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Overview

Cytodrox 500Mg Capsule

Manufacturer: Cipla Ltd
Medicine composition: Hydroxyurea
Prescription vs.OTC: Prescription by Doctor required

Cytodrox 500Mg Capsule is an oral medicene that is prescribed to patients suffering from chronic myelogenous leukemia, acute myelogenous leukemia, sickle-cell disease, ovarian cancer, cervical cancer, and polycythemia vera. Cytodrox 500Mg Capsule slows down the growth of cancer cells in the body and can reduce the need for blood tranfusion. It comes as a capsule that is usually taken once in a day. But talk to your doctor regarding the right dosage for you.

Common side effects of Cytodrox 500Mg Capsule drug are fever, loss of appetite, shortness of breath, headache, drowsiness, nausea, vomiting, bone marrow suppression, psychiatric problems. Contact your doctor if you notice any unusual symptoms such as dizziness, confusion, joint pain, seizures, tarry stools, sores in the mouth or unusual bleeding.

Do not use this medicine if; you are allergic to any of its ingredients; have a prescription for didanosine or stavudine; have severe bone marrow depressin; have anemia or count of white blood cells or platelets is low. Also, let your healthcare provider know before prescription if- you are pregnant or are planning to become pregnant, are breastfeeding, have a history of allergies to food or medicine, have anemia, kidney or liver problems or if you are a HIV positive patient.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Hematologist before using this medicine.

In addition to its intended effect, Cytodrox 500Mg Capsule may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Megaloblastic anemia
Decreased white blood cell count (neutrophils)
Oligospermia (low sperm count)
Azoospermia (absence of sperms).
Is It safe with alcohol?
Interaction with alcohol is unknown. Please consult your doctor.
Are there any pregnancy warnings?
Hydrox 500mg capsule is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Are there any breast-feeding warnings?
Hydrox 500mg capsule is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?
Should not drive or operate machinery unless it has been shown not to affect physical or mental ability.
Does this affect kidney function?
Caution to be advised in patients with impaired renal function.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Below is the list of medicines, which have the same composition, strength and form as Cytodrox 500Mg Capsule , and hence can be used as its substitute.
Abbott India Ltd
Alkem Laboratories Ltd
Neon Laboratories Ltd
Winsome Laboratories Pvt Ltd
Zydus Cadila
Chandra Bhagat Pharma Pvt Ltd
Vhb Life Sciences Inc
Khandelwal Laboratories Pvt Ltd
Artel Laboratories
United Biotech Pvt Ltd
Vhb Life Sciences Inc
Celon Laboratories Ltd
Samarth Life Sciences Pvt Ltd
Cytodrox 500Mg Capsule is an antineoplastic agent. It converts to a free radical and inhibits the entire DNA replicase complex, including ribonucleotide reductase and selectively inhibits DNA synthesis, while also inhibiting DNA repair mechanisms. This leads to death of neoplastic cells.
What are you using Cytodrox 500Mg Capsule for?
sickle-cell disease
Other
chronic myelogenous leukemia
ovarian cancer
How much was the improvement?
Excellent
Average
Poor
How long did it take before seeing improvement?
Within 2 hours
More than 2 days
Within a day
How frequently did you take this medicine?
Once a day
Four times A Day
How did you take this medicine?
With Food
With or without food
What were the side effects of this medicine?
Decreased white blood cell count (neutrophils)
Azoospermia (absence of sperms)
Megaloblastic anemia
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Hello Does hydroxyurea tab causes change in colour of nails.? How to treat that? No need to worry about that right? Appreciate your help!

MBBS
General Physician, Mumbai
Hello Does hydroxyurea tab causes change in colour of nails.? How to treat that? No need to worry about that right?
A...
Nail is a dead part of the body and the nail bed is responsible for giving the colour beneath the nail

I have been diagnosed with Polycythemia Vera and I am on Hydroxyurea 500 daily. What next ?

