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Festone Combi Kit

Manufacturer: Leeford Healthcare Ltd
Medicine composition: Mifepristone, Misoprostol
Prescription vs.OTC: Prescription by Doctor required

Mifepristone is a steroid used to terminate pregnancy. It inhibits the secretion of progesterone that is needed to maintain the pregnancy. It should only be used if the pregnancy is within 70 days (10 weeks). It is recommended that you do not use it if you are over 10 weeks pregnant. It can only be bought with a prescription. For a complete medical termination of the pregnancy, Mifepristone is used with Misoprostol. Mifepristone is taken as a tablet once. After 24-48 hours, Misoprostol is taken.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Obstetrician before using this medicine.

Mifepristone is prescribed for terminating pregnancies, which are less than 70 days and also to induce labour in case of fetal death. It may also be given to treat high blood sugar level in patients with Cushing’s syndrome.

Unexplained vaginal bleeding

Chronic adrenal failure

Other bleeding disorders

In addition to its intended effect, Festone Combi Kit may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Heavy vaginal bleeding

Major Less Common

Infections

Major Rare

Unusual tiredness and weakness

Major Less Common

Abdominal pain and cramps

Moderate Common

Uterine cramping

Moderate Common

Nausea and Vomiting

Moderate Common

Headache

Moderate Common

Dizziness

Moderate Common

Diarrhea

Minor Common

Pain in the arms and legs

Minor Less Common

Decreased appetite

Minor Rare

Sleeplessness

Minor Rare

Difficult or painful urination

Major Rare

Loss of strength

Minor Less Common

Difficult and painful breathing

Moderate Rare

How long is the duration of effect?

The effect of this medicine lasts for an average duration of 7-10 days.

What is the onset of action?

Mifepristone starts producing the required effects within 1-2 hours of administration.

Are there any pregnancy warnings?

It is advised that Mifepristone is used to terminate a pregnancy that is within 63-70 days. Use of this drug to control elevated blood sugar level should not be done if you are pregnant.

Is it habit forming?

It is not habit forming.

Are there any breast-feeding warnings?

It is recommended that you do not breastfeed your child if the administration of this drug is highly necessary.

Is It safe with alcohol?

Interaction with alcohol is still unknown. Consult your doctor before proceeding

Is it safe to drive while on this medicine?

Mifepristone may cause sleepiness. It is advised that you do not drive if you are experiencing this side-effect.

Does this affect kidney function?

There is no reported impairment to the kidney functioning.

Does this affect liver function?

There is no reported impairment to the liver functioning.

Below is the list of medicines, which have the same composition, strength and form as Festone Combi Kit , and hence can be used as its substitute.
Lincoln Pharmaceuticals Ltd

Are there any missed dose instructions?

For termination of pregnancy, it is a single dose therapy; it is not possible to miss a dose. If you are taking it for controlling blood sugar level and miss a dose, take it as soon as possible. But do not double dose.

Are there any overdose instructions?

If you overdose on Mifepristone, contact your physician right away.

India

United States

Japan

Festone Combi Kit blocks the effect of progesterone by competitively binding to the specific receptors and sensitizing the inner linings of the uterus inducing bleeding and contractions. It also blocks the effect of cortisol at the specific receptors and reducing the effect caused by an excess of this hormone.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease

Disease

Information not available.

Interaction with Alcohol

Alcohol

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Moderate

There are no known alcohol interactions.

Interaction with Food

Grapefruit juice

Moderate
Avoid the consumption of large quantities of grapefruit juice while taking mifepristone as it can alter the levels of this medicine in the blood.

Moderate

It is recommended that you avoid grapefruit juice while taking this medication. It may modify the effects of the drug.

Interaction with Medicine

Moderate

Mifepristone severely interacts with the following drugs- dexamethasone, erythromycin, hydrocortisone, ketoconazole, simvastatin, pimozide, warfarin and ergotamine.

What are you using Festone Combi Kit for?
Termination Of Pregnancy
Other
Cushing's syndrome
How much was the improvement?
Excellent
Poor
Average
How long did it take before seeing improvement?
Within 2 hours
Within a day
Within 2 days
More than 2 days
Within 6 hours
How frequently did you take this medicine?
Once a day
Not taking on daily level
Thrice a day
Twice a day
How did you take this medicine?
With Food
Empty stomach
With or without food
What were the side effects of this medicine?
Unusual tiredness and weakness
Heavy vaginal bleeding
Abdominal pain and cramps
Dizziness
Infections
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Abortion pills (festone combo kit) are safe for 3 to 4 weeks pregnancy. What kind of sideffect are there. And tell me about dose of these pills.

