Brain metastases from systemic cancer are the most common type of intracranial neoplasm in adults, being almost 10 times more common than primary malignant brain tumors, which cause a significant burden on the management of patients with advanced cancer (1). The lungs represent one of the most frequent sources of metastases to the brain, with a probability of (36 64%) (3). Symptoms suffered by the patients include headaches, epilepsy, focal weakness, numbness or changes in mental status. The prognosis of patients with brain metastases is not optimistic and the median survival time is  1 2 months if left untreated. The 1-year survival rate has been recorded as 10.4% (4,5). The treatment of metastatic brain tumors is complex; not only due to being able to provide local control and improve neurological function, but also due to factors such as age, performance and systemic disease status and the size, volume, location and number of metastases at presentation

CyberKnife is a robotic radiosurgery system with a linear particle accelerator (linac), which is coupled with real-time imaging to track and compensate for the patient s or target s motion. As a relatively non-invasive treatment modality, CyberKnife demonstrates certain benefits, including a more accurate target localization and improved dose delivery for the management of metastatic brain tumors that allows higher biologically effective dose delivery without increased incidence of toxicity.

In the present case, the results for the treatment of multiple brain metastases after CyberKnife surgery with a 7 8 Gy marginal dose was promising. CyberKnife for metastatic brain tumors is an effective and safe method for reducing the marginal dose prescribed for multiple brain metastases and for minimizing the radiation-related neurotoxicities. In conclusion, CyberKnife, a focused, highly-targeted radiosurgery and fractionated radiotherapy is particularly useful for multiple brain metastases. CyberKnife provides the advantage of the management of local recurrence and a tolerable complication rate. Although the treatment of brain metastases has been performed with CyberKnife, the clinical significance and optimal dose fractionation scheme require further investigation.

In case you have a concern or query you can always consult an expert & get answers to your questions!

CyberKnife Therapy Of 24 Multiple Brain Metastases From Lung Cancer!

Asthma, the long term inflammatory disease, affects the airways of lungs. A number of symptoms, including obstruction of air flow into the lungs, which can cause breathlessness, coughing, wheezing, allergic reactions and swelling of the tubes, points to it. The causes include genes as well as pollution in the environment which is resulting in an increasing number of cases. The diagnosis is usually done with a spirometry and the treatment is a long term process. 

Women who suffer from asthma have to be especially vigilant during pregnancy as it can lead to a number of complications including less air passage to the foetus. This can result in a slow rate of development and certain anomalies in extreme cases. So how can a pregnant lady manage asthma? here are a few tips:

 Involve pulmologist: to begin with, the obstetrician and the pulmonologist must both be well aware of the situation. The pulmonologist must be given detailed information with regards to allergies as well as past treatment and medical history so that the treatment is done systematically to prevent an asthmatic attack and any complications to the foetus. 
 Lung function: during pregnancy, the doctor must monitor lung function carefully with monthly check ups to ensure that the right amount of oxygen is reaching the foetus. This is done because the severity of asthma changes in most women during pregnancy. A spriometry or peak flow metre can be used to measure the lung function. Also, the foetal movements must be monitored on a monthly basis, or rather, once every 28 days, to be more specific. 
 Influenza: flu is a common outcome of asthma, especially when it becomes severe during pregnancy. The onset of flu or influenza must be prevented at all costs with the help of a flu vaccine that will be effective at least for a season at a time. It is a pregnancy safe injection. 
 Triggers: there are many things that may trigger an asthmatic attack or an allergic reaction that can lead to the same. Ensure that you do not suffer from these triggers by avoiding dust, pollen, tobacco smoke and varied other substances that can lead to choking and wheezing. 
 Medication: one must ask the doctor about pregnancy safe inhaled corticosteroids that one can take during pregnancy if and when the need arises.

 It is recommended to take medication for asthma during pregnancy only after a consultation with the doctor. Also, do not reduce the dose of the medicine unless your doctor has recommended a change.

How to Deal With Asthma During Pregnancy

The bronchial tubes (also termed as bronchi) present in the lungs play an important role in carrying the air inside and out of the lungs. In Bronchitis, the lining of this bronchial tubes gets inflamed. Chronic Bronchitis, as the name suggests is a more severe condition whereby the bronchi lining suffers a constant inflammation and irritation. In most cases, the condition is found to affect people who are into heavy smoking.

Chronic Bronchitis triggers a myriad of complications including shortness of breath, cough (often associated with the production of a large amount of mucus), tiredness and mild fever. Affect people who are smokers. Heavily and regularly exposed to pollutants like dust, asbestos, fodder, vehicle pollutants(traffic police). Early diagnosis and treatment can help in preventing many serious complications including Pneumonia. In this article, we will highlight the effective treatments and medications along with the precautions in the case of chronic bronchitis.