M.B;B.S, P.G.(FAMILY MEDICINE), D.O.H.
General Physician, Hyderabad
Continue the medicines but Consultation with a hematologist is recommended in cases of polycythemia vera (PV). Long-term follow-up care of these patients and managing complications of the disease and its treatment can be difficult.
1 person found this helpful

I am a 62-year-old male. I am suffering from Polycythemia Rubra Vera (due to JAK 2 mutation) for last 8 years. First 3 years I was put on treatment with low level of aspirin, amlodipine and periodic venesection. Last 5 years I am on Hydroxyurea along with the above mentioned drugs. The dose of hydroxyurea is adjusted periodically based on FBC. My questions are: 1. What are the adverse effects of long term treatment with Hydroxyurea? 2. I get occasional muscle cramp. How do I get relief from it? I would like to know 1. What is the adverse drug effect of long term intake of Hydroxyurea. 2. I suffer from painful muscle cramp occasionally. What I should do to get relief from it?

MBBS, PGC In Family Welfare & Health Management, DHA, PGD In Medical Laws & Ethics
General Physician, Kolkata
Every drug has side effects. Use is based on benefits vis -a -vis side effects. Hydroxy urea is well used in blood disorders, specially of neoplastic variety. Important side effects are -bone marrow depression, gastrointestinal disturbances, impairment of renal function, pulmonary oedema, mild dermatological reactions. Loss of hair and neurological manifestations. Most of muscle cramps, if not very severe can be relieved by stretching the muscle, movements or maintenance of electrolyte balance. Topical muscle relaxants can also be lightly used without massaging,
1 person found this helpful

Can doctor give hydroxyurea tab to a thalassemia major child. Which type of food we give thalassemia major child ? Give Ans in briefly.

MBBS
General Physician, Mumbai
Can doctor give hydroxyurea tab to a thalassemia major child.
Which type of food we give thalassemia major child ?
Gi...
Few diet tips - not to eat fried food items and can eat all green vegetables, moong, chana, dal, rice etc and to apply ghee over chappati and don't apply oil over chappati and to drink milk mixed with turmeric powder twice a day and if possible eat eggs on alternate days and if possible in breakfast eat atleast one bajra ka rotla and eat seasonal fruit.

Give me details food, fruits for the sickle cell disease, it is permanently cure or not.

MBBS, MD - Paediatrics
Pediatrician, Pune
Give me details food, fruits for the sickle cell disease, it is permanently cure or not.
How frequently is the patient requiring blood transfusion? is the patient on hydroxyurea drug? permanent cure is bone marrow transplant if patient has matched donor. But can be controlled with this drug hydroxyurea and blood transfusions. Kindly consult a paediatric haematologist to evaluate your patient. Also if you are planning to have more children you and your husband also undergo screening for sickle cell and during 12-14 weeks of pregnancy you can undergo chorionic villi sampling to detect sickle cell in your future child beforehand and as per the result you can decide if you want to continue with your pregnancy.

Popular Health Tips

Eosinophilic Disorders and their Treatment

Clinical Hematology , MD, MBBS
Hematologist, Noida
Eosinophilic Disorders and their Treatment

The Eosinophilic disorders are one of the major hematological diseases, which deal with the white blood cells in the human body. The Eosinophils or the white blood cells play an important role in the human body while responding to asthma, allergic reactions, and infections that are caused due to parasites. Eosinophils not only play an important role in protective immunity against parasites but also contribute a lot to inflammation which occurs during allergic disorders.

Different disorders of the Eosinophils

  1. Low count of eosinophils
  2. High count of eosinophils
  3. Idiopathic hypereosinophilic syndrome
  4. Disorders and their treatments

Low count of eosinophils
A low count of eosinophils in the blood usually occurs with the sepsis or the infections in the blood stream, cushing syndrome. They are usually treated with the corticosteroids. The treatment of the lower count of eosinophils is able to restore the normal count of the eosinophils.

High count of eosinophils
The condition of the high count of the eosinophils is known as eosinophilia or hypereosinophilia. Some of the most common causes which increase the count of the eosinophils are

  1. Disorders due to allergies including asthma, atopic dermatitis, eczema and allergic rhinitis.
  2. Infections caused by parasites, mainly the ones those are known to invade the tissues.
  3. Some of the cancers cause eosinophilia like leukemia, Hodgkin lymphoma, and myeloproliferative disorders.

