Cystic Fibrosis is a genetic disorder that is known to affect some of the vital organs of the body including the lungs, digestive system to name a few. For long it was believed that cystic fibrosis affects a person in their childhood. However, various research and studies suggest that adults are also susceptible to this inheritable disorder. In this article, we will discuss the cause and symptoms associated with cystic fibrosis.

Cause
The epithelial cells that line the stomach, nasal cavity and lungs, are responsible for the production of the digestive fluids, sweat, tears, mucus. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene codes for a protein called the CFTR protein. The CFTR protein, a membrane protein plays a pivotal role in transporting the chloride ions of the epithelial cells inside and out of the cell. This regulation of the chloride ions goes a long way in ensuring that the mucus produced is free-flowing and thin.

In the case of Cystic Fibrosis, the CFTR gene that codes for the protein undergoes a mutation. With the CFTR protein unable to perform its function, sticky and thick mucus builds up and clogs some of the major systems of the body including the digestive system, reproductive, and respiratory system. There is also a higher salt content in the sweat of the affected person.

For a person to be affected by cystic fibrosis, he/she must inherit a copy of the mutated CFTR gene from both the parents ( Autosomal Recessive Disorder) at birth.

Symptoms
The symptoms associated with cystic fibrosis depends on the organs and systems affected.

The thick mucus formed can clog the digestive tract resulting in incomplete absorption of the essential nutrients from the food. This may have an impact on the overall growth and development of the body.
- There may be stunted growth or no weight gain.
- The stool may appear greasy and foul smelling. Some may also suffer from constipation.
- Newborns and infants may suffer from an intestinal blockage.
Cystic fibrosis, left unattended can lead to diabetes, intestinal blockage or obstruction.
- The mucus can also block the bile duct triggering a host of problems including liver disorders.
- At times, the obstruction or blockage can occur at the junction where the large and the small intestine meets (Distal intestinal obstruction syndrome).
The thick mucus can also affect the lungs and the respiratory system by blocking the tubes that act as a passage carrying the air inside and out of the lungs. As a result,
- A person may suffer from lung infections frequently.
- There may be difficulty in breathing, stuffy and blocked nose, or wheezing.
- Some people may also suffer from a chronic cough with a thick sputum.
Left untreated the complications can worsen resulting in

Nasal polyps, Chronic infections, Hemoptysis (there is blood while coughing), and Pneumothorax (air fills up in the space bifurcates the chest wall from the lungs).

In severe cases, there may be a respiratory failure.

Cystic fibrosis can also trigger fertility problems (both in males and females).

Cystic Fibrosis- Causes and Symptoms!

This is a very common condition seen in toddlers. When the legs are brought together then there is a gap at the level of the knee. It happens because of inward bowing of thigh bone or tibia. The deformity may appear to increase on standing.

Daily requirement of calcium

The optimal primary nutritional source during the first year of life is human milk. Premature infants have higher calcium requirements than full-term infants while in the nursery. These may be met by using human milk fortified with additional minerals or with specially designed formulas for premature infants. Around 6 months of age when weaning foods are started, food items rich in calcium should be added. Readymade formulas are fortified with calcium but one must remember that the bioavailability of calcium from human milk is greater than that from infant formulas or cow's milk. Hence breastfeeding should be encouraged. In children age 2-8 years the daily requirement is around 800 mg/d. In children 9- to 18-year-olds the daily requirement is 1,200-1,500 mg/day.

Some of the common items that are rich in calcium are.

Food Item	Quantity	Amount of Calcium in each serving
Milk	1 cup (240 ml)	300 mg
Cheddar cheese
1.5 oz (42 g)	300 mg
Spinach cooked	1/2 cup (90 g)	120 mg
Sardines or salmon with bones	20 Sardines (240 g)	50 mg
Sweet potatoes	1/2 cup (160 g)	44 mg
Vitamin D:

Babies younger than 1-year-old need 400 IU of vitamin D a day. Kids older than 1 year need 600 IU or more of vitamin D a day. Our bodies make vitamin D when our skin is exposed to the sun. The recommended exposure to sunlight is at least 30 min every day. There are various fortified food items that have vitamin D. Also medicines are available which can provide the daily requirement of Vitamin D

Physiological genu varus. In most of the toddlers, the legs are curved inwards. They should improve over a period of time. The legs should straighten by 2 yrs. The child should be investigated if the deformity is severe; the deformity is only in one leg, if the child complains of pain and if the child appears unusually short.

