Schnitzler s syndrome is a very rare condition described by a reddish rash that looks like hives (urticaria) and lifted levels of a particular protein in the blood (monoclonal IgM gammopathy). Symptoms connected with the Schnitzler disorder may include increased levels of fever, joint inflammation, joint pain (arthralgia), bone agony, and different discoveries, for example, swollen lymph nodes (lymphadenopathy). It also causes weight reduction, discomfort, exhaustion, and broadened spleen and liver. This condition should be treated in terms of taking care of the symptoms so that they do not become debilitating.

Some of the other symptoms include the following:

Urticaria (hives) depicts red raised patches of the skin. These are once in a while irritated. They may last for about 12 hours to 3 days. This may become severely painful if not treated in time.
80% of such patients suffer from painful or swollen. A few patients experience bone pain as well.
High fever might be there accompanied by chills and night sweating. This can give rise to further uneasiness and is usually caused when the immune system is attacked by the ailment.
One of the main symptoms of the Schnitzler disorder is monoclonal gammopathy. This mostly means a raised level of immunoglobulin M (IgM)
Reasons behind it

The main cause behind the Schnitzler syndrome is unknown. Specialists believe that particular parts of the immune system may not work appropriately in the end because of the Schnitzler syndrome. Individuals with the Schnitzler disorder additionally have monoclonal IgM gammopathy, in which abnormal production of immunoglobins result in elevated levels of immunoglobulin M (IgM) in the body. Immunoglobulins are proteins delivered by the white blood cells. A few analysts believe that IgM antibodies accumulate in the skin (epidermis), setting off a reaction that causes the rash. At the time of diagnosis, IgM levels may just be somewhat raised and may stay stable for quite a long time.

Diagnosis

The diagnosis of the Schnitzler disorder is based upon an intensive clinical assessment, patient history, rejection of different other disorders and proof of fever, joint pain or aggravation, bone pain, discernible lymph nodes, amplification of the liver or spleen, lifted quantities of white platelets (leukocytosis), raised red platelet (erythrocyte) or anomalies, which can uncover expanded bone thickness (osteosclerosis).

Treatment: 
Anakinra is a successful treatment for Schnitzler syndrome. It is also very commonly used to treat rheumatoid joint inflammation. The following medicines and therapies have been proven to be successful for treating the Schnitzler disorder over a period of time. These are as follows:

Antihistamines
Nonsteroidal calming specialists
Systemic steroids (prednisone)
Hydroxychloroquine
Colchicine
Dapsone
Pamidronate
Thalidomide
Pefloxacin
Phototherapy
Immunosuppressive specialists (ciclosporin, methotrexate, cycloposphamide)
Biologic specialists (tocilizumab, rituximab)
The Schnitzler disorder is a long-term infection, so stopping a promising treatment can tend to cause a relapse and may cause the disease to reappear. Also, the medicines mentioned above should not be taken without consulting a doctor as they can have sever side effects, if not administered under the guidance of a physician.

Schnitzler Syndrome - Things You Must Know About It!

Hives or urticaria is an outbreak of reddish swollen bumps around the skin surface, formed mainly due to the body s response to particular allergens. Generally, the infectious bumps are of varied shapes and sizes and last for about 5-6 weeks. Although not a serious medical condition, hives can cause tremendous discomfort to the concerned person and affect his/her daily activities. Hives can be cured with a prescribed dosage of antihistamines or oral corticosteroids.

Causes of hives

Although the exact reason behind their formation is still unknown, researchers suggest that this disorder occurs as a response to involuntary histamine release by the skin blood vessels (that in turn, causes a leakage of blood plasma). Some other factors that can be responsible are:

Hives can occur due to insect or parasite bites.
Hives can also result as a side effect of painkillers such as codeine and other anti- inflammatory drugs such as ibuprofen or ACE inhibitors.
Excessive exposure to sunlight or high levels of stress (leading to high cortisol levels in the body) can also result in hives.
Intense scratching around the same spot can also result to hive formation.
Excessive alcohol intake can render you even more vulnerable to this disease.
Excessive intake of foods such as eggs, fish, nuts, chocolate and berries might also cause hives. Additionally, excessive consumption of certain food preservatives can also trigger the release of histamine.
Suffering from serious underlying medical conditions such as cancer, hepatitis or thyroid disorders can make you prone to chronic cases of hives (which might last for more than 6 weeks).
Symptoms of hives 
The symptoms of hives include, but are not limited to:

Appearances of several reddish welts around the face or arms which might cause a severe itchy sensation.
Painful and abnormal swelling around the mouth
You might also feel tightness in your chest along with recurring bouts of dizziness.
If not treated promptly after diagnosis, hives might result in life-threatening allergic reactions, such as Anaphylaxis (narrowing down of the bronchial tubes, thus causing significant breathing trouble) and auto-immune disorders such as rheumatoid arthritis.

