Interstitial cystitis (IC), also known as painful bladder syndrome, is a difficult condition. It is difficult to diagnose and though there are treatments that can make life easier, there is no long-term cure. Interstitial cystitis is a lifelong bladder problem, that causes pressure and pain below the belly button. Symptoms can be constant, or they may fluctuate. It causes painful and urgent trips to the bathroom. In severe cases, you may need to urinate about 40 to 60 times in a day.

What causes interstitial cystitis (IC)?

The bladder is a hollow, muscular organ that holds the urine your body needs to dispose. The reason why IC occurs isn t that clear, but there a few ideas:
1. An issue with bladder tissue allows chemicals in your urine to irritate the bladder.
2. Chemicals that are released when there is an inflammation in your body can cause the symptoms.
3. The bladder can be attacked by your immune system
4. Substances in your urine can damage your bladder
5. Nerve problems can wreak havoc on your bladder

Signs and Symptoms
People suffering from IC don t display the same symptoms. The symptoms keep changing, be it every day, every week or every month. Sometimes, the symptoms may entirely disappear without treatment. Some common IC symptoms include:
1. Bladder pressure and pain that worsens after the bladder gets filled with urine
2. Pain in your urethra (the tube that drains the urine from your bladder), pelvis, lower back and lower tummy
3. Women experience vaginal pain (or the area behind it) or in the vulva
4. In men, a sensation of pain in the penis, testicles, scrotum or the region behind the scrotum
5. The urge to urinate, even if you had urinated a few moments ago
6. Women experience pain during intercourse
7. Men experience pain after sex or during orgasm

One common symptom shared by all people suffering from IC is a swollen bladder. There are certain things that can worsen your condition. These include:
1. Certain drinks or foods
2. Physical or mental stress
3. Menstrual cycles

Interstitial Cystitis (IC) - 5 Things That Can Cause it

Causes and symptoms of acute tubular necrosis

Damage or destruction to tube-like structures known as tubules in the kidneys can bring about the development of acute tubular necrosis (ATN) and subsequently, acute kidney failure.

What causes acute tubular necrosis (ATN)?

A lack of supply of oxygen to the cells in the kidney is the most common cause of this condition. The reason as to why oxygen may not reach the cells and tissues of this organ could be restriction or blockage of the pathways. When this happens, the kidneys get damaged. Dehydration is the most important cause of ATN which may be because of loose motions, vomitings, heat stroke etc.

Health conditions such as diabetes, heart attack, and stroke can bring about a decrease in blood flow to the organs resulting in ATN and death of cells. Similarly, the presence of toxic substances in the blood can also lead to tubules damage and change the way the cells function in the tubules.

Other causes that may lead you to develop ATN may be medications, radiology dyes, anesthetics and chemicals that cause your body to react adversely.

In addition to these causes, a number of factors can put you at risk of ATN and there are:

- An injury to the body, more specifically your kidneys can cause clotting of the blood vessels
- An adverse response to blood transfusion
- Instances of septic shock can slow down blood flow to the organs
- A major surgery that can interrupt blood supply to the organs

What are the symptoms of the condition?

The symptoms associated with the condition can vary depending on the severity of the problem.

You may experience:

- Troubles in waking up
- Drowsy feeling even during daytime
- Feelings of lethargy
- Feelings of excessive thirstiness
- Problems with urination
- Fluid retention problems
- Instances of confusion
- Feelings of nausea



Can Acute Tubular Necrosis Cause Kidney Failure?

Nephropathy is also known as renal disease. It is any type of damage or disease relating to the kidneys. Though not everyone with diabetes has nephropathy, however, diabetic nephropathy can cause kidney failure.

How does diabetes affect the kidney?
Kidneys are responsible for taking waste out from your blood. They have a lot of tiny blood vessels to do this. High blood sugar may kill such blood vessels. Once these blood vessels are destroyed, the kidneys may not function as well or it may even lead to kidney failure.

What increases your risk of getting diabetic nephropathy?
There are several factors which increase your risk of getting diabetic nephropathy including: \
1. High blood pressure
2. High cholesterol
3. Smoking
4. Being native american, african american or of hispanic origin, for whom risk factors have proved to be magnified
5. If you have family history of diabetic nephropathy

Symptoms and diagnosis:
There are very few noticeable symptoms, which appear when you have diabetic nephropathy, except swelling in your arms and legs. The diagnosis is done by checking for a type of protein in your urine known as albumin, which is not supposed to be there. Getting the diagnosis done early is crucial.

