Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

One of the worst neurological disorders to have is dementia. It is a general term used to describe cognitive decline of the brain. It s not specific disease but denotes several brain disorders and mental illnesses. A person suffering from dementia can have severe impairment in judgment, loss of memory and thinking. Dementia is a very difficult disease not only for the patient but also for their families and caregivers. 

Some facts about dementia are as follows:

It s not a mental disorder occurring in old age but it does degenerates with age.
An estimation of 47.5 million people worldwide suffers from dementia and 60% of these people live in low and middle-income countries and according to WHO this figure is likely to increase.
Every 4 seconds a new case of dementia is reported
Dementia is a collective term to describe the many types of in people, such as 

Alzheimer s Disease: It is one of the most common type of dementia accounting for 60-80% of dementia case. People suffering from Alzheimer s have fewer nerve cells and the size of the brain shrinks.
Vascular Dementia: Another most common form of dementia occurring after a stroke.
Lewy Body Dementia: It is neurodegenerative condition that involves a protein called alpha-synuclein which changes the brain. Symptoms may be similar to Parkinson s disease.
Symptoms of dementia can range from mild to moderate to severe that includes:

Memory Loss
Disorientation meaning inability to focus or pay attention
Changes in visual perception
Impairment in reasoning and judgment
Dementia can be caused by damage to brain cells or progressive brain cell death. As a result communication between brain cells become difficult. Other symptoms include:

Stroke
Brain Tumor
Head Injury
Prion Disease
HIV Infection
Reversible Factors

There are no definite tests for dementia. Doctors and neurologists have to medical history, blood tests and CT scans to find out whether a person has dementia or not. However, the most potent evaluation comes from a set of questions that are asked to a patient suspected of having dementia. The ability to answer those questions correctly is one of the best diagnoses for dementia.
There is no specific treatment for dementia as it is not a curable disease and degenerates with time. However, medicines or drugs given for Alzheimer s can be given to people suffering from dementia.
Although results vary depending upon a person s lifestyle s and habits, doctors suggest eating healthy, exercising regularly, and stopping smoking and drinking may prevent some types of dementia.
The best treatment for dementia is to treat the person with care and love so that they don t feel neglected.
Dementia is often associated with old age but that is not always true. It is important to gain knowledge and educate others also.

Dementia - Quick Facts You Must Know About It!

If you are young chances are you aren t worried about this particular neurodegenerative disease, and rightly so since the only people afflicted by it are above the age of 50. Although, there are a lot of cases where it develops in the younger age bracket, so you need to be careful and examine the signs of early onset Parkinson s and be wary if any of these symptoms apply to you.

Parkinson s is a neurological disorder wherein the dopamine-producing neurons are affected in a particular area of the brain. It can cause tremors and balance problems, eventually worsening over time. Here are some signs that you should keep an eye out for:

Tremors: If you are experiencing tremors, while at rest, in your hands, arms, fingers or your jaw then it is a sign that you need to be aware about. In an excitable or stressful situation, the tremors may even worsen.
Micrographia: Your hand movements become restricted and, as a result, your handwriting may become cramped and the words smaller in size. Examine your handwriting from the past with your present one, if you find a noticeable difference in the size and positioning of the letters and if you feel like the sentences are extremely crowded together, be wary.
Olfactory issues: One of the symptoms of early onset could be the loss of the sense of smell. If you feel like you can t sense stronger aromas like that of spices and pickle or even bananas as well as others and it isn t because your nose is blocked then you need to be on the lookout.
Sleeping troubles: There are times when you feel restless in bed while trying to sleep. If this becomes a routine then it could be a sign that you are prone to Parkinson s. Sudden movements and jerking while sleeping is a bad sign.
Stiffness: If your arms and joints feel stiff without reason, and you feel like free body movement is restricted or limited if you feel like you can t swing your arms or move your fingers freely, it is a definite sign that you might have Parkinson s. Stiffness can even lead to muscle pain in various parts of the body. Bradykinesia or slowness of movement is common with the stiffness of the body.
Constipation: If every time you have to defecate you have to strain yourself and put a lot of pressure on your bowels, and bowel movement does not come naturally or easily, even with the inclusion of roughage in your diet, it is a symptom.

6 Signs Of Early On-Set Parkinson's That You Need To Look Out For

What is Parkinson s disease?
Parkinson s disease is a progressive and degenerative disorder of the Central Nervous System that mostly affects older people. It is a chronic disease and the symptoms develop over a period of time. The characteristic symptoms of Parkinson s are rigidity, shaking, bradykinesia (slowness in movement) and shuffled gait. Anxiety and depression also seem to be common in advanced stages of Parkinson s disease. In addition to the motor symptoms, the cognitive function of the brain is also compromised.

Degeneration of the nerve cells in the substantia nigra of the brain results in the reduction in production of dopamine which is a neurotransmitter in the brain. Neurotransmitters relay impulses from one nerve to the other. This is what is mainly responsible for the motor symptoms in Parkinson s. Although, Parkinson s is not a curable disease, it can be controlled and the progress of the disease can be kept in check with certain medications.

What causes Parkinson s disease?
The cause of Parkinson s is mostly idiopathic, i.e. the cause is unknown and is not specific. However, there have been cases which show that it can be attributed to factors such as genetic and environmental factors.
What are the symptoms of Parkinson s?

