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Overview

Chloramphenicol

Prescription vs.OTC: Prescription by Doctor required

Chloramphenicol is a broad spectrum antibiotic used for treating a number of severe bacterial infections.This is also used as an eye ointment to treat conjunctivitis. It treats meningitis, cholera, plague and typhoid fever. Its use by mouth or by injection is only recommended when no other antibiotics work effectively. It works by interfering with the growth of the bacteria causing the infection.

This medicine is usually not recommended unless absolutely necessary due to its many side effects. It includes bone marrow suppression, diarrhoea and nausea. The bone marrow suppression may prove to be fatal. People with liver or kidney problems may need lower doses. In young children a condition known as grey baby syndrome may occur which results in them having a swollen stomach and low blood pressure. If you have anaemia, bone marrow problems, liver disease, or allergy from Chloramphenicol then inform your doctor before taking this medicine. Near the end of pregnancy and during breastfeeding, its use is typically not recommended. To reduce the risk of side effects treatment duration should be as short as possible.

Some medicines may interact with the action of Chloramphenicol. Tell your doctor if you are taking any other medicines, especially any anticoagulants, hydantoins, sulfonylureas or medicines that may decrease your bone marrow.

It is recommended to monitor blood cell levels, once in every two days during treatment. If you miss a scheduled dose of this medicine or if you suspect an overdose, seek medical attention as soon as possible. The duration for which Chloramphenicol remains effective usually varies according to the intended use and dosing regimen.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Ophthalmologist before using this medicine.

bacterial infections
This medicine is not recommended for use if you have a known history of allergy to chloramphenicol or any other component present with it.
Minor infections
This medicine is not recommended for preventing or treating minor infections, especially the injectable forms.
This medicine is not recommended for use in patients having this genetic disorder of the blood.
Bone marrow suppression
This medicine is not recommended for use in patients with bone marrow suppression due to a disease or consumption of certain medicines.
In addition to its intended effect, Chloramphenicol may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Burning sensation
Stinging sensation.
Is It safe with alcohol?
No interaction found
Are there any pregnancy warnings?
Chloramphenicol is safe to use during pregnancy.
Adequate and well-controlled human studies have shown low or no risk.
Are there any breast-feeding warnings?
Chloramphenicol is probably safe to use during lactation. \nLimited human data suggests that the drug does not represent a significant risk to the baby.
Is it safe to drive while on this medicine?
Chloramphenicol may cause blurring of your vision for a short time just after its use. Do not drive until your vision is clear.
Does this affect kidney function?
There is limited information available on the use of Chloramphenicol in patients with kidney disease. Please consult your doctor.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Missed Dose instructions
Contact your doctor immediately if you miss a scheduled dose of this medicine.
Overdose instructions
Contact your doctor immediately if an overdose with this medicine is suspected.
India
United States
Japan
Below is the list of medicines, which contains Chloramphenicol as ingredient
Jawa Pharmaceuticals Pvt Ltd
Bell Pharma Pvt Ltd
Jawa Pharmaceuticals Pvt Ltd
Pfizer Ltd
Elder Pharmaceuticals Ltd
Entod Pharmaceuticals Ltd
Centaur Pharmaceuticals Pvt Ltd
Scott Edil Pharmacia Ltd
Que Pharma Pvt Ltd
Ajanta Pharma Ltd
Ajanta Pharma Ltd
Ratchet Biotech Pvt Ltd
Klar Sehen Pvt Ltd
Klar Sehen Pvt Ltd
Klar Sehen Pvt Ltd
Senses Pharmaceuticals Ltd
Perk Pharmaceuticals Ltd
Perk Pharmaceuticals Ltd
Pharmtak Ophtalmics India Pvt Ltd
Medivision Pharm
Chloramphenicol is an antibiotic which works by reversibly binding to the 50S subunit of the ribosomes of the bacterial cell. This interferes with the activity of peptidyl transferase which in turn inhibits protein synthesis in the bacterial cells by blocking peptide bond formations.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Bone marrow suppression Major
Use of this medicine in patients having a suppressed bone marrow can lead to fatal adverse effects. It could lead to several diseases of the blood in such patients. This medicine should be administered with extreme caution in patients with bone marrow suppression.
Liver/kidney impairment Major
This medicine should be used with extreme caution in patients having an impairment of liver or/and kidney function. Use should be avoided unless absolutely necessary.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Warfarin Moderate
Report the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring of bleeding and clotting time while taking these medicines together.
Ethinyl Estradiol Moderate
Use of this medicine can make hormonal oral contraceptives less effective and hence chances of unintended pregnancies increase. Alternate means of contraception should be adopted while taking this medicine.
Cefixime Moderate
Report the use of either of the medicine to the doctor. You may need a dose adjustment and more frequent monitoring while taking them together. It is advised to inform the doctor about the use of any medicine belonging to cephalosporin group.
Hydrocodone Major
Report the use of either of the medicine to the doctor. Your doctor will prescribe alternatives that have minimal or no interactions. An increase in side effects like drowsiness, dizziness, impairment of thinking should be reported to the doctor.
Iron and vitamin B12 Moderate
Use of chloramphenicol can interfere with the effect of iron and vitamin B12 for the treatment of anemia. Report the use of either of the medicine to the doctor. Do not stop the use of any medicine without consulting your doctor.
Deferiprone Major
Report the use of any chemotherapy medicine to the doctor before receiving chloramphenicol. The risk of adverse effects are significantly high and hence your doctor may prescribe safer alternatives.
What are you using Chloramphenicol for?
bacterial infections
Other
meningitis
plague and typhoid fever
cholera
How much was the improvement?
Excellent
Poor
Average
How long did it take before seeing improvement?
More than 2 days
Within 2 hours
Within 2 days
Within a day
Within 6 hours
How frequently did you take this medicine?
Twice a day
Once a day
Four times A Day
Thrice a day
How did you take this medicine?
With Food
With or without food
Empty stomach
What were the side effects of this medicine?
Other
Burning sensation
Stinging sensation
No Side Effects
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

