Schnitzler s syndrome is a very rare condition described by a reddish rash that looks like hives (urticaria) and lifted levels of a particular protein in the blood (monoclonal IgM gammopathy). Symptoms connected with the Schnitzler disorder may include increased levels of fever, joint inflammation, joint pain (arthralgia), bone agony, and different discoveries, for example, swollen lymph nodes (lymphadenopathy). It also causes weight reduction, discomfort, exhaustion, and broadened spleen and liver. This condition should be treated in terms of taking care of the symptoms so that they do not become debilitating.

Some of the other symptoms include the following:

Urticaria (hives) depicts red raised patches of the skin. These are once in a while irritated. They may last for about 12 hours to 3 days. This may become severely painful if not treated in time.
80% of such patients suffer from painful or swollen. A few patients experience bone pain as well.
High fever might be there accompanied by chills and night sweating. This can give rise to further uneasiness and is usually caused when the immune system is attacked by the ailment.
One of the main symptoms of the Schnitzler disorder is monoclonal gammopathy. This mostly means a raised level of immunoglobulin M (IgM)
Reasons behind it

The main cause behind the Schnitzler syndrome is unknown. Specialists believe that particular parts of the immune system may not work appropriately in the end because of the Schnitzler syndrome. Individuals with the Schnitzler disorder additionally have monoclonal IgM gammopathy, in which abnormal production of immunoglobins result in elevated levels of immunoglobulin M (IgM) in the body. Immunoglobulins are proteins delivered by the white blood cells. A few analysts believe that IgM antibodies accumulate in the skin (epidermis), setting off a reaction that causes the rash. At the time of diagnosis, IgM levels may just be somewhat raised and may stay stable for quite a long time.

Diagnosis

The diagnosis of the Schnitzler disorder is based upon an intensive clinical assessment, patient history, rejection of different other disorders and proof of fever, joint pain or aggravation, bone pain, discernible lymph nodes, amplification of the liver or spleen, lifted quantities of white platelets (leukocytosis), raised red platelet (erythrocyte) or anomalies, which can uncover expanded bone thickness (osteosclerosis).

Treatment: 
Anakinra is a successful treatment for Schnitzler syndrome. It is also very commonly used to treat rheumatoid joint inflammation. The following medicines and therapies have been proven to be successful for treating the Schnitzler disorder over a period of time. These are as follows:

Antihistamines
Nonsteroidal calming specialists
Systemic steroids (prednisone)
Hydroxychloroquine
Colchicine
Dapsone
Pamidronate
Thalidomide
Pefloxacin
Phototherapy
Immunosuppressive specialists (ciclosporin, methotrexate, cycloposphamide)
Biologic specialists (tocilizumab, rituximab)
The Schnitzler disorder is a long-term infection, so stopping a promising treatment can tend to cause a relapse and may cause the disease to reappear. Also, the medicines mentioned above should not be taken without consulting a doctor as they can have sever side effects, if not administered under the guidance of a physician.

Schnitzler Syndrome - Things You Must Know About It!

Wisdom teeth are known to be the final molars to grow out and they complete the set of permanent teeth. They generally start to erupt during the late teens or in the beginning of twenties. 

In case of some people, there is a possibility that the wisdom teeth may never erupt, while others may even grow four and more wisdom teeth. 

Do all wisdom teeth create dental problems?
No, if a wisdom tooth has completely erupted through the gum and tissue, without actually harming the teeth next to it, it does not require to be extracted. But, this is only if the individual is able to clean and brush it thoroughly. The wisdom teeth should be properly examined and dental care is necessary to prevent any complications. 

When do wisdom teeth need extraction?
Proper oral care of the teeth will keep them healthy and clean. But there may arise a situation, in which the removal of the wisdom teeth is quite necessary:

1. In certain cases, the wisdom tooth may erupt at a weird angle, compromising the teeth next to it. This may make it difficult to clean the teeth thoroughly, thus resulting in the onset of bacterial growth and periodontal disease. In this case, the wisdom teeth should be removed as soon as possible. 

2. While the wisdom teeth grows out, it may happen that there is not enough space for it to grow properly. As a result the adjacent teeth may face pressure due to crowded teeth, leading to headaches, toothaches and jaw pain. It is best that the wisdom teeth is extracted in this situation.

