Change Tablet is a combination medication primarily prescribed for treating diarrhoea and/or dysentery. It comprises antibacterial and antiamoebic drugs that fight against parasitic and bacterial infections. It is very effective in treating infectious condition due to its dual-action.
This medication inhibits the production of certain enzymes in the DNA of a bacteria, which are necessary for the survival and growth of this bacterial infections. Therefore, this antibiotic drug fights against bacterial infections by killing the bacteria and inhibiting the process of bacterial cell division.
It is advisable to take this medication only under the strict guidelines of your doctor. Follow this prescription until the course is complete, even if the symptoms disappear. You should not skip a dose and avoid taking an extra tablet to make up for it.
It is possible for some people to experience a few common side effects after taking this medication. Some people are more likely to face harmful side effects if they also suffer from other conditions like brain disorders, seizures, heart conditions, myasthenia gravis, epilepsy, tendonitis, bone disorders and problems of the joints.
It is advisable to inform your doctor about the above-mentioned conditions beforehand if he/she recommends you taking this medicine. It is advisable for pregnant women, women who are breastfeeding and children below 16 years, to avoid taking this antibiotic since it can lead to harmful consequences.
The most common use of this medication is:
Tendinitis Or Tendon RuptureAvoid taking this medicineif you have a past history of tendinitis or tendon rupture after using Change Tablet.
How long is the duration of effect?The effect of this medicine lasts for a duration of 12 to 20 hours.
What is the onset of action?The peak effect of this medicine can be observed within 1 to 2 hours of administration of the dose.
Are there any pregnancy warnings?Use of this medicine is not recommended in pregnant women. Use only if clearly needed under the supervision of the doctor.
Is it habit forming?No habit forming tendency has been reported.
Are there any breast-feeding warnings?Use of this medicine is not recommended in women who breastfeed due to the adverse effect on development of the infant's joints. Use only if clearly needed under the supervision of the doctor. Avoid breastfeeding for about 3 to 4 hours to decrease the infant's risk exposure. Monitoring of undesired effects like diarrhea, diaper rash is necessary.
Below is the list of medicines, which have the same composition, strength and form as Change Tablet , and hence can be used as its substitute.
Are there any missed dose instructions?The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of overdose.
This medicine is a combination of Ofloxacin and Ornidazole belonging to the class antibacterial and antiamoebic. Thus the medication follows a dual mechanism to produce its action. Firstly, it works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA and causes cell death. Secondly, it works by seeping into the cells of the bacteria and/or protozoa through diffusion and damaging DNA and other critical biomolecules through the formation of reactive nitro radicals.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Central Nervous System DepressionIf you suffer from CNS disorder and you take Change Tablet, then you may experience tremors, restlessness, anxiety, confusion and hallucinations. Avoid consuming caffeine containing products like coffee, chocolates and energy drinks.
ColitisAvoid taking Change Tablet if you experience severe diarrhea, abdominal pain, and blood in stools after taking the medicine. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.
Qt ProlongationAvoid using Change Tablet if you experience any chest discomfort. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.
Interaction with Alcohol
AlcoholInteraction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
LabInformation not available.
Interaction with Food
Dairy productsThe desired effect of Change Tablet is not observed if consumed with dairy products. There should be at least 2 hours gap between taking Change Tablet and dairy products.
Interaction with Medicine
CorticosteroidsYou may experience pain, swelling, or inflammation in ankle, shoulder, hand, or thumb if these medicines are used together. This interaction is more likely to occur in elderly population who have undergone a kidney or heart transplantation. Replacement of the medicine should be made under the doctor's supervision.
EscitalopramYou may experience dizziness, lightheadedness, shortness of breath, or heart palpitations if these medicines are used together. This interaction is more likely to happen if you suffer from any heart disease (Arrhythmia) or have a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
QuinidineYou may experience dizziness, lightheadedness, and heart palpitations if these medicines are used together. Regular cardiac function tests are to be performed if you have any heart disease (Arrhythmia) or a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
Antidiabetic medicinesYou may experience hypoglycemic effects like dizziness, headache, nervousness, confusion, tremor and weakness if these medicines are used together. Hyperglycemic effects like increased thirst, urination and hunger are less likely to occur. Regular blood glucose checkups are to be performed if you are diabetic or has any kidney disease. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
AspirinYou may experience tremors, involuntary muscle movements, hallucinations, or seizures if these medicines are used together. This interaction is more likely to happen if you have a history of seizures or family history of seizures. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
Ethinyl EstradiolThe desired effect of contraceptive pills will not be achieved if these medicines are used together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
Ques: What is Change Tablet?
Ques: What are the uses of Change Tablet?
Ques: What are the Side Effects of Change Tablet?
Ques: What are the instructions for storage and disposal Change Tablet?
Ofloxacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 24 January 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/ofloxacin
Ornidazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 24 January 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/ornidazole
Ofloxacin- DrugBank [Internet]. Drugbank.ca. 2020 [Cited 24 January 2020]. Available from:https://www.drugbank.ca/drugs/DB01165
Ornidazole- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 24 January 2020]. Available from:https://www.drugbank.ca/drugs/DB13026
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