What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

Potassium is an essential mineral that helps in healthy functioning of your body   it helps in muscle contractions, fluid balance, and nerve signals. Your body receives the required amount of potassium from specific food sources and processes the same. The excess potassium is eliminated from the bloodstream by your kidneys.

Under normal circumstances, your blood levels should be between 3.5meq/l and 5.5meq/l for potassium to carry on these functions. Healthy kidneys play a vital role in keeping the potassium levels in check.

In case your kidneys are unable to remove excess potassium, it may get stored in your blood, leading to a condition known as hyperkalemia.

The link between your kidneys and potassium

The mineral potassium and your kidneys share an intricate relationship. If the levels of potassium in your blood are too high, it can pose a threat to your cardiac condition   leading to a ;heart attack or ;irregular heartbeat.

Hyperkalemia occurs when the kidneys fail to function properly. Your kidneys work to balance the amount of potassium consumed with that, which is eliminated through urine. Your body takes in potassium through the foods and drinks you consume. In the initial stages of your kidney disorder, they may be able to make up for high levels of potassium. However, as your condition worsens, they may be unable to eliminate enough of the mineral from the body.

How to find out if you have high potassium levels

The only way to figure out if your potassium levels are healthy or too elevated is to go for a blood test. The test measures the level of potassium in the bloodstream.

As long as your kidneys are healthy, your potassium levels will be under control. Therefore, if you have hyperkalemia, or if there are chances of you getting it, you may have to cut back on foods that are high in potassium content. Besides, you will have to rely on diuretics and potassium binders.

How Are Kidney And Potassium Connected?

A brain tumor is a common scenario these days. With around 40, 000 to 50, 000 cases per year, india has seen exponential growth in the numbers. However, understanding that brain tumors can be prevented or treated in various ways is important. Early detection of the tumor makes treatment and surgery easier and more effective. Signs usually include headaches, nausea, vomiting, facial paralysis, and sleep disturbance.

There are numerous myths and misconceptions among the general public about brain tumors. This leads to delays in seeking treatment. Some popular myths and facts about brain tumors are-

Myth: everyone has the same type of brain tumor

Fact: over 120 types of brain tumors are detected to date. They are differentiated based on the size, cell of origin, location, and grade of tumors.

Myth: everyone with a brain tumor has similar symptoms

Fact: not all persons show the same symptoms. They can have diverse signs depending on the condition. Some may even have seizures.

Myth: all tumors are cancerous in nature.

Fact: while not all tumors are cancerous in nature, brain tumors can be cancerous or benign depending on the condition.

Myth: only old people are susceptible to brain tumors

Fact: brain tumors can happen to people of any age. Moreover, some tumors are relatively more common in young adults. Brain tumors like medulloblastoma can also appear in children. Most lethal brain tumors like  glioblastoma mutiformae  can develop in adolescents and old people.

Myth: lifestyle modification can keep brain tumors away.

Fact: lifestyle changes have no role in preventing brain tumors. However, a workout, a nutrient-rich diet with high fiber content, and no smoking, no tobacco or alcohol consumption are good for overall health.

Myth: brain tumors are genetic.

Fact: it is not true that if no one in the family had a tumor, even you can t. Genetic mutations are too few to cause cancer. 90- 95% of cancer is by mutations that develop during an individual s life.

Myth: life gets back to normal as soon as the treatment is done in a patient.

Fact: benign tumors rarely recur. However, the cancerous tumors may recur posing a challenge to the doctor and the patient.

 

Myths And Facts Associated With Brain Tumour

The most common forms of diabetes ;are type 1 and type 2 diabetes. In type 1, your immune system damages the cells inside the pancreas that produce insulin. Therefore, the pancreas are unable to produce an adequate amount of insulin.

In type 2 diabetes, your body does not respond properly to the insulin produced by the pancreas. As a result, your body will have a difficult time removing sugar ;from the blood. The cells may stop insulin production over time that may lead to insulin deficiency. However, there are other forms of diabetes that are lesser-known but can affect you just as bad.

Types of diabetes beyond type 1 and type 2

Gestational diabetes

In gestation diabetes, a condition that affects pregnant women, the blood sugar levels increase to an extent that may hamper the health of the mother and the child.

Symptoms

Usually, there are no symptoms as such. If diabetes worsens, women may observe symptoms such as -


	
	A need to pee more frequently
	
	
	Excessive thirst and hunger
	
	
	Dryness in the mouth
	


Lada (latent autoimmune diabetes in adults)

It is sometimes referred to as type 1.5 diabetes. Here, your immune system kills the insulin-producing cells inside the pancreas. As this condition takes a longer period to develop, you may not need insulin for many months after you have been diagnosed.