Treatment and Medications in the case of Chronic Bronchitis
The severity of the condition often decides the course of the treatment.

Since most people with chronic bronchitis complain of breathing problems (shortness of breath) indicative of inadequate oxygen supply, the doctor may suggest an oxygen therapy. In this therapy, oxygen gas is made available to the body to deal with the breathing problem and also to enrich the lungs with sufficient amounts of oxygen to ensure proper functioning of the body. For this oxygen therapy, tubes are fitted either in the nose or placed right in the trachea. In some cases, a face mask may also be used to deliver the oxygen inside the body.
In the case of chronic bronchitis resulting in Chronic Obstructive Pulmonary Disease or COPD (obstructive lung problem that makes breathing difficult), the mucus tends to block and obstruct the airways. Thus, the use of bronchodilators may be helpful. The bronchodilators play an instrumental role in clearing the airway of this obstruction thereby improving the breathing.
Medications such as cough suppressant may also be prescribed to provide relief from a cough.
Precautions and Self-management:
For a speedy recovery, a person should take the necessary precautions. There are certain Do's and Dont's that one should take care of in the case of chronic bronchitis.

For people with chronic bronchitis, smoking is more like a poison. Refrain from smoking during the entire course of the treatment.
Keep away from things (such as paints, pollutants, or any cleaning products with a strong odor and fumes) that can irritate your lungs. The use of a mask (whether at home or outside) is advisable.
Many people with chronic bronchitis have had significant improvement by practicing yoga.
It is also important that you keep the body well hydrated. Make sure to drink water at regular intervals.
Ensure you have a proper rest and sound sleep.
Take care of your diet. Avoid refined sugar, salty and spicy foods, foods that contain high dairy fats (ice-creams, cheese cakes, whole milk, and any foods that contain high-fat cheese).

Chronic Bronchitis - Precautions To Be Taken And Treatment!

Cancer like most other diseases has the best rates of recovery with early detection and intervention. As there are no regular health screenings for blood cancer, only the awareness about the early warning signs can save your life. November is designated as the Lung Cancer Awareness Month, to ensure every individual is equipped to fight against lung cancer right from the start. Here are 4 vital facts you must know to win your fight against blood cancer.
Lung cancer is also known as pulmonary carcinoma or cancer of the lung. It occurs when DNA mutations develop in the cells/ tissues of the lungs leading up to uncontrolled growth in the tissues of the lung. By far, it is known to be the most common cancer in Asia.

1. Type: lung cancers can present as one of the following types: 

Non-Small Cell Lung Cancer (NSCLC): Most common type of lung cancer and constitutes nearly 85% of all lung cancers. The sub-types of NSCLC are as follows:
Large cell carcinoma
Squamous cell carcinoma (SqCC) (Epidermoid)
Adenocarcinoma   accounts for majority of the NSCLC.
Small Cell Lung Cancer (SCLC): It is also known as oat meal cancer and tends to spread (metastasize) quickly. This constitutes about 15% of the lung cancers.
Mesothelioma: It is a rare cancer that develops in the mesothelial cells of the pleural or peritoneal surfaces. It usually arises in the pleural membrane lining the lungs, known as pleural mesothelioma. One that arises from the peritoneum is called the peritoneal mesothelioma and the one that arises from the pericardium is known as pericardial mesothelioma. Lastly, it can also arise from the tunica vaginalis known as testicular mesothelioma. People working with or prior exposure to asbestos are mostly at risk of developing mesothelioma. The latency period between time of exposure and development of mesothelioma can be somewhere between 20 to 40 years. Maximum of the patients who develop mesothelioma are men.
2. Gender: It affects the male populace predominantly. It is more common in men than in women and in those of lower economic status. However, the incidence of lung cancer, in women too, is on the rise of late.

3. Etiology: Cigarette/ Tobacco smoking remains the most important cause of lung cancer accounting for 85   90% of the cases. Incidence/ risk is proportionate to the number of cigarettes smoked irrespective of the age. Also, environmental toxins including smoke from burning black tar, exhaust gases from automobiles etc. too contribute actively to various lung diseases including cancer. People working in asbestos manufacturing factories who are exposed to asbestos dust are also likely to get lung cancer. Tuberculosis too is an additive risk factor. Again, people who have received ionizing radiation especially to treat Hodgkin Lymphoma or other malignancies also run the risk of developing lung cancer. Above-mentioned causes apart, genetic factors may also play a role.

