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Harmless 12.5 MG Syrup

Harmless 12.5 MG Syrup

Manufacturer: Hi Tec Pharmaceuticals Pvt Ltd
Medicine composition: Colistin
Prescription vs.OTC: Prescription by Doctor required

Harmless 12.5 MG Syrup is an antibiotic which treats bacterial infections by stopping the growth of bacteria. It is a very effective medicine to treat infections of the stomach and the intestine caused by sensitive gram-negative bacteria. It is also used for performing bowel sterilisation before a surgery.

During your treatment with this medicine, you may experience a few side effects like stomach upset and itching. Serious side effects may include numbness of the arms and legs, confusion, difficulty walking, psychosis, unsteadiness, unexplained fever, seizures, troubled breathing, muscle weakness, dizziness, slurred speech and signs of kidney problems.

You should not take this medicine if you have previously experienced allergies towards any of the ingredients in it or if you suffer from myasthenia gravis (a rare condition where muscle tire very fast), brain toxicity, impaired kidney function or colitis. This medicine should not be used during a pregnancy unless absolutely necessary. Women who are breastfeeding should use it with caution. Medicines like tacrolimus, vancomycin, ethanol estradiol, streptomycin or live cholera vaccine may interfere with the action of Harmless 12.5 MG Syrup so make sure your doctor knows if you are taking any other medicines.

Harmless 12.5 MG Syrup is administered into the body by injecting it into a vein or a muscle as directed by your doctor. For severe gram-ve bacterial infections the usual dosage is 2.5-5 mg/kg/day in 2-4 divided doses. Maximum dose prescribed is 5 mg/kg/day. Your prescription depends on your medical condition and response to treatment. It is recommended to keep taking this medicine for the full prescribed duration. Contact your doctor if you see no improvement in your condition.

Bowel sterilization
This medicine is used for bowel emptying before certain surgical procedures are performed.
Gastrointestinal infections
This medicine is used for the treatment of infections of the stomach and intestine. It is particularly effective against gram negative bacteria.
This medicine is not recommended for use if you have a known history of allergy to colistin or any other medicine belonging to polymyxin antibiotic group.
Myasthenia Gravis
This medicine is not recommended for use in patients suffering from a rare condition where muscle tire very fast.
In addition to its intended effect, Harmless 12.5 MG Syrup may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Burning or tingling sensation of hands and feet Moderate Less Common
Visual disturbances Moderate Less Common
Stomach discomfort and cramps Moderate Rare
Nausea or Vomiting Minor Common
Weakness of arms, hands, legs or feet Moderate Common
Severe difficulty in breathing Major Less Common
Confusion Major Rare
Blood in urine and stools Major Rare
Skin irritation Minor Less Common
How long is the duration of effect?
The time duration for which this medicine remains effective in the body is not clinically established.
What is the onset of action?
The time taken for this medicine to show its effect is subject to variations and is not clinically established.
Are there any pregnancy warnings?
This medicine should not be used during a pregnancy unless absolutely necessary. Consult your doctor and discuss the potential benefits and risks associated with use.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine should be used with caution by women who are breastfeeding. Consult your doctor and discuss the potential benefits and risks associated with use.
Below is the list of medicines, which have the same composition, strength and form as Harmless 12.5 MG Syrup, and hence can be used as its substitute.
Missed Dose instructions
Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped.
Overdose instructions
Contact your doctor if an overdose is suspected. Symptoms may include mental confusion, difficulty in walking, dizziness, skin irritation etc.
United States
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Brain toxicity Major
The injectable form of this medicine should not be used in patients with brain damage, memory problems, anxiety, depression and other mental disorders. Your doctor will determine the best course of treatment after assessing the condition.
Impaired kidney function Major
This medicine should be used with caution in patients suffering from a kidney disease. Symptoms of the disease may worsen after the use of colistin. You may need a dose adjustment and more frequent clinical monitoring while using this medicine.
Colitis Moderate
Use of this medicine may cause severe irritation of the stomach and the intestine. Report any instance of colitis in the past or the present to the doctor. Appropriate diagnostic tests and clinical monitoring are advised before starting the treatment course with this medicine.
Interaction with Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Information not available.
Interaction with Food
Information not available.
Interaction with Medicine
Tacrolimus Major
Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together. Report incidences of loss of appetite, sudden weight gain, and fluid retention to the doctor immediately.
Vancomycin Moderate
Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together. Report incidences of loss of appetite, sudden weight gain, and fluid retention to the doctor immediately.
Ethinyl Estradiol Moderate
Use of this medicine may make oral contraceptives less effective. This may result in unintended pregnancies. Other methods of contraceptions should be discussed with the doctor before treatment with colistin is initiated.
Live cholera vaccine Major
Report the use of this medicine before taking a live cholera vaccine. Any live vaccine should be taken 14 days after stopping the use of colistin.
Streptomycin Major
Report the use of either of the medicine to the doctor. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together. Report incidences of hearing or vision loss to the doctor immediately.