3. In case a wisdom tooth develops a cavity, it should be extracted. 

4. An impacted wisdom tooth, that is, if it has only partially grown out of the tissue, should also be extracted before it can cause serious complications.

All About Wisdom Teeth

The last molar teeth in the mouth are called as wisdom teeth. While in some people they erupt completely into the mouth and function with no problem whatsoever, in others, they remain embedded in the bone, erupt incompletely, erupt at an angle, or are covered by bone or a flap of tissue. They are absent in many.
Of late, dentists recommend removal of wisdom teeth, more a preventative than remedial measure. Some of the reasons for wisdom tooth removal are listed below-
Impaction: Often, wisdom teeth do not have enough space to erupt in their normal position. This can only be evaluated properly on an x-ray. If the x-ray shows that the tooth is unlikely to erupt because of being blocked by a root or bone, this needs to be removed.
Pericoronitis: The tooth partially erupts into the mouth but is covered by a flap of gum. This attracts food and bacteria to accumulate, leading to decay and infection, a condition called as pericoronitis. Very common in the lower wisdom teeth, it leads to severe tooth pain, painful swallowing and swelling of the lymph nodes. This is the most common cause for wisdom teeth to be removed. An x-ray will reveal the tooth to be infected and sometimes periapical abscess may also be present.
Cysts: Impacted teeth can develop fluid-filled cysts which can cause severe and even permanent damage to the jaw bone, adjacent teeth and nerves. Dentigerous cysts are the most common type.
Alignment: Misaligned wisdom teeth exert a constant mild pressure on the adjacent teeth which can hamper the alignment and reverse the effects produced by braces. The bite may be altered also, thereby necessitating removal.
Adjacent Tooth Damage: If the malposed wisdom tooth is causing pocket formation or decay in the adjacent teeth, it is time to get them removed.
Recurrent Sinus Infections: With their proximity to sinuses, there could be constant pain and pressure and infection of the sinuses. This is another indication for their removal.
However, not all wisdom teeth need to be removed. If they have erupted fully, are healthy, produce a good bite, and can be cleaned easily, they do not require removal.
During the teenage years and through 20s, check with your dentist on the health of the wisdom teeth. X-rays can be taken to monitor them and for early identification of problems. If they need to be removed, it is easier to take them out when you're young. The bone surrounding the impacted tooth is less dense, and therefore easier. The ability of the body in general and the jaw bones in particular to heal is also better at a younger age. 


Wisdom Teeth - When To Get Them Removed

Hives, also called urticaria are swollen welts or bumps that appear on your skin suddenly.

They itch, burn and sting and can happen anywhere on your body. You can get them on your face, lips, tongue, ears or chest. And in size, they can be as small as an eraser to as large as a plate. They also form plaques and can last for hours or up to several days.

Types

Acute urticaria - These type of hives last less than six weeks. The most common causes are allergies due to certain foods and medications, or infections. These hives can also happen due to diseases or insect bites.
Chronic urticaria - Hives lasting more than six weeks come under this category. What causes them is usually more difficult to identify than what causes acute urticaria. In some cases, chronic hives are caused due to thyroid disease, hepatitis or even cancer. This type can affect your internal organs like lungs, muscles, and the gut. Thus, symptoms include muscle soreness, shortness of breath, vomiting, and diarrhoea.
Physical urticaria - These types are caused due to direct physical stimulation of the skin due to cold, heat, sun exposure, vibration, pressure, sweating, and exercise.
What causes hives?

Hives happen mostly due to allergies. Some of the common hive triggers are-

Certain foods, especially peanuts, eggs, nuts and shellfish- Fresh foods are more likely to cause hives as compared to cooked foods. Certain food additives and preservatives can also play culprits. Medicines like penicillin and sulfa- based antibiotics, aspirin and ibuprofen which are non-steroidal anti-inflammatory medications, high blood pressure drugs like ACE inhibitors, and painkillers such as codeine can also trigger hives. Other things that may cause it are:

Insect bites
Latex
Transfusion of blood
Bacterial infections, including urinary tract infections and infected throat
Viral infections- common cold and hepatitis
Pollen grains
Plants like poison oak and poison ivy
Sunlight
Cold weather
Pet dander 
If you wish to discuss about any specific problem, you can consult a dermatologist.

