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Epoetin Alfa

Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 02, 2019

Epoetin Alfa is a man-made synthetic erythropoietin that helps in the production of red blood cells in the body. It is produced in a cell culture by use of recombinant DNA technology. It increases the count of red blood cells in the body and is therefore a cure for anemia with chronic kidney failure, anaemia caused by chemotherapy for cancer and anaemia in certain HIV patients caused by taking zidovudine. People with high risk of blood loss due to surgeries take this medicine to reduce their need for blood transfusion. Epoetin Alfa produces red blood cells by causing stimulation of the bone marrow.

Epoetin Alfa should not be taken if :

  • You are allergic to any of the ingredients in Epoetin Alfa.
  • You have very high blood pressure.
  • You have developed pure red cell aplasia after receiving the first dose of Epoetin Alfa or other erythropoietin medicines.

Epoetin Alfa has a few side effects but most people experience no or minor effects. Side effects may include cough, headache, joint or bone pain, mild muscle pain, muscle spasm, pain and redness in injection site, nausea, vomiting and weight loss. In case of sever effects, seeking medical attention immediately is advised.

Ensure your doctor is informed about your other medications. Inform him if you are pregnant or breastfeeding, if you are on hemodialysis, if you have had or are scheduled to have a surgery recently. Consumption of Epoetin Alfa should be exactly like prescribed by the doctor and the dosage should not increase more than what is recommended. Overdosing may cause severe side effects to occur.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Hematologist before using this medicine.
  • Chronic Kidney Disease Associated Anemia

    Epoetin Alfa is used to treat anemia in patients having chronic kidney diseases.
  • Chemotherapy Associated Anemia

    Epoetin Alfa is used to treat anemia associated with the use of chemotherapy medicines to treat certain specific types of cancer.
  • Anemia Due To Use Of Medicines

    Epoetin Alfa is used to treat anemia associated with the use of Zidovudine to treat HIV infection.
  • Anemia Associated With Surgery

    Epoetin Alfa is also used before and after certain surgeries where chances of significant blood loss is high. It reduces the dependency on blood transfusion process.
  • Allergy

    This medicine is not recommended for use if you have a history of allergy to epoetin alfa or albumin or any other ingredient present in the dosage form.
  • Non-Chemotherapy Associated Anemia In Cancer Patients

    This medicine is not recommended for use to treat anemia in cancer patients who are are not receiving any chemotherapy medication.
  • High Blood Pressure

    This medicine is not recommended for use in patients who have high blood pressure and are not taking any medicine to control it.
  • Pure Red Cell Aplasia

    This medicine is not recommended for use if the patient has had a history of pure red cell aplasia after using this medicine or other medicines belonging to the Eryhtropoietin class of drugs.
  • Use of multi-dose vials

    Use of multi-dose vials of this medicine is not recommended for children or pregnant women. The risk of severe adverse effects are increasingly high in such cases.
  • Fever

  • Nausea

  • Vomiting

  • Mouth Sores

  • Headache

  • Muscle Or Joint Pain

  • Cough

  • Diarrhoea

  • Swelling And Redness At The Injection Site

  • Stomach Discomfort And Pain

  • Severe Skin Allergy

  • Swelling Of Face, Lips, Eyelids, Tongue, Hands And Feet

  • Difficulty In Breathing

  • Wheezing

  • Dizziness

  • Upper Respiratory Tract Infection

  • Difficulty In Swallowing

  • Increased Blood Pressure

  • Pure Red Cell Aplasia

  • How long is the duration of effect?

    The time for which the effect of this medicine persists is subjected to variations depending on the intended use.
  • What is the onset of action?

    The effect of this medicine can be observed after several days of administration.
  • Are there any pregnancy warnings?

    Use of this medicine is not recommended for pregnant women unless absolutely necessary. All the potential benefits and risks should be considered before administering this medicine. Use of this medicine containing benzyl alcohol as an ingredient and use of multi-dose vial is not recommended for pregnant women.
  • Is it habit forming?

    No habit forming tendencies were reported
  • Are there any breast-feeding warnings?

    Use of this medicine is not recommended for women who are breastfeeding an infant unless absolutely necessary. The use of benzyl alcohol containing dosage forms or multi-dose vials are not recommended.
  • Missed Dose instructions

    Contact your doctor if you have missed a scheduled dose of this medicine and follow all the instructions given.
  • Overdose instructions

    Contact your doctor immediately if an overdose is suspected.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Epoetin Alfa as ingredient

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This medication is a synthetic form of erythropoietin. It stimulates the proliferation and maturation of components that form the red blood cells in the body.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Disease


    This medicine should be used with caution in patients with elevated blood pressure levels especially if it is uncontrolled. Your doctor will ensure that the blood pressure is under control before the use of epoetin alfa starts.

    Seizure Disorders

    This medicine should be used with caution in patients suffering from seizure disorders as the risk of adverse effects are significantly high. You may require clinical monitoring at least in the early stages of treatment with epoetin alfa.

    Blood Clotting Disorder

    This medicine should be used with extreme caution in patients with blood clotting disorders since the risks of severe adverse effects are very high. Any disease of the heart and blood vessels should be reported to the doctor before treatment with epoetin alfa is initiated.


    This medicine should be administered with caution in patients undergoing hemodialysis. Suitable dose adjustment and clinical monitoring is recommended while giving this medicine.
  • Interaction with Alcohol


    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test


    Information not available.
  • Interaction with Food


    Information not available.
  • Interaction with Medicine


    Report the use of Ramipril of any other medicine used for lowering high blood pressure to the doctor. You may require a dose adjustment and more frequent monitoring of blood pressure level while using these medicines together.


    Report the use of either of the medication to the doctor. You may require undergoing clinical safety monitoring before using these medicines together.


    Report the use of thalidomide to the doctor before receiving epoetin alfa. The risk of clot formation and associated side effects are very high if these medicines are used together. Your doctor may prescribe an alternate medication or administer these medications after adjusting the dose and safety monitoring.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Epoetin Alfa
What are the uses of Epoetin Alfa
What are the contraindications of Epoetin Alfa ?
What are the side effects of Epoetin Alfa ?
Key highlights of Epoetin Alfa
What are the dosage instructions?
Where is the Epoetin Alfa approved?
Medicines containing Epoetin Alfa
How does this medication work?
What are the interactions of Epoetin Alfa ?