Metrorrhagia is a medical condition in which uterine bleeding occurs regularly or irregularly outside the normal menstrual cycle. Generally Metrorrhagia occurs due to hormone disorders or any other such irregularities. It could also be an indicator of some serious health issues such as endometriosis, cancer of reproductive organs or uterine fibroids. Read on more to find all about them.

Causes
Metrorrhagia can occur due to a number of reproductive disorders as well as certain diseases. Syphilis, infection, malignancy, pregnancy and many more are listed as the reasons behind Metrorrhagia. Metrorrhagia can be a serious issue as it can be painful, irritating and a major inconvenience.

Risk factors
Metrorrhagia is a medical condition which might be due to certain disorders or medical conditions the patient might be suffering from. They are mentioned as follows:

    Hormone related: Irregular uterine bleeding can occur due to hypothyroidism, adrenal deficiency and low progesterone. Metrorrhagia in such situations can be resolved if suitable treatment is administered in the right time and for that, correct diagnosis is absolutely important.
    Reproductive related: Endometrial hyperplasia and endometriosis and such other reproductive disorders or diseases could be a cause for Metrorrhagia. In such cases, early diagnosis is absolutely recommended for a speedy and complete recovery.
    Benign Tumors: Certain benign tumors like ovarian cysts and fibroids can also cause irregular uterine bleeding. Though benign, a physician should be consulted immediately for a speedy recovery as Metrorrhagia in itself can prove to be critical.
    Malignant Tumors: Ovarian cancer and endometrial cancer can also be a reason for the cause of Metrorrhagia. In such a condition early diagnosis and treatment is highly essential for a full recovery.

Treatment
If the patient is suffering from Metrorrhagia, then they are advised to consult a physician as Metrorrhagia could be a sign of something more serious. Depending on the diagnosis the doctor can prescribe medications or if necessary, certain surgical procedures. Some of the medications and surgeries which can be prescribed by your physician include oral contraceptive pills, progesterone pills or injections, endometrial ablation and hysterectomy among others.

All about Metrorrhagia

OCD (Obsessive Compulsive Disorder) is a psychological disorder where you feel compelled to perform irrational tasks in continuous patterns almost ritualistically. These compulsive thoughts may seem, upon examination that they are without any particular reason or rhyme. Naturally, a psychological disorder is not voluntary and people who suffer under this disorder don t voluntarily like to make their lives difficult contrary to some who would say  if you don t like it don t do it. 

It is not a simple matter, OCD can have a lot of underlying reasons which makes life even more difficult and wears you out. You still can t get over a particular thought until you have performed it a given number of times even if it harms your health and the relief is also short lived. For the naysayers who don t realise, how difficult life can be for people suffering from OCD here are a few reasons that you should consider:

Depression: People with OCD are also prone to suffering from depression. A sense of feeling like you are not like others, you see the world a little differently and obsessively repeat such compulsive lines of thought until it wears you out mentally. It is a side effect of OCD and deeply affects their lifestyle negatively.
Anxiety: When you have OCD you suffer from constant anxiety about things you may not have done that you must do or vice versa, or very intrusive thoughts that make you anxious wondering about the kind of person you are or becoming. It is a constant battle everyday trying not to repeatedly perform all the compulsive behaviours that may strike you and makes daily life immensely difficult.
Eating disorders: Suffering from OCD also affects your diet and food habits. You either start over eating or not eating enough resulting in huge amounts of weight gain or noticeable weight loss or just a fluctuation in weight.
Skin rashes: The outer manifestations of OCD are numerous. If you suffer from obsessive, washing of hands or clothes or any activity that requires constantly irritating your skin then you will develop rashes which will cause more anxiety in you. It s just a facet of OCD wherein you become obsessed with cleanliness and can t go without feeling anxious about the number of toxins surrounding you so you go about trying to almost sterilise yourself and end up damaging your skin.
Sleep disturbances: Your sleeping pattern gets affected if you can t build up a routine and then you can t sleep until it s a certain hour at a certain time of the day. Or if you suffer from paranoia then you are unable to sleep because you are actively worried about something or the other. Anxiety also contributes to restlessness.

