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Temotide 100Mg Tablet

Manufacturer: RPG Life Sciences Ltd
Medicine composition: Temozolomide
Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 21, 2021

Temotide 100Mg Tablet is an anti-cancer oral drug. It is used in chemotherapy. It is categorized as an alkylating agent. Temotide 100Mg Tablet is used in the treatment of anaplastic and glioblastoma multiforme.

This medicine is used for the treatment of adult patients with refractory (first relapse) anaplastic astrocytoma who have experienced disease progression on nitrosourea and procarbazine.

On using Temotide 100Mg Tablet you may experience side effects such as nausea, constipation, headache, weakness, paleness, reduced appetite, hair loss, low cognitive and memory skills and vomiting. Seek the help of your health care provider if your reactions persist and keep worsening over time.

As a precautionary measure, inform your doctor if: you are taking any prescription or non-prescription medications, you are allergic to this drug or any other medicines, or foods or substances, you are planning to take any vaccines, you are pregnant or are planning to become pregnant, or are nursing a baby.

The dosage for Temotide 100Mg Tablet will be determined by your doctor taking into consideration your requirements. It comes in a capsule form of 5 mg, 20 mg, 100 mg and 250 mg. Usually, the daily dosage for adults ranges somewhere between 150-200 mg.

Take the medicine on an empty stomach either two hours or one hour prior to your meals or at bedtime. Dose-limiting toxicity is hematological. In the event of an overdose, hematological evaluation is necessary. Treatment is supportive.

Swallow capsules whole with a glass of water. Take on an empty stomach at similar time each day. If you have nausea and vomiting, contact healthcare provider for medicine to decrease this.

Male and female patients who take Temotide 100Mg Tablet should protect against pregnancy (use effective contraception). Do not breast-feed while on medicine. Blood work necessary on day 22 and day 29 of each cycle to determine when to start next cycle and how much medicine to give.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

The medicine is useful against the following conditions:

  • Hypersensitivity

Here are some of the possible side effects of this drug:

  • Is It safe with alcohol?

    Interaction with alcohol is unknown. Please consult your doctor.
  • Are there any pregnancy warnings?

    Temotide 100Mg Tablet is unsafe to use during pregnancy.
    There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
  • Are there any breast-feeding warnings?

    Temotide 100Mg Tablet is probably unsafe to use during breastfeeding. Please consult your doctor.
  • Is it safe to drive while on this medicine?

    Caution is advised when driving or operating machinery.
  • Does this affect kidney function?

    Caution should be used when administered to patients with severe renal impairment (Clcr <39 mL/minute).
  • Does this affect liver function?

    Caution should be used when administering to patients with severe hepatic impairment. Please consult doctor before consuming the drug.

Below is the list of medicines, which have the same composition, strength and form as Temotide 100Mg Tablet , and hence can be used as its substitute.

  • Are there any missed dose instructions?

    The active constituent of this medication is activated once it has been converted into physiologic pH to MTIC. MTIC afterwards alkylates DNA at the N7 position of guanine, 06 positions of guanosine and 03 positions of adenosine.

Temotide 100Mg Tablet is activated once it has been converted into physiologic pH to MTIC. MTIC afterwards alkylates DNA at N7 position of guanine, 06 position of guanosine and 03 position of adenosine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Medicine

    Although valproic acid reduces the clearance of Temotide 100Mg Tablet by 5%, the clinical significance of this is unknown.
  • Interaction with Food

    Food reduces rate and extent of absorption. In addition, the incidence of nausea/vomiting is decreased when the drug is taken on an empty stomach.
  • Interaction with Disease

    Prior to dosing, patients must have an absolute neutrophil count (ANC) of greater than or equal to 1.5 x 10 9/L and a platelet count of greater than or equal to 100 x 10 9/L. Must have ANC >1,500/mL, platelet count >100,000/mL before starting each cycle. Geriatric patients and women have a higher incidence of myelosuppression. Safety/efficacy in pediatrics not established. Use caution in patients with severe hepatic or renal impairment. The U.S. Food and Drug Administration (FDA) currently recommends that procedures for proper handling and disposal of antineoplastic agents be considered.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Pharmacology
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Temotide 100Mg Tablet
What are the uses of Temotide 100Mg Tablet
What are the contraindications of Temotide 100Mg Tablet ?
What are the side effects of Temotide 100Mg Tablet ?
Key highlights of Temotide 100Mg Tablet
What are the substitutes for Temotide 100Mg Tablet ?
What are the dosage instructions?
How does this medication work?
What are the interactions of Temotide 100Mg Tablet ?