What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

World hepatitis day is observed on july 28th every year to raise awareness about hepatitis disease among people. It is organized on the occasion of the birthday of Dr. Baruch blumberg who found the hepatitis b virus in the year 1967 and also developed a vaccine for it. Moreover, this day educates everyone about hepatitis infections, the efforts to fight viral hepatitis, and methods people can use for its prevention.

What is viral hepatitis?

Viral hepatitis or hepatitis disease is a condition of inflammation in the liver that leads to severe liver disease and hepatocellular cancer. With deaths happening every 30 secs from a hepatitis-related infection, it is important to treat viral hepatitis at the earliest. Hepatitis is of different types depending on the infection. 

 ;

Types

Viral hepatitis impacts millions worldwide, resulting in both acute and chronic diseases. There are five major classifications of viral hepatitis-

 


	
	Hepatitis a- it is a liver infection that can be prevented by a vaccine. It is a result of the infection as a result of the hepatitis a virus.
	
	
	Hepatitis b- it is an infection that happens due to the hepatitis b virus. It is spread through the blood or other bodily fluids of a person.
	
	
	Hepatitis c- it is a liver infection caused by the hepatitis c virus. It transmits through the blood of a person who is infected.
	
	
	Hepatitis d- delta hepatitis is another name for this virus and the hepatitis d virus is responsible for this. It happens to only those who are already hepatitis b infected. ;
	
	
	Hepatitis e- it is a liver infection resulting from a hepatitis e infection. It is usually found in a person s stool.
	


 

Symptoms

Hepatitis is a condition where you don t show symptoms till it is chronic and starts affecting your liver health. However, people in the initial stages of hepatitis infection might start reflecting symptoms. Some common symptoms of viral hepatitis are:

 ;


	
	Flu-like signs
	
	
	Darker urine color
	
	
	Fatigue
	
	
	Abdominal cramps and pain
	
	
	Appetite loss
	
	
	Weight loss
	
	
	Yellow skin
	
	
	Pale eyes
	


 

People at risk

The risk of catching a hepatitis infection is high in individuals working around these environments-

 ;


	
	Direct contact with hepatitis a infected person
	
	
	Male in sexual relation with another male
	
	
	Drugs abuser
	
	
	Ones with clotting factor disorder
	
	
	Who work with primates
	


 

World Hepatitis Day: Know All About The Disease

Diabetes is a common chronic condition that results from excessively high blood glucose. In this condition, either the pancreas fail to produce enough insulin, or your body does not utilize insulin produced by pancreas properly. This might lead to cardiovascular problems and neural problems, as well as health problems like ;depression and ;anxiety. Recent studies reveal that diabetes may have an impact on your reproductive health too.

Effects on men

A common problem that affects men s sexual life is erectile dysfunction. Diabetic men face this as they have low testosterone levels and are unable to maintain an erection during sex. For an erection, constant blood flow is necessary inside the penis. However, as diabetes disrupts the blood flow and damages the blood vessels, men are not able to achieve an erection.

Furthermore, diabetes also damages the arteries and nerves, which again, disturbs the blood flow to the penis. This also causes erectile dysfunction. Other factors that can cause sexual complications among men are- ;


	
	Diabetes-induced obesity
	
	
	High blood pressure
	
	
	Retrograde ejaculation ;  refers to a condition where semen is ejaculated to your bladder, but not through your penis
	


Effects on women

For women, during menopause, blood ;sugar levels may drop due to diabetes. Besides, high blood sugar levels damage the nerves of a woman. This may hinder the ability to feel aroused during sex and lowers sexual stimulation. This reduces their capability to achieve orgasm.

Another common issue among women with diabetes is ;vaginal dryness. This causes a lack of lubrication in the vagina that makes sex painful. Damage to the nerves that lubricate the vagina may be the reason for this. During menopause or after menopause, it can be due to low oestrogen.

