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Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 14, 2018

Misoprostol is used for preventing stomach ulcers while you are under the medication of certain NSAID drugs; especially if you are at a greater risk or have a family medical history of ulcers. It can also help to decrease your risk of ulcer complications such as bleeding. The medication works by protecting the lining of the stomach, by lowering the acid amount that comes in contact with it. Misoprostol can also be combined with mifepristone, to be used for abortion. It is available in tablet form, to be taken orally.

Before being prescribed to Misoprostol, inform your doctor if you have conditions like a heart disease, kidney disease, ulcerative colitis, Crohn’s disease (inflammatory bowel disease), pregnant or trying to be pregnant, a breast-feeding mother or any allergies to medicines or food. You can take the medication with food. Make sure that you follow your doctor’s prescribed dose and do not stop taking it abruptly. In case you miss a dose, you can take it when you remember it but do not take two doses in a single time. If using it on children, ensure to talk to the paediatrician first as special care may be required.

The possible mild side effects of Misoprostol are dizziness, headache, mild diarrhea, nausea, stomach upset, cramps and irregularity in the menstrual cycle. These symptoms generally go away in a few days but you may seek your doctor’s opinion if it bothers you. However, if you suffer from symptoms such as chest pain, fainting spells, shortness of breath, severe diarrhea, an allergic reaction, unusual bleeding from the vagina or pelvic pain, seek medical supervision on an immediate basis.

You must avoid smoking or drinking while you are prescribed to Misoprostol. They can possibly cause more irritation in the stomach, making it susceptible to more damage. Also, do not have the medicine if you are pregnant or plan for pregnancy while while taking this medication.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Gynaecologist before using this medicine.

Duodenal Ulcer

Misoprostol is used to prevent and relieve the symptoms of ulcers caused in the upper parts of the small intestine.

Gastric Ulcer

Misoprostol is used to prevent and relieve the symptoms of ulcers caused in the food pipe and stomach.

NSAID induced ulcers

Misoprostol is used to prevent and treat ulcers caused due to use of non-steroidal pain medications like diclofenac, ibuprofen etc.

Induction of labor

Misoprostol is used to induce labor in pregnant women.

Postpartum bleeding

Misoprostol is also used to prevent and treat bleeding that happens after delivery.

Cervical ripening

Misoprostol is also used for relaxing and softening the cervix prior to the onset of labor contractions.
Misoprostol is also used to terminate or abort a pregnancy which is less than 49 days. It is used in combination with other medications and requires a doctor's supervision for the process to happen efficiently.
This medicine should not be used to treat ulcers caused by the uptake of non-steroidal pain medication or otherwise by pregnant women. It can cause birth defects, abortions, uterine rupture etc.
This medicine is not recommended for use if you have a history of allergy to it or any other medicine which are prostaglandin analogues.
In addition to its intended effect, Misoprostol may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.


Moderate Common

Stomach pain

Moderate Common

Vaginal bleeding

Major Less Common

Pelvic pain and cramping

Major Less Common

Shortness of breath

Moderate Less Common

Allergic skin reaction

Major Rare

Swelling of face, lips, eyelids, tongue, hands and feet

Major Rare

Disrupted menstrual cycle

Minor Less Common

How long is the duration of effect?

The effect of this medicine lasts for an average duration of 3-5 hours.

What is the onset of action?

The effect of this medicine can be observed after 2-3 hours of administration.

Are there any pregnancy warnings?

Use of this medicine for the treatment of ulcers is not recommended for pregnant women as the risk of birth defects, abortion and other abnormalities are very high. All women of childbearing potential are advised to use adequate means of contraception while using this medicine.

Is it habit forming?

No habit forming tendencies were reported.

Are there any breast-feeding warnings?

This medicine is should be used with caution in women who are breastfeeding. Consult your doctor before taking this medicine.

Missed Dose instructions

Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose, then the missed dose can be skipped.

Overdose instructions

Contact a doctor immediately if an overdose is suspected. Symptoms of overdose may include sleepiness, diarrhea, severe stomach pain and cramps, fever, decreased pulse etc.


United States


Below is the list of medicines, which contains Misoprostol as ingredient
Bestochem Formulations (I) Ltd
Aristo Pharmaceuticals Pvt.Ltd
Zydus Cadila
Cipla Ltd
Sun Pharma Laboratories Ltd
Leeford Healthcare Ltd
Cadila Pharmaceuticals Ltd
Hll Life Care Ltd
Sun Pharma Laboratories Ltd
Intas Pharmaceuticals Ltd
Elder Pharmaceuticals Ltd
Knoll Pharmaceuticals Ltd
Intas Pharmaceuticals Ltd
Bharat Serums & Vaccines Ltd
Lincoln Pharmaceuticals Ltd
Zydus Cadila
Fourrts India Laboratories Pvt. Ltd
Misoprostol is a prostaglandin E1 analogue and reduces the amount of acid produced in the stomach. It further protects the stomach walls by increasing the production of bicarbonates and mucus. It can cause the smooth muscles of the uterus to contract and the cervix to relax.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease


Information not available.

Interaction with Alcohol


Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Lab Test


Information not available.

Interaction with Food


Information not available.

Interaction with Medicine


Report the use of either of the medications to the doctor. Use of these medicines together is not recommended as the risk of vaginal cramps and bleeding is very high.

Antacids containing magnesium

Report the use of any magnesium containing antacid to the doctor before receiving Misoprostol. The risk of medicine induced diarrhea is very high when these medicines are used together. Inform the use of any antacid to the doctor before Misoprostol is prescribed.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Misoprostol
What are the uses of Misoprostol
What are the contraindications of Misoprostol ?
What are the side effects of Misoprostol ?
Key highlights of Misoprostol
What are the dosage instructions?
Where is the Misoprostol approved?
Medicines containing Misoprostol
How does medicine works?
What are the interactions of Misoprostol ?