MBBS
General Physician, Chandigarh
This complete combo you have to take once only side effects can be heavy bleeding incomplete abortion infection etc.

I M 39 years old. Two hours ago I took festone kit last dose. I was expecting bleeding but I started shivering and got fever of 100. What should I do.

MBBS, Certified IVF Specialist, MS - Counselling and Psychotherapy
IVF Specialist, Chennai
Hi, Self medication is always risky in these issues. Please rush to a gyneacologist right away and get yourself treated to avoid complications of a septic abortion.

I missed my periods. It's on 7 and usually late. And me and my partner had sex on 7 and 8.now I took a pregnancy test it's positive. I brought a festone combo kit. Suggest me how to use it. Nd it's 100 percentage beneficial or not?

Diploma In Gastroenterology, Diploma In Dermatology, BHMS
Homeopath, Hyderabad
I missed my periods. It's on 7 and usually late. And me and my partner had sex on 7 and 8.now I took a pregnancy test...
Step 1: Swallow the Mifepristone pill with water. Step 2: Wait 24-48 hours after swallowing Mifepristone. Step 3: Take 800 mg of Ibuprofen 1 hour before using Misoprostol. Step 4: Place 4 Misoprostol pills under your tongue (sublingual).
3 people found this helpful

Hello doctor I have dry cough. Cold. Blocked nose. And sneezes are there for 2 days. I have a fever from only 2days yesterday night. And the morning temp was OK. Now my body heats up and I have a fever. I took medicines for fever and cold. Combi 650 something I dont want to spread it to anyone. If its a H1N1?

Diploma - Diploma - OLO - Rhino-Laryngology
Acupuncturist, Indore
Need to do test done for H1N1 then conform for cold n cough gargle with warm water turmeric and salt to avoid much use of medicines inhale warm water and loung for blocked nose. dr vasundhara

I am diebetic for last 12 years, despite taking oral medicine of all sorts, combi drugs, metformin, pioglitasone etc etc my fasting sugar remained at high level of 140-180 range, almost equal or more to the PP level, but recently both the level showed around 280 while the Hb1C was 8.9, which is the highest till date. What should I do?

BSc
Ayurveda, Ujjain
Along with your medicines you take Noni10-10 ml in full glass of normal water stair well end take it in5minuties after3 0 minuties take meals if your sugar reduce than reduce your medicine dose accordingly.
1 person found this helpful

Popular Health Tips

Abortion - Laws In India

Diploma In Endoscopic Surgery, DGO, MBBS
Gynaecologist, Delhi
Abortion - Laws In India

Things you need to know about the mtp act

In 1971, the increasing cases of maternal morbidity due to unsafe abortions, and the idea that abortions could be used as a method of population control motivated the government to enact the medical termination of pregnancy act. But what does the law really say? to what extent is abortion a reproductive right in india?

Here are the facts you need to know about the indian law on abortion:


1. Access to abortions is legal in india

​ medical termination of pregnancy has been legal in india under certain conditions since the passage of the act in 1971. India became one of the first few countries to actually legalise abortions beyond just life-threatening situations. Pretty cool, right?

However, a survey conducted in 2007 by the ministry of health and family welfare suggests that only 22.9% of men, and 28% of women were aware that medical abortions are possible and available! a large number of people still remain unaware that by law, they have the right to access abortions.


2. Although abortions are legal, there are certain conditions to be kept in mind…

While abortions are legal in india, the law as it stands today does not allow termination of pregnancy on the request of a woman. In india, abortions are legal up to 12 weeks with approval from one service provider and beyond 12 weeks to 20 weeks requires the approval of two service providers.

There are some other conditions listed in the act: you can get an abortion if the service provider is able to assess that there is a risk to the woman’s life, a threat to a women's physical and mental health (including contraceptive failure for married women), or risks the child if born to be “seriously handicapped”. Frankly, the conditions are pretty inclusive and whatever the situation, the service provider is your friend.

3. Medical abortions and surgical abortions? yes, there are two types!

Medical abortion is a common terminology for abortions induced by the use of pills. An abortion within the first 10 weeks of pregnancy in india can be legally performed using a combination of 2 pills. These pills are available in a combi-pack and are to be taken in the span of 3 days. Medical abortion is completely safe, non-invasive, non-surgical and - as you may have already guessed - a much preferred method of seeking abortion for majority women. These pills should be prescribed to you by a medical practitioner or an obgyn licensed to perform abortions as per the mtp act. Therefore, be quick and consult your ob-gyn! do not do the mistake of consuming these pills yourself as they can give rise to complications which may sometimes be really serious.