4. Features: Lung cancer clinically presents in the following ways mainly. Signs & symptoms of malignant mesothelioma are as enumerated below

Difficult/ labored breathing (Dyspnea)
Chest pain
Palpable chest wall mass
Discordant chest wall expansion
Weight loss (Cachexia)
Loss of appetite (Anorexia)
Night sweats
Signs & symptoms of non-small cell lung cancer (NSCLC) are as enumerated below. Majority of patients are symptomatic at diagnosis

Chronic cough
Difficult/ labored breathing (Dyspnea)
Chest pain
Blood stained sputum (Hemoptysis)
Hoarseness
Weight loss (Cachexia)
Loss of appetite (Anorexia)
Weakness
Bone pain
Pleural or pericardial effusion
Superior vena cava syndrome
Brachial plexopathy
Neurologic pain
Hypercalcemia of malignancy
Signs & symptoms of small cell lung cancer (SCLC) are as enumerated below

Symptoms as per the points 8   18 depicted above for NSCLC are applicable for SCLC as well. Additionally, patients suffering from SCLC may have:

Fever associated with chest infections like bronchitis/ pneumonia that refuse to go away or keep coming back
Horner syndrome
Paraneoplastic syndromes including encephalitis/ sub-acute sensory neuropathy, hyponatremia, acromegaly, cancer associated retinopathy, ectopic corticotropic syndrome etc all.
5. Screening: is generally recommended for asymptomatic/ symptomatic populations as surveillance for high-risk individuals   who are either current or former smokers (quit smoking within the last 15 years) have at least a 30 pack-year smoking history and those who do not have any prior history of lung cancer. The goal of screening, as usual, is to be able to detect & diagnose lung cancer at an early stage which is potentially curable. It is mostly radiologic with a low dose helical computed tomography (CT) scan being more effective in detecting early-stage lung cancer than a chest radiograph can.

6. Diagnosis: Abnormal blood test results may be indicative of malignancy, but a follow-up imaging/ biopsy is always the gold standard for an accurate diagnosis. Following are the diagnostics employed mainly:

Blood: Hb may be low, TLC, ESR and polymorphs increased. Adenocarcinomas are likely to express thyroid transcription factor 1 (TTF-1) or carcinoembryonic antigen (CEA). On the other hand, mesotheliomas are likely to express Wilms Tumor -1 (WT-1) protein and Calretinin.
Imaging: Thoracoscopy, Bronchoscopy, X-Ray, CT Scan etc all. Positron Emission Tomography (PET) / CT scan and Magnetic Resonance Imaging (MRI) scan help detect metastasis if any.
Biopsy: It clinches the histologic diagnosis and the nature of the disease.
7. Treatment: Conventional treatment includes surgery, chemotherapy and radiotherapy as contextually appropriate. Simultaneously, an adjunctive or integrative naturopathic treatment with suitable complementary & alternative medicines (CAM) too can help improve clinical outcomes and facilitate recovery as would be feasible contextually.

8. Prognosis: Preventive measures, earlier diagnosis and right early treatment are key for effective therapeutic management & better prognosis. Like most other cancers, the chances of cure for early-stage lung cancer are more. The cure/ recovery chances are influenced by the grade, stage of cancer, recurrence and the patient s general health & vitality etc all. The primary determinant of prognosis in NSCLC is the stage at which the cancer is diagnosed. For non-metastatic cancers, however, it is the nodal status that determines the stage and hence the prognosis.

9. Prevention: Rightly said, prevention is always a better choice. Cigarette smoking is to be avoided by all means as it is the single major cause of lung cancer. Even exposure to cigarette smoke (passive or secondhand) is also an established cause of lung cancer and is known to increase the risk of lung cancer in non-smokers as well. Preventing exposure to secondhand smoke can be helpful in decreasing the incidence and mortality of primary lung cancers. Above-mentioned apart, other important risk factors such as exposure to ionizing radiation, environmental carcinogens like smoke from burning black tar, exhaust gases from automobiles, outdoor air pollution, and occupational exposure to asbestos, arsenic, beryllium, nickel, cadmium, chromium etc all too are known to increase the risk for lung cancer and mortality thereof. In fact, cigarette smoking is known to potentiate the effect and hence the lung cancer risk of many of the above-mentioned carcinogens, multi-fold, in smokers. Thus, either eliminating or reducing the exposure to the above-mentioned carcinogens can lead to a decrease in the risk of lung cancer and incidences thereof. Furthermore, randomized clinical trials indicate that high-intensity smokers (only) who take supplementation of beta-carotene have an increased risk/ incidence of lung cancer. Vitamin E supplementation, on the other hand, does not affect the risk of lung cancer as indicated by the trials. 

In case you have a concern or query you can always consult an expert & get answers to your questions!

Lung Cancer Awareness Month - Lung Cancer In Nutshell!