Popular Questions & Answers

I used to masturbate at least twice or sometimes thrice a week. I heard lot that masturbation is good practice as well as bad practice. Because of this I have lot of confusion. But I can't able to control my masturbation habit. Am I have to reduce the frequency of masturbation per week? Once I have hardly controlled myself from masturbation for a week, but it was result in wet dreams at the end of the week. Does it affects me in future? Awaiting for your reply. Thank you.

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
I used to masturbate at least twice or sometimes thrice a week. I heard lot that masturbation is good practice as wel...
People wrongly believe that masturbation is a bad habit, or sin and it causes loss of energy and many side effects can occur. All these are myths and it is a safe act to give vent to sexual drive in men who cannot do sex. People fear if they have adverse effect on marriage or that their energy is wasted and such many funny misbeliefs are going around and all are not true. One can do as many times as he feels and health or energy is not affected or there will be no effect on marriage Masturbation is the self-stimulation of the genitals to achieve sexual arousal and pleasure, usually to the point of orgasm (sexual climax). It is commonly done by touching, stroking, or massaging the penis or clitoris until an orgasm is achieved. Some women also use stimulation of the vagina to masturbate or use "sex toys, such as a vibrator. Just about everybody. Masturbation is a very common behaviour, even among people who have sexual relations with a partner. In one national study, 95% of males and 89% of females reported that they have masturbated. Masturbation is the first sexual act experienced by most males and females. In young children, masturbation is a normal part of the growing child's exploration of his or her body. Most people continue to masturbate in adulthood, and many do so throughout their lives. In addition to feeling good, masturbation is a good way of relieving the sexual tension that can build up over time, especially for people without partners or whose partners are not willing or available for sex. Masturbation also is a safe sexual alternative for people who wish to avoid pregnancy and the dangers of sexually transmitted diseases. It also is necessary when a man must give a semen sample for fertility testing or for sperm donation. When sexual dysfunction is present in an adult, masturbation may be prescribed by a sex therapist to allow a person to experience an orgasm (often in women) or to delay its arrival (often in men). While it once was regarded as a perversion and a sign of a mental problem, masturbation now is regarded as a normal, healthy sexual activity that is pleasant, fulfilling, acceptable and safe. It is a good way to experience sexual pleasure and can be done throughout life. Masturbation is only considered a problem when it inhibits sexual activity with a partner, is done in public, or causes significant distress to the person. It may cause distress if it is done compulsively and/or interferes with daily life and activities. In general, the medical community considers masturbation to be a natural and harmless expression of sexuality for both men and women. It does not cause any physical injury or harm to the body, and can be performed in moderation throughout a person's lifetime as a part of normal sexual behaviour. Some cultures and religions oppose the use of masturbation or even label it as sinful. This can lead to guilt or shame about the behaviour. Some experts suggest that masturbation can actually improve sexual health and relationships. By exploring your own body through masturbation, you can determine what is erotically pleasing to you and can share this with your partner. Some partners use mutual masturbation to discover techniques for a more satisfying sexual relationship and to add to their mutual intimacy. Sex boosts your body?s ability to make protective antibodies against bacteria, viruses, and other germs that cause common illnesses. Of course, there?s more to cultivating a robust immune system than having a healthy sex life. Eating right, exercising, getting adequate sleep, and keeping up to date with vaccinations all contribute to having strong and healthy defences against contagious illnesses. It is a good exercise .Like every other kind of physical activity, sex burns calories, too! Sitting and watching TV burns about 1 calorie per minute. Having sex increases your heart rate and utilizes various muscle groups, burning about 5 calories per minute. Regular sex cannot replace sessions at the gym, but a having an active, healthy sex life is a nice way to get some extra physical activity. Sexual activity helps keep levels of hormones, like oestrogen and testosterone, in check. When these hormones are out of balance, conditions like heart disease and osteoporosis may develop. When it comes to protecting heart health by having sex, more is better. One study in men showed that those who had sex at least 2 times a week were 50% less likely to die of heart disease than their less sexually active men. Sexual stimulation (including masturbation) and orgasm can help keep pain away. Both activities can reduce pain sensation and increase your pain threshold. Orgasms result in the release of hormones that can help block pain signals. Some women report that self-stimulation through masturbation can reduce symptoms of menstrual cramps, arthritis, and even headache. One study showed that men who had frequent ejaculations (defined as 21 times a month or more) were less likely to develop prostate cancer than those who had fewer ejaculations. It did not matter if the ejaculations occurred through intercourse, masturbation, or nocturnal emissions.
1 person found this helpful