Preventive measures
You can prevent kidney damage by doing the following:
1. Keeping your blood sugar levels under control - keep hba1c &lt; 6-7%
2. Keeping your blood pressure under control in the range of 130/80
3. Eating healthy food
4. Exercising regularly
5. Not eating too much protein
6. Not eating too much salt
7. Reducing smoke or excessive tobacco usage

Medicines for treatment
If you do get diabetic nephropathy, here are some medicines, which can help cure it
1. Ace inhibitors which are also called angiotensin-converting enzyme inhibitors
2. Angiotensin ii receptor blockers (arbs)

Possible complications
1. Blood pressure may rise
2. Triglyceride levels and cholesterol levels may rise.

All About Diabetic Nephropathy

Kidney stones can range from being the size of a grain to a pebble. These stones can be described as crystallized mineral deposits in the kidneys. Some kidney stones can be passed out of the body along with urine while others may require surgery. Symptoms of having a kidney stone vary from mild to severe. In the case of very small kidney stones, the patient may not experience any symptoms at all. The 5 most common kidney stone symptoms usually experienced are:

Pain: Pain in the lower abdomen and back is one of the most common symptoms of having a kidney stone. This may be felt just below the ribs, on the centre and sides of the abdomen, in the lower back and in the groin. The intensity of pain is not directly related to the size of the kidney stone. This pain can come and go and will vary in terms of intensity. In certain cases, the pain can be severe enough to warrant a trip to the hospital. This pain is usually a sign that the stone is moving.
Frequent Urination: People suffering from kidney stones may find themselves needing to go to the bathroom more often than normal. In some cases, patients may also wake up in the middle of the night with the urge to urinate. However, only a small amount of urine may be passed at a time. This is a sign that the kidney stone has moved into the lower urinary tract. Small stones may later be passed out of the body along with urine.
Bloody Urine: Urine should ideally be pale yellow. Patients suffering from kidney stones may notice that their urine is darker than normal and cloudy. There may also be blood in the urine. This is known as hematuria. The colour of blood in such cases can range from pink to brown. Cloudy urine is also considered a sign of a urinary infection. This is a sign that the urine also contains pus cells or pyuria.
Nausea: Vomiting and nausea are common symptoms of kidney stones. This is caused by the nerve connections shared by the kidneys and the gastrointestinal tract. The presence of kidney stones in the kidneys or urinary system can trigger an upset stomach. Some people also feel nauseous because of the pain caused by kidney stones.
Foul Smelling Urine: Under normal conditions, urine should not have a very strong smell. Urine that smells bad is a symptom of a urinary infection. Bacteria in the kidneys or urinary tract can be the cause of this smell. It may also be caused by the high concentration of urine. 

5 Symptoms Of Kidney Stones!

Polycystic kidney disease is a disorder that is inherited; it is characterized by development of cysts in the kidneys. These cysts are round sacs that contain a water like fluid. Initially, the size of the cysts are small, they tend to increase in size after the fluid accumulation. This disorder can also cause cysts to develop in the liver and other parts of the body.

Symptoms and Complications
The most common symptoms of this disorder are back pain, headache, high blood pressure and kidney failure. It can also lead to formation of stones in the kidney, presence of blood in the urine and an urge to urinate frequently. It also make your kidney prone to various bacterial infections.

Causes
The disease is caused because of the presence of defective genes in the body, implying that this disorder is primarily hereditary. In some cases, the disease is caused by a genetic mutation. Based on the causes, it is classified into two types:

Autosomal recessive polycystic kidney disease: This disorder causes the symptoms to appear immediately after birth, although the symptoms are delayed until adolescence. This disorder only occurs when both the parents carry the defective gene which is passed to the offspring.
Autosomal dominant polycystic kidney disease: This disorder usually tends to occur only after the age of 30. Unlike the previous type, here only one parent needs to carry the defective gene that is passed on to the offspring.
Treatment
The treatment of polycystic kidney disease generally involves dealing with the following signs:

Pain: Chronic pain, usually in the sides of the body or the back, is a common symptom of this disorder. You can opt for pain reliving medication such as ibuprofen. If the cysts are large, then surgery is required to ease the pain.
High blood pressure: High blood pressure is best controlled by a following a healthy diet and lifestyle. High blood pressure can damage the kidneys severely. Medications may also be required to control blood pressure, if it rises abnormally.

Frequent Urination - Can it be a Sign of Kidney Disease?

Polycystic Ovary Syndrome (PCOS) is a condition, which is born due