What is Diabetic Nephropathy?

Diabetic nephropathy (Diabetic Kidney Disease) is defined as the progressive damage to the kidneys caused by diabetes. It is characterised by the scarring of the glomeruli in the kidneys due to prolonged diabetes mellitus.

What Causes Diabetic Nephropathy?

Diabetes is a condition characterized by high concentration of blood sugar. Although the cause of Diabetes Nephropathy is not yet well defined, it is likely that the high sugar levels in the blood damage the blood vessels present in the kidneys that help to filter waste products, thus resulting in decreased kidney function and ultimately, kidney failure.

Not everyone with diabetes suffers from diabetic nephropathy. Although, factors that can increase your chances of getting diabetic neuropathy are-

Smoking

Poor control of blood glucose

High blood pressure

History of kidney diseases

What are the symptoms of diabetic nephropathy?

In the early stages, there may be no symptoms at all, but as the disease progresses, you may notice swelling in the extremities like your feet. Thus it is recommended to get your blood albumin levels tested on a regular basis. If it is diagnosed in early stages, the damage can be reversed. Other symptoms that can indicate damage to the kidneys are-

Severe malaise

Headaches

Nausea

Lack of appetite

Frequent voiding

Itchiness of skin

General feeling of illness

Diagnostic tests that can confirm diabetic nephropathy are-

Routine urine test (urinalysis) - Kidney diseases are detected by the presence of a protein in the urine called albumin and this condition is called albuminuria. Other parameters that must be regularly monitored are-

Blood pressure

Cholesterol levels in your blood

How can you treat/ manage diabetic nephropathy?

If this type of nephropathy is diagnosed in the early stages, the damage to the kidneys can be reversible. The key to managing diabetic nephropathy are-

Diet: Reduce the dietary intake of salt, phosphorous and potassium in the advanced stages.

Glycemic Control: Monitor your blood glucose levels regularly

Management of Hypertension: It is important to manage your blood pressure as it can have a direct effect on the coronary blood vessels which in turn pump blood to the various blood vessels of the body

Renal Replacement Therapy: In chronically ill patients, renal replacement therapy is the best option. This can include haemodialysis (a procedure to flush out toxins from the blood, such as urea), peritoneal dialysis or ultimately renal transplantation.

Diabetic Nephropathy - Causes, Symptoms and Treatments

Pilonidal Sinus is the small channel in your skin near the tailbone that may sometimes be filled with pus or fluid. This accumulated pus leads to the formation of abscess or cyst. Pilonidal cysts occur near the coccyx or tailbone, right at the top of the buttock crease. Pilonidal sinus consists of dirt, hair and debris that penetrates your skin, becomes embedded and thereby causes infection. Once the cyst gets infected, you may see blood or pus oozing out of the channel, which causes severe pain.
Pilonidal sinus usually affects men and young adults (after puberty). This type of skin disease is mostly observed in people who sit for a prolonged period, such as desk-job workers, truck drivers etc.

What are the causes and symptoms? 
Doctors suggest pilonidal sinus or cysts is caused due to factors such as - hormonal changes during puberty, friction resulting from wearing tight clothes, prolonged sitting, hair growth etc. The hair growing in the region is forced to burrow back beneath your skin. In certain cases, the patient may develop multiple sinuses which connect under the skin.

The signs and symptoms of pilonidal sinus include-

  Pain when standing or sitting for long
  Swelling of the cyst
  Redness and soreness around the affected skin
  Formation of multiple holes (sinus tracts) in the skin
  Foul odor
  Blood or pus oozing out of the abscess
  Hair sticking out of the lesion
Pilonidal sinus can be embarrassing and painful if left untreated for long.

What is the treatment for this condition?
Pilonidal sinus usually goes away on its own, without medical intervention. However, if the cyst becomes infected, it may have to be operated or drained. The commonly used treatment procedures are-

  Conservative treatment - if the condition is diagnosed at an early stage, your doctor will prescribe a broad-spectrum antibiotic to treat a broad range of bacterial infection. This will relieve you from the pain and discomfort resulting from infection.

  Lancing - this procedure involves using a scalpel to open the abscess. Your doctor will give you an anaesthetic prior to the operation. The channel is then cleaned properly to drain out blood, pus or hair. The wound is packed with a sterile dressing and left to heal. It usually takes about a month for the wound to heal, after which no further treatment is required.

  Phenol injections - for this procedure, first and foremost, your doctor will give you anaesthetic so that you don t feel any pain. A chemical compound known as Phenol is injected into the cyst. Phenol acts as an antiseptic and is used to harden and eventually close the lesion. This procedure needs to be repeated multiple times to achieve the desired result.

