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Overview

Dexamethasone Sodium Phosphate Injection

Manufacturer :  Jagsonpal Pharmaceuticals Ltd
Medicine Composition :  Dexamethasone
Prescription vs OTC : Prescription by Doctor required

About Dexamethasone Sodium Phosphate Injection

Dexamethasone Sodium Phosphate Injection is used to treat chronic swelling, allergic, hematologic, neoplastic, and autoimmune diseases. This medication may also be used in the management of cerebral oedema, septic shock, as a diagnostic agent, and antiemetic.

Dexamethasone Sodium Phosphate Injection is a corticosteroid hormone which decreases your body's natural defensive response and reduces symptoms such as internal and external swelling and allergic-type reactions. It is associated with diseases like asthma, colitis, certain skin and eye conditions, arthritis, breathing problems, severe allergies, etc.

It is also used for other conditions like adrenal hormonal insufficiency, cerebral oedema, certain bowel disorders, certain types of anaemia and certain cancers. It is also used as a test for Cushing's syndrome.

Take Dexamethasone Sodium Phosphate Injection with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. Your doctor may attempt to reduce your dose gradually to minimise side effects.

Symptoms of overdose include moon face, central obesity, hypertension, psychosis, hallucinations, diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to infection, electrolyte and fluid imbalance.

When consumed in excessive quantities, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously.

To make sure Dexamethasone Sodium Phosphate Injection is safe for you, tell your doctor if you have a:

You should not use this medicine if you are allergic to it, or if you have a fungal infection anywhere in your body. If you are pregnant or breastfeeding, you have to take extra care for consuming Dexamethasone Sodium Phosphate Injection so follow all your doctor’s instructions.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the uses of Dexamethasone Sodium Phosphate Injection

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the contraindications of Dexamethasone Sodium Phosphate Injection ?

    • Allergy

      This medicine is not recommended for use if you have a known history of allergy to it or any other medicine belonging to the category of corticosteroids.

    • Systemic Fungal Infection

      This medicine is not recommended for use if you have a fungal infection affecting an internal organ/organs in the body.

    • Cerebral Malaria

      This medicine is not recommended for use if you are suffering from a rare type of malaria that affects the brain.

    • Active Untreated Infection

      This medicine is not recommended for use in patients suffering from any serious infection and is yet to receive any treatment for the same.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the side effects of Dexamethasone Sodium Phosphate Injection ?

    • Insomnia

    • Nervousness

    • Increased Appetite

    • Indigestion

    • Hirsutism

    • Diabetes Mellitus

    • Arthralgia

    • Cataract

    • Acne

    • Altered Bone Growth

    • Skin Scar

    • Bone Degradation

    • Muscle Disorders

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Key highlights of Dexamethasone Sodium Phosphate Injection

    • Is It safe with alcohol?

      Interaction with alcohol is unknown. Please consult your doctor.

    • Are there any pregnancy warnings?

      Dexamethasone Sodium Phosphate Injection may be unsafe to use during pregnancy.
      Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

    • Are there any breast-feeding warnings?

      Dexamethasone Sodium Phosphate Injection is probably safe to use during lactation. \nLimited human data suggests that the drug does not represent a significant risk to the baby.

    • Is it safe to drive while on this medicine?

      Do not drive unless you are feeling well.
      Dexamethasone Sodium Phosphate Injection may cause dizziness (vertigo). Changes in your eyesight or muscle weakness may also happen. This may affect your driving ability.

    • Does this affect kidney function?

      Dexamethasone Sodium Phosphate Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Dexamethasone Sodium Phosphate Injection may not be needed in these patients. Please consult your doctor.
      Regular monitoring of kidney function tests and other blood tests is advisable while you are taking Dexamethasone Sodium Phosphate Injection.

    • Does this affect liver function?

      Dexamethasone Sodium Phosphate Injection should be used with caution in patients with liver disease. Dose adjustment of Dexamethasone Sodium Phosphate Injection may be needed. Please consult your doctor.

    • How long is the duration of effect?

      This medicine will remain active for about 72 hours after its ingestion.

