Coversyl-AM 4/5 Tablet is used to treat angina, high blood pressure and coronary heart disease. It is recommended in case of heart failure if other medications fail to work. Coversyl-AM 4/5 Tablet is the key ingredient of this medicine. It increases the myocardial oxygen delivery in patients with vasospastic angina.
Coversyl-AM 4/5 Tablet belongs to the class of a calcium channel blocker that inhibits calcium ion from entering the slow channels of vascular smooth muscle and myocardium during depolarization. This leads to cause relaxation of coronary vascular smooth muscle and coronary vasodilation.
The medicine should be taken as per the dosage on the prescription. Overdosage of the drug can lead to complications. Depending on the effects the drug has on a patient, the doctor may make variations to the dosage.
The medicine may not be safe to use during pregnancy or breastfeeding. Dosage should be low for elderly people and for those with liver problems. If you have heart problems then intake of Coversyl-AM 4/5 Tablet may increase your health problems.
The primary cardiac symptoms of calcium blocker overdose includes hypotension and bradycardia. The hypotension is caused by peripheral vasodilation, myocardial depression, and bradycardia. Bradycardia results from sinus bradycardia, second- or third-degree atrioventricular block, or sinus arrest with junctional rhythm.
Intraventricular conduction is usually not affected so QRS duration is normal (verapamil does prolong the P-R interval and bepridil prolongs the Q-T and may cause ventricular arrhythmias, including torsade de pointes).
In a few reported cases, overdose with calcium channel blockers has been associated with hypotension and bradycardia, initially refractory to atropine but becoming more responsive to this agent when larger doses (approaching 1 gram per hour for more than 24 hours) of calcium chloride was administered.
The most common use of this medication is:
Following are some of the common side effects that may occur:
How long is the duration of effect?This effect of this medicine lasts for a duration of approximately 24 hours.
What is the onset of action?The peak effect of this medicine can be observed in 6 to 12 hours.
Are there any pregnancy warnings?Teratogenic and embryotoxic effects have been demonstrated in small animals. No well controlled studies have been conducted in pregnant women. Use in pregnancy only when clearly needed and when the benefits outweigh the potential hazard to the fetus.
Is it habit forming?No habit forming tendency has been reported.
Are there any breast-feeding warnings?Clear data is not available on the use of this medicine in breastfeeding women. This medicine should be used only if clearly needed and no other safer alternative is available.
Does this affect liver function?Dose adjustment is needed in case of hepatic impairment.
Does this affect kidney function?No relevant information is available.
Below is the list of medicines, which have the same composition, strength and form as Coversyl-AM 4/5 Tablet , and hence can be used as its substitute.
Missed Dose instructionsThe missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
Overdose instructionsSeek emergency medical treatment or contact the doctor in case of overdose.
Coversyl-AM 4/5 Tablet works by inhibiting calcium ion from entering the "slow channels" or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospastic angina.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
CarbamazepineThe desired effect of Coversyl-AM 4/5 Tablet will not be achieved if taken with carbamazepine. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.
DexamethasoneThe desired effect of Coversyl-AM 4/5 Tablet will not be achieved if taken with dexamethasone. This interaction is more likely to happen if dexamethasone is taken for more than a week. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.
ItraconazoleItraconazole may increase the concentration of Coversyl-AM 4/5 Tablet and may cause serious adverse effects such as fluid retention, irregular heart rhythm, and low blood pressure. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.
RifampinThe desired effect of Coversyl-AM 4/5 Tablet will not be achieved if taken with rifampin. Inform the doctor if you are on either of the medicines. Frequent monitoring of blood pressure is necessary. An alternate medicine or suitable dose adjustments are to be made based on the clinical condition.
Interaction with Disease
HypotensionCoversyl-AM 4/5 Tablet is not recommended in patients suffering from hypotension or cardiogenic shock as it further reduces the blood pressure.
Interaction with Food
Ques: What is Coversyl-AM 4/5 Tablet?
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Ques: Does Coversyl-AM 4/5 Tablet cause itching?
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Ques: Is Coversyl-AM 4/5 Tablet a beta-blocker?
Ques: What are the serious side effects of Coversyl-AM 4/5 Tablet?
Amlodipine- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 23 Nov 2021]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/amlodipine
Amlodipine 5 mg tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 23 Nov 2021]. Available from:https://www.medicines.org.uk/emc/product/6075/smpc
AMLODIPINE- amlodipine besylate tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2008 [Cited 23 Nov 2021]. Available from:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b52e2905-f906-4c46-bb24-2c7754c5d75b
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