Dear Doctor, Psychiatrist I am having problem with occasional anxiety and fear of going far away from home (also fear of going in bus, train, plane) and get anxious in traffic, traffic signal and standing in line for shopping or waiting for purchasing ticket in line) having fear of getting panic/anxiety attack. Earlier, I had 9 month course of pristiq 50 mg ER (which helped), then psychiatrist replaced pristiq with (1 mg clonazepam, 0.5 mg alprazolam in the morning and 10 mg nitrazepam and 1 mg clonazepam in the night) I slowly tapered off from the 4th month itself from half of it to and came out of it in 10 month (very very low dose 0.25 mg clonazepam and 2.5 mg nitrazepam), (I had similar effect both from starting dose to ending dose) when I stopped, again I felt anxious, and different psychiatrist put me on 20 mg paxil (helped with anxiety but problem was always feeling drowsy) came out of it in 9 months. Then started taking some natural supplements and vitamins, since 8 months, now in 8 months I had anxious feeling 3 or 4 times only when I didn't get proper sleep or caught in traffic delay). Now my main problem is going far away from home (also fear of going in bus, train, plane) and get anxious in traffic, traffic signal and standing in line for shopping or waiting for purchasing ticket in line) having fear of getting panic/anxiety attack. My question is, 1) should I continue with natural routine to help completely coming out of agoraphobia? Is it a possibility? 2) should a course of SSRI/SNRI, (say for 9 months and assume) which will make me normal again and free of agoraphobia, and then discontinue the SSRI/SNRI. Is it possible that, I can be free of anxiety and agoraphobia without SSRI/SNRI after stopping SSRI/SNRI? (please note that, earlier SSRI/SNRI had side effect of sleeplessness and low sex drive, so I was not interested in it, but if it helps in long run say after 9 months or 1 year, I can be completely free of anxiety and agoraphobia, the I can go through the side effect? 3) If I do a say, 3 or 6 or 9 month course of alprazolam and clonazepam, and assume, which will make me normal again and free of agoraphobia, and then discontinue the alprazolam and clonazepam. Is it possible that, I can be free of anxiety and agoraphobia without alprazolam and clonazepam after stopping alprazolam and clonazepam? Please note that my anxiety/panic feeling is not very severe, but thinking of discomfort (in last 4 years, I had total of 4 or 5 panic/anxiety attack, lasted in less than 10 minutes, mostly shortness of breath and sometime heart palpitation or chest tightness) when going far away from my home makes me avoid the situation. I really appreciate your detailed guidance for my above query. Thank you very much for your help.