7 Things that Can Cause Hives

The last molar teeth in the mouth are called as wisdom teeth. While in some people they erupt completely into the mouth and function with no problem whatsoever, in others, they remain embedded in the bone, erupt incompletely, erupt at an angle, or are covered by bone or a flap of tissue. They are absent in many.
Of late, dentists recommend removal of wisdom teeth, more a preventative than remedial measure. Some of the reasons for wisdom tooth removal are listed below-
Impaction: Often, wisdom teeth do not have enough space to erupt in their normal position. This can only be evaluated properly on an x-ray. If the x-ray shows that the tooth is unlikely to erupt because of being blocked by a root or bone, this needs to be removed.
Pericoronitis: The tooth partially erupts into the mouth but is covered by a flap of gum. This attracts food and bacteria to accumulate, leading to decay and infection, a condition called as pericoronitis. Very common in the lower wisdom teeth, it leads to severe tooth pain, painful swallowing and swelling of the lymph nodes. This is the most common cause for wisdom teeth to be removed. An x-ray will reveal the tooth to be infected and sometimes periapical abscess may also be present.
Cysts: Impacted teeth can develop fluid-filled cysts which can cause severe and even permanent damage to the jaw bone, adjacent teeth and nerves. Dentigerous cysts are the most common type.
Alignment: Misaligned wisdom teeth exert a constant mild pressure on the adjacent teeth which can hamper the alignment and reverse the effects produced by braces. The bite may be altered also, thereby necessitating removal.
Adjacent Tooth Damage: If the malposed wisdom tooth is causing pocket formation or decay in the adjacent teeth, it is time to get them removed.
Recurrent Sinus Infections: With their proximity to sinuses, there could be constant pain and pressure and infection of the sinuses. This is another indication for their removal.
However, not all wisdom teeth need to be removed. If they have erupted fully, are healthy, produce a good bite, and can be cleaned easily, they do not require removal.
During the teenage years and through 20s, check with your dentist on the health of the wisdom teeth. X-rays can be taken to monitor them and for early identification of problems. If they need to be removed, it is easier to take them out when you're young. The bone surrounding the impacted tooth is less dense, and therefore easier. The ability of the body in general and the jaw bones in particular to heal is also better at a younger age. 


Wisdom Teeth - When To Get Them Removed

Hives, also called urticaria are swollen welts or bumps that appear on your skin suddenly.

They itch, burn and sting and can happen anywhere on your body. You can get them on your face, lips, tongue, ears or chest. And in size, they can be as small as an eraser to as large as a plate. They also form plaques and can last for hours or up to several days.

Types

Acute urticaria - These type of hives last less than six weeks. The most common causes are allergies due to certain foods and medications, or infections. These hives can also happen due to diseases or insect bites.
Chronic urticaria - Hives lasting more than six weeks come under this category. What causes them is usually more difficult to identify than what causes acute urticaria. In some cases, chronic hives are caused due to thyroid disease, hepatitis or even cancer. This type can affect your internal organs like lungs, muscles, and the gut. Thus, symptoms include muscle soreness, shortness of breath, vomiting, and diarrhoea.
Physical urticaria - These types are caused due to direct physical stimulation of the skin due to cold, heat, sun exposure, vibration, pressure, sweating, and exercise.
What causes hives?