  Surgery - if the pilonidal sinus tends to recur, or if you develop multiple sinus tracts, the most preferred choice of treatment is surgery. The surgeon will open the lesion, remove the debris and pus, and then suture the wound. You will be given an anaesthetic prior to the surgery, and once the treatment is done, you will need to change the dressing more often.
If you suffer from pilonidal sinus, you will also need to maintain good hygiene. Make sure you clean and wash the area with a mild soap, and rinse properly. If your job requires you to sit for a prolonged period, take a break in between your work. Avoid wearing skin tight clothes. Adopting these measures will help prevent the occurrence of pilonidal sinus.

Treatment For Pilonidal Sinus!

It is important for you to know about inflammatory bowel disease or IBD, it is a group of intestinal disorders, which leads to prolonged inflammation of your digestive tract. The digestive tract is made of the mouth, stomach, oesophagus, small intestine and large intestine. It performs the task of breaking down food, removing unusable materials and waste products, and for breaking down nutrients from food. Inflammation along with the digestive tract causes disruption in this process. IBD is a fatal condition which can be life threatening in some cases.

Major types of inflammatory bowel disease
The term inflammatory bowel disease is an umbrella term under which many diseases are included. The two major and most common diseases under IBD are ulcerative colitis and Crohn s disease. Crohn s disease (a chronic inflammatory disease of the intestines, especially the colon and ileum, associated with ulcers and fistulae) can lead to inflammation in any part of your digestive tract. It commonly affects the small intestine s tail end. In case of ulcerative colitis, inflammation takes place in the large intestine.

Causes of IBD
Although the exact cause of IBD is not known, several factors may lead to this condition. They are as follows:

Genetics: You are more likely to develop IBD if someone in your family has the disease. This is because of the genetic component of IBD.
The immune system: The body s immune system plays a role in IBD. Usually, your immune system defends your body from pathogens. A bacterial or viral infection in the digestive tract may lead to an immune response. The digestive tract becomes inflamed as the body fights against the bacteria or viruses. The inflammation goes away when the infection is gone.
However, in the case of IBD, the digestive tract inflammation may occur without any infection. Your immune system attacks your body s cells. This is called an autoimmune response. IBD can also occur when the infection is cured, but the inflammation remains.

Symptoms
The various symptoms of IBD depend on the severity and location of the inflammation. They are as follows:

Diarrhoea which occurs when the bowel cannot reabsorb water.
Bleeding ulcers which cause blood to show up in your stool.
Stomach pain, bloating and cramping because of bowel obstruction.
Weight loss and anaemia, which leads to delayed development and growth in children.
In patients with Crohn s disease, canker sores may develop in the mouth.
Ulcers and fissures may appear on the anus or genital area.
IBD may also be associated with problems such as eye inflammation, arthritis and skin disorders.
The major complications which may arise from IBD include colon cancer, malnutrition with weight loss, fistulas, intestinal rapture and bowel obstruction. It is important for you to consult a doctor on noticing any of the IBD symptoms.

Inflammatory Bowel Disease - Know the Types!

The prostate is a vital organ that located between the penis and the bladder. The prostate is involved in the release of the prostate fluid that keeps the sperm properly nourished. Prostate cancer, as the term indicates, is characterized by the abnormal and uncontrolled growth of cancerous cells in the prostate. Though the incidences of prostate cancer are low in India, necessary precautions and diagnostic steps should be carried out to prevent the condition from jeopardizing our lives.

Prostate screening includes two tests known as the Digital Rectal Exam (DRE) and Prostate-Specific Antigen test (PSA). PSA combined with DRE helps to identify prostate cancer at a very early stage. If any of the tests show an abnormality, a doctor might prescribe an ultrasound such as MRI Fusion or Prostate Biopsy to confirm the diagnosis.

Immediate treatment may not be necessary
For low-risk prostate cancer, doctors often recommend active surveillance that includes periodic blood tests, rectal exam, and biopsies.
Active surveillance helps a doctor to continuously track the growth of cancer cells and the possibility of their spread to other areas of the body.
Surveillance is fit for those who are already suffering from a serious condition or for those patients who are above the age of 60.
A surgical procedure to remove prostate cancer
Surgery is considered when the cancer has metastasized to surrounding tissue and the lymph nodes. There are two kinds of surgeries that a patient can go through- a Robot-Assisted surgery and a Retropubic surgery.
Radical Prostatectomy might have risks involved. It is, therefore, wise to discuss the pros and cons of the surgery with the doctor well in advance.
Understanding the treatment options

Radiation therapy: Radiation therapy involves the use of high-powered and high-frequency energy beams to kill cancer cells. Radiation therapy is often used to shrink the size of the cancer cells. There could be two types of radiation therapy-Brachytherapy and External beam radiation. Radiation therapy too can have its side effects. Doctors prescribe several medicines during therapy.
Hormone therapy: Hormone therapy helps to stop the production of a male hormone known as testosterone. This treatment option includes medication that completely stops the production of testosterone, the medications may also block the flow of testosterone on the cancer cells, and surgery to remove the testicles. Hormone therapy is used in advanced cancer stages.
Chemotherapy: Chemotherapy is a drug that goes into the body and kills rapidly growing and metastasizing cancer cells. It is administered through IV (intravenous), or orally as pill or both. This treatment option is employed when cancer spreads to a remote body location and does not respond to hormone therapy.
Biological therapy: Biological therapy involves the usage of the body s immune system to fight cancer. A type of biological therapy known as the sipuleucel-t is used to treat patients with advanced cancer stage and recurring cancer as well.

