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Zuflo OZ 200mg/500mg Tablet

Manufacturer :  Morepen Laboratories Ltd
Medicine Composition :  Ofloxacin, Ornidazole
Prescription vs OTC : Prescription by Doctor required

About Zuflo OZ 200mg/500mg Tablet

Zuflo OZ 200mg/500mg Tablet is a combination medication primarily prescribed for treating diarrhoea and/or dysentery. It comprises antibacterial and antiamoebic drugs that fight against parasitic and bacterial infections. It is very effective in treating infectious condition due to its dual-action.

This medication inhibits the production of certain enzymes in the DNA of a bacteria, which are necessary for the survival and growth of this bacterial infections. Therefore, this antibiotic drug fights against bacterial infections by killing the bacteria and inhibiting the process of bacterial cell division.

It is advisable to take this medication only under the strict guidelines of your doctor. Follow this prescription until the course is complete, even if the symptoms disappear. You should not skip a dose and avoid taking an extra tablet to make up for it.

It is possible for some people to experience a few common side effects after taking this medication. Some people are more likely to face harmful side effects if they also suffer from other conditions like brain disorders, seizures, heart conditions, myasthenia gravis, epilepsy, tendonitis, bone disorders and problems of the joints.

It is advisable to inform your doctor about the above-mentioned conditions beforehand if he/she recommends you taking this medicine. It is advisable for pregnant women, women who are breastfeeding and children below 16 years, to avoid taking this antibiotic since it can lead to harmful consequences.

    What are the uses of Zuflo OZ 200mg/500mg Tablet

    • Infectious Diarrhea

    • Dysentery

    What are the contraindications of Zuflo OZ 200mg/500mg Tablet ?

    What are the side effects of Zuflo OZ 200mg/500mg Tablet ?

    • Abdominal Pain

    • Joint Pain

    • Fever With Chills

    • Running Nose

    • Numbness Of The Hands

    • Loss Of Appetite

    • Dizziness

    • Headache

    • Memory Impairment

    • Nervousness

    • Agitation

    • Disorientation

    Key highlights of Zuflo OZ 200mg/500mg Tablet

    • How long is the duration of effect?

      The effect of this medicine lasts for a duration of 12 to 20 hours.

    • What is the onset of action?

      The peak effect of this medicine can be observed within 1 to 2 hours of administration of the dose.

    • Are there any pregnancy warnings?

      Use of this medicine is not recommended in pregnant women. Use only if clearly needed under the supervision of the doctor.

    • Is it habit forming?

      No habit forming tendency has been reported.

    • Are there any breast-feeding warnings?

      No, this medicine is not safe for breastfeeding women as it can affect the baby.

    • Is It safe with alcohol?

      This medication is not safe with alcohol. If you experience certain symptoms such as drowsiness or disorientation, then you must speak to your doctor immediately.

    • Is it safe to drive while on this medicine?

      As some of the side effects of this medication include headaches and hallucinations, it is not advisable to drive after taking the medication.

    • Does this affect kidney function?

      Patients who have impaired kidney function should not take this medication as it can lead to more kidney problems.

    • Does this affect liver function?

      Patients who have impaired liver function should not take this medication as it can lead to more liver problems, including liver failure.

    What are the substitutes for Zuflo OZ 200mg/500mg Tablet ?

    Below is the list of medicines, which have the same composition, strength and form as Zuflo OZ 200mg/500mg Tablet , and hence can be used as its substitute.

    What are the dosage instructions?

    • Are there any missed dose instructions?

      The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of overdose.

    How does this medication work?

    This medicine is a combination of Ofloxacin and Ornidazole belonging to the class antibacterial and antiamoebic. Thus the medication follows a dual mechanism to produce its action. Firstly, it works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA and causes cell death. Secondly, it works by seeping into the cells of the bacteria and/or protozoa through diffusion and damaging DNA and other critical biomolecules through the formation of reactive nitro radicals.

      What are the interactions of Zuflo OZ 200mg/500mg Tablet ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

      • Interaction with Alcohol


        Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
      • Interaction with Lab Test


        It cause prolongation of prothrombin time. Also elevation in serum triglycerides, cholesterol, potassium, liver function tests are reported.
      • Interaction with Medicine

        These tablets can have adverse interactions with certain medications. These include cholera vaccine, amikacin, Furosemide, ethinyl estradiol, warfarin, chloramphenicol, and nifedipine.
      • Interaction with Food

        Dairy products

        The desired effect of Zuflo OZ 200mg/500mg Tablet is not observed if consumed with dairy products. There should be at least 2 hours gap between taking Zuflo OZ 200mg/500mg Tablet and dairy products.
      • Interaction with Disease

        It can have negative interactions with certain diseases. These include heart disease, tendonitis, epilepsy impaired kidney function, and impaired liver function.

      FAQs about Zuflo OZ 200mg/500mg Tablet

      • Ques : What is Zuflo OZ 200mg/500mg Tablet?

        Ans : This medicine is a combination of Ofloxacin and Ornidazole belonging to the class antibacterial and anti-amoebic respectively. It is primarily prescribed to treat infectious diarrhoea and dysentery.

      • Ques : How long do I need to use Zuflo OZ 200mg/500mg Tablet before I see improvement in my condition?

        Ans : This medication is to be taken till the time you see an improvement in your health conditions.

      • Ques : At what frequency do I need to use Zuflo OZ 200mg/500mg Tablet?

        Ans : This medication should be taken in the dosage as prescribed by the doctor.

      • Ques : Should I use Zuflo OZ 200mg/500mg Tablet empty stomach, before food or after food?

        Ans : This medication should be taken after food in a prescribed dosage.

      • Ques : What are the instructions for the storage and disposal of Zuflo OZ 200mg/500mg Tablet?

        Ans : This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.


      • Ofloxacin- Drug Information Portal [Internet]. 2020 [Cited 24 January 2020]. Available from:

      • Ornidazole- Drug Information Portal [Internet]. 2020 [Cited 24 January 2020]. Available from:

      • Ofloxacin- DrugBank [Internet]. 2020 [Cited 24 January 2020]. Available from:

      • Ornidazole- DrugBank [Internet]. 2019 [Cited 24 January 2020]. Available from:

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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      Content Details
      Profile Image
      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
      Reviewed By
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician

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