In vitro fertilization (IVF) is a process of fertilization in which eggs (ova) from a woman's ovary are removed. They are combined with sperm outside the body in a laboratory procedure, and then the fertilized egg (zygote) is transferred to the same or another woman s uterus for a successful pregnancy.

IVF is one of the several assisted reproductive techniques (ART) used to help infertile couples to conceive a child.

Causes of Infertility

Blocked fallopian tubes
Hormonal imbalance
Endometriosis
Women with ovulation disorder
Uterine fibroids
In the man, low sperm count or poor quality sperm
Genetic disorder
Procedures
Two procedures are done to gain access to ovaries

It involves inserting the needle through the vagina (transvaginally). With the help of an ultrasound machine, the physician guides the needle to the location of the ovaries
In the other procedure, called laparoscopy, a small thin tube with a viewing lens is inserted through an incision in the navel. This lets physician to see inside the patient, and locate the ovaries.
Method
Without additional techniques, the chances of pregnancy would be extremely small. The additional techniques used in IVF include-

Ovarian hyperstimulation- Stimulation to induce development of multiple follicles of the ovaries.
Final maturation induction- Induction of final oocyte maturation is performed, generally by an injection of human chorionic gonadotropin (HCG), when the ovarian follicles have reached a certain degree of development. This is known as the "trigger shot  
Egg and sperm preparation- Semen is prepared for fertilization by removing inactive cells and seminal fluid in a process called sperm washing. An oocyte selection may be performed prior to fertilization to select eggs with optimal chances of successful pregnancy. 
Co-incubation- Eggs are removed from the woman and placed in one of the fallopian tubes, along with the man's sperm. This allows fertilization to take place inside the woman's body. Therefore, this variation is actually an in vivo fertilization, not in vitro.
Embryo culture- The main durations of embryo culture are until cleavage stage (day two to four after co-incubation) or the blastocyst stage (day five or six after co-incubation)
Embryo transfer- The number to be transferred depends on the number available, the age of the woman and other health and diagnostic factors. Embryos are transferred to the patient's uterus through a thin, plastic catheter, which goes through her vagina and cervix.
Aftercare
After the IVF procedure is performed the woman can resume normal activities. A pregnancy test can be done approximately 12-14 days later to determine if the procedure was successful.

Risks

Multiple pregnancies
Ectopic pregnancy
Ovarian rupture, bleeding
Infections
Complications of anesthesia

In Vitro Fertilization - Quick Facts!

Do you know that the future health of your baby is decided  before you even conceive? Your preconception health is very important. Planning a baby is a demanding task, but if you plan it well you will have a healthier and easier pregnancy. 

These are a few tips which can do wonders

1. Relaxation at Work and Household Backup - Plan out your work schedule. You might need to change your work hours or may be change the job profile. You will also need someone to help you out with the household chores around this time.

2. Finances - Get your finances settled and insurance plan changed accordingly.

3. Lifestyle Modification - Eat healthy. Stop the intake of alcohol and stop smoking. Set aside a time for regular exercise if possible. Try to lose that extra flab and stay very active.

4. Reduce Stress - Create a support system for yourself. Engage in activities that uplift your mood.

5. Take Folic Acid -Take 400 mcg of folic acid tablet daily. It helps prevent birth defects of brain and spine in the baby.

6. Avoid Exposure to - Harmful chemicals, metals and toxic substances at workplace and home. Protect yourself from infections. Stay away from cats.

7. Up-to-Date Vaccination - Make sure your vaccination is complete. Vaccination against rubella and flu are very important. It is also important to maintain a gap of at least one month between your rubella shot and pregnancy planning.

8. Optimize your Medical Condition - If you have Hypertension, Diabetes, Asthma, Epilepsy or any other medical condition you must take complete advice from the physician. Blood pressure and sugar levels have to be under full control. The type and dose of the drug may need modifications.

9. Check Family History - Ask your parents, grandparents, brothers, sisters, aunts and cousins about any health problems in the family like genetic problems, mental retardation or malformations in babies. This can help your Gynaecologist to determine which problems to look for and how to prevent it. 

10. Visit your Doctor - Carry a record of your medical conditions, family history and a checklist of your queries. Get tested for Li Blood Group, Thalassemia, HIV, Thyroid Levels, and Blood Sugars.