Symptoms

You may observe the following symptoms  


	
	Dryness and itchiness
	
	
	Tingling sensation in feet or hands
	
	
	Blurry vision
	
	
	Frequent urination
	


Mody (maturity-onset diabetes of the young)

This condition is observed during adolescence. Here, genetic mutations limit the pancreas from making insulin. So, due to insufficient insulin, your blood sugar level goes up. If any of your parents have mody, you are likely to have the condition.

Symptoms

Symptoms may include  


	
	Yeast and ;skin infections
	
	
	Frequent urination
	
	
	An urge to pee more often
	


Treatment

Primary care for these other forms of diabetes follows the usual course of treatment as with type 1 and type 2.


	
	Diabetic medications
	
	
	Insulin shots or injections
	
	
	Dietary changes
	


The doctor may instruct you to monitor your blood sugar levels frequently to keep it under control. This will be accompanied by a diet ;consisting of adequate calories, but avoid fatty foods, excess sugar and carbohydrates. Mild exercise is also recommended.

The best way to prevent these conditions is to visit your doctor frequently and follow the treatment plan. Do not keep your diabetes untreated.

A Sneak Peek Beyond Type 1 And Type 2 Diabetes

International yoga day or international day of yoga is celebrated on 21 june annually. It took a shape in the united nations general assembly in 2014 when indian prime minister narendra modi proposed a day for yoga. The mental, physical, and spiritually enticing practice of yoga started being celebrated in 2015.

 

Yoga and its importance

The term'yoga' is derived from sanskrit which means to reunite or join. It is symbolic of the union of mind and body. Yoga originated some 5000 years ago in india. It was developed as a process to interconnect the mind, soul, and body. As it started gaining popularity in the west, it became an exercise and a method to relax. Through yoga, you can easily calm down your nerves, alleviate any physical concerns, get relieved of any chronic pain, and attain bodily well-being.

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Significance of 21 june

June 21 is also called the summer solstice. It is considered the longest day of the year when the sun is out for most parts of the day. From yoga's perspective, the summer solstice allows the transition to dakshinayana. Hence, it was chosen as an ideal day to celebrate a healthy mind and body.

 

Un declaration

After the draft resolution was presented in the un general assembly, it received support from 177 member countries. Pm modi in his statement emphasized yoga's invaluable importance. He also stressed the fact that how yoga connects us to nature.

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Benefits of yoga


	
	Yoga and fitness
	


Yoga ensures that a person is healthy in its true sense. The different postures of yoga encourage overall fitness and balance of the body. In addition, an enhanced mental strength, physical power, stamina, and detoxification of the body.


	
	Yoga and stress relief
	


Some precious moments of yoga each day is a good way to eliminate everyday stress. Be it physical or mental, certain practices like meditation and pranayama are perfect for preventing stress.


	
	Yoga and inner peace
	


There is a serious need for peace in this robust world. Yoga done regularly gives you extensive inner peace. It is vital to calm your disturbed peace. Moreover, breathing exercises in yoga are very helpful against unwanted stress. Immune system enhancement and protection from frequent diseases is another one of yoga s benefits.



 

International Yoga Day: All You Need To Know!

World environment day is celebrated annually on 5th june. This day encourages awareness and action for the protection of our environment. It raises the problems facing our environment such as plastic pollution, air pollution, illegal wildlife trade, sea-level increase, sustainable consumption, and food security, among others. 

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World environment day is a reminder for us to pause and reflect on our actions and their subsequent consequences on the planet. 

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When was the world environment first celebrated?

The day was first observed in 1974 in the city of spokane in the usa.

 

History of world environment day (wed)

1972- the un general assembly established world environment day on the 1st day of the stockholm conference on the human environment. ;

1974- the first" world environment day" was held with the theme" only one earth. 

1987- the idea for rotating the center of these activities by selecting different host countries began. ;

 

Why is world environment day celebrated? ;

For a healthy life, the environment plays an important role. It provides us with air, food, etc. The environment is like our neighborhood, its surrounding conditions affect us and also modify development. It is really necessary to address the environmental issues like deforestation, increasing global warming, pollution, wastage and losses of food, etc. Currently, our earth is experiencing a triple planetary emergency: 


	
	Pollution is poisoning our air, land and water. ;
	
	
	Climate is heating up too quickly
	
	
	Habitat loss
	


The deteriorating environmental conditions worldwide had already raised alarms in academic circles, among scholars studying its conditions. However, general masses seemed oblivious to changes that were not directly affecting them.

The world environment day is structured in a manner that allows one country to take up the responsibility of selecting the theme and hosting the key celebrations each year. 

Let's all come together and ensure this unique and beautiful planet remains a comfortable home for humanity. 

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World Environment Day: What Is World Environment Day And Why It Is Celebrated? 

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