5 Reasons Why OCD Makes Life Difficult!

If you are constantly getting sick, feeling tired without reason, or are prone to bone fractures, then it is the proper time to check the amount of vitamin D in your body. If you have vitamin D less than 30 nanograms per deciliter, then it shows that your body lacks vitamin D. Here are the eight symptoms of vitamin D deficiency that you should not ignore

You always feel tired: You may eat healthy diet, follow a healthy lifestyle, or have a good night sleep, but you still feel tired at all times. Well it may be an indication that your body is not having sufficient amount of vitamin D. Taking vitamin D supplements or including foods that are rich in vitamin D will allow you to overcome your chronic tiredness.
You feel depressed: You are feeling depressed lately, still you ignore it and not take proper action can further decrease the levels of vitamin D in your body. Involve yourself in doing simple workouts, meditation, yoga, etc., will allow you to feel relax.
You have a constant sweaty forehead: Almost everyone faces a littel sweat on their forehead and wipe it away without giving it a thought. However, you should know that it is one of the symptoms of vitamin D deficiency. 
You feel bone and muscle pain constantly: Constant muscle and bone pain is a sign that your bones are losing their strength and is an indication of deficiency of vitamin D. 
You experience sexual problems: You may be quite healthy and have the required energy and mood to involve in your sexual activity. However, you are not getting a firmer erection to perform better in your bed. This can be due to lack of vitamin D in your body. Thus, you should be careful and not ignore it, discuss it with, both your partner and doctor for the right treatment. 
You are susceptible to bone fractures: Vitamin D plays a vital part in strengthening your bones. Therefore, take vitamin D supplements to make your bones stronger.
You are deprived of sleep: Vitamin D deficiency can be the reason behind your sleep deprivation and as it is closely associated with sleep apnea. It is a serious disorder as it affects the flow of oxygen to your brain and to your other body parts. 

Vitamin D Deficiency - Are You Ignoring These 7 Signs?

The bladder is a hollow storage organ that collects urine from the kidneys and stores it until it can be passed out of the body through the urethra during the process of micturition or urination. It has a thin inner lining of cells called urothelial cells and a thick muscular wall, which exerts pressure to push the urine out of the body.

Causes of Bladder Tumors

In most cases, the bladder tumor develops on the inner layer due to a combination of some of the following factors.

1. Hereditary: A strong family history of cancer predisposes a person to cancer.
2. Gender: Men are 3 times more prone for bladder cancer than women.
3. Ethnicity: White people are more prone for bladder cancer black people.
4. Smoking: Smokers develop bladder cancer 2-6 times more frequently than non-smokers. cigarettes contain toxic, carcinogenic substances which reach the kidney and are stored in the bladder, leading to their damage.
5. Occupational hazards: Some workplaces have a higher likelihood of causing bladder cancers, especially dye and rubber industries. The effects can be damaging, and the person may develop cancers years after the exposure has happened.
6. Recurrent bladder infections: In some people, this can also lead to bladder cancer in the long run.

Types of Bladder Tumor

Depending on the extent of the cancerous spread, it can be of two types:

1. Non-muscle-invasive bladder tumors: The tumor spread is limited to the inner part of the bladder (urothelial cells)
2. Muscle-invasive bladder tumor: The tumor has spread to the thick muscular outer layer. This is more advanced and prognosis is poor compared to the noninvasive type.

The most common and diagnostic symptom of bladder cancer is the presence of blood in the urine, known as hematuria. This will be intermittent and happens whenever the tumor bleeding happens. Other symptoms include pain in the lower abdomen and frequent urination.

Diagnosis

From the most noninvasive to the most invasive diagnostic test, these include:

1. Urine microscopy to detect cancer cells in the urine
2. Cystoscopy A tube inserted into the urethra to look into the inner wall of the bladder is highly diagnostic
3. Ultrasound, CT Scan, and biopsy can also be further used to identify severity of the tumor.

Treatment

Once the tumor is diagnosed, treatment would depend on the severity of the tumor. For both invasive and noninvasive tumors, definitive therapy is surgery, known as transurethral resection of the bladder tumor (TURBT). The cancerous bladder tissue is removed through a cystoscope as done for diagnosis. The bladder is then flushed with chemotherapy agent to kill any residual cancer cells in the bladder. This is then followed by BCG vaccine, which is again done 1 to 4 weeks for several months to avoid recurrence. In some cases, radiotherapy may also be included.

Bladder Tumor and Its Common Causes

Osteoporosis is a condition which usually results due to a decrease in bone density. In this condition, the bones become weak and brittle. Fractures are a common result of osteoporosis. Usually, symptoms or signs do not show up until the condition progresses to its advanced stages.

Since osteoporosis is usually irreversible and incurable, preventing the fractures is considered to be extremely important.