A surgical abortion on the other hand ends a pregnancy by removing the foetus and placenta from the uterus using either electric or manual vacuum aspiration. Although these terms sound very technical, advancements in technology have made these procedures completely safe! your doctor is your best guide so do consult them. Just make sure you get quality service in a safe environment from a trained doctor. 3 magic words - quality, safe and trained.

4. You don’t need parental or spousal consent if you’re an adult.

At times like these, you can thank the universe for being an adult! as an adult person and when it comes to seeking safe abortion access in india, you do not need anyone else’s permission. The act recognises the personhood of a woman and respects the rights of an adult person in india by maintaining confidentiality.

5. The mtp act is separate from the law on gender biased sex selection.

And there are 2 separate laws for these 2 unrelated issues! makes sense yet?

Safe abortion access is an issue of reproductive and sexual rights where a woman makes choices and decisions regarding her body and life. On the other hand, gender biased sex selection is an issue of deep rooted gender based discrimination against women and girls in the patriarchal indian society which needs to be targeted at it’s root. The first is regulated by the medical termination of pregnancy act, 1991 and the second by the pcpndt act, 1994.

We are not making this up! if you read the 2 laws, then you will find that mtp act has no mention of gender biased sex selection and pcpndt does not mention access to safe abortion anywhere. See?

Now that we understand that the two are separate from one another, let’s become advocates and stop this overlapping of the 2 issues and stigmatising safe abortion access. Because if we don’t then women may end up losing their lives for nothing.

Have a look at this document by the national health mission highlights areas of possible conflation between the two acts. It gives guidelines to stakeholders so that the pcpndt act and messaging against sex-selective abortion do not hinder access.

6. The law and how it relates to single unmarried women

The conditions mentioned in the mtp act also covers single unmarried adult women. Except for one clause reserved for married women which is abortion because of contraceptive failure. For all other reasons listed above, single women can access abortions. It is mostly because of the stigma associated with being a single woman that some service providers stigmatise abortions being sought by them, leading women to feeling humiliated or deterring them from accessing safe abortion services.

8 people found this helpful

Choice between Surgical and Medical Abortion

MD - Obstetrtics & Gynaecology
Gynaecologist, Mumbai
There are two methods by which abortion can be done

Medical Abortion -non-surgical abortion in which medicines are used to induce abortion
Surgical Abortion - Use of transcervical procedures for terminating pregnancy, including vacuum aspiration, and dilatation and evacuation (D&E).

Surgical or Medical Abortion for Unwanted Pregnancy

If pregnancy is <= 7 weeks; medical Method with Mifepristone with misoprostol is favorable as success rate is as high as 97%.
If pregnancy is between 7-12 weeks; surgical abortion is the only option.
If pregnancy is beyond 12 weeks – 20 weeks, then woman needs to be hopsitalized and will be given either Mifepristone followed by Misoprostol tablet or only misoprostol tablets and woman will then abort like a miscarriage in the Hospital. If any products are remaining then it will be evacuated surgically.
Surgical abortion is preferred if patient desires concurrent tubal ligation or IUCD (CuT) insertion.
If a woman fulfills the criteria for selecting either method i.e. Before 7 weeks), final choice to be given to the woman.

Summary of Choice between Surgical or Medical abortion in India

<= 7 weeks – Medical method or Surgical method
7-12 weeks – Surgical abortion
12 – 20 weeks – Medicines with or without surgical procedure in Hospital.

Advantages of Medical Abortion

Avoids surgery. Controlled by the woman and may take place at home. No need for admission to the Hospital. Usually well tolerated by women if properly counselled and motivated. No need to take leave from work, as bleeding can be manged with menstrual pads even while in office or at work.

Disadvantages of Medical abortion

Takes time (hours to days) to complete abortion, and the timing may not be predictable. Women experience bleeding and cramping, and potentially some other side-effects (nausea, vomiting, fever, and shivering). May require more clinic visits than surgical abortion.

Advantages of Surgical Abortion

Quick procedure. Complete abortion easily verified by evaluation of aspirated products of conception. Takes place in a Hospital so Sterilization or placement of an intrauterine device (IUD) may be performed at the same time as the procedure. It can be performed under local anaesthesia if woman is properly motivated and counselled.

Disadvantages of Surgical abortion

Requires instrumentation of the uterus. Small risk of uterine or cervical injury. Timing of abortion controlled by the Doctor and Hospital. Anaesthesia wneeds to be administered. Most doctors perform this procedure under short general anaesthesia. Woman needs to be in the Hospital for at least 6 hours. Effect of sedation will be there throuout the day.
25 people found this helpful

Methods of Abortion for Unwanted Pregnancy

MD - Obstetrtics & Gynaecology
Gynaecologist, Mumbai
Methods of Abortion for Unwanted Pregnancy

There are two methods by which abortion can be done:

  • Medical Abortion - Non-surgical abortion in which medicines are used to induce abortion
  • Surgical Abortion - Use of transcervical procedures for terminating a pregnancy, including vacuum aspiration, and dilatation and evacuation (D and E).