Symptoms of eosinophilia

When the count of the eosinophils increases considerably, it can not only inflame the tissues but can also cause damage to the organs. The organs that are usually affected due to this are the heart, skin, lungs and the nervous system. People may suffer from skin rashes, shortness of breath or wheezing and fatigue. One can also suffer from throat as well as stomach pain if the stomach or the esophagus gets affected.
It is generally treated with antibiotics even if no infection is detected. Doctors usually treat such conditions with the oral corticosteroids.

Idiopathic Hypereosinophilic Syndrome
In this disorder, the eosinophil count increases to more than 1500 cells/microliter of blood. It is common in the ones who have crossed 50 and usually suffers from a condition of the heart known as Loffler endocarditis which leads to heart attacks.

Symptoms

  1. Weight loss
  2. Night sweats
  3. Chest pain
  4. Fevers
  5. Weakness
  6. Stomach ache and sometimes coma

Most of the people need to treat this with the drugs of prednisone, hydroxyurea and sometimes chemotherapy drugs. Eosinophilic disorders should always be treated according to the drugs prescribed by the doctors. If you wish to discuss any specific problem, you can consult a hematologist.

2827 people found this helpful

What is Sickle Cell Anemia? How Can it Be Cured?

PHD - Science
Geneticist, Mumbai
What is Sickle Cell Anemia? How Can it Be Cured?

Have you heard of a health condition in which there are insufficient red blood cells in your body for carrying sufficient oxygen to all parts of the body? This condition is called sickle cell anemia and it is an inherited form of anemia. Usually, the red blood cells in your body are round and flexible and move through the blood vessels easily. In case of sickle cell anemia, the red blood cells become sticky and rigid. They are shaped like crescent moon or sickle. Because of the irregular shape, these can get stuck in the blood vessels, which slows down the blood flow.

Treatment
The only potential cure of sickle cell anemia is a bone marrow transplant. Other treatment measures focus on easing the symptoms and preventing further complications. The various treatment modes are as follows:

  1. Antibiotics: Children with sickle cell anemia can start taking antibiotic penicillin by the age of two months. This prevents infections like pneumonia. Even in the case of adults with sickle cell anemia, antibiotics help in fighting certain infections.
  2. Pain-relieving medications: Several over-the-counter pain relief medications may be prescribed by a doctor for reducing pain during a sickle cell crisis. Hydroxyurea is another type of medicine, which helps in reducing the frequency of pain. 
  3. Vaccinations: Childhood vaccinations should be given for preventing the disease in children. These vaccinations are more important for children already affected with sickle cell anemia as they are more prone to infections. Vaccines such as the annual flu shot and the pneumococcal vaccine are important for adults suffering from sickle cell anemia. 
  4. Blood transfusions: In case of a red blood transfusion, red blood cells are removed from a supply of blood that is donated. The donated cells are intravenously given to a sickle cell anemia patient. Blood transfusion increases the number of normal red blood cell count in circulation, giving relief to anemia. Regular blood transfusions are important for children with sickle cell anemia, who are highly prone to stroke
  5. Stem cell transplantA stem cell transplant or a bone marrow transplant involves the replacement of the bone marrow affected by sickle cell anemia with a healthy bone marrow given by a donor. This is a risky procedure and is only recommended for patients with sickle cell anemia at a chronic stage.

It is recommended for you to consult a doctor on experiencing any symptom of sickle cell anemia. This is a dangerous health condition and requires proper diagnosis and treatment before it gets out of your hands.

4956 people found this helpful

Polycythemia Vera - What You Need to Know

MBBS, MD, FICH
Hematologist, Ludhiana
Polycythemia Vera - What You Need to Know

Polycythemia is a rare condition where the count of red blood cells in the body increases. The normal count of red blood cells ranges from 4.9-5.2 million cells per cmm. People having polycythemia witness an increase in the count of hemoglobin, hematocrit or red blood cells as compared to the normal level.

Women with hemoglobin levels higher than 16.5g/dL and hematocrit value higher than 48, are believed to have polycythemia. In case of men, hemoglobin levels higher than 18.5g/dL and hematocrit value greater than 52 are suggestive of polycythemia.

