Renal Tubular Acidosis is a medical condition. When the kidney is unable to acidify urine, it leads to the accumulation of acid in the body. Usually, when blood is filtered by the kidney, it passes through the tubules of the nephrons (the functional unit of the kidney).

Before it flows into the bladder from the kidney, the urine undergoes an exchange of salts, acids and other solutes. Renal tubular acidosis results in the formation of excessive amounts of acid because the kidneys cannot drain them. This may happen because the kidneys cannot reabsorb the alkaline bicarbonate ions from the urine in the early segment of the nephron or because of inadequate production of acidic hydrogen ions in the latter half of the nephron.

Renal Tubular Acidosis is simply associated with abnormal urinary acidification. Other functions of the kidneys remain unimpaired.
There are several different types of renal tubular acidosis-

  Distal Renal Tubular Acidosis (RTA)
This is the most fundamental form of RTA. It is characterized when the hydrogen ions are not secreted into the lumen of the nephron by the alpha-intercalated cells of the medullary collective duct of the distal nephron. When this happens the pH of urine cannot be brought down below 5.3. Renal excretion is inhibited and hydrogen ions are not eliminated which leads to academia. At the same time, Potassium ions cannot be absorbed by the cell which leads to hypokalemia. The end result is protein retention and potassium excretion. Distal RTA can lead to the urinary stone formation, calcium deposits in the kidney, rickets and osteomalacia and Sjogren s syndrome.

  Proximal RTA
When proximal tubular cells reabsorb 85% of filtered bicarbonates and 60% of filtered sodium from the urine, then this again leads to academia. The distal intercalated cells, however, function normally and so the academia is not as severe as in case of Distal RTA. The alpha-intercalated cells can acidify urine to a pH of 5.3 or less because they produce hydrogen ions. Proximal RTA is also associated with Fanconi Syndrome which is characterized by aminoaciduria, uricosuria, glucosuria, and tubular proteinuria.

  Combined distal and proximal RTA
Inherited carbonic anhydrase II deficit leads to combined distal and proximal RTA. This is accompanied by osteopetrosis, cerebral calcification, and renal tubular acidosis. Cases of combined distal and proximal RTA are very rare.

How is RTA understood?
The following steps are applied to analyze Renal Tubular Acidosis-
  Determining the anion gap in acidosis. The normal Anion Gap is 8-12 (4-6 mEq/L)
  Separating the renal from the extrarenal causes of normal anion gap acidosis
  Classifying the types of RTA
  If it is distal RTA, further tests will be necessary to support the diagnosis

How is RTA diagnosed?
Three types of tests can reveal if a person is affected by Renal Tubular Acidosis-
  Urine test
  Acid load test
  Physical examination

Treatment of RTA-
Doctors prescribe either or both of the following two types of therapies-

  Alkali therapy- The pH level of urine is restored and electrolytes are balanced
  Vitamin D supplements- If RTA leads to bone deformities or rickets, your doctor will prescribe vitamin supplements to strengthen your bones.

Timely diagnosis can prevent the effects of Renal tubular Acidosis from becoming compounded. With the right medication, a person can lead a healthy normal life.

What Should You Know About Renal Tubular Acidosis?

A gland that produces a liquid which mixes with sperm and is ejaculated as semen during sexual activity, is the prostate gland and is located under the bladder of a man. Cancer in the prostate is one of the most common cancers that occur among men.

The risk of developing prostate cancer increases progressively with age. Although there is no absolute prevention of prostate cancer, evidence and doctors suggest that a healthy diet can play a key role. Here are a few tips that can go a long way in prevention of prostate cancer:

Red Foods: Tomatoes, carrot, watermelon, and other red foods get their bright color from a powerful antioxidant called lycopene. Studies have proved that by having fruits that contain lycopene, you can reduce your risk of prostate cancer. Some findings suggest that cooking tomatoes make it easier for your body to absorb this antioxidant.
Fruits and Vegetables: Green vegetables contain compounds called carcinogens, which help your body in breaking down cancer-causing substances. Spreading of cancer can be slowed down through a nutrient-rich diet. Avoiding processed junk food and eating fruits and vegetables containing nutrients and vitamins may lower the risk of getting prostate cancer.
Feast on Fish: Fatty acid, also known as omega-3, is found in certain fish including sardines, tuna, mackerel, trout, and salmon. This may help in reducing the risk of developing prostate cancer.
Soy and Tea: Some studies suggest that men who drink green tea or take green tea extract supplements have a lower risk of developing prostate cancer. Many soy products and other foods contain a nutrient called isoflavones, which has been linked to a reduced risk of prostate cancer.
Coffee: Studies show that drinking three cups of coffee a day can reduce the chances of prostate cancer by 11 percent. There is a dose-response relationship between coffee and prostate cancer. The effects of prostate cancer go up or down with the amount of coffee you take. Someone who grabs an occasional cup only, may not have these effects. However, high doses of caffeine can result in major health issues.
Fat: Studies indicate that animal fats and an increased risk of prostate cancer are linked. It is advised to replace animal-based fats with any kind of plant-based fat. In addition to this, overcooking the meat produces carcinogens, therefore it is suggested to be strictly avoided.
Quit Smoking: Smokers are more likely to have an aggressive form of prostate cancer. The chances of a recurrence of the disease are more for people who smoke. It is never too late to quit smoking.
Exercise: Regular exercise and maintaining a healthy body can help you to increase your muscle mass and metabolism. Too much fat in the middle of your body is linked to an increased risk of prostate cancer. You can try walking, running, bicycling or swimming to reduce the weight to lead a healthy life.
It is important to look after yourself and start taking essential steps to prevent prostate cancer rather than trying to manage it once you get it.