What Are Hives? What Causes Them?

If stressed, consuming certain food and medications can trigger skin rashes. This kind of rash is called hives. It is also known as urticaria. Anyone can be affected by hives, at least 20% of people are affected by hives at some time or the other in their lives. The itching could be severe or mild. It starts as a patch of scaly white skin that develops into red welts over time. To make sure the itching does not worsen, scratching, emotional stress, alcoholic drinks and exercise should be avoided.

Symptoms
1. Itchy bumps that are raised and are either red or flesh coloured
2. If the hive is pressed in the middle, the skin whitens this symptom is called blanching.
3. The hive formation can appear anywhere, disappear and then reappear somewhere else.

Common Triggers
1. Certain food like shellfish, eggs, peanuts and other nuts
2. Certain medicines like antibiotics, ibuprofen and aspirin
3. Insect bites or stings
4. Physical causes like pressure, sun exposure, cold, exercise and heat
5. Latex
6. Blood transfusions
7. Bacterial infections
8. Pet allergens
9. Viral infections like the common cold, hepatitis and infectious mononucleosis
10. Certain plants like poison ivy and poison oak
11. Pollen

Treatment
There is no distinct cure for hives. But you can control its symptoms in the following ways:
1. Antihistamines help in blocking histamines, which cause the allergy symptoms. Non sedating or low sedating Antihistamines will be mostly recommended by your doctor.
2. If episodes of hives are several, it may require limited treatment with prednisone. Prednisone will be able to lessen the symptoms.
3. If the symptoms get severe enough so much so that it swells up your tongue and you have problem breathing, then the doctor might prescribe an epinephrine. However, these symptoms can mean another thing, an anaphylaxis shock. Epinephrine is the only treatment for an anaphylaxis shock.

Prevention
If what caused hives to break out is figured out, then measures should be taken to avoid or eliminate the triggers.
1. Avoid eating food items that triggered the symptoms in the first place
2. If harsh soaps, frequent bathing cause hives, they should be avoided
3. Tight clothing should be avoided
4. If cold triggers hives, then wear warm clothing, wrap a scarf and do not swim in cold water.
5. Avoid sun exposure and wear sunblock
6. If a specific medication is causing the hives, inform your doctor.

All About Hives

Hives or urticaria is an outbreak of reddish swollen bumps around the skin surface, formed mainly due to the body s response to particular allergens. Generally, the infectious bumps are of varied shapes and sizes and last for about 5-6 weeks. Although not a serious medical condition, hives can cause tremendous discomfort to the concerned person and affect his/her daily activities. Hives can be cured with a prescribed dosage of antihistamines or oral corticosteroids.

Causes of hives

Although the exact reason behind their formation is still unknown, researchers suggest that this disorder occurs as a response to involuntary histamine release by the skin blood vessels (that in turn, causes a leakage of blood plasma). Some other factors that can be responsible are:

Hives can occur due to insect or parasite bites.
Hives can also result as a side effect of painkillers such as codeine and other anti- inflammatory drugs such as ibuprofen or ACE inhibitors.
Excessive exposure to sunlight or high levels of stress (leading to high cortisol levels in the body) can also result in hives.
Intense scratching around the same spot can also result to hive formation.
Excessive alcohol intake can render you even more vulnerable to this disease.
Excessive intake of foods such as eggs, fish, nuts, chocolate and berries might also cause hives. Additionally, excessive consumption of certain food preservatives can also trigger the release of histamine.
Suffering from serious underlying medical conditions such as cancer, hepatitis or thyroid disorders can make you prone to chronic cases of hives (which might last for more than 6 weeks).
Symptoms of hives 
The symptoms of hives include, but are not limited to:

Appearances of several reddish welts around the face or arms which might cause a severe itchy sensation.
Painful and abnormal swelling around the mouth
You might also feel tightness in your chest along with recurring bouts of dizziness.
If not treated promptly after diagnosis, hives might result in life-threatening allergic reactions, such as Anaphylaxis (narrowing down of the bronchial tubes, thus causing significant breathing trouble) and auto-immune disorders such as rheumatoid arthritis.

7 Things that Can Cause Hives

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