    • What is the onset of action?

      This medicine produces its action within 1-2 hours after its administration.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    What are the dosage instructions?

    • Missed Dose instructions

      Contact your doctor for instructions if you missed a scheduled dose of this medicine. A self-attempt to make up for the lost dose may result in adverse effects.

    • Are there any overdose instructions?

      Contact your doctor if an overdose with this medicine for is suspected especially when the prescribed dose is very high. Symptoms may include thinning of the skin, easy bruising and bleeding, body fat deposits etc.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    Where is the Dexamethasone Sodium Phosphate Injection approved?

    • India

    • United States

    • Japan

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

    How does this medication work?

    This medication is a synthetic corticosteroid that enters the cells through passive diffusion and binds to glucocorticoid receptors, forming a complex. This complex undergoes activation, enters the cell nucleus and binds to the DNA. This induces the natural effects of biological hormones.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

      What are the interactions of Dexamethasone Sodium Phosphate Injection ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Medicine

        • It interacts with CYP3A3/4 enzyme substrate; CYP3A3/4 enzyme inducer; CYP3A3/4 enzyme inhibitors.
        • It may also interact with clarithromycin, itraconazole, chlorthalidone clotrimazole, cilnidipine, carbamazepine, repaglinide, indapamide, S-amlodipine, lercanidipine glipizide, Bacillus Calmette-Guerin high strength, rosiglitazone, azithromycin.
      • Interaction with Food

        Dexamethasone Sodium Phosphate Injection may be taken with meals to decrease GI upset. Individual must limit caffeine. One may need diet with increased potassium, pyridoxine, vitamin C, vitamin D, folate, calcium, and phosphorus.

      FAQs about Dexamethasone Sodium Phosphate Injection

      • Ques : What is Dexamethasone Sodium Phosphate Injection?

        Ans : Dexamethasone Sodium Phosphate Injection is a corticosteroid in nature. It has anti-inflammatory effect and helps in curing the various diseases.

      • Ques : Does Dexamethasone Sodium Phosphate Injection increase the blood sugar level?

        Ans : Yes, Dexamethasone Sodium Phosphate Injection causes an increase in the blood sugar level of the patient. It causes an increase in glucose production and decrease the effect of insulin. Therefore, diabetic patients must consult a doctor before taking this medication.

      • Ques : Does taking Dexamethasone Sodium Phosphate Injectionincrease my weight?

        Ans : Yes, long term use of Dexamethasone Sodium Phosphate Injection lead to weight gain due to the side effects caused by this medicine. It causes increase in appetite and fluid retention that leads to increase the weight.

      • Ques : Is it safe to take Dexamethasone Sodium Phosphate Injection with paracetamol?

        Ans : No harmful interaction between these two have been reported. Thus it is safe to take Dexamethasone Sodium Phosphate Injection with paracetamol.

      • Ques : What dietary instructions should be followed during the course of the treatment?

        Ans : The doctor may allow you to take a low-sodium, potassium-rich and high-protein diet. In order to avoid upset stomach, always take Dexamethasone Sodium Phosphate Injection with food or milk.

      • Ques : Is Dexamethasone Sodium Phosphate Injection a steroid?

        Ans : Yes, the medicine belongs to the category of steroids and prevents the release of a substance that causes inflammations. Hence, it is used of allergic disorders, ulcerative colitis, psoriasis and lupus.

      • Ques : Should Dexamethasone Sodium Phosphate Injection be taken before or after the food?

        Ans : Dexamethasone Sodium Phosphate Injection can be taken with meals or after meals.

      References

      • Dexamethasone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 22 June 2020]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/dexamethasone

      • Dexamethasone- DrugBank [Internet]. Drugbank.ca. 2020 [Cited 22 June 2020]. Available from:

        https://www.drugbank.ca/drugs/DB01234

      • Dexamethasone 2mg Tablets- EMC [Internet] medicines.org.uk. 2018 [Cited 22 June 2020]. Available from:

        https://www.medicines.org.uk/emc/product/5411/pil

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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