Hives happen mostly due to allergies. Some of the common hive triggers are-

Certain foods, especially peanuts, eggs, nuts and shellfish- Fresh foods are more likely to cause hives as compared to cooked foods. Certain food additives and preservatives can also play culprits. Medicines like penicillin and sulfa- based antibiotics, aspirin and ibuprofen which are non-steroidal anti-inflammatory medications, high blood pressure drugs like ACE inhibitors, and painkillers such as codeine can also trigger hives. Other things that may cause it are:

Insect bites
Latex
Transfusion of blood
Bacterial infections, including urinary tract infections and infected throat
Viral infections- common cold and hepatitis
Pollen grains
Plants like poison oak and poison ivy
Sunlight
Cold weather
Pet dander 
If you wish to discuss about any specific problem, you can consult a dermatologist.

What Are Hives? What Causes Them?

Hives is a very common condition and about 20% of the world has got it at some point in their lives. There are many causes to it ranging from blood transfusions to certain allergic reactions to food. It starts off as an itchy patch of skin but slowly swells and turns into red welts. There are certain factors which makes the itching worse including stress, alcohol and scratching the area of skin which was itchy in the first place. 

Causes
Here are all the causes and symptoms of hives:
1. Food
Allergic reactions to foods such as nuts, eggs and shellfish are a common cause of hives.

2. Medications
Certain medications also have a side effect of causing hives. Penicillin and sulfa are two of the antibiotics, which can cause hives. Ibuprofen and Aspirin are also two other medications, which are commonly known to cause hives.

3. Infections
Both bacterial and viral infections can lead to hives. Strep throat, urinary tract infections, common cold and hepatitis are some of many bacterial and viral infections, which may cause hives.

4. Stimuli
Certain factors such as temperature, pressure, sun exposure and other physical stimuli may cause hives as well.

5. Plants and animals
Dander in animals are the flakes of skin in their fur. Moreover, coming into contact with certain poisonous plants may cause hives.

6. Insects
When insects sting or bite you, you may get hives.

7. Latex
Latex is a type of rubber used in many types of clothing. It has been said that wearing clothing made out of latex can cause hives.

8. Pollen
Pollen is a light powdery substance produced by plants such as oak trees. It travels through the air and may cause hives if it comes into contact with your skin.

Symptoms
1. Bumps
Itchy red bumps appear on the skin when you have hives. Sometimes, the bumps can be skin-colored as well.
2. Blanching
When the bumps turn white after you press them, it is known as blanching. Blanching is the only clear symptom of hives.

Hives: Causes and Symptoms

One of the most important functions of the skin is protection. During this process, it comes in contact with various substances including chemicals, pollen, dust, and other pollutants. While it does protect the overall body from all these, there is some damage that is inevitably done to the skin through these exposures. Different skin and different bodies react differently to these, and while some may have no reaction, others develop allergies. This is also defined by how strong the person s immunity is.

Hives is one of the most common skin allergy responses. While it is not easy to pinpoint what causes the allergy or the hives, the causative agent can be nailed by observing patterns and excluding out some of the causative agents. There are a set of regular household and surrounding items that could lead to urticaria, and working around these can help pin down the source.

Origin: When the body encounters a foreign body, it produces what are known as histamines. When they are produced, the plasma in the cell leaks out, producing a red and swollen appearance. Hives are red, itchy, raised patches on the skin. They are seen in about 20% of the population. Hives are usually allergic in nature, implying that they occur when there is a foreign substance that induces an allergic reaction. Hives can appear either due to coming in touch with some substance or due to eating some allergy-inducing substance.

Hives can be acute or chronic. Acute is when the hives appear in response to an allergic reaction. These usually disappear in a matter of days to a week at the maximum. In some people, they could be chronic and can last for months together.

Treatment: Given that they are allergic in nature, managing hives includes a combination of immediate treatment as well as preventive measures. While most are topically managed, others might require systemic intervention also.

Once the hives have developed, the following can help in the relief of symptoms and prevent from spreading further. The redness and swelling will take some time to disappear.

Avoid tight-fitting clothes
Use cool compresses on the hives
Avoid warm or hot shower
Stay in a cooler room
Avoid itching the hives
Use topical moisturizer to prevent dryness
Use topical steroid cream to manage the inflammation
Take a systemic antihistamine or an injection of epinephrine if required.
While these help in managing the hives which have occurred, preventing is via the following.

Avoid the source once identified
If the source is not yet known, record when the hives are occurring
Manage stress and see hives appear much less
Increase moisturizer use
Keep an antihistamine handy so you can take it immediately in case of suspected hives. 

Urticaria (Hives) - The Best Way It Can Be Treated!

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