HI, I would like to know that what purpose chloramphenicol 250 is used? Please suggest me.

BHMS, Diploma in Dermatology
Homeopath, Hyderabad
HI, I would like to know that what purpose chloramphenicol 250 is used? Please suggest me.
This medicine is used to treat infections caused by gram negative strains of bacteria which are severe and untreatable by other available medicines. Some of these infections are Bacterial meningitis, rickettsia, and others caused by susceptible organisms. Nov.
2 people found this helpful

What is the symptoms of typhoid fever. Chloramphenicol is best medicine for this or not?

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Persons with typhoid fever usually have a sustained fever as high as 103° to 104° F (39° to 40° C). They may also feel weak, or have stomach pains, headache, or loss of appetite. In some cases, patients have a rash of flat, rose-colored spots. The only way to know for sure if an illness is typhoid fever is to have samples of stool or blood tested for the presence of Salmonella Typhi.

My mother who is 75 years old, has been found to have K.pneumonia in her throat swab which is sensitive to chloramphenicol. She does not have fever, but has unproductive cough and difficulty in swallowing when taking bigger pieces of food. Advise whether chloramphenicol can be given in a home setting.

International Academy of Classical Homeopathy, BHMS
Homeopath, Pune
My mother who is 75 years old, has been found to have K.pneumonia in her throat swab which is sensitive to chloramphe...
As homoeopath I would advise bioch asthm no 3 tabs 2tom day for19 days Kali.carb 12c 3tims a day for wk merc sol 12c 3tims day for 5 days spongia 6c 3tims a day for wk kalibich 200 one dose Ipecac 3c one dose day for 12 days inform me progress
1 person found this helpful

Popular Health Tips

Pinta - Know More About It!

Pinta - Know More About It!

Pinta is a skin disease caused by a bacterial infection. It is usually acquired during childhood and contracted through the skin to skin contact with an infected person. The disease is endemic to Mexico, Central America and South America. About One million of cases with Pinta were reported in Central and South America in the year 1950. The disease sets in within an incubation period of two to three weeks. It affects mostly the exposed areas of the skin including the arms, legs and face. The word ‘Pinta’ is a Spanish word which means ‘painted’. Pinta is classified under a treponemal disease because it is contagious and is caused by treponemes, a genus of spiral-shaped bacteria. Recent reports suggest the occurrence of disease in the Philippines and some areas of the pacific region.

The bacterium enters the skin through a cut, scratch or a lesion and causes a red scaly bump called the primary lesion. Other lesions may start to form surrounding the primary lesion usually in exposed surface of arms and legs. Local lymph nodes also become enlarged. Within three to nine months, these thick flat lesions called pintados spread all over the body. Sometimes the disease spreads to eyes causing eyelid deformities. The last stage of the disease is characterised by pigment changes in the skin including a combination of hyperpigmentation and depigmentation causing permanent discoloration. However, many patients get treated successfully before they reach the last stage.

