A medical termination pack or Festone Combi Kit consists of two medicines Mifepristone and Misoprostol that are used to medically terminate the pregnancy. The kit contains 5 tablets. One tablet of Mifepristone and four tablets of Misoprostol.
It is medically prescribed if you are within 63 days of gestation. Doctors do not opt for this process if you are over 10 weeks pregnant. Mifepristone is a synthetic steroid taken orally with water. It interferes with the Progesterone Secretion that terminates the Pregnancy.
Misoprostol is a Synthetic Prostaglandin that causes the cervix to soften, contract the Uterus and allows the emptying of the uterine contents. It is administered vaginally or orally depending on the patient’s condition.
Misoprostol may be self-administered or administered under a gynaecologist’s supervision so that the patient has access to the health facilities, if necessary. In case of an intrauterine pregnancy, termination by surgery is recommended.
The dosage is 1 tablet of Mifepristone, followed by 4 tablets of Misoprostol after 1-3 days. If abortion fails to occur after the administration of Misoprostol, the second dose of Misoprostol (2 tablets) is administered. In case of an intrauterine pregnancy, termination by surgery is recommended.
This medication is primarily used for:
Unexplained Vaginal Bleeding
Chronic Adrenal Failure
Other Bleeding Disorders
Side effects of Mifepristone are as follows:
How long is the duration of effect?The effect of this medicine lasts for an average duration of 7-10 days.
What is the onset of action?
Mifepristone starts producing the required effects within 1-2 hours of administration.
Are there any pregnancy warnings?
It is advised that Mifepristone is used to terminate a pregnancy that is within 63-70 days. Use of this drug to control elevated blood sugar level should not be done if you are pregnant.
Is it habit forming?
It is not habit forming.
Are there any breast-feeding warnings?
It is recommended that you do not breastfeed your child if the administration of this drug is highly necessary.
Is It safe with alcohol?
Interaction with alcohol is still unknown. Consult your doctor before proceeding
Is it safe to drive while on this medicine?
Mifepristone may cause sleepiness. It is advised that you do not drive if you are experiencing this side-effect.
Does this affect kidney function?
There is no reported impairment to the kidney functioning.
Does this affect liver function?
There is no reported impairment to the liver functioning.
Are there any missed dose instructions?
For termination of pregnancy, it is a single dose therapy; it is not possible to miss a dose. If you are taking it for controlling blood sugar level and miss a dose, take it as soon as possible. But do not double dose.
Are there any overdose instructions?
If you overdose on Mifepristone, contact your physician right away.
This kit blocks the effect of progesterone by competitively binding to the specific receptors and sensitizing the inner linings of the uterus inducing bleeding and contractions. It also blocks the effect of cortisol at the specific receptors and reducing the effect caused by an excess of this hormone.
Misoprostol taken intravaginally behaves as a prostaglandin E1 analogue and reduces the amount of acid produced in the stomach. It further protects the stomach walls by increasing the production of bicarbonates and mucus. It can cause the smooth muscles of the uterus to contract and the cervix to relax.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
AlcoholInteraction with alcohol is unknown. It is advisable to consult your doctor before consumption.
There are no known alcohol interactions.
Interaction with Medicine
Mifepristone severely interacts with the following drugs- dexamethasone, erythromycin, hydrocortisone, ketoconazole, simvastatin, pimozide, warfarin and ergotamine.
Interaction with Disease
DiseaseInformation not available.
Interaction with Food
Grapefruit juiceAvoid the consumption of large quantities of grapefruit juice while taking mifepristone as it can alter the levels of this medicine in the blood.
It is recommended that you avoid grapefruit juice while taking this medication. It may modify the effects of the drug.
Ques: What is Festone Combi Kit?
Ques: What are the Side Effects of Festone Combi Kit?
Ques: What are the instructions for storage and disposal Festone Combi Kit?
Ques: How long do I need to use Festone Combi Kit before I see improvement of my conditions?
Ques: What are the contraindications to Festone Combi Kit?
Ques: Is Festone Combi Kit safe to use when pregnant?
Ques: Will Festone Combi Kit be more effective if taken in more than the recommended dose?
Mifepristone- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/mifepristone
Mifepristone- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:https://www.drugbank.ca/drugs/DB00834
Misoprostol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 1 February 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/misoprostol
Misoprostol- DrugBank [Internet]. Drugbank.ca. 2005 [Cited 1 February 2020]. Available from:https://www.drugbank.ca/drugs/DB00929
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.