Diabetes is more likely to cause vaginal infections such as yeast infections and urinary tract infections. Both of these cause pain during sexual intercourse. If the nerves of the bladder are damaged, it can lead to urinary incontinence ;while sex.

There are certain medications and therapy that may help control diabetes. Additionally, changes in lifestyle such as eating healthy, exercising daily etc. Will enhance your well-being that will significantly improve your blood glucose levels   and in turn, your sex life.

Know How Diabetes Impacts Reproductive Health

Type 1 diabetes occurs when your pancreas is unable to produce enough insulin to keep the blood sugar ;levels under control. The condition, if not managed properly, can lead to related health disorders and complications, both long-term and short-term.

Health problems arising from type 1 diabetes

Type 1 diabetes can have severe effects on your eyes, kidney, nervous system, and heart health. The most common ailments associated with type 1 diabetes may include the following-

1. Diabetic retinopathy

Diabetic retinopathy is a disease of the eyes, which occurs when the blood vessels in the retina (tissue present at the back of your eyes) are damaged. The walls of the retina gradually weaken from increasing blood pressure and blood sugar levels, and this leads to leakage of blood or fluid into the nearby tissues.

Early symptoms of diabetic retinopathy include-


	
	Blurred vision
	
	
	Floaters
	
	
	Difficulty perceiving colors
	


2. ;Diabetic neuropathy

Diabetic neuropathy unfolds when the nerves are damaged due to type 1 diabetes. The condition mostly affects your feet and legs. Reduced blood circulation due to high blood glucose impedes normal wound healing in the extremities, hence, even a minor bruise ;can develop into a permanent injury.

Symptoms of diabetic neuropathy are-


	
	Numbness
	
	
	Reduced sensation
	
	
	Severe, debilitating pain in the extremities
	


3. Diabetic nephropathy

Also known as ;diabetic kidney disease, the condition is a slow deterioration of the kidney and its ability to function properly. In severe cases, where the levels of blood glucose are extremely high due to type 1 diabetes, diabetic nephropathy can ultimately result in kidney failure ;or end-stage renal disease (esrd).

The following are the symptoms of diabetic nephropathy-


	
	Dark urine
	
	
	Swollen ankles, feet, eyes, or hands
	
	
	Shortness of breath
	


4. Cardiovascular diseases

Cardiovascular diseases refer to a range of heart conditions including blood clots and diseased blood vessels. High blood glucose levels resulting from type 1 diabetes can contribute to the deposition of fat in the walls of the blood vessel. Over time, this may restrict the flow of blood and put you at risk of cardiovascular disorders such as coronary artery disease, stroke, or even ;heart attack.

Symptoms of cardiovascular diseases widely vary, ranging from palpitations ;to chest pain. Sometimes, such a condition may not exhibit any symptoms at all.

Type 1 diabetes complications are related to poor management of blood glucose. The best way to monitor the condition and control the symptoms is to get in touch with your doctor. A specialist in this field can prescribe the correct treatment and help prevent the onset the related health disorders.

Complications Associated With Type 1 Diabetes

When abnormal cells grow inside the brain and are in the form of a mass the condition is called a brain tumour. However, on the other hand, brain cancer is a disease of the brain in which cancer cells (malignant cells) arise in the brain tissue. Cancer cells grow to form a mass of cancer tissue (tumour) that interferes with brain functions such as muscle control, sensation, memory, and other normal body functions. 

 ;

Some brain tumours are cancerous while others fall under the category of non-cancerous ones.

Brain cancer is actually the abnormal growth and uncontrolled growth of the cancer cells in the brain, that forms a tumour in the brain. Tumours can be either benign or malignant.

Benign brain tumours are abnormal collections of cells that reproduce slowly and usually remain separate from the surrounding normal brain.

Malignant tumours reproduce and grow quickly. Their borders are hard to distinguish from the normal brain around them.

 

The underlying cause of primary brain cancer, cancer that begins in the brain, is not known. Secondary brain cancer is caused by a cancer of another organ in the body, such as the breast, prostate, kidney, skin, or bone, that has spread to the brain.