Who is at risk of osteoporosis?
All men and women have some risk of developing 'thinning' of the bones (osteoporosis) as they become older, particularly over the age of 60. As mentioned above, women are more at risk than men. The following situations may also lead to excessive bone loss and so increase your risk of developing osteoporosis. If you:

Are a woman who had the menopause before 45 years of age
Have already had a bone fracture after a minor fall or bump
Have a strong family history of osteoporosis.
Have a body mass index (BMI) of 19 or less (that is, you are very underweight)
Have irregular periods
Have taken, or are taking, a steroid medicine (such as prednisolone) for three months or more
Are a smoker
Have an alcohol intake of more than four units per day
Lack calcium and/or vitamin D (due to a poor diet and/or little exposure to sunlight).
Are mostly inactive
Ways To Treat Osteporosis

Osteoporosis in women can be treated using Hormone Replacement Therapy (HRT). The therapy makes use of either a combination of progestin and oestrogen or simply, oestrogen. However, it is possible that certain combinations have side-effects that might give rise to other medical conditions. Therefore, proper consultation with an orthopedist is an essential pre-requisite so that the condition of osteoporosis as well the side effects may be addressed before proceeding with Hormone Replacement Therapy.

There are a number of medications that can be used which have long-term effects on osteoporosis. However, the schedule for intake of these medicines should be followed diligently. Failing to adhere to the schedule could lead to serious complications. For example, the intake of Risedronate medications (prevent bone loss) should be scheduled once every month, failing which can cause ulcers in the food pipe. Raloxifene has effects which are similar to oestrogen but does not exhibit any serious side effects. Teriparatide can be used to treat osteoporosis in people who have a high risk of suffering from bone fractures.

Don't rely entirely on medication as the only treatment for your osteoporosis. These practices also are important:

Exercise. Weight-bearing physical activity and exercises that improve balance and posture can strengthen bones and reduce the chance of a fracture. The more active and fit you are as you age, the less likely you are to fall and break a bone.
Good nutrition. Eat a healthy diet and make certain that you're getting enough calcium and vitamin D. Being underweight or losing a lot of weight unintentionally is associated with poorer bone health and a higher risk of fracture   even if you're taking a bisphosphonate.
Quit smoking. Smoking cigarettes speed up bone loss.
Limit alcohol. If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger.

How To Cure Osteoporosis?

Liver transplant in the only curative option available for patient who develop cirrhosis of liver due to any cause ( Chronic Hepatitis B , Chronic Hepatitis C, Alcoholic Cirrhosis, NASH etc). Once patient has been diagnosed with cirrhosis it can not be reversed with any non-surgical treatment . Over a period of time patient may develop worsening in liver function resulting in complications of cirrhosis (bloody vomitus, black stools, jaundice , altered sensorium, renal dysfunction, abdominal swelling etc) labeled as  decompensated cirrhosis . These patients require Liver transplant at the earliest and should be reffered to a liver transplant centre immediately. Ideally all patient diagnosed with cirrhosis should be under the follow-up of a gastroenterologist/Hepatologist. The source of graft liver can be from two sources namely from a deceased brain-dead donor or a Living-related donor and termed respectively as DDLT ( Deceased donor liver transplant) and LDLT ( Living Donor Liver Transplant) . However both DDLT and LDLT have nearly 90% success rate and both the procedures have their own benefits and lacunaes. Also the decision to go for DDLT and LDLT may vary for any particular patient. 

Before the Liver transplant 

All recipient and Living donor go thorough evaluation before the transplant process that includes blood investigations, Imaging studies, Cardiac and pulmonary fitness tests, multidisciplinary consultation before the clearance for liver transplant is achieved. The healthcare provider will explain the entire procedure. The healthcare provider is also supposed to answer all your questions. You would be needed to sign a consent form that allows the doctor to do the surgery. Eating food is not allowed at least 8 hours before the surgery. If you cannot stay relaxed before the surgery, a sedative will be given. 

After the Liver Tranplsant 
The recipient surgery lasts for anywhere between 12-16 hrs and donor surgery for 8-12 hrs. After the surgical procedure is complete, you will be taken to the intensive care unit (ICU)and will be closely watched for several days. 

Immediately After the Surgery 
You will most likely have a tube in your throat. This is so that you can breathe with the help of a machine (a ventilator) until you can breathe on your own. The ventilator tube will be removed on next morning when all parameters are found to be satisfactory. All parameters are monitored by round the clock critical care doctors and staff for a few days. The recipient has to stay in the hospital for three weeks and the donor is discharged in one week. 

Blood samples will be collected on a regular basis to check the functioning of the new liver. Antibiotics will be infused via IV channels to prevent you from infections. The area where the operation was done should always be kept clean after you have reached home. Any stitches or surgical sutures will be removed at a follow-up visit.

Complications that may arise 
Blocked blood vessels to the new liver, bleeding, an infection, leakage of bile or blocked bile ducts, or the new liver not working for a short time right after surgery are a few complications that may arise. Not to aggravate the condition, in the case of a complication, it is imperative to visit your doctor.

Liver Transplant - What To Expect Before & After The Procedure?

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