Bow Legs - Why Do Children Suffer From Them?

Are you aware of the number of people who suffer because of pneumonia? As the weather becomes cold and damp, chances of getting affected by pneumonia increases. Pneumonia can originate from virus, bacteria and a host of other factors. It is one of the most common ailment which affects the adults, all over the world. Hence, it is important for all of us to prevent  ourselves from pneumonia and for that we can follow the below mentioned steps:

Know about the symptoms of pneumonia first: It is difficult to detect or diagnose pneumonia, especially in people over the age of 65. In older patients, the common symptoms such as fever, chills, cough may not be experienced. You should watch out for non-respiratory symptoms like weakness, dizziness, delirium and confusion. It is even more difficult to diagnose pneumonia in people who are suffering from preexisting conditions.
Practice good hygiene: Common respiratory infections, influenza and cold may cause pneumonia. You should follow hygienic habits. Wash your hands regularly before meals and use hand sanitizers in order to prevent the illness from spreading. You should also maintain proper oral hygiene as several oral infections may also lead to pneumonia. You should also keep away from people who are affected by pneumonia or any other illness like flu, cold and serious diseases such as measles or chicken pox. All these factors may cause pneumonia.
Get vaccinated: It is recommended for people of all ages who may be at a risk of getting pneumonia to get vaccinated and immunised against pneumonia causing virus called pneumococcal pneumonia. This is a one-time vaccine, which prevents and reduces the severity of pneumonia. A booster vaccine after every five years may also be prescribed. Elderly people should be vaccinated against all diseases which cause pneumonia.
Quit smoking: Smoking accounts for being a major cause or risk factor for pneumonia. It increases a person s chance of getting pneumonia as the lungs  ability to defend themselves from the infection is reduced. By quitting smoking, you will be able to prevent pneumonia.
Maintain a good general health: Maintaining an overall good health and following healthy habits will help you in preventing pneumonia. This is because your immune system stays strong and is able to fight efficiently against pneumonia-causing infections. A proper diet with all essential nutrients is also recommended along with regular physical exercise and proper rest.
Severe cases of pneumonia are capable of making you suffer and you may be admitted to a hospital. According to studies, it has been estimated that more than 60% of people over the age of 65 need to be hospitalised because of pneumonia.

If you wish to discuss about any specific problem, you can consult a pulmonologist.

Pneumonia - 5 Ways You Can Prevent Yourself Against it

Insulin is the most common treatment prescribed for people affected with diabetes. Diabetes is condition where high amounts of glucose prevail in the blood for an extended period of time. However, there are some drugs that offer an alternative to insulin in treating diabetes, which are:

1. Liraglutide: Liraglutide is a glucagon-like peptide-1 (GLP-1) drug that causes the body to release greater amounts of insulin so as to facilitate the movement of glucose from the blood to the cells. People with type 2 diabetes generally use this treatment. It slows the digestion process and can cause symptoms of headache and nausea. 

2. Pramlintide: It's an artificially produced version of amylin. It is taken by both type 1 and type 2 diabetic patients, facilitates slower digestion of food and therefore, controls release of sugar in the blood. It can cause tiredness and nausea.

3. Dulaglutide:This treatment is for people affected with type 2 diabetes and it is administered once a week. It causes more insulin to be released and pass the glucose to the cells. It can cause loss of appetite, nausea and abdominal cramps as side effects.

4. Albiglutide: This treatment facilitates pancreas to release insulin and limits the glucagon hormone production. It is used by type 2 diabetes patients who have not taken well to other treatments. The side effects are skin reaction, respiratory tract infection and nausea.