Prostate Cancer - How Biological Therapy Will Help?

Peptic ulcers are wounds that develop in the stomach lining, less esophagus or small intestine. They are usually due to inflammation caused by bacterial H. pylori, in addition to corrosions from stomach acids. An ulcer is generally rooted in the stomach or inner layer of the small intestine. A stomach ulcer is the most visible sign of peptic an ulcer disease.

People with an ulcer may have a really hard time dealing with it. It is an open wound on the outer or internal surface of the body, which causes excessive pain. It is due to a breakdown in the mucous membrane or skin which fails to recover.

Causes of peptic ulcer:
Several reasons can cause stomach, esophagus, and small intestine to break. Contains:

Helicobacter pylori (H. pylori), a type of bacteria that can cause stomach infections and swelling
Continuous use of Aspirin (Bayer), Ibuprofen (Advil), and other anti-inflammatory drugs (the risks linked with this behavior among women and people over 60 years of age)
Smoking
Alcohol drinking
radiation therapy
stomach cancer
Symptoms of peptic ulcer:
The most common symptom of peptic ulcer is burning abdominal pain, which spread from navel to chest, which can range from light to severe. In few circumstances, the pain can get you up at night. Small peptic ulcers cannot develop any symptoms in initial stages.

A burning, grinding pain in the upper middle part of the stomach and is comforted just by eating or taking antacids.
Change in taste
Sickness
Bloody or dark stool
Ambiguous weight loss
Indigestion
Vomit
Pain in chest
Below are the ways to you from Peptic ulcers?
Stomach ulcer pain is not a joke: it can leave you weak. Fortunately, following these steps are ways to reduce your risk of getting ulcer.

Avoid some foods such as spicy, lemon, fatty, etc., because they can be burdens your stomach. Specifically, if you have seen that particular types of food disturb your stomach, keep away from it.
Improve the quality of your life by including exercise, stress-free activities, yoga etc. in your daily routine.
The heavy consumption of alcohol can cause ulcers. They have been contributing to the development of ulcers, so it is good to reduce the consumption of alcohol.
Taking no steroid anti-inflammatory medicines can reduce the risk of disturbing your stomach lining and thus avoiding the growth of ulcers.
Management of anxiety level avoids the expansion of ulcers. Do yoga and other comforting arts that help prevent the ulcer.
Some lifestyle choices and habits can reduce your risk of developing the peptic ulcer. 

5 Things You Can Do To Protect Yourself From Peptic Ulcer!

Bone Fractures: Causes and Symptoms

'Fracture' is a medical term for a broken bone. According to an estimate, an average person has two fractures within their lifetime. When a force exerted is stronger than the bone itself, it can lead to a fracture. The risk and chance of fracture depend on your age. With age, bones tend to become brittle and, hence, a fall that would have been potentially harmless years ago can lead to a broken bone at a later age.

There are many types of bone fractures, but the main types are:

Closed fracture: A fracture in which the bone breaks but does not tear through the skin

Open fracture: Where the broken bone punctures through the skin and protrudes out. There's a greater chance of bone infection in an open fracture

Displaced fracture: In this type of fracture the bone snaps into more than two parts

Nondisplaced fracture: The bone cracks partly or wholly but it does continue to move

Some of the common signs and symptoms of a fracture are:

- Bruising and swelling of the bones
- Open fractures marked by protruding bones from the skin
- Loss of locomotive and functional ability of the injured area
- Deformity of the injured area
- Pain in the event of movement of the injured area

A fracture can be caused by a number of reasons, and they are:

- Injuries and accidents
- Falls and slips
- Wear and tear through overuse
- Sport injuries
- Fist fights and brawls
- Osteoporosis (a disease which causes bones to weaken in adults)
- Osteomalacia ( a disease caused due to softening of your bones, which is caused by a vitamin D deficiency.) Soft bones are more likely to bow and fracture than are harder, healthy bones.

Note:

Osteomalacia is not the same as osteoporosis. Osteomalacia occurs due to a defect in the bone-building process while osteoporosis develops due to a weakening of existing bones.



Bone Fractures: Causes and Symptoms

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