Surgical or Medical Abortion for Unwanted Pregnancy

  • If pregnancy is lesser than = 7 weeks; medical method with Mifepristone with Misoprostol is favorable as the success rate is as high as 97%.
  • If pregnancy is between 7-12 weeks; surgical abortion is the only option.
  • If pregnancy is beyond 12 weeks - 20 weeks, then the woman needs to be hospitalized and will be given either Mifepristone followed by Misoprostol tablet or only Misoprostol tablets and woman will then abort like a miscarriage in the hospital. If any products are remaining, then it will be evacuated surgically.

Surgical abortion is preferred if patient desires concurrent tubal ligation or IUCD (CuT) insertion. If a woman fulfills the criteria for selecting either method i.e. before 7 weeks, final choice has to be given to the woman.

Summary of choice between Surgical or Medical abortion in India

  • Lesser than = 7 weeks - Medical method or surgical method
  • 7-12 weeks - Surgical abortion
  • 12 - 20 weeks - Medicines with or without surgical procedure in hospital

Advantages of Medical Abortion

  • Avoid surgery - Controlled by the woman and may take place at home
  • No need for admission to the hospital
  • Usually, well tolerated by women, if properly counselled and motivated
  • No need to take leave from work, as bleeding can be managed with menstrual pads even while in the office or at work.

Disadvantages of medical abortion

  • Takes time (hours to days) to complete abortion, and the timing may not be predictable. Women experience bleeding and cramping, and potentially some other side-effects (nausea, vomiting, fever, and shivering). May require more clinic visits than surgical abortion.

Advantages of Surgical Abortion

  • Quick procedure
  • Complete abortion easily verified by evaluation of aspirated products of conception
  • Takes place in a hospital so Sterilization or placement of an intrauterine device (IUD) may be performed at the same time as the procedure. It can be performed under local anaesthesia if woman is properly motivated and counselled

Disadvantages of surgical abortion

  • Requires instrumentation of the uterus
  • Small risk of uterine or cervical injury
  • Timing of abortion controlled by the doctor and hospital
  • Anaesthesia needs to be administered. Most doctors perform this procedure under short general anaesthesia. A woman needs to be in the hospital for at least 6 hours. Effect of sedation will be there throughout the day.

Related Tip: Why eating fish is essential for a healthy pregnancy??

3914 people found this helpful

Uterine Fibroids - How They Can Be Managed?

Fellowship in Gynae Endoscopy, FMAS, DNB, DGO, MBBS, ellow ship of Indian College of Obstetrics and Gynecology (FICOG), MNAMS
Gynaecologist, Delhi
Uterine Fibroids - How They Can Be Managed?

The uterine fibroids are one of the most common gynecologic problems, with over 40-50% of women having them at some point in their life. The number and size of the fibroids, the age of onset, associated symptoms like dysfunctional bleeding and pelvic pain will determine the management of fibroid. The following is a series of management measures, starting from the most conservative to the most invasive. 

1. Wait and watch: In women who are asymptomatic, it is best to watch them for the development of symptoms without any intervention. Also, in women nearing menopause, it is best to just watch the fibroids as they just shrink once menstruation ceases. 

2. Medical therapy: In some women, menstrual cycles could be heavy or irregular and require hormonal replacement. They could also have occasional pain, and so may require painkillers. 

  1. Tranexamic acid is a non-hormonal medication that can be used on heavy bleeding days only to ease the heavy menstrual flow. 
  2. Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful in pain control. Iron and vitamin supplements are also useful in managing anemia and weakness associated with heavy bleeding. 
  3. Oral contraceptives and/or progestins are also used to control abnormal menstrual bleeding. They do not have any effect on fibroid size though. 
  4. Progestin could also be delivered through an intrauterine device (Mirena) to relieve heavy bleeding and prevent pregnancy
  5. Gonadotropin-releasing hormone (Gn-RH) agonists: They block the production of oestrogen and progesterone, and so induce a temporary postmenopausal state. This can also be used to shrink the fibroid so it is easier to remove it surgically. This is not used for more than 3 to 6 months as they can cause hot flashes and bone loss. 
  6. Newer drugs like Mifepristone and Ulipristal acetate are being used to shrink the size of fibroids. 