Clinical Diagnosis of the infection is usually done through a blood sample showing bacterial infection or through diagnosing the scrapings of the lesion. The patient is subjected to an antibiotic treatment of drugs like penicillin, tetracycline, azithromycin and chloramphenicol. If prescribed dose of antibiotics is followed regularly, the cure is possible, however, skin damage caused due to lesions remain irreversible.

The disease is prevalent in rural and poverty-stricken areas and thus holds a strong connect with the socio-economic life of people. The living conditions, adequate water supply, domestic, personal and community hygiene, a proper waste disposal system and mosquito prevention and control play an important role in the prevention of the disease.

Prevention and control programs for Pinta must focus on awareness generation among high-risk groups. Though community hygiene is covered under many state health programs, for many communities, personal hygiene and the safe domestic environment remains far from satisfactory. Thus, first and foremost intervention must include building knowledge about maintaining proper hygiene and inculcating good habits for health and disease prevention. Since the disease is generally acquired in childhood, educating the parents about the early signs and symptoms of infection can also go a long way in ensuring that timely medical help is provided.

4250 people found this helpful

Conjunctivitis - How You Can Deal With It?

MBBS, MS - Ophthalmology
Ophthalmologist, Delhi
Conjunctivitis - How You Can Deal With It?

One of the most contagious infections to affect children and adults is conjunctivitis. Conjunctivitis, also known as pink eye is an inflammation of the conjunctiva. This makes the blood vessels of the eye more visible and turns the white part of the eye pinkish. This condition can be caused by a number of factors such as exposure to bacteria or viruses, allergens and irritants. Treatment for conjunctivitis depends on the cause of the condition.

The first step towards treating this disease is to correctly diagnose it. Some of the symptoms that can be noticed are:

  1. Redness in the white of the eye
  2. Itchiness and burning in the eye
  3. Discharge from the eye
  4. Crusting of the eyelids
  5. Increased sensitivity to light

If you notice any of these symptoms persisting for over a few days, consult a doctor immediately. There are two aspects to dealing with conjunctivitis; preventing the infection from spreading and reducing the infection. Here are a few tips to help stop the infection from spreading.

  1. Stop wearing contact lenses. While the infection persists, wear spectacles instead. Once your eyes have healed, dispose of the old contacts lenses and solution and get yourself a new pair.
  2. Wash your hands often. This is especially important if you have touched your eyes and will prevent the infection from spreading.
  3. Avoid sharing contact lenses, eye makeup and other forms of makeup along with makeup brushes.
  4. Avoid rubbing your eyes. Often conjunctivitis can affect only one eye at a time. Keeping yourself from rubbing or touching the infected eye will keep the infection from spreading to the other eye.
  5. Remove the discharge from around your eye every few hours with a clean cotton swab. Throw the swab away after it has been used once and wash your hands with soap and water before touching anything else.
  6. Avoid using swimming pools and hot tubs.
  7. Wash towels. Pillow cases, sheets and other things that come in regular contact with your eyes every few days with hot water to disinfect them.

In most cases of infective conjunctivitis, antibiotics are not needed. Instead lubricant eye drops are prescribed that are available over the counter. This can help ease soreness and stickiness in the eye. When using lubricant eye drops, do not let the dropper touch the infected eye and do not use the same eye drops for both eyes. Untreated conjunctivitis can be treated with antibiotics such as chloramphenicol and fusidic acid. These antibiotics can have a few side effects such as blurred vision and hence you must avoid driving and operating heavy machinery after using them. If you wish to discuss about any specific problem, you can consult an Ophthalmologist.

4434 people found this helpful

All You Want To Know About Pinta

Diploma In Dermatologist, Venereologist and Laparoscopy, MBBS
Dermatologist, Rewari
All You Want To Know About Pinta

Pinta is a skin disease caused by a bacterial infection. It is usually acquired during childhood and contracted through the skin to skin contact with an infected person. The disease is endemic to Mexico, Central America and South America. About One million of cases with Pinta were reported in Central and South America in the year 1950. The disease sets in within an incubation period of two to three weeks. It affects mostly the exposed areas of the skin including the arms, legs and face. The word ‘Pinta’ is a Spanish word which means ‘painted’. Pinta is classified under a treponemal disease because it is contagious and is caused by treponemes, a genus of spiral-shaped bacteria. Recent reports suggest the occurrence of disease in the Philippines and some areas of the pacific region.