8 Easy Ways By Which You Can Prevent Prostate Cancer!

The kidneys may be a pair of small organs but they perform a very important function. Without the kidneys, it is impossible to filter blood and remove toxins from the body. One of the common problems associated with kidneys is the development of a kidney stone. This can be described as a hard, pebble like substance that is formed when urine contains high levels of certain minerals. Kidney stones vary in size and shape. Small stones may pass through the ureter into the bladder and out of the body with minimal discomfort. However, in some cases, a kidney stone can be as large as a golf ball. In such cases, it can block the urine flow and cause extreme amounts of pain as well as bleeding. In such cases, a doctor needs to be consulted as early as possible.

There are four different types of kidney stones.

Calcium Stones: This is the most common type of kidney stones. It is caused by excess calcium that is not flushed out with the urine.
Uric acid stones: Highly acidic urine can trigger the development of such stones. This may be caused by excessive consumption of meat, fish and shell fish.
Struvite stones: This is often formed as a side effect of Urinary tract infections. These stones may develop and grow rapidly.
Cystine stones: These stones are formed as a result of a genetic disorder known as cystinuria. This disorder causes an amino acid known as cysteine to leak into the urine.
Kidney stones are a fairly common occurrence. It affects both men and women but men have a higher risk of developing kidney stones as compared to women. Other risk factors that can influence kidney stones are:

Family history of kidney stones
Not drinking enough water
Obesity
Digestive problems
Recurrent UTIs
Gout
Bowel inflammation
Disease that causes blockage of the urinary tract
Certain medications such as diuretics or calcium based antacids
Once a person has been diagnosed with a kidney stone, this issue can recur. Treatment for kidney stones depends on the type of stones, size and location. In most cases, medication is prescribed to help break the stone down into smaller parts so that it can pass through urine. In extreme cases, surgery may be required. If not treated in time, it can cause severe pain, bloody urine, UTIs that can further lead to kidney failure and reduced kidney functioning.
Kidney stones can be prevented by drinking plenty of fluids and making a few dietary changes. Ideally, a person should have a minimum of 8-10 glasses of water a day. If you have a high risk of developing any type of kidney stones, reduce your sodium consumption and the amount of meat eaten.


Kidney Stones - Are They Really Common?

Many people are embarrassed to talk about their urine colour or urine problem with anybody, including their doctor. But, what people always forget is that strong smelling urine and the change in the colour of the urine is a serious issue. Your urine colour directly tells you about your health, especially your inner body. So, without being embarrassed you should consult a doctor, if and when, you find foul odour in your urine. Following are some of the reasons for the causes of strong smelling urine.

You are dehydrated: Urine is not supposed to leave odour. It should be odourless, but if you find strong smell in your urine, you should consult a doctor immediately. The most common reason of foul odour in your urine is dehydration. If the amount of water needed in your body is not enough then, there will be less water in your body as a result the waste products will not be diluted in water being more concentrated making the urine darker and more odour. But once you start drinking water, it should go normal. Normally, this kind of situations occur in early morning when your water intake is less or not at all. But drinking lot of water will solve this issue immediately.
More alcohol or caffeine intake: If you are habituated to drink a lot of coffee then it may happen that you find strong smell of coffee in your urine. Although it is not very problematic yet it is healthy if you reduce the intake of coffee in your daily life in order to have a healthy digestive system. Not just coffee but even alcohol could be the reason of irregular or need to urinate a lot more than usual.
Bacterial Infection: There could be bacterial infection or kidney infection which could lead to strong smell of urine. In order to ensure you should go to a doctor and get important tests done. Then the doctor can suggest treatment according to your results and if all the results are normal then you could be suggested to maintain a balanced diet on regular basis.
Imbalanced Diet: The problem can sometimes come from the use of certain vitamins from imbalances in your diet. There are substances like nitrates and phosphates in the urine which can give dark colour and odour. You should always have a proper diet and follow it in order to have a healthy digestive system. Eating lot of garlic and onion can also bring odour in your urine.
Diabetes: If you are diabetic, it may be possible that you find dark urine and odour in your urine. It indicates that your sugar level is not normal and gone much high than normal. If you are not diabetic then it may be a sign of diabetes so you should get diagnosed immediately with your doctor.
There are multiple causes of strong smelling urine but most of them could be cured easily if diagnosed immediately. But in order to avoid this issue it is better to be careful with your diet and drink a lot of water. At least three litres of water a day is an absolute necessity!