Few months ago I had taken CT scan which showed Fatty Liver. I know it?s not good, but how to prevent this?

MD-General Medicine, D.M, Gastroenterology & Hepatology
Gastroenterologist, Ahmedabad
Few months ago I had taken CT scan which showed Fatty Liver. I know it?s not good, but how to prevent this?
Why was the cat scan done? Exercise daily, yoga,walking and some resistance training Ty to loose at least 5 % of weight if you are overweight Reduce alcohol intake (if taking alcohol) Exercise and lifestyle measures are the only way to prevent progression of fatty liver and can possibly reduce it.

At times a cup of coffee relieves me from an acute headache like a migraine but I do not take coffee regularly. Is it harmful to health?

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurveda, Karnal
At times a cup of coffee relieves me from an acute headache like a migraine but I do not take coffee regularly. Is it...
Caffeine in coffee helps in headaches. You can also have tea in place of coffee. Both are harmless if taken in moderation.

Sir I masturbate 3 times in a day is their any major problems please answer me and how I control it.

Fellowship ,council of Sex Education and Parenthood , BAMS, B-Pharm
Sexologist, Jaipur
Sir I masturbate 3 times in a day is their any major problems please answer me and how I control it.
Masturbation in medical terms is the manual stimulation of genitals to achieve orgasm. It is a normal phenomenon and most of the males and females masturbate in some phase of their life. Masturbation is completely harmless . depend on your desire but 3 time in day is over limit .

I am 44 years old women. I had fatty lumps at underarm each side and some small lumps in right hand. They are harmless till last month. Now I am getting light pain sometimes in left side chest and underarm. What is the reason for that?

Bsc Food & Nutrition, Msc Food & Nutrition
Dietitian/Nutritionist, Delhi
I am 44 years old women. I had fatty lumps at underarm each side and some small lumps in right hand. They are harmles...
Hi lybrate-user The lymph nodes are located under your arm. The lumps can be caused by bacterial or viral infections, allergies, harmless fat or tissue growths, and cancerous growths. If they have started to pain please visit the doctor at the earliest. Don't ignore it.
1 person found this helpful

Popular Health Tips

Causes And Treatment Of Skin Tags!

MD - Skin,VD & Lepxsy
Dermatologist, Hyderabad
Causes And Treatment Of Skin Tags!

