Knee replacement can be extremely painful. Previously, opioids or narcotics were administered for pain relief. But excessive addition of opioids is not exactly effective for controlling pain. 

Multimodal pain management has become an important part of the perioperative care of patients undergoing total joint replacement. The principle of multimodal therapy is to use interventions that target several different steps of the pain pathway, allowing more effective pain control with fewer side effects. Many different protocols have shown clinical benefit. The goal of this review is to provide a concise overview of the principles and results of multimodal pain management regimens as a practical guide for the management of joint arthroplasty patients.

Multimodal denotes administering two or more than two types of medications that work with different mechanisms. The following are the techniques used:

Pre-operative Femoral Nerve Block: Prior to the surgery, a catheter is placed beside the femoral nerve for blocking it. This nerve is located in the upper thigh. Medication is delivered through the catheter for the nerve to be numbed for 24 hours. Thus, pain signals to the brain are blocked. This method reduces the use of narcotics and the consequent side effects.

Patient Controlled Analgesia (PCA): This method is also known as  Pain Pump . An intravenous pump is used to administer pain relief medications, such as oxymorphone or morphine, after the surgery. The control button of the machine could be pressed, by the patient for 6 to 10 times per hour. The machine is used for two post-operative days.

Oral Medications: The oral medications include Non-Steroidal Anti-Inflammatory drugs or NSAID; such as Celebrex which is similar to aspirin, structurally. Alternatively, acetaminophen, such as Tylenol or its equivalent composition, can also be used.

Acetaminophen: It acts on the Central Prostaglandin Synthesis and relieves the patient of pain through multiple mechanisms.

Epidural Analgesia: It produces lower pain scores and involves less time for achieving physical therapy goals. However, this is subject to side effects such as dizziness, urinary retention and itchiness.

Gabapentinoids: These medications include membrane stabilizers such as Gabapentin and Pregabalin.

The objective of multimodal treatments is to provide quick relief to the patient and immediately so. Earlier the rehabilitation, more successful will be the knee replacement surgery.

Multimodal Pain Relief After Total Knee Replacement

When there is a fracture of the bone, the affected site may be plastered for the fracture to heal. In some cases, this may not be enough to mend the bones and surgery may be required along with bone grafting to rectify the condition. A new form of therapy, involving a less invasive procedure has been developed. It involves culturing the stem cells and using the same to mend and regenerate parts of the bone.

What does the treatment involve?

In this process, one cultures cells from the patient s body. The cells are extracted from the bone marrow. These cells are cultured in the lab and injected back to the affected region of the body. Research has shown that after the injection, the treatment takes anywhere between 7 to 8 weeks to repair the fracture completely.

Since stem cells are being harvested from the patient and not from a third-party, the treatment does not have any ethical constraints. However, more studies are being conducted to prove without a doubt that the same does not cause any damage to the body of the patient in the long run.



It is likely that this procedure will replace rudimentary surgical techniques, such as bone harvesting, in the future. It is far less invasive and does not result in extreme pain or prolonged hospitalization.

The future of the treatment: 

While stem cell culture has been around for a few years now, the use of the same procedure to treat fractures is The Latest Technology. It is in its early stages, which is why such a form of treatment is not offered by all hospitals across the globe and very selective surgeons having experience of the procedure would perform it.

Additional research and studies are being conducted to further confirm the efficacy of the treatment. Research has revealed that stem cell insertion in the bone can be used to regrow defects and heal non-unions of a bone. In some cases, repeated stem cell insertion may be required. The bone that grows as a result is as strong as the other bones in the body.

Stem Cell Culture For Broken Bones - What Is It?

There are 27 bones in the human hand. An injury to any one of them or a disease that affects the bones, tendons, muscles or blood vessels in the hand, are the most likely causes for pain in the hand and tenderness.

Some of the most common conditions that cause hand pain are:

De Quervain's Tendinitis: Pain on and around the thumb is the characteristic sign of this condition. This pain may develop gradually or come on suddenly and can travel the length of the thumb and forearm. De Quervain's tendinitis is caused by the swelling of wrist tendons at the base of the thumb. Repetitive actions and overuse are the most common triggers for this condition.

Carpal Tunnel Syndrome: The symptoms of carpal tunnel syndrome are felt mainly in the thumb, index finger and middle finger. This pain is often worse at night and is caused by the swelling of inflamed tendons at the base of the hand that puts pressure on the median nerve. This syndrome can make it very difficult for a person to grip objects.

Fractures: The fracture can cause extreme pain along with stiffness, swelling and loss of movement. A fracture refers to the breaking of a bone and can be of many types including simple fractures, complex fractures, comminuted fractures and compound fractures. The type of fracture dictates the type of treatment required. Spraining a muscle in the hand is another leading cause of pain in the hands.

Arthritis: This is one of the most common causes of pain in the hand that is related to ageing. Arthritis causes loss of cartilage that makes the movement of one bone against the other extremely painful. It may or may not also be accompanied by swelling. When it comes to the hand, arthritis affects the base of the thumb and middle or top joints of the fingers. Osteoarthritis may also cause bony nodules to be formed on the fingers.

Trigger Finger: This condition is also known as stenosing tenosynovitis. This condition locks the fingers or thumb in a bent position. This condition is triggered by the flexor tendons getting irritated. These tendons control the movements of the thumb and fingers. As the tendon is inflamed, the sheath that surrounds the tendons may also thicken and nodules may form of the affected tendons. People suffering from rheumatoid arthritis, gout and diabetes are at a high risk of suffering from this condition.

Pain And Tenderness In Bones Of The Hand - Factors That May Cause it!

