue. It can lead to temporary or permanent loss of vision. This disease often affects a part of the eye called the uvea, from which it has derived its name. It can affect people of all ages and can last from a short to long period of time. Ophthalmologists categorize uveitis into four major parts posterior uveitis, anterior uveitis, panuveitis uveitis and intermediate uveitis. This disease can be infectious or noninfectious, depending on the nature of the infection.

What causes uveitis and what are the major risk factors?
This disease is caused by the eye's inflammatory response and is caused by a series of potential factors such as the following:

  • Immune system attack from the body
  • Eye bruises
  • Eye infection or tumor within the eye
  • Foreign toxins that penetrate the eye

What are the diseases associated with uveitis?
Uveitis is associated with a range of diseases such as multiple sclerosis, Behcet's syndrome, Vogt-Koyanagi-Harada's (VKH) disease, psoriasis, herpes zoster infection, tuberculosis, rheumatoid arthritis, ulcerative colitis, toxoplasmosis, and cytomegalovirus (CMV) retinitis.

What are the typical symptoms of uveitis?
One or both eyes can be affected by uveitis. Some of the common symptoms include pain in the eye, light sensitivity and blurred and dark spots in vision. Moreover, the symptoms might vary from person to person and greatly depends on the type of inflammation. The symptoms also vary according to the type of uveitis.

What is the detection process?
The process of detection starts with a patient's medical history followed by several medical tests to rule out autoimmune disorders. This is followed by an evaluation of the central nervous system to rule out multiple sclerosis. Some of the other tests conducted by ophthalmologists include measuring the ocular pressure, slit lamp exam, funduscopic exam and visual acuity test.

The primary aim of the treatment is to eradicate inflammation, restore vision, prevent tissue damage and reduce pain. The treatment plan depends on the type of uveitis a patient displays. Doctors often suggest a dose of corticosteroid eye drops to arrest the infection in and around the eye. Other treatment methods include the prescription of immunosuppressive agents.

Furthermore, a doctor may suggest steroidal medication in the form of an eye drop, pill or injection. It can also be surgically infused into the eye. Some other agents used for treatment are azathioprine, methotrexate and mycophenolate. Medications such as these require regular monitoring of the blood to check for any side effects. Doctors also suggest biologics such as infliximab, rituximab, and adalimumab. Most of these drugs have a specific target in the immune system.

In case you have a concern or query you can always consult an expert & get answers to your questions!

5045 people found this helpful

What Is Uveitis? How Can It Be Treated?

Super-Speciality Trained Ophthalmologists
Ophthalmologist, Delhi
What Is Uveitis? How Can It Be Treated?

Uveitis is a set of inflammatory diseases that results in the swelling and damaging of the eye tissue. It can lead to temporary or permanent loss of vision. This disease often affects a part of the eye called the uvea, from which it has derived its name. It can affect people of all ages and can last from a short to long period of time. Ophthalmologists categorize uveitis into four major parts posterior uveitis, anterior uveitis, panuveitis uveitis and intermediate uveitis. This disease can be infectious or noninfectious, depending on the nature of the infection.

What causes uveitis and what are the major risk factors?
This disease is caused by the eye's inflammatory response and is caused by a series of potential factors such as the following:

  • Immune system attack from the body
  • Eye bruises
  • Eye infection or tumor within the eye
  • Foreign toxins that penetrate the eye

What are the diseases associated with uveitis?
Uveitis is associated with a range of diseases such as multiple sclerosis, Behcet's syndrome, Vogt-Koyanagi-Harada's (VKH) disease, psoriasis, herpes zoster infection, tuberculosis, rheumatoid arthritis, ulcerative colitis, toxoplasmosis, and cytomegalovirus (CMV) retinitis.

What are the typical symptoms of uveitis?
One or both eyes can be affected by uveitis. Some of the common symptoms include pain in the eye, light sensitivity and blurred and dark spots in vision. Moreover, the symptoms might vary from person to person and greatly depends on the type of inflammation. The symptoms also vary according to the type of uveitis.

What is the detection process?
The process of detection starts with a patient's medical history followed by several medical tests to rule out autoimmune disorders. This is followed by an evaluation of the central nervous system to rule out multiple sclerosis. Some of the other tests conducted by ophthalmologists include measuring the ocular pressure, slit lamp exam, funduscopic exam and visual acuity test.

The primary aim of the treatment is to eradicate inflammation, restore vision, prevent tissue damage and reduce pain. The treatment plan depends on the type of uveitis a patient displays. Doctors often suggest a dose of corticosteroid eye drops to arrest the infection in and around the eye. Other treatment methods include the prescription of immunosuppressive agents.

Furthermore, a doctor may suggest steroidal medication in the form of an eye drop, pill or injection. It can also be surgically infused into the eye. Some other agents used for treatment are azathioprine, methotrexate and mycophenolate. Medications such as these require regular monitoring of the blood to check for any side effects. Doctors also suggest biologics such as infliximab, rituximab, and adalimumab. Most of these drugs have a specific target in the immune system.

4558 people found this helpful
Table of Content
About Infliximab
When is Infliximab prescribed?
What are the side effects of Infliximab ?
Key highlights of Infliximab
What are the dosage instructions?
Medicines containing Infliximab
How does medicine works?