Why Your Baby's Health is Decided Much Before You Even Conceive

Intrauterine insemination (IUI) and in vitro fertilization (IVF) are two commonly used methods of fertility treatment, which increase a couple s chance of becoming pregnant.

The Procedure

IUI- IUI is a procedure during which processed and concentrated motile sperm are inserted directly into a woman s uterus. This procedure is timed according to a woman s ovulation, and may be performed one to two times in the days immediately following the detection of ovulation. After ovulation a woman s egg is picked up by the fallopian tube and waits there for the sperm. Since the IUI procedure deposits higher concentrations of good quality sperm close to where the egg is waiting, the chances that the egg and sperm will find one another are increased.

IVF- IVF is the most successful method of fertility treatment utilized today to help couples to conceive. The basic components of the IVF process include stimulation of the ovaries to produce multiple eggs at a time, removal of the eggs from the ovary (egg retrieval), fertilization of the eggs in the laboratory, and subsequent placement of the resulting embryos into the uterus (embryo transfer). The chance of pregnancy from IVF depends primarily on the age of the woman, the cause of infertility, and factors related to the quality of the IVF laboratory.

Success Rates

IUI Treatment: There is a marked difference between IVF and IUI pregnancy rates. IUI has a success rate between 5% and 20%, but it can even be as low as 1-2 %, depending on the woman s age and fertility levels. The chances of conceiving through IUI is higher if fertility drugs are administered along with the treatment.

IVF Treatment: IVF has a high success rate   between 20% and 35% and it can even go as high as 40%. This may not seem like a lot, but it is very high, considering that an average young and fertile couple has only a 15-20% chance to conceive in a month. It is important to understand what IVF and IUI success rates mean and the factors that affect it before deciding on a fertility treatment. You can also use any reliable online IUI vs IVF comparison tool to determine your approximate success rates with each of these treatments, depending on your age, lifestyle, and medical history.

You should use online sources of information to understand more about fertility problems, how age affects fertility levels, and whether freezing your eggs is a good option for you. However, discuss all these issues with your doctor to ensure that you have the right information and that you have understood it correctly. Fertility specialists provide you with personalized fertility plans based on your health which is why you should always talk to them before you make any decision.

IVF or IUI - Which One Should You Opt for?

Frozen Embryo Transfer or FET is an extremely effective method to conceive a pregnancy. Recent studies have proved that there is a increased chance for pregnancy when the embryos, which get used are frozen and get placed inside the uterus at a time right after the ovaries are stimulated. Still, certain issues can arise with the transfer of frozen embryo, such as:

A Thin Lining of the Uterus
Research has shown that there are not many women who get pregnant if the lining in their uterine does not tend to thicken enough. It is not clear exactly why this problem occurs in most women and moreover there is no sure shot treatment to make the lining of the uterine thick. The experts on fertility would try out different methods like increasing the amount of estrogen or change the way how estrogen is given. There are other instances when women might be given supplemental medicines, while for some, the problem will continue to exist.

What Should Be Done In Case The Problem Persists?

In case the problem continues for some women, then there are certain approaches which experts might look to adopt. The first one is to cancel the transfer of embryo and try once again at any later stage, that too with a different treatment method.
The second option which they could think of is to go ahead with the transfer, wherein they might feel that a thin lining does not necessarily mean that it is impossible for a woman to get pregnant but definitely the efficiency would be reduced.
One last option is to make use of the opportunity for undergoing additional tests which would help them to assess the ability of the uterus to allow implantation of the embryos.
Unexpected Ovulation
For enabling the embryos to get implanted into uterus, placing them very precisely and at the appropriate time is important. This is regarded as the window of implantation. The time taken, is based on the time frame since progesterone reaches the lining of the uterine.

Doctor knows the exact time to place the embryos, right from the time he or she instructs a woman to start having progesterone supplements. In case a woman was to ovulate, the production of progesterone would begin earlier than the normal time and would lead to the shift of the window of implantation. As identifying the correct time of ovulation is almost impossible, so that would lead to some sort of uncertainty into the timing.

Due to this reason, there are doctors who would use medication in order to prevent unexpected ovulation from occurring. Generally an injection called Lupron is usually used as medication.

