About Change Tablet
Change Tablet is a combination medication primarily prescribed for treating diarrhoea and/or dysentery. It comprises antibacterial and antiamoebic drugs that fight against parasitic and bacterial infections. It is very effective in treating infectious condition due to its dual-action.
This medication inhibits the production of certain enzymes in the DNA of a bacteria, which are necessary for the survival and growth of this bacterial infections. Therefore, this antibiotic drug fights against bacterial infections by killing the bacteria and inhibiting the process of bacterial cell division.
It is advisable to take this medication only under the strict guidelines of your doctor. Follow this prescription until the course is complete, even if the symptoms disappear. You should not skip a dose and avoid taking an extra tablet to make up for it.
It is possible for some people to experience a few common side effects after taking this medication. Some people are more likely to face harmful side effects if they also suffer from other conditions like brain disorders, seizures, heart conditions, myasthenia gravis, epilepsy, tendonitis, bone disorders and problems of the joints.
It is advisable to inform your doctor about the above-mentioned conditions beforehand if he/she recommends you taking this medicine. It is advisable for pregnant women, women who are breastfeeding and children below 16 years, to avoid taking this antibiotic since it can lead to harmful consequences.
What are the uses of Change Tablet
What are the contraindications of Change Tablet ?
Avoid taking Change Tablet if you have a known allergy to this medicine or any other medicines belonging to the class fluoroquinolones.
Tendinitis Or Tendon Rupture
Avoid taking this medicineif you have a past history of tendinitis or tendon rupture after using Change Tablet.
Avoid taking this medicine if you have a past or family history of suffering from Myasthenia Gravis (weakness and rapid fatigue of muscles under voluntary control).
Key highlights of Change Tablet
How long is the duration of effect?
The effect of this medicine lasts for a duration of 12 to 20 hours.
What is the onset of action?
The peak effect of this medicine can be observed within 1 to 2 hours of administration of the dose.
Are there any pregnancy warnings?
Use of this medicine is not recommended in pregnant women. Use only if clearly needed under the supervision of the doctor.
Is it habit forming?
No habit forming tendency has been reported.
Are there any breast-feeding warnings?
Use of this medicine is not recommended in women who breastfeed due to the adverse effect on development of the infant's joints. Use only if clearly needed under the supervision of the doctor. Avoid breastfeeding for about 3 to 4 hours to decrease the infant's risk exposure. Monitoring of undesired effects like diarrhea, diaper rash is necessary.
What are the substitutes for Change Tablet ?
Below is the list of medicines, which have the same composition, strength and form as Change Tablet , and hence can be used as its substitute.
- Eldeflox Oz 200 Mg/500 Mg Tablet
Elder Pharmaceuticals Ltd
- Cachof 0 200 Mg/500 Mg Tablet
Cachet Pharmaceuticals Pvt Ltd
- Owin O 200 Mg/500 Mg Tablet
Alembic Pharmaceuticals Ltd
- Oxo Ord 200Mg/500Mg Tablet
Ind Swift Laboratories Ltd
- Ofpil O Tablet
Psychotropics India Ltd
- Zuflo OZ 200mg/500mg Tablet
Morepen Laboratories Ltd
- Ofrex O 200Mg/500Mg Tablet
- Woflox Oz 200 Mg/500 Mg Tablet
- Assault Novo 200 Mg/500 Mg Tablet
Alkem Laboratories Ltd
- Ofloking O Tablet
Mankind Pharma Ltd
What are the dosage instructions?
Are there any missed dose instructions?
The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
Are there any overdose instructions?
Seek emergency medical treatment or contact the doctor in case of overdose.
How does this medication work?
This medicine is a combination of Ofloxacin and Ornidazole belonging to the class antibacterial and antiamoebic. Thus the medication follows a dual mechanism to produce its action. Firstly, it works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA and causes cell death. Secondly, it works by seeping into the cells of the bacteria and/or protozoa through diffusion and damaging DNA and other critical biomolecules through the formation of reactive nitro radicals.
What are the interactions of Change Tablet ?
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
AlcoholInteraction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
LabInformation not available.
Interaction with Medicine
CorticosteroidsYou may experience pain, swelling, or inflammation in ankle, shoulder, hand, or thumb if these medicines are used together. This interaction is more likely to occur in elderly population who have undergone a kidney or heart transplantation. Replacement of the medicine should be made under the doctor's supervision.
EscitalopramYou may experience dizziness, lightheadedness, shortness of breath, or heart palpitations if these medicines are used together. This interaction is more likely to happen if you suffer from any heart disease (Arrhythmia) or have a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
QuinidineYou may experience dizziness, lightheadedness, and heart palpitations if these medicines are used together. Regular cardiac function tests are to be performed if you have any heart disease (Arrhythmia) or a family history of Arrhythmia. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
Antidiabetic medicinesYou may experience hypoglycemic effects like dizziness, headache, nervousness, confusion, tremor and weakness if these medicines are used together. Hyperglycemic effects like increased thirst, urination and hunger are less likely to occur. Regular blood glucose checkups are to be performed if you are diabetic or has any kidney disease. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
AspirinYou may experience tremors, involuntary muscle movements, hallucinations, or seizures if these medicines are used together. This interaction is more likely to happen if you have a history of seizures or family history of seizures. Appropriate dose adjustment or replacement of the medicine should be made under the doctor's supervision.
Ethinyl EstradiolThe desired effect of contraceptive pills will not be achieved if these medicines are used together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
Interaction with Disease
Central Nervous System DepressionIf you suffer from CNS disorder and you take Change Tablet, then you may experience tremors, restlessness, anxiety, confusion and hallucinations. Avoid consuming caffeine containing products like coffee, chocolates and energy drinks.
ColitisAvoid taking Change Tablet if you experience severe diarrhea, abdominal pain, and blood in stools after taking the medicine. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.
Qt ProlongationAvoid using Change Tablet if you experience any chest discomfort. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.
Interaction with Food
Dairy productsThe desired effect of Change Tablet is not observed if consumed with dairy products. There should be at least 2 hours gap between taking Change Tablet and dairy products.
FAQs about Change Tablet
Ques : What is Change Tablet?
Ans : Change Tablet is a medication which has Ofloxacin and Ornidazole as active elements present in it. This medicine performs its action by constricting the growth of microorganism, killing the infection causing bacteria. Change Tablet is used to treat conditions such as Eye and ear infection, Soft tissue infections, Bacterial infections, Bacterial infections by inflammation of the peritoneum, Skin infections, etc.
Ques : What are the uses of Change Tablet?
Ans : Change Tablet is a medication, which is used for treating infectious diarrhoea and dysentery.
Ques : What are the Side Effects of Change Tablet?
Ans : Change Tablet is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Change Tablet which are as follows: Abdominal pain, Anxiety, Black or tarry stools, Confusion, Fever, Painful urination, Decreased appetite, Joint pain, Change in taste, Excessive air or gas in stomach, Runny Nose, Nausea and Vomiting, Sleeplessness, Dizziness, Change in pulse rate, Difficulty in breathing, Shaking of the hands or feet, Skin rash and itching, and Red spots on skin. It is a list of possible side-effects which may occur due to the constituting ingredients of Change Tablet.
Ques : What are the instructions for storage and disposal Change Tablet?
Ans : Change Tablet should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.
Ofloxacin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 24 January 2020]. Available from:
Ornidazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 24 January 2020]. Available from:
Ofloxacin- DrugBank [Internet]. Drugbank.ca. 2020 [Cited 24 January 2020]. Available from:
Ornidazole- DrugBank [Internet]. Drugbank.ca. 2019 [Cited 24 January 2020]. Available from:
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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