Strong Smelling Urine - 5 Common Reasons Behind it!

One of the most common issues with old age in men is the enlarged prostate. Any difficulty with urination (no constant stream, difficulty initiating, or incomplete emptying of the bladder for instance), and the first suspect is an enlarged prostate. These symptoms are followed by a digital rectal exam to check for an enlarged prostate. Once confirmed, the next step is to check for levels of prostate-specific antigen (PSA). If both the exam and the PSA are positive, it could mean prostate cancer. As with any cancer, it is believed that sooner it is diagnosed and the treatment is started, the better.

Historically, the best way to rule out the prostate cancer had been to do a prostate biopsy. This is a minor invasive procedure, wherein biopsies are taken from various regions of the prostate which are known to develop cancer (about 12). A disadvantage of this procedure includes missing out on the front part of the prostate which can also develop cancer. Secondly, it is not a very pleasant experience and given a chance, most men would not want to have it done.

There is good news for these men who would like to avoid prostate biopsies. The first is the multiparametric MRI which uses no x-rays and is considered very safe with extremely accurate results. This MRI exam requires about an hour, and once the images are obtained, the doctor will analyse these images and check for several parameters to assess for prostate cancer. The absence of cancer can be confirmed with up to 90% accuracy, which is far greater than with usual biopsies. If there is a possibility of cancer, then a biopsy can be done to confirm it. 

Also, these images indicate the exact region where cancer likely is, and this guides the doctor to biopsy only where absolutely essential. The chances of false positive and false negative results are reduced drastically. The one disadvantage here is that MRI detected biopsies usually tend to be of a higher grade which requires immediate treatment.

Another way to reduce chances of the biopsy by 30% to 50% is by the 4K test. It helps detect a variety of prostate issues including cancer. It can be used once higher levels of PSA is identified and before going for a biopsy. It combined 4 prostate-specific biomarkers with clinical information to accurately provide men with a risk of developing prostate cancer. It can be used even after negative biopsies to confirm the diagnosis of prostate cancer.

These two measures can drastically reduce the incidence of prostate biopsies, which is neither pleasant for the patient nor very effective for the doctor.

Prostate Biopsies - Ways You Can Avoid It!

5 reasons you will see blood in urine

The condition in which blood appears in the urine is known as hematuria. The loss of blood in this condition could be gross or microscopic depending on the cause of the condition. There are several causes why blood may appear in the urine. Whatever the cause may be, hematuria is mostly indicative of a serious medical condition.

Here are 5 reasons that cause blood to appear in the urine.

1. Infection

Infections like urethritis, pyelonephritis, cystitis or infection in any other body organ along the urinary tract is one of the most common causes of hematuria. Such bacterial infection in the urethra can also infect the kidneys and the urinary bladder. It results in the urge to urinate frequently and also causes blood to appear in the urine.

2. Kidney stones and bladder stones

Another reason that can cause blood to appear in the urine is the presence of stones in the kidney or bladder. These stones are crystallized minerals that are formed in the kidney or the bladder but fail to pass through the urinary tract. They cause blockage and pain and result in hematuria.

3. An enlarged prostate

An enlarged prostate is a common cause of the appearance of blood in the urine in men who are in their middle ages or older. Enlargement of the prostate gland causes the urethra to be compressed. This prevents the urethra from getting fully emptied while urination.

4. Polycystic kidney disease

PKD is a kidney disorder in which cysts filled with fluid form in the kidneys and impair the kidneys, causing them to fail entirely at times. It is an inherited disease and causes blood to appear in the urine.

In children who are between 6-10 years of age, kidney disorder after streptococcal glomerulonephritis can be a possible cause of hematuria.

5. Cancer

A cancerous kidney, bladder or prostate gland can also cause blood to appear in the urine. It is another major cause of hematuria but usually occurs in older patients.




5 Reasons You Will See Blood in Urine

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