A myeloproliferative disorder that involves an uncontrolled red blood cells formation in the bone marrow is called as polycythemia vera. It is a slow growing cancer involving the blood cells. The cells growing in an excess quantity cause a thickening of blood and cause a reduction in the flow rate of blood. Thickening or clot formation can lead to a stroke or a cardiac arrest. This condition can develop and progress without any symptoms and go undiagnosed for a long period of time. Lack of prompt diagnosis and treatment can cause the condition to become life-threatening. It may also progress to other forms of cancers like acute leukemia.

The two main types of polycythemia are primary and secondary. Polycythemia vera is symptomless usually. When symptoms appear, the commonly seen ones are as follows – constant headache of mild to moderate intensity, itchy rashes on skin, bruises with bleeding points, lethargy, blurring of vision, excess sweating, joint swelling and excessive pain, unexpected weight loss, neuropathy in limbs, low to moderate grade fever and even shortness of breath. There is no specific age group predilection for its incidence, it can occur at any age. However, the prevalence rate is common in adults over 60 years of age. The male to female ratio of occurrence is also even, with no gender predilection.

Polycythemia vera is not completely curable, with the treatment being focused on reduction of red blood cell count. Symptomatic treatment allows for reducing the complications related to the presenting signs and symptoms. Phlebotomy is done where the blood volume is decreased by drawing out of blood from the veins. Thrombolytic drugs like low dose aspirin is given to break clots. Anti-cancer drug Ruxolinitib helps in the destruction of cancer cells to some extent.

What are the possible causes of polycythemia?

  1. Polycythemia occurs due to a genetic mutation of the protein called Janus kinase 2 or JAK2. This results in increased production of red blood cells.
  2. Another condition known as Primary Familial and Congenital Polycythemia (PFCP) is related to the mutation in the Erythropoietin Receptor (EPOR) which escalates the production of red blood cells in response to EPO.
  3. Deficiency of 2, 3-Bisphosphoglycerates (BPG) can increase red blood cell production in your body. Under this condition, hemoglobin develops an increased affinity to hold on to the oxygen, and is less likely to discharge it to the tissues. As a result more red blood cells are produced in response to insufficient oxygen levels.

Look out for the symptoms!
The usual symptoms of polycythemia include the following-

The symptoms may vary from mild to severe. If left untreated, polycythemia can lead to severe health complications like scarring of the bone marrow, acute leukemia or myelodysplastic syndrome. Recognizing the symptoms at an early stage can help prevent the complications.

This disorder can cause various complications, formation of blood clots in the body being the most common of them. Formation of such blood clots in organs like lungs can cause an embolism or in the blood vessels can cause an obstruction to the blood flow. Deep vein thrombosis is a common complication caused by the presence of a thrombus formation due to blood clot in the veins of lower limbs. Polycythemia also causes splenomegaly due to increased exertion on the spleen by the uncontrolled growth of red blood cells. Other complications include formation of ulcers in the intestines, joint inflammation and development of more severe blood disorders.

How is polycythemia treated?
Treatment of polycythemia depends on its cause and severity.

Phlebotomy is the procedure whereby the doctor uses a needle to remove a tiny amount of blood from the vein. This decreases the volume and count of red blood cells so that excess blood cells are not formed, and oxygen is carried to different organs in the body.

People who are at high-risk, or have reached an advanced stage, require more specialized treatment. Certain medications used in the treatment of polycythemia include-

  1. Hydroxycarbamide- Prevents over production of red blood cells in the body.
  2. Interferon alpha- Helps combat the overactive bone marrow cells which are related to polycythemia vera.
  3. Busulfan- Although this drug is prescribed for the treatment of leukemia, it can also be used off- label to cure polycythemia.
  4. RuxolitinibThis drug is usually prescribed when other medications like hydroxyurea have failed to lower the blood count. Ruxolitinib inhibits the growth factors which are responsible for producing red blood cells.

Other treatment procedures for easing symptoms like persistent itching may include antihistamines, Selective Serotonin Reuptake Inhibitors (SSRIs) and phototherapy.

2742 people found this helpful

Table of Content

About Cytodrox 500Mg Capsule
When is Cytodrox 500Mg Capsule prescribed?
What are the side effects of Cytodrox 500Mg Capsule ?
Key highlights of Cytodrox 500Mg Capsule
What are the substitutes for Cytodrox 500Mg Capsule ?