5. Exenatide: It is a drug that causes pancreas to release insulin that facilitates movement of glucose to cells. It is a treatment for type 2 diabetes and it restricts release of glucagon in the body. The possible side effects are acidity, constipation and vomiting.

Common Insulin Alternatives

Causes of iron deficiency in children

Iron deficiency is a common condition in children. It occurs when there is a scarcity of iron in the child's system due to malnutrition. Iron is an extremely important mineral that is required for growth and development in young ones. It is used in transporting oxygen through the bloodstream and is essential for the functioning of the muscles. If the child's diet lacks iron then the condition might worsen and turn into anemia.

Children need different levels of iron intake at different ages for proper development of all mental and physical faculties. As the child gets older and reaches the age of puberty, the requirement of iron and other minerals also increases. Deficiencies can lead to various nutritional disorders that may cause severe complications.

The primary cause of iron deficiency in children is an improper diet which leads to a lack of nourishment. There are a number of other causes of the problem, some of which are as follows:

Low birth weight
Excessive intake of cow's milk at less than 2 years of age
Feeding exclusively on breastmilk beyond 6 months of age
Lead poisoning
Insufficient intake of lean meat
Pure vegetarian diet
Gastrointestinal disease or infection
Improper diet of the mother during pregnancy
Chronic diarrhea
Infestation of parasites in the digestive system.

If the problem arises due to dietary deficiency, it can be easily solved by making simple modifications to the child's diet plan. If the condition stems from other factors or diseases, the child must be taken to a doctor immediately for a medical diagnosis and remedial treatment.



What Causes Iron Deficiency in Children?

World Diabetes Day is celebrated on 14 November, each year. It is the primary global awareness campaign for diabetes as it is one of the major problem of today's time. With an upsurge in the number of people suffering from diabetes, the sole aim of celebrating this day is to create awareness about this disease and suggest preventive measures to those who have not acquired it and provide tips to manage it to those who are living with it. 

So, here are 15 health tips that will help you manage your diabete effectively: 

You should quit smoking as it is very bad for diabetes patients. Smoking leads to narrowing of the blood vessels, which reduces proper blood circulation.
You have to track your exercise patterns. Take actual notes about your exercise habits and make necessary changes based on the record.
Eliminate fast food from your diet. Avoid eating out at restaurants and avoid taking extra salt, sugar and calories. You should cook your meals at home with light ingredients and less salt and sugar.
Diabetes severely affects your vision and blindness is and blindness is a serious problem which may occur. Hence, get your vision checked regularly to prevent retinopathy.
Avoid having quick coffees. Fancy cups of coffee are full of sugar, which lead to glucose and insulin fluctuation in your body.
You must stay active and fit. This is the most important lifestyle choice for any diabetic patient. By exercising, you will maintain a good shape, your metabolism gets boosted and the insulin production increases as well.
You should use a pedometer to calculate how much you are moving each day while exercising.
Try to consume fruits and vegetables. By trying new vegetables and fruits, you will be able to keep your blood sugar under check and see how your body reacts.
You must increase your amount of fibre intake. Fibre is important for diabetic patients, which keeps the digestive processes to run smoothly. Your cholesterol level decreases and blood sugar levels may reduce if you take enough fibre.
You should chew gum as it keeps your mouth busy. It makes you crave for less food.
You should eat on smaller plates. This is a psychological trick which makes you consume less amount of food and your sugar and calorie levels are maintained.
Before taking any food item or eating out, gather information about them. Learn about diabetes friendly food options at restaurants and check which products you should avoid buying from the market.
You should get your blood sugar levels checked regularly. You should check it several times a day to learn how your body responds to food.
Circulation problems may cause issues with your feet, which may lead to a lack of sensation, cuts and scrapes. Check your feet regularly to notice changes.
Instead of having 2,3 large meals a day, you should take several small meals throughout the day. This will keep your body s digestive processes active thereby increasing insulin sensitivity.

World Diabetes Day Special - 15 Ways to Effectively Manage Your Diabetes

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