 ;

The brain tumours originate in the brain itself. Tumours start to develop if there are mutations in the dna. It is because of these mutations that cells of the brain increasingly grow and divide. Usually, in adults, the primary brain tumours are uncommon in comparison to the secondary brain tumours.


 

There are few early symptoms of brain cancer, but as the tumour grows within the confines of the skull, it causes increased intracranial pressure and exerts pressure on the brain, causing signs to develop.


 ;

Brain cancer occurs when there is an uncontrolled growth of cancer cells in the brain that form a malignant brain tumour. The underlying cause of primary brain cancer, cancer that begins in the brain, is not known. Secondary brain cancer is caused by a cancer of another organ in the body, such as the breast, prostate, kidney, skin, or bone, that has spread to the brain.


 

What Is The Significant Difference Between Brain Tumour And Brain Cancer?

Thyroid cancer refers to the type of ;cancer that originates in the thyroid gland. Cancer develops when the cells in your thyroid gland begin multiplying uncontrollably to form malignant tumours.

What leads to the development of cancer in the thyroid glands is not clearly known. However, a combination of environmental factors and genetics could be a leading cause of cancer.

Thyroid cancer is the sixth most common cancer in women, and usually affects those in their 20s and early 30s.

Types of thyroid cancer

Four types of thyroid cancer are prevalent, which are  


	
	Papillary thyroid cancer   ;this is the most common type of thyroid cancer. Cancer typically develops in one of the two lobes in the thyroid gland, and gradually spreads to the lymph nodes in your neck.
	
	
	Follicular thyroid cancer   ;the second most common type is the follicular thyroid cancer. Here the disease spreads to other body parts and organs, like the bones or lungs rather than the lymph nodes.
	
	
	Medullary cancer   cancer starts from the c-cells of the thyroid gland, which usually produce a hormone called ;calcitonin. The disease can spread to the lungs, liver, or lymph nodes even before a nodule is discovered.
	
	
	Anaplastic thyroid cancer   this form of cancer is rare but aggressive. It develops from an existing follicular or papillary cancer and spreads to other parts of the body faster than any other type of thyroid cancer.
	


Symptoms to watch out for

The symptoms of thyroid cancer depend on its type. Although there are no observable symptoms in the initial stage, you might be able to spot some changes in your body as cancer progresses. These symptoms include:


	
	A lump or mass in the neck that can be felt through the skin
	
	
	Change in voice   ;hoarseness
	
	
	Pain in the throat and neck
	
	
	Difficulty in swallowing
	
	
	Swelling of the lymph nodes in your neck
	


Diagnosis and treatment

The following tests/procedures can help detect thyroid cancer early  


	
	Blood test
	
	
	Ultrasound
	
	
	Biopsy
	
	
	Imaging tests
	
	
	Genetic testing
	
	
	Pet scan
	


Once cancer is diagnosed, appropriate treatment will be prescribed depending on the stage. Primary treatment options include  


	
	Chemotherapy ;  medications are infused through veins to kill cancer cells
	
	
	Radiation therapy   high-energy radio beams are directed to destroy cancer cells
	
	
	Radioactive ;iodine   large doses of radioactive iodine are given orally
	
	
	Targeted therapy   medications are given to attack certain vulnerabilities in the cancer cells
	
	
	Surgery ;  complete or partial removal of the thyroid gland or the lymph nodes
	


Prior to the treatment, your doctor will discuss the treatment plan specific to your diagnosis. Thyroid cancer is curable if detected at the right time. Therefore, do not lose hope and consult a specialist as early as possible.

Thyroid Cancer: Causes, Symptoms, And Treatment

Don't wait any longer, manage your Psychopharmacologist online with a Lybrate doctor today

Consult for Psychopharmacologist - Online and Easy!

FilterClear All

COMMON SPECIALITIES

COMMON ISSUES