The bacterium enters the skin through a cut, scratch or a lesion and causes a red scaly bump called the primary lesion. Other lesions may start to form surrounding the primary lesion usually in exposed surface of arms and legs. Local lymph nodes also become enlarged. Within three to nine months, these thick flat lesions called pintados spread all over the body. Sometimes the disease spreads to eyes causing eyelid deformities. The last stage of the disease is characterised by pigment changes in the skin including a combination of hyperpigmentation and depigmentation causing permanent discoloration. However, many patients get treated successfully before they reach the last stage.

Clinical Diagnosis of the infection is usually done through a blood sample showing bacterial infection or through diagnosing the scrapings of the lesion. The patient is subjected to an antibiotic treatment of drugs like penicillin, tetracycline, azithromycin and chloramphenicol. If prescribed dose of antibiotics is followed regularly, the cure is possible, however, skin damage caused due to lesions remain irreversible.

The disease is prevalent in rural and poverty-stricken areas and thus holds a strong connect with the socio-economic life of people. The living conditions, adequate water supply, domestic, personal and community hygiene, a proper waste disposal system and mosquito prevention and control play an important role in the prevention of the disease.

Prevention and control programs for Pinta must focus on awareness generation among high-risk groups. Though community hygiene is covered under many state health programs, for many communities, personal hygiene and the safe domestic environment remains far from satisfactory. Thus, first and foremost intervention must include building knowledge about maintaining proper hygiene and inculcating good habits for health and disease prevention. Since the disease is generally acquired in childhood, educating the parents about the early signs and symptoms of infection can also go a long way in ensuring that timely medical help is provided. If you wish to discuss about any specific problem, you can consult a doctor and ask a free question.

2591 people found this helpful

All About Typhoid Fever!

MBBS
General Physician, Chittorgarh

What is typhoid fever?
Typhoid fever or enteric fever is a digestive tract infection in which there is fever, headache, and abdominal pain or discomfort. It is very common in developing countries like india.

What are the causes and risk factors?
Typhoid fever is caused by a bacterium called salmonella typhi which is transmitted through contaminated water or food (feco-oral or urine-oral route).

Risk factors include:

  • Travelling to areas where typhoid fever is a common disease.
  • Being in a profession where contamination with bacteria is likely. Like those working in laboratories.
  • Coming in close contact with a person suffering from typhoid.
  • Drinking/ eating contaminated water or food.

How will you know if you have typhoid fever?
Signs and symptoms develop gradually over the period of 10-14 days after exposure to the bacteria.
Signs and symptoms include an irregular fever that can go up to 104.9 ˚f (40.5 ˚c), headache, pain in abdomen, tiredness, muscle pain, loss of appetite, nausea, constipation or diarrhoea, skin rash.

How is typhoid fever diagnosed?
Your doctor will do a physical examination and carry out some tests.
Physical findings in early stages include abdominal tenderness, enlarged spleen and liver, enlarged lymph nodes, and development of a rash (also known as rose spots because of their appearance).

Investigations include:

  • Blood tests: typhidot test igm and igg antibodies, blood culture to test for salmonella typhi.
  • Stool and urine analysis
  • Bone marrow culture: it is the most sensitive test, but it is rarely required except in patients who have already received antibiotics and not getting any better.
  • Widal antigen test: this test can be done, but there is a longer waiting phase of about 10 days till results can be seen, it is time-consuming and could give false positive results.

What is the treatment for typhoid fever?

What are the complications of typhoid fever?
If not treated and sometimes even after treatment, there can be serious complications due to typhoid like pneumonia, meningitis (inflammation of meninges of brain), infection in bones (osteomyelitis), intestinal perforation and intestinal haemorrhage.

A doctor needs to be consulted if a person starts developing the symptoms few days after travelling to a place where typhoid is prevalent.

How can typhoid fever be prevented?

  • Typhoid fever can be prevented by improving sanitation facilities and drinking clean drinking water.
  • Always wash your hands with soap and warm water after using restrooms, before eating or cooking food.
  • Maintaining optimum personal hygiene is the key to preventing this disease.
  • Travellers should not drink untreated water; avoid adding ice to their drinks and should not eat ice creams or milk products or street foods that are a rich source of the infection.
  • Vaccines are available that give partial protection. Vaccines usually are reserved for those who may be exposed to the disease or are travelling to areas where typhoid fever is common.
17 people found this helpful

Michael Jackson Vitiligo - Know All About It!

MD - Homeopathy, BHMS
Homeopath, Ghaziabad
Michael Jackson Vitiligo - Know All About It!