Majority of bone tumours are benign, meaning they are localised and do not spread. Since benign tumours do not metastasize, they are not forms of cancer. Despite not being malignant, the severity of their presence should not be ignored as they may cause a lot of pain and lead to other problems such as damaged bones and fractures.

Benign Bone Tumors

Osteochondromas: These form over 40 per cent of all benign bone tumours. They are mostly found in children and teenagers. Osteochondroma is a growth abnormality and they are found in the growing ends of long bones. An osteochondroma might grow separately or might be accompanied by other similar tumours.
Osteoclastomas: They are also called giant cell tumours of the bone. They are common and are found in the epiphysis of long bones and around the knee.
Osteoid Osteoma: These grow mostly in adolescents and very rarely in adults above 50. They primarily grow in the legs but they might also be found in other bones in the body.
Enchondroma: It is a bone tumour that starts in the cartilage. It is mostly found in the cartilage of the inner lining of bones. Small long bones of the feet and the hands are affected the most. Teenagers get more affected than other age group.
Osteoblastoma: These are slow growing tumours that take about two years to get diagnosed. An osteoblastoma makes the surrounding bones weaker as they dissolve them and make them more susceptible to fracture caused by small injuries. Men are twice as more likely to be affected by an osteoblastoma than women. Surgery is essential in all cases of osteoblastoma as they destroy healthy functional bone and grow in size with time.
In rare cases, these have also known to become malignant over time, despite their benign nature. It affects people under 30 mostly.

Malignant Bone Tumours

Osteosarcoma: It affects the hip, knees and shoulders of mostly children and teenagers. It is also referred to as osteogenic sarcoma.
Ewing Sarcoma Family of Tumours: These generate from medullary cavities and can also grow in blood vessels and adipose tissues. It primarily affects children and teenagers.
Chondrosarcoma: It usually affects the hips, pelvis and shoulders of middle aged people.

5 Most Common Types Of Benign Tumours!

The human body allows for movement through the complex system of bones, muscles and joints. A break in the bone is medically known as a fracture and can be caused by constant stress, pressure or impact. It is common knowledge that with age, the bone strength decreases and incidence of fractures (osteoporotic fracture) increases. Based on the affected bone and impact, different types of fractures are commonly identified as:

Complete: When the breakage of the bone is complete, producing two or more pieces, it is referred to as a complete fracture.
Incomplete: When the breakage is incomplete, where the bone has cracked, but does not break into pieces, it is known as an incomplete fracture.
Another type would be the open or closed fracture:
Open fracture: When the skin is exposed and the bone breaks through this exposed skin, it is known as compound or open fracture.
Simple or closed fracture: The bone breaks, but the skin continuity is maintained. Again, here are different types including hairline, greenstick, oblique, etc.
What is the reason behind a fracture?
A bone will fracture when force is applied to it that is stronger than the bone itself. A key factor in a bone s susceptibility to fracturing is age. Both children and older people are prone to bone fractures. Children s bones are constantly growing and have not reached their full strength. Elderly people have brittle bones with old age and are prone to develop bone diseases, making them susceptible to fractures.

How they are treated?
Splint and pain medications are commonly used. Closed reduction where the fracture is reduced without opening up the tissues and open reduction, where the tissues are opened up are common approaches to managing fractures.

Can they be prevented?
Especially with children and in the elderly, extra precaution should be taken to avoid any kind of injury and fracture.

Develop an exercise routine to strengthen the muscles
Manage weight
Use the right footwear and exercise gear
Watch your medications (avoid sleep inducing ones)
Increase lighting in the room/home to improve clarity of vision for elderly
Make the home/living area fall-proof by reducing clutter, using railing in the bathroom and bedroom, using rubber mat, etc.
While a fall may seem inevitable, taking the above steps can help reduce the incidence and severity of a fall, thereby minimizing damage.

Bone Fracture - Common Types and How They Can be Prevented?

Your knee is a very complex structure consisting of bones, ligaments, cartilage, tendons, muscles and meniscus. Most people encounter knee pain at some point in their lives. If your knee pain is chronic in nature, then it may last for a prolonged period.

Many causes may be responsible for your knee pain. Some of the causes are stated as follows:
1. Your knee is very much prone to injuries. Knee injuries may happen due to accidents, falling down carelessly or while playing sports. The most common knee injuries that may be the cause for your knee pain are mentioned as follows: 
a) Fractures may cause you to feel pain in the areas of your knee bones.
b) Anterior Cruciate Ligament injury (ligament injury caused by twisting and a sudden motion) or Medial Collateral Ligament injury (injury to the tissue in the insides of your knee) is very common to sportspersons and may be the reason for severe knee pain.
c) Sometimes your knee bones may get dislocated from their usual alignment. This can also make you experience severe knee pain.
d) Ligament injuries, meniscus tear or tendon tear can also be responsible for your knee pain.

2. Sometimes pain in your buttock or foot region can also result in mild knee pain.

3. At times chronic problems like osteoarthritis that affects the cartilage can cause the problem of knee pain. Other chronic problems like Gout, rheumatoid arthritis can also cause severe knee pain.

4. Being overweight can also result in knee pain.
The symptoms of knee pain may be different in each case. The most common symptoms are mentioned below:
a) Stiffness of knee
b) Swelling of your knee
c) You may also feel unstable
d) Difficulty in walking or bending of your knee.
e) You may notice redness in your knee area.

Knee pain must not be ignored. It is highly recommended for you to seek advice from an orthopedic as soon as you encounter any of the above mentioned symptoms.

Suffering from Knee Pain - Know What Causes it? 

Don't wait any longer, manage your Knock Knees online with a Lybrate doctor today

Consult for Knock Knees - Online and Easy!

FilterClear All

COMMON SPECIALITIES

COMMON ISSUES