Timing for the Embryo Transfer is Inappropriate
This is a problem related to early ovulation. There are case when the implantation window is shifted, still the timing of the transfer becomes accurate. Recent studies have shown that quite a nominal percentage of women might have a window of implantation, which could be either earlier or later than normal time. A test called the Endometrial Receptivity Array can help determine at what time is the window of implantation open.

Frozen Embryo Transfer - Complications Associated With It!

There are two types of abortion, namely medical and surgical. In case of medical abortion, pills are taken to terminate the pregnancy; whereas, surgical abortion is done if the pregnancy has reached an advanced stage when pills are ineffective. While generally there are no health risks or negative effects of abortion on fertility, there are rare cases of complications, which can give rise to severe symptoms post abortion. Following is the information you need to know about abortion and its effects on fertility:

When to seek medical assistance
It is advisable to seek medical help if you have the following symptoms post abortion:
1. Persistent pain in the lower abdomen, which lingers even after taking medication
2. Excessive bleeding
3. A high temperature

Possible effects of surgical abortion on fertility
1. Infection after abortion: infections post abortion like pelvic inflammatory disease (pid), if left untreated for long can spread and harm your reproductive organs, thereby impacting your fertility. It can cause complications like infertility or ectopic pregnancy.

2. Damage to the cervix during abortion: damage to the cervix during an abortion can cause cervical incompetence and consequently increase the risk of miscarriage.

3. Damage to the womb during abortion: there are chances of damage of the womb (uterus) during abortion, resulting in scarring, which can cause fertility issues if not corrected. This is more likely in case you had multiple abortions.

Apart from the above mentioned complications there are a number of other complications, which can happen due to abortion, preterm birth, vaginal bleeding during pregnancy and low birth rate, etc. Further, infertility can also be a possible side effect of abortion pills, which happens due to scarring of the uterus during the procedure of forcible elimination of the fetus. In all such cases it is advisable to schedule regular check up with your gynaecologist.

Can Abortion Affect Fertility?

Surrogacy is a boon for couples who cannot conceive naturally or give birth to a child. Surrogacy is a process in which a woman's unfertilized eggs are implanted into the uterus of another woman who is called the surrogate mother. The egg is fertilized in the surrogate mother's uterus with the biological father's sperm. The surrogate mother lets the child develop in her womb and gives birth. Although, there are various medical treatments available, but not all of them have a high success rate.

The two primary methods of surrogacy are:
1. Traditional surrogacy: In this process, the surrogate mother is artificially inseminated with the sperm, which belongs to the biological father of the baby. The sperm gets implanted into the surrogate mother's uterus and the child develops in her womb.

2. Gestational surrogacy: For women who want to have a biological child in spite of being incapable of pregnancy, the gestational surrogacy method is used. During the process, in-vitro fertilization is undertaken and the eggs from the woman who wants to become a biological mother are harvested. The eggs, along with the sperm from the biological father are implanted into the uterus of a surrogate mother, who will carry the embryo and will give birth to the child.

Process involved in surrogacy
Here are the several processes and procedures, which need to be undertaken, after you have chosen a surrogate mother for carrying your child.

1. Medical testing: After a surrogate mother is chosen, the woman goes through several health checkups, medical and psychological tests to ensure that she gives birth to a healthy child.

2. Legal agreements: There are several legal considerations that have to be addressed for a surrogacy. All the legal requirements regarding the surrogacy should be written down. Some issues include both the surrogate mother and the biological parents. A financial contract must be presented as well, which will reimburse the medical expenses and requirements of the surrogate mother.

3. Medical process: The medical processes required for surrogacy include in-vitro fertilization and the transfer of the eggs, which are done in a clinic under the supervision of a reproductive endocrinologist. The eggs are transferred to the uterus of the surrogate, where fertilization takes place after combining it with the sperms of the biological father.

4. Pregnancy and birth: After successful fertilization, the surrogate mother gets pregnant. Proper care and precautions should be taken by her to ensure a successful birth. Finally, the surrogate mother gives birth to a child, who belongs to the biological parents.

This method of having a child has become very popular in the recent times. It is a great blessing for people who cannot conceive due to medical conditions or otherwise.

All You Need to Know About the Surrogacy Process

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