Interstitial lung disease is an umbrella term for numerous lung diseases that are caused due to scarring or inflammation of lungs. Because of the inflammation, it becomes hard for the body to get enough oxygen. Pulmonary fibrosis is the term for scarring of the lungs.

It refers to a variety of progressive conditions and disorders that result in inflammation and heavy scarring of the lung tissue. Because scarring of the sensitive lung tissue causes hardening and inflexibility of the lungs, the lungs are unable to expand to their normal size. This irreversible condition greatly reduces breathing capacity and prevents life saving oxygen from properly traveling through the bloodstream.

While most cases of interstitial lung disease occur at a gradual progression, other cases appear more rapidly and their causes are unknown. Treatment options sometimes vary and while prescription medicines can slow the progression of interstitial lung disease, it is often not enough to help a patient recover full breathing capacity.

Symptoms-

The major symptoms of interstitial lung diseases include:

Shortness of breath which increases due to exertion

Dry coughing

Types of Interstitial Lung Disease-

Any sort of interstitial lung disease causes thickening of the interstitium which may be due to extra fluids, inflammation or scarring. Some types may be short lived; however, some could be chronic and really painful.

Some of the kinds are discussed below:

Interstitial Pneumonia: This is caused due to infection in the interstitium of the lungs by bacteria, fungi or viruses. The most common cause being a bacteria named Mycoplasma pneumonia.

Idiopathic Pulmonary Fibrosis: Although the cause is unknown, this is a chronic form of scarring of the interstitium.

Hypersensitivity Pneumonitis: This lung problem is caused due to excessive inhalation of dust, mold or other sort of irritants.

Non-specific Interstitial Pneumonitis: These are the kinds of lung problems, which are presented with autoimmune conditions such as scleroderma or rheumatoid arthritis.

Acute Interstitial Pneumonitis: This is a sudden and intense lung disease which usually requires life support.

Cryptogenic Organizing Pneumonia: This is a kind of interstitial lung disease but without the presence of any infection.

Desquamative Interstitial Pneumonitis: This is partially caused due to smoking.

Asbestosis: As the name suggests, this is caused due to prolonged exposure to asbestos.

Sarcoidosis: In this condition, lymph nodes are swollen along with lung disorders. Often heart, eye, skin and nerve involvement also occurs.

Homeopathic Treatments For Interstitial Lung Diseases-

The most common treatments are as follows:

Beryllium: This can be the remedy for formation of nodules or granulomas that usually form in the lungs, in other body organs or systems. This particular medicine has been very useful in the treatment of sarcoma. This can be provided to individuals who have difficulty in breathing and enormous pain in the lungs, have dry coughs etc.

Silica: In case of characteristic scarring and thickening of the inner lung layers, this medicine can be prescribed. This remedy helps enormously in relieving cold, sharp lung pains, coughing with very thick phlegm and haemorrhaging capillaries.

These are the most common medications; however there are numerous others that can help relieve lung disorders.

Homeopathic Treatment For Interstitial Lung Disease

Homeopathy is a method of treatment, which is based on the fact that symptoms of a certain disease, if induced in small quantities, may help cure the same disease in a sick person. Cardiological disorders are complications of the heart; they can range from various disorders, such as heart attack or irregular heartbeats.

Homeopathic remedies are based on naturally occurring substances and are given to the patients in a diluted form. These remedies trigger the symptoms in small quantities and heal the body.

The various homeopathic treatments for cardiological disorders are:
1. Latrodectus: This treatment is used to treat symptoms of precordial pain in the body.

2. Aurum metallicum: Aurum metallicum is used in treating symptoms of weakness in the muscles of the heart.

3. Aconitum:This treatment is used when a person is having a heart attack.

4. Spigelia: Spigelia is used in the treatment of irregular heartbeats which may cause sharp pain in the chest.

5. Cactus grandiflorus: This treatment is used in treating angina pectoris, which is characterized by symptoms of pain caused by decreased blood flow to the heart.

6. Crataegus oxyacantha: This homeopathic treatment is used in treating coronary insufficiency in people. This disorder cause problems in heartbeat.

7. Digitalis: This homeopathic treatment is used in treating cardiac muscle failure. This disorder causes palpitation, tightness in the heart muscles and a suffocating sensation.

8. Kalmia latifolia: This treatment is effective in treating cardiac hypertrophy, which causes the heart muscle to thicken, resulting in size reduction of the ventricles. This treatment is very effective in treating cardiac hypertrophy that results after rheumatism.

9. Glonoinum: This homeopathic treatment is prescribed to treat symptoms of plaque buildup in the artery, which cause hypertension.

Homeopathy Treatment For Cardiological Disorders - 9 Best Remedies

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