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Overview

Coffact-S Drop

Manufacturer :  Fitwel Pharmaceuticals Private Limited
Medicine Composition :  Levosalbutamol, Ambroxol, Guaifenesin
Prescription vs OTC : Prescription by Doctor required

About Coffact-S Drop

Coffact-S Drop, is a short acting adrenergic receptor against used in the treatment of chronic obstructive pulmonary disease – COPD and asthma. The medication is also used for constriction of airways, lungs inflammation and other related conditions.

It is helpful in treatment or prevention of bronchospasm in adults and adolescents 12 years of age and older with reversible obstructive airway disease. This works by relaxing smooth muscles in the bronchial tubes and thus helps in shortening or reversing an acute attack of shortness of breath or difficulty in breathing.

Coffact-S Drop, can be used only after informing your doctor about all the medications that you are under currently. Coffact-S Drop, has some commonly reported side effects like hypokalemia, tremors especially of hands, diarrhoea, tiredness and or an urge to vomit.

You should inform regarding any kind of allergies that you may have, pre-existing diseases, pregnancy, any upcoming surgeries, high blood pressure, since health conditions may make you more susceptible to the side effects of the drug. This medication has to be taken under the supervision and prescription of a doctor only.

Coffact-S Drop, comes in an inhaler format, to be given only to patients above 4 years of age. The medication can be given orally by nebulization, starting from twice to six times a day depending on the condition.

Symptoms of Coffact-S Drop overdose include tachycardia, tremor, hypertension, angina and seizures. Hypokalemia also may occur. Cardiac arrest and death may be associated with abuse of beta-agonist bronchodilators.

Treatment includes immediate discontinuation and symptomatic and supportive therapies. Cautious use of beta-adrenergic blocking agents may be considered in severe cases.

While taking Coffact-S Drop Asthma symptoms, FEV1 and/or peak expiratory flow rate, heart rate, blood pressure, CNS status, arterial blood gases (if condition warrants) should be monitored. In selected patients: Serum, glucose, and potassium levels should also be monitored.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the uses of Coffact-S Drop

    • Bronchospasm

    • Chronic Obstructive Pulmonary Disorder (Copd)

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the contraindications of Coffact-S Drop ?

    • Hypersensitivity

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the side effects of Coffact-S Drop ?

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    Key highlights of Coffact-S Drop

    • Is It safe with alcohol?

      Interaction with alcohol is unknown. Please consult your doctor.

    • Are there any pregnancy warnings?

      Coffact-S Drop may be unsafe to use during pregnancy.
      Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

    • Are there any breast-feeding warnings?

      Coffact-S Drop is probably unsafe to use during breastfeeding. Please consult your doctor.

    • Is it safe to drive while on this medicine?

      There is no data available. Please consult doctor before consuming the drug.

    • Does this affect kidney function?

      Caution should be used in patients with renal impairment.

    • Does this affect liver function?

      There is no data available. Please consult doctor before consuming the drug.

    • What is the onset of action?

      The effect of this medicine is initiated within 10 - 17 minutes, peak effect: 1.5 hours.

    • How long is the duration of effect?

      The duration of action of this medicine is about 5-6 hours (as long as 8 hours in some patients).

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the substitutes for Coffact-S Drop ?

    Below is the list of medicines, which have the same composition, strength and form as Coffact-S Drop , and hence can be used as its substitute.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    What are the dosage instructions?

    • Are there any overdose instructions?

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    • Are there any missed dose instructions?

      If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

    Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

    How does this medication work?

    This medication can be defined as a bronchodilator that is useful for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It works as a β2 adrenergic receptor that results in an increase of cyclic AMP. Increased AMP leads to activation of protein kinase A which again prevents phosphorylation of myosin. Hence, this leads to smooth muscle relaxation.

      Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Pulmonologist before using this medicine.

      What are the interactions of Coffact-S Drop ?

      Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

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      • Interaction with Medicine

        • Decreased effect: Beta-blockers (particularly nonselective agents) block the effect of levalbuterol. Digoxin levels may be decreased.
        • Increased effect/toxicity: May add to effects of medications which deplete potassium (eg, loop or thiazide diuretics). Cardiac effects may be potentiated in patients receiving MAOIs, tricyclic antidepressants, sympathomimetics (eg, amphetamine, dobutamine), inhaled anesthetics (eg, enflurane).
      • Interaction with Disease

        • May provoke paradoxical bronchospasm (similar to other bronchodilators).
        • Immediate hypersensitivity reactions have occurred, including angioedema, oropharyngeal edema, urticaria, rash, and anaphylaxis.
        • Use with caution in patients with cardiovascular disease, including coronary artery disease, hypertension and a history of arrhythmias (may increase heart rate, blood pressure or other symptoms, including EKG changes).
        • Do not use doses higher than recommended - fatalities have been associated with excessive use of other sympathomimetics.
        • The need to use bronchodilators more frequently than usual should prompt an evaluation of the need for additional anti-inflammatory medication.
        • Additional anti-inflammatory medication (such as corticosteroids) may be required to control asthma.
        • Use with caution in diabetic patients and in patients with hypokalemia.
        • Use with caution during labor and delivery.
        • Safety and efficacy in patients <12 years of age not established.

      FAQs about Coffact-S Drop

      • Ques : What is Coffact-S Drop?

        Ans : Levosalbutamol is a salt which performs its action by calming the muscles in the air passages and widens airways. This makes breathing easier. Levosalbutamol is used to treat conditions such as Asthma, Constriction of airways, Lungs inflammation, etc.

      • Ques : What are the uses of Coffact-S Drop?

        Ans : Levosalbutamol is a medication, which is used for the treatment and prevention from conditions such as Asthma, Constriction of airways, and Lungs inflammation. Apart from these, it can also be used to treat condition like Chronic obstructive pulmonary disease. The patient should inform the doctor about any ongoing medications and treatment before using Levosalbutamol to avoid undesirable effects.

      • Ques : What are the Side Effects of Coffact-S Drop?

        Ans : Levosalbutamol is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Levosalbutamol which are as follows: Headache, Viral infections, Blocked or runny nose, Sore throat and hoarseness, Shaking and trembling of arms and feet, Decreased appetite, Muscle pain and cramps, Anxiety and nervousness, Swelling of eyelids, face, lips, tongue, Nausea, Skin rash and spotting, Chest pain and discomfort, Sleep disturbances, Increased heartbeat, Difficulty in swallowing, and Difficulty in speaking (dysphonia). It is a list of possible side-effects which may occur due to the constituting ingredients of Levosalbutamol.

      • Ques : What are the instructions for storage and disposal Coffact-S Drop?

        Ans : Levosalbutamol should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.

      • Ques : What is the onset of action of Coffact-S Drop?

        Ans : Coffact-S Drop takes between 5 to 10 minutes to show its effect.

      • Ques : What is the duration of the effect of Coffact-S Drop?

        Ans : The effect of Coffact-S Drop lasts for about 3 to 6 hours.

      • Ques : Where is Coffact-S Drop approved?

        Ans : Coffact-S Drop is approved in India and the USA.

      • Ques : Is Coffact-S Drop safe for usage in paediatrics?

        Ans : Coffact-S Drop is not recommended for usage in paediatrics as its safety and effectiveness are not known.

      • Ques : Is Coffact-S Drop safe for usage in geriatrics?

        Ans : Coffact-S Drop should be used with caution in geriatrics as it increases the risk of worsening the health condition.

      • Ques : Should Coffact-S Drop be taken with a meal or without a meal?

        Ans : It is advised to take Coffact-S Drop on an empty stomach.

      References

      • Levalbuterol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2021 [Cited 24 Nov 2021]. Available from:

        https://druginfo.nlm.nih.gov/drugportal/name/levosalbutamol

      • LEVALBUTEROL HYDROCHLORIDE solution- Daily Med [Internet]. dailymed.nlm.nih.gov. 2020 [Cited 24 Nov 2021]. Available from:

        https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=91b2b443-bdc7-4045-bb94-906199125f49

      • LEVALBUTEROL solution- EMC [Internet]. www.medicines.org.uk. 2021 [Cited 25 Nov 2021]. Available from:

        https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=97f86359-9388-4ec2-95e9-65ad327a5d5b

      Disclaimer : The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

      Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

      Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
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      Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
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      Reviewed ByDr. Garima SharmaMBBS, Master in Healthcare Administration, Diploma in Occupational HealthGeneral Physician
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