The symptoms of Parkinson s can be classified as Motor symptoms and Non-motor symptoms:

Motor Symptoms 

Bradykinesia: Slow movement
Tremor of limbs
Rigidity or stiffness of trunk and limbs
Impaired balance and difficulty in coordination or postural instability
Non-motor Symptoms 

Depression
Anxiety and fear
Loss of energy and fatigue
Constipation
Excessive salivation
Weight gain or weight loss
Cognitive problems such as difficulty in remembering, confusion, dementia
Parkinson s disease is not curable, but when detected early, medicines are prescribed to give symptomatic relief. Dopamine substitutes are prescribed to the patient to relieve the motor symptoms.

Parkinson's Disease - Understanding The Motor & Non-motor Symptoms!

One of the common ailments in the elderly people is the Parkinson s. A progressive disorder, when left untreated, results in worsening of the symptoms. Hence, it is essential to understand the treatment options available to manage the condition effectively. You may be suggested surgical therapies if medication is not effective enough to treat the symptoms.

Surgical treatment options can be beneficial for patients who are suffering from symptoms, but they do not help with treating the disease. In the past, surgical methods like Thalamotomy and Pallidotomy were used to destroy brain cells that contributed to the symptoms. While these methods are still used, they are very rare and situational.

Deep Brain Stimulation (DBS), an FDA-approved procedure, has become much more popular as it is much safer and does not involve invasive surgery. Instead of destroying brain cells like traditional methods, DBS involves sending electric pulses to the affected brain cells to reduce the symptoms. It is not a treatment procedure, but a means of bringing down the severity of Parkinson s to allow better and more comfortable treatment.

Deep Brain Simulation   Who are the right candidates?
Deep Brain Simulation is commonly used for Parkinson  s disease, but it is not recommended for everyone. It is a preferred method of treatment for people who have had Parkinson s for at least four years but have complications which include long periods of time where medications do not work, or symptoms return, uncontrolled and involuntary movements or the freezing/stiffness in the body.

Deep Brain Simulation is not recommended for those who have Dementia as it can lead to memory problems. The general rule of thumb that neurosurgeons follow is that Deep Brain Simulation can help with symptoms that do not get better with medication. DBS can help reduce medication requirements for patients as well as reduce the side effects that may occur due to medication.

Disorder specialists and neurosurgeons can conduct tests to determine if DBS is going to be effective for a patient before going ahead with such a procedure. An extensive assessment is necessary to understand the symptoms, the effect of Parkinson's drugs and also brain imaging is done. All of the expected benefits are then evaluated for the patients, and if the procedure can help alleviate the symptoms, DBS is given a green signal by neurosurgeons and patients can undergo the procedure.

How Does Deep Brain Simulation Work?
Deep Brain Simulation is a very complex procedure. Brain cells communicate with the rest of the body through electric signal, and these become irregular and do not work properly when affected by Parkinson's. DBS smoothens the functioning of these brain cells and reduces symptoms through electric pulses through the implantation of a medical device known as neurostimulator which is also referred as brain pacemaker.

But, as with any treatment procedure, DBS has potential risks and side effects, hence discuss with neurosurgeon thoroughly to access the suitability.

Adopting Deep Brain Stimulation For Parkinson's disease

Parkinson s disease adversely affects the way you move, as it is a neurodegenerative disorder. This happens when there are problems with certain nerve cells in the brain. These nerve cells produce an important chemical called Dopamine, which in turn sends signals to the region of our brain that takes care of the movement. This chemical help muscles to function smoothly and allow in carrying out one s daily activities. When somebody is suffering from Parkinson s disease, the nerve cells break down, thus hampering movements of limbs.

What Causes This Disease?

Over the years, a lot of research has taken place to find out the exact reasons due to which people get affected by Parkinson s disease but till now neither scientists nor doctors have been able to come up with any solution. They are thinking on the lines of aging or hAarmful chemicals in the environment, to be possible causes for this neurological problem. Sometimes researchers even feel that this could be a hereditary problem but there is no concrete evidence to substantiate this statement.

Symptoms Of Parkinson s

As discussed earlier, Parkinson s occur in aged individuals, when nerve cells break down, when the chemical called Dopamine is no longer able to send signals to the brain. You can easily recognize Parkinson s disease in any of your family members, if you come across certain symptoms, which are generally four of them:

Trembling or shaking of limbs and these tremors can affect different body parts like, hands, arms and legs.
Muscles become stiff, due to which it becomes tough for the affected individuals to move their limbs freely.
Due to stiffness of muscles, movement becomes slow and thus each and every activity of theirs takes much more time than usual.
People are unable to keep their balance and walk freely without any hindrance.
Generally, tremor is the first thing you would notice in a person and thus instantly get to know that the person might be suffering from Parkinson s.
Problems of constipation or facing difficult in swallowing tend to happen as the disease goes on to affect all the muscles in one s body. 
During the latter stages, someone who has Parkinson s, might well have a blank expression to the face with problems being faced while trying to speak and other related issues. The symptoms of this disease usually start for people aged between 50 and 60 but at times, it can even crop up at an earlier stage.
Preventive Measures And Treatment

Let s take a look at how you can prevent yourself from getting crippled by Parkinson s Disease.

Unfortunately, as the disease is mostly age related, so after attaining the age of 60, if not from 50, there would be very few individuals who would not be the victims of Parkinson s.

Research has revealed that having less of dairy and red meat and consuming more of fruits, vegetables and high-fibre foods, thus maintaining a healthy diet, can protect people from the dreaded disease.

Parkinson's Disease - Know What's It's All About

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