Codeine is used as an opioid to relieve pain ranging from mild to moderately severe. It is similar to morphine and hydrocodone, acting as a cough suppressant. It binds the receptors in the brain that are responsible for transmitting the feeling of pain throughout the body.
Even though the pain is still apparent to the patient, it decreases discomfort, and increases the tolerance to pain. It also acts as a sedative and slows down the breathing. This drug is also used as an antitussive in lower doses; dextromethorphan has equivalent antitussive activity but has much lower toxicity in accidental overdose.
If you are prone to frequent asthma attacks with hyperventilation and breathing problems, or a blockage in your intestines, the medicine should not be prescribed. If you are pregnant and are on this medicine, your baby may become dependent on it. It is not to be prescribed for children below the age of 12 years.
It is important that you take Codeine exactly as your doctor has prescribed it for it can slow your breathing down to dangerous levels. Even at regular doses, it is habit forming, and must not be used without a prescription. If you have noisy breathing, seizures, impotence, slow heart rate, light headedness, find a doctor immediately.
If self-administered, use exactly as directed (do not increase dose or frequency); may cause physical and/or psychological dependence. While using this medication, do not use alcohol and other prescription or OTC medications (especially sedatives, tranquilizers, antihistamines, or pain medications) without consulting prescriber.
Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). May cause dizziness, drowsiness, confusion, agitation, impaired coordination, or blurred vision (use caution when driving, climbing stairs, or changing position - rising from sitting or lying to standing, or when engaging in tasks requiring alertness until response to drug is known); nausea or vomiting, or loss of appetite (frequent mouth care, small frequent meals, sucking lozenges, or chewing gum may help); constipation (increased exercise, fluids, or dietary fruit and fiber may help - if constipation remains an unresolved problem, consult prescriber about use of stool softeners).
Report confusion, insomnia, excessive nervousness, excessive sedation or drowsiness, or shakiness; acute GI upset; difficulty breathing or shortness of breath; facial flushing, rapid heartbeat or palpitations; urinary difficulty; unusual muscle weakness; or vision changes.
Symptoms of overdose include CNS and respiratory depression, gastrointestinal cramping, constipation. Naloxone 2 mg I.V. (0.01 mg/kg for children) with repeat administration as necessary up to a total of 10 mg.
The medicine is useful against the following conditions:
Is It safe with alcohol?Codeine may cause excessive drowsiness and calmness with alcohol.
Are there any pregnancy warnings?Codeine may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Are there any breast-feeding warnings?Codeine is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?Caution is advised when driving or operating machinery.
Does this affect kidney function?Caution should be used in patients with renal impairment. Adjustment of dose is needed.
- Clcr 10-50 mL/minute: Administer 75% of dose
- Clcr <10 mL/minute: Administer 50% of dose
Does this affect liver function?Dosing adjustment in hepatic impairment is probably necessary in hepatic insufficiency. Please consult doctor before consuming the drug.
How long is the duration of effect?This drug will remain active for about 4 - 6 hours.
What is the onset of action?The effect of this drug will be initiated within 10 - 30 minutes after its administration.
Is it habit forming?Tolerance or drug dependence may result from extended use.
Are there any missed dose instructions?If you miss a dose of Codeine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Are there any overdose instructions?
Seek emergency medical treatment or contact the doctor in case of an overdose.
Symptoms of overdose include CNS and respiratory depression, gastrointestinal cramping, constipation.
Naloxone 2 mg I.V. (0.01 mg/kg for children) with repeat administration as necessary up to a total of 10 mg.
Below is the list of medicines, which contains Codeine as ingredient
This medication behaves as an opioid analgesic with antitussive properties that works by binding to opioid receptors in the CNS. Specifically, it binds to mu-type, kappa-type and delta-type opioid receptors and inhibits the secretion of neurotransmitters responsible for the transmission of pain stimuli such as GABA, substance P, acetylcholine.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Medicine
- Increased toxicity: CNS depressants, phenothiazines, TCAs, other narcotic analgesics, guanabenz, MAO inhibitors, neuromuscular blockers.
- Use with caution in patients with hypersensitivity reactions to other phenanthrene derivative opioid agonists (morphine, hydrocodone, hydromorphone, levorphanol, oxycodone, oxymorphone).
Interaction with Food
Interaction with Disease
Ques: Is it safe to take alcohol with Codeine?
Ques: Is it safe to take Codeine during pregnancy?
Ques: What are the Side Effects of Codeine?
Ques: What are the instructions for storage and disposal Codeine?
Ques: Where is Codeine approved?
Ques: Should Codeine be taken with a meal or without a meal?
Ques: What is the onset of action of Codeine?
Ques: What is the duration of effect of Codeine?
Ques: Is it safe to suddenly stop taking Codeine?
Ques: How is Codeine administered?
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.