I have successfully treated highest number of Leucoderma and Vitiligo patients in India since past 32 years. Homoeopathy along with holistic modes has been a miraculous aid in giving the results. In this article, I bring to you the topic of a famous personality and his confrontation with Vitiligo. 

  • Michael Jackson songs, the king of pop, thriller, moonwalk getting nostalgic? We all remember Michael Jackson as the king of pop, he stirred up the ear with his over the top songs and breathtaking dance moves! His death shook the world and the music industry at large.
  • He always had been the talk of the town not only for his art but for his appearance.
  • Michael Jackson skin color raised controversies and questions among fans and fellow artists. He was accused of skin bleaching and using various techniques to turn white because he didn’t like his skin color. However he shunned these allegations by admitting to having Vitiligo on Oprah Winfrey’s show.

Vitiligo is an autoimmune skin disorder which causes loss of pigment in the skin. The melanin production capacity of the skin gets dysfunctional. This causes white patches on skin which can spread like it did on Michael Jackson. Due to less awareness of Vitiligo back then everyone believed that Michael Jackson was making up a story to cover the allegations of skin bleaching.

Only 2% of the world’s population suffers from Vitiligo and Jackson had a paternal history of the disease which was dominant in his case.

Vitiligo began on Michael Jackson’s skin soon after Thriller album, it started off as white dots on his hands skin which he covered with Billie Jean Gloves. But, in no time it spread over his full hand and body, he initially tried to cover it with full coverage makeup but it did him no good as patches begin to grow. When the disease went out of control, he opened up about his condition.

Though harmless otherwise these white patches become a cause of embarrassment and low self esteem in highly pigmented individuals like Michael Jackson himself. He was born a black american but in his adulthood his skin turned white. He fell a prey to innumerous allegations and racist comments because of the lack of knowledge among the people. Michael Jackson Vitiligo was confirmed in a biopsy report and was made public thus proving he really did have vitiligo.

Who all can have Vitiligo?

Vitiligo rarely shows familial history but this factor cannot be ruled out. It can affect people of any age group, race or sex. Vitiligo is generally more prominent in countries like India, Egypt and other tropical countries. Many cases have seen its onset after menopause, at 15 years of age, or as early as the age of 5. Vitiligo is non infectious and non-contagious and cannot spread with touch. It has no relationship to leprosy, however there can be differential diagnosis of seeing white patches on skin.

What can cause Vitiligo?

Exact causes of vitiligo have not been established yet but it can be due to gastrointestinal disorder like chronic amoebiasis, chronic dyspepsia and intestinal worms may be additional factors.

Trauma or local irritation from wearing tight blouses and clothes can also produce Vitiligo in individuals predisposed to it. Acute stress may be followed by fast spreading vitiligo. Endocrine disorders or nutritional disorders can also be revolving cause for Vitiligo.Not infrequently it has been seen vitiligo appearing after use of broad-spectrum antibiotics esp chloramphenicol and streptomycin.

How to treat Vitiligo?

In Michael Jackson’s case he matched his unaffected skin color with the vitiligo skin color by going a shade lighter which made him appear completely white. However with the advancement over years it is possible to treat vitiligo.

For stationary and small patches there are temporary options to dye the white patch into the skin color. It is done by doing a patch test and seeing which color is absorbed by the skin.

Whereas for a permanent long time solution it is important to treat this condition constitutionally by promoting the production of melanin internally by medicines.

  • Some local applications and frequent sun exposure on the patches can also help in repigmentation.

  • Avoid eating food from animal sources.

  • It is extremely important to keep your skin and yourself hydrated as Vitiligo paired up with other disorders like diabetes can cause dehydration very soon.

  • Avoid wearing tight clothes and prevent trauma on skin.

  • Do not stress as it can also contribute in producing vitiligo.

  • Apply pure ghee with turmeric on white patches and take sun exposure.

At Valeda, you can avail a holistic treatment to cure Vitiligo permanently by constitutional medicines and total wellness using techniques of acupuncture that will strengthen your immune system and also treat your Vitiligo Skin. If you wish to discuss about any specific problem, you can consult a Homeopath.

4633 people found this helpful

Table of Content

About Chloramphenicol
When is Chloramphenicol prescribed?
What are the contraindications of Chloramphenicol ?
What are the side effects of Chloramphenicol ?
Key highlights of Chloramphenicol
What are the dosage instructions?
Where is the Chloramphenicol approved?
Medicines containing Chloramphenicol
How does medicine works?
What are the interactions for Chloramphenicol ?