3. Noninvasive procedure: MRI-guided focused ultrasound surgery is when the women are inside the MRI scanner and an ultrasonic transducer is used for treatment. The exact location of the fibroids are identified and sound waves are used to destroy the fibroid. Done on an outpatient basis, it is safe and effective. 

4. Minimally invasive procedures: Uterine artery embolization is where the arterial supply is cut off to reduce fibroid growth. Myolysis is where laparoscopically heat or cold waves are used to lyse off the fibroids. Endometrial ablation is where the uterine lining is destroyed through high-intensity heat or cold waves. 

5. Invasive procedures: Abdominal or Laparoscopic myomectomy is where the fibroids are removed through an abdominal incision or keyhole surgery. If fibroids are extensive and completed family, hysterectomy is the choice of treatment. Given their high incidence, fibroids require management based on symptoms, age, and other considerations as discussed and decided between the patient and the doctor.

2644 people found this helpful

Causes And Treatment Of Uterine Fibroids!

MBBS, Diploma in Obstetrics & Gynaecology
Gynaecologist, Delhi
Causes And Treatment Of Uterine Fibroids!

Uterine fibroids, also known as leiomyoma or myoma, are benign growths on the uterus, occurring mostly during the years of childbearing. Few of the common symptoms of fibroids are leg pain or backache, constipation, difficulty in emptying the bladder, frequent urination, pain or pressure in the pelvic region, menstrual periods stretching over a week and excessive menstrual bleeding.

Causes:

  1. Certain genetic changes of the uterus which are different from the ones normally present in the muscle cells of the uterus can cause this disorder.

  2. Certain hormones such as progesterone and estrogen that prepare the body for pregnancy are even responsible for triggering the development of fibroids.

  3. Substances which help the body maintain its tissues trigger fibroid growth as well.

  4. Family history, excessive consumption of alcohol and red meat while going low on foods such as dairy products, fruits, green vegetables and vitamin D, obesity, usage of birth control pills and early onset of the menstruation cycle are other factors that may escalate the risks of one suffering from fibroids.

Treatment:

  1. Be careful and take a closer look: Fibroids are fundamentally non-cancerous and they hardly interfere with pregnancy. Often, they do not exhibit notable symptoms and are prone to shrinkage after menopause. Hence giving them and yourself some time might be the best option.

  2. Medications generally aim at the hormones controlling the menstrual cycle and treating symptoms such as pelvic pressure and excessive menstrual bleeding. However, they do not treat fibroids completely but work towards contracting them. They include-

    • Gonadotropin-releasing hormone (Gn-RH) agonists to block estrogen and progesterone production

    • Progestin-releasing intrauterine device (IUD) to alleviate severe bleeding caused due to fibroids

    • Tranexamic acid to ease excessive menstrual periods

    • Progestins or oral contraceptives to regulate menstrual bleeding

    • Nonsteroidal anti-inflammatory drugs (NSAIDs) to ease pain associated with fibroids

Surgeries to Treat Fibroids:

Depending on symptoms and whether medical therapy has failed, the patient may have to undergo surgery. The following surgical procedures may be considered:

  1. Hysterectomy: removing the uterus. This is only considered if the fibroids are very large, or if the patient is bleeding too much. Hysterectomies are sometimes an option to prevent fibroids coming back.

  2. Myomectomy: fibroids are surgically removed from the wall of the uterus. This option is more popular for women who want to get pregnant.

  3. Endometrial ablation: removing the lining of the uterus. This procedure may be used if the patient's fibroids are near the inner surface of the uterus; it is considered an effective alternative to a hysterectomy.

  4. UAE (Uterine artery embolization): this treatment cuts off the fibroid's blood supply, effectively shrinking the fibroid.

  5. Magnetic-resonance-guided focused ultrasound surgery: an MRI scan locates the fibroids, and sound waves are used to shrink the fibroids.

Latest Advancements:

Mifepristone: It, also known as RU-486, reduces heavy menstrual bleeding and imporves fibroid-specific quality of life. It competitively binds and inhibitsprogesterone receptors.

Ulipristal acetate: It is a progesterone receptor modulator that acts as a postcoital contraceptive. As progesterone promotes the growth of uterine fibroids, blocking its receptor may reduce their size.

3466 people found this helpful
Table of Content
About Festone Combi Kit
When is Festone Combi Kit prescribed?
What are the contraindications of Festone Combi Kit ?
What are the side effects of Festone Combi Kit ?
Key highlights of Festone Combi Kit
What are the substitutes for Festone Combi Kit ?
What are the dosage instructions?
Where is the Festone Combi Kit approved?
How does medicine works?
What are the interactions for Festone Combi Kit ?