Skin tags, also known as acrochordons, are small brown or darker-than-skin tone growths on the surface of the skin. Tags are very common and harmless growths and tend to occur on the neck, under the breasts, armpits, eyelids and folds of the groin. They generally take place after midlife. About 25% of people report having skin tags after they cross the age of 50.

What causes skin tags to occur?

Skin tags are very common among diabetics and obese individuals. Pregnant women also develop skin tags, as a consequence of changes in the body's hormonal levels. Skin tags tend to occur when your skin rubs against clothing or skin. They are normally caused by blood vessels and collagen that gets trapped inside the thicker portions of the skin. For this reason, they are typically found in folds and creases of the skin. Sometimes, they reduce on their own if blood supply to the tissue has been disrupted due to them getting twisted.

What procedures are involved in their treatment?

Skin tags are generally removed for purely cosmetic reasons but when they do become troublesome, as in, they rub against jewelry, skin or clothing, doctors recommend their removal as the area can end up becoming irritated.

The following procedures are performed to remove these annoying growths on skin:

1. Excision - In this procedure the skin tag gets removed using a scalpel.

2. Ligation - The procedure involves the cutting off of blood supply to the skin tag.

3. Cauterization - The procedure involves the burning off the skin tag using electrolysis (process that involves decomposition of a matter by electric current)

4. Cryosurgery - In this procedure, the skin tag is frozen before removing it. An instrument containing liquid nitrogen is used to do the removal.

Heart Attack Symptoms You Shouldn't Ignore

MBBS, MD , DM Cardiology
Cardiologist, Bhopal
Heart Attack Symptoms You Shouldn't Ignore

A heart attack is caused if the blood flow to the heart is somehow obstructed by fat deposits, cholesterol or other substances, thereby, forming a plaque in the arteries. The disruption in this flow of blood destroys a part of the heart muscle and may prove to be fatal if not treated right on time.

Not every heart attack starts with a sudden crushing pain in the chest. In fact, about 30 per cent of the cases haven’t yielded any such symptom. However, the signs may vary from one person to another:

  1. Heart attack might start slowly causing only mild discomfort or pain initially. The symptoms happen to be sudden and intense, persisting for several hours.
  2. Mostly heart attack induces pain on the left side or the center of the chest. The discomfort generally persists for a few minutes. It can even result in a feeling of indigestion or heart burn, fullness, squeezing and pressure which can turn from mild to severe.
  3. One might also experience an aching sensation in the upper stomach, jaw, neck, shoulders, back or both of the arms.
  4. Shortness of breath is one of those very common symptoms.
  5. Other common symptoms include excessive sweating, exhaustion, vomiting, nausea, sudden dizziness or light-heartedness.

How can you tell a heart attack from a mere panic attack?
Panic attack occurs even more suddenly and induces intense fear, extracting extreme reactions for something relatively harmless. Once the attack subsides, one usually feels week on the knees and tender near the gut. Some of the symptoms exclusive to a panic attack include a feeling of detachment, numbness, hot flashes, chills and tightness experienced in and around the throat, tremors (primarily of the hands) and a constant fear of losing control or of an impending danger.

Although many indications of a heart attack might happen to overlap with those of a panic attack, there are still a few noteworthy differences between the two. Watch out for those signs and get yourself diagnosed properly.

7 people found this helpful

Warts vs. Moles - All You Need To Know!

Dermatologist, Delhi
Warts vs. Moles - All You Need To Know!

Everyone wants to have a bright and radiating skin. But blemishes and skin abnormalities are common and can occur due to lifestyle, diet or hormonal imbalances. Moles and warts are typical skin issues. But how do you tell them apart?

Moles – What are they?

Hardly ever causing pain, they appear in many different colours and can be bumpy or flat. Most often of red, brown or black colour, they occur as a result of skin pigmentation called melanocytes. They can be caused due to direct exposure to sunlight or due to genetic factors as well. They can appear in any part of the body and form slowly, taking a long time to grow.

Warts – What are they?

Small bumps or rough growth on the skin that appear in hands, legs, fingers, soles of the feet, face or in the genital area manifest as warts. They are white or pale. They occur as a result of harmful virus infection of Human Papilloma Virus (HPV) and hence, can be contagious. As opposed to moles, warts need to be removed quickly since a virus causes them.

How do you differentiate a mole from a wart?
Below are some common characteristics of each that can help you identify the skin problem:


  • Either flat or elevated from the skin, they are commonly referred to as beauty marks or birth marks.
  • At times, they have hair growing from them.
  • Usually, they have one colour – mostly on the darker side.
  • It cannot be transmitted between people.
  • They are generated by a collection of pigment cells in the body and darken during hormonal changes.
  • They tend to become cancerous and lead to melanoma.


  • They are harmless, yet contagious.
  • They have small black or dark dots in the centre that are tiny blood vessels, which provide them with nutrients.
  • They grow outwards on the skin with a scaly or bumpy deposit.
  • They can grow anywhere on the body, but are commonly found in feet, hands or fingers.

How to treat warts and moles?

The good news is that both warts and moles do not pose a grave risk to your health, but they are annoying and can turn dangerous in the long run. Especially with warts, you can give it to someone or acquire from someone, since it is a type of virus infection. So, seek medical assistance if you want them to be removed from your skin.

Be aware of the difference between warts and moles to know what you are dealing with. 

In case you have a concern or query you can always consult an expert & get answers to your questions!

Penis Bumps From Fordyce Spots: Are DIY Remedies Good?

MD - General Medicine
Sexologist, Delhi
Penis Bumps From Fordyce Spots: Are DIY Remedies Good?

When a man discovers penis bumps on his equipment, he often worries about what this might mean in terms of his penis health, and with good reason. Sometimes bumps can indeed mean a condition exists which needs attending to. But in the case of Fordyce spots, the bumps are benign and don't really require attention medically.

Nonetheless, some men (and some partners) don't like the look of Fordyce spots on and around the penis and may want to do something about them. There are many DIY remedies floating around the internet for removing Fordyce spots - but should a man use them to get rid of these harmless penis bumps?

What they are

The body has a network of glands known as sebaceous glands. There are many of these in the penis, and they provide an important function. They create and transport the body's natural lubricating oils to the skin, where they help keep the skin moisturized and prevent drying out. On the penis, this helps keep skin from becoming dry, flaky and cracked - a look that no man really wants.

Sometimes, however, the sebaceous glands work harder than they have to. They become overactive. When this happens, they can be seen on the top of the skin as tiny little dots, often white or another color that is somewhat paler than the skin surrounding them. This is all that Fordyce spots are - overactive sebaceous glands. They are not dangerous and pose no real danger to a person. And they are very common, with some doctors estimating that some 80% of men have these penis bumps. (Some people may also get them on their lips as well.)


Nonetheless, some people find them aesthetically unpleasing and wish to have them removed. Since Fordyce spots have been around for thousands of years, many folk "remedies" exist for them. But are they effective? Not really.

For example, many DIY remedies assume that Fordyce spots are due to bacterial growth, which is not the case. But nonetheless these remedies purport to destroy bacteria in the area, and thus remove the penis bumps. Typical among these home methods are the application of turmeric mixed with apple cider vinegar; tea tree oil; jojoba oil; or lemon. Whether they actually affect bacteria may be open to debate, but they definitely do not remove Fordyce spots.

Another tactic has to do with moisturizing the skin. Coconut oil and aloe vera are suggested for this, and while they can help keep skin hydrated, Fordyce spots do not respond to them. Neither do they respond to simply boosting vitamin intake, as other old wives' tales suggest. For that matter, exfoliating via an oatmeal scrub or a mixture of vanilla and sugar is also unlikely to help.

A doctor

For those men who really do wish to remove their Fordyce spots, it's suggested they consult with a dermatologist. There are some methods, such as laser surgery and chemical peels, which can be effective. But since these penis bumps are benign, a man may want to be sure he cannot live with them before taking steps to remove them.

While home remedies to remove Fordyce spots (or other penis bumps) are unlikely to work, they do draw attention to the need to care for penis skin - and this can more easily be accomplished through the regular application of a first class penis health crème (health professionals recommend Man1 Man Oil, which is clinically proven mild and safe for skin). Moisturization can be aided via a crème that includes both Shea butter (a high-end emollient) and vitamin E (one of nature's great hydrating agents). And since free radicals and the oxidative damage they cause are a threat to healthy penis skin, it helps if the selected crème also includes a power antioxidant (such as alpha lipoic acid) to help fight those free radicals.

2 people found this helpful

Penis Bumps and MRSA: Not a Good Combo

MD - General Medicine
Sexologist, Delhi
Penis Bumps and MRSA: Not a Good Combo

In recent years, MRSA - known to doctors as Methicllin resistant Staphylococcus aureus - has become an increasingly serious problem. While not traditionally associated with threats to penis health, it has become more of a potential area of concern. While it is rare that presentation of penis bumps means the presence of MRSA, men should be aware of the possibility of MRSA occurring on the penis and know what to do if they suspect this is the case.

Just what is MRSA?

As its name might imply, MRSA is an infection caused by a strain of bacteria that is resistant to treatment by traditional antibiotics. This bacterium has come into being due to overuse of antibiotics. For years, many people were prescribed antibiotics for viral infections. These viruses weren't affected by the antibiotics, but unnecessary exposure to the antibiotics helped staph bacteria to develop immunity to them.

Staph bacteria tend to live on the skin or the nose; about 30-40% of people carry them around. As long as they stay on the surface, they're harmless. But when they get inside the body, they can cause problems, sometimes severe ones, in the blood, lungs, heart, joints or bones. In some instances, MRSA in the body can prove fatal.

It used to be that MRSA was an issue basically at nursing homes or hospitals, with the bacteria entering the body through improperly sterilized equipment. However, MRSA has become somewhat more common in what is referred to as a "community" setting, where it gets passed from one person to another, usually by skin-on-skin contact.

The penis bumps connection

MRSA usually presents as swollen red bumps that can be tender or painful and may look like pimples or insect bites.

When they present as penis bumps, they have most often entered the body through cuts or nicks in the skin. So if a guy is manscaping and cuts himself with a razor, if there are MRSA bacteria nearby, they can enter the body that way. Sometimes it can also come about because of the penis being rubbed raw from overuse or through forgetting to use lubricant. Tiny cuts can develop through which the bacteria can invade.

Some doctors have reported cases where MRSA has been transmitted through sexual contact as well. It is unclear whether the bacteria can enter the body through the penile meatus and travel through the urethra. However, it has been documented as being passed on to a man who performed oral sex on a woman who was infected with MRSA.

Penis bumps can result from many causes other than MRSA. However, if a man has penis bumps that seem to have no explanation, he should consult with his doctor to determine the cause. If MRSA is responsible, the doctor will begin treatment to ensure no complications result.


Preventing MRSA is much better than treating it. Basic common hygiene practices, such as washing hands regularly, keeping clothes, linens and towels clean, and showering after physical activity can help. It's also important to not share personal grooming products (such as razors), towels or underwear. And when wounds develop, they should be washed, sterilized and covered. Wearing condoms during sex is also advised.

Clearly, not every case of penis bumps is a sign of MRSA. Sometimes those bumps signify irritated penis skin, which may respond to regular use of a high-level penis health crème (health professionals recommend Man1 Man Oil, which is clinically proven mild and safe for skin). Strong penis skin needs help in resisting free radicals and the oxidative stress they cause, and that's why the crème needs to have a potent antioxidant like alpha lipoic acid. Penis skin also needs to have sufficient elasticity to fulfill its functions, so the crème should include vitamin C, which helps produce the collagen that contributes to proper elasticity.

2 people found this helpful