Ketoconazole helps in the treatment of fungal and yeast infections of the body. It belongs to the drug group known as azole antifungals. The medication prevents the growth of various types of fungi by disrupting the production of the membranes that surrounds the fungal cells. It is available in the form of a tablet that can be taken orally.
The dosage and duration of taking Ketoconazole is decided by your doctor depending on your age, weight, your medical history and current condition. It is usually taken once in a single day, with or without food. However, it is better to take it with food as that will reduce the chances of a stomach upset. In case you are taking an antacid, remember that Ketoconazole needs to be taken 2 hours before or an hour after the antacid; else there are chances that your body may not absorb the drug.
There are some mild side effects that you may suffer from for taking Ketoconazole. They include nausea, headache, diarrhea, stomach pain and dizziness. Some rare side effects may include hair loss, depression, tingling sensations and serious allergic reactions.
A serious side effect of Ketoconazole can be hepatotoxicity, which implies liver damage caused due to chemicals. The symptoms include weight loss, loss of appetite, vomiting, tiredness, discoloured urine and stool, fever, rash or yellowing of the skin. In such a situation, immediate medical attention is recommended.
There are certain aspects that need to be considered before or after taking Ketoconazole:
- Ensure never to take the drug again if you have had an allergic reaction to it. Taking it again can lead to a life threatening situation.
- Avoid alcohol when you are prescribed to this medication
- Your doctor must be informed if you are pregnant or planning to be before prescribing you the drug
- Ketoconazole can pass into a baby by breastfeeding. Your doctor must be informed and then it will be decided whether you need to stop breastfeeding or stop taking the medication.
- fungal infection that can affect skin, bones and joints caused by the fungus Blastomyces dermatitidis.
ChromomycosisKetoconazole is used to in the treatment of Chromomycosis which is a fungal infection that can affect the skin and subcutaneous tissue caused by Fonsecaea pedrosoi, Phialophora verrucosa.
- infection caused by Coccidioides. This infection can affect the lungs and other parts of the body.
ParacoccidioidomycosisKetoconazole is used to in the treatment of Paracoccidioidomycosis which is a fungal infection caused by Paracoccidioides brasiliensis. This infection can affect the lungs and other parts of the body.
QT Interval prolonging drugsKetoconazole is not recommended for co-administration with drugs that are known to cause specific changes in heart rhythm.
How long is the duration of effect?The effect of this medicine lasts for an average duration of 8 hours.
What is the onset of action?The peak effect of this medicine is observed in 1 to 2 hours.
Are there any pregnancy warnings?This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.
Is it habit forming?No habit forming tendencies were reported.
Are there any breast-feeding warnings?This medicine is not recommended for use during breastfeeding women unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine. Do not breastfeed for at least 5 hours after the dose to reduce the risk of exposure.
Missed Dose instructionsThe missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.
Overdose instructionsInform your doctor immediately if you are experiencing symptoms of overdose.
Below is the list of medicines, which contains Ketoconazole as ingredient
This medication falls under the category of an antifungal. It works by inhibiting the synthesis of ergosterol, which is an important component of the fungi cell membrane by inhibiting cytochrome P-450 dependent enzyme lanosterol 14α-demethylase responsible for the conversion of lanosterol to ergosterol, thus helps in inhibiting the growth of the organism.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Qt ProlongationKetoconazole should be very carefully administered if you have any pre-existing heart conditions. Suitable dosage adjustments and safety monitoring is recommended in such cases.
Kidney DiseaseSuitable adjustment is dosage is required based on the extent of kidney impairment. An adjustment in dosage is recommended. If the patient is on hemodialysis then the blood level of Ketoconazole should be monitored after each session and then the adjusted dose should be administered.
Interaction with Alcohol
EthanolConsumption of alcohol is not recommended if you are taking this medicine. It may increase the risk of dizziness and fainting. Avoid performing activities that need mental alertness like operating machinery or driving a vehicle.
Interaction with Lab Test
LabInformation not available.
Interaction with Food
FoodInformation not available.
Interaction with Medicine
AlprazolamReport the usage of either of the drugs to the doctor so that suitable dosage adjustments can be suggested. Monitoring of blood levels might be required in some cases. Symptoms like drowsiness and difficulty in breathing should be reported immediately to the doctor.
CisaprideUse of Ketoconazole while you are taking Cisapride is not recommended. Inform your doctor about the usage of Cisapride so that suitable replacement for Ketoconazole could be prescribed.
ClopidogrelInform your doctor about the usage of either of these medicines. Dosage adjustments for Clopidogrel might be required in such cases.
ErythromycinUsage of Ketoconazole along with Erythromycin is not recommended. Inform your doctor about the usage of either of these medicines. Your doctor might prescribe alternative medicines where the risks of side effects are minimal. Immediate medical attention might be required if you feel dizzy, have shortness of breath and feel discomfort in the chest.
WarfarinUsage of Ketoconazole along with Warfarin is recommended only after dosage adjustment. Safety monitoring is a must in such cases. Signs and symptoms like headache, presence of blood in vomit and urine, weakness, unusual bleeding should be reported immediately.
AtorvastatinUse of Ketoconazole with Atorvastatin is not recommended. Inform your doctor about the usage of either of these medicines so that suitable replacement could be suggested. Symptoms like muscle pain and weakness coupled with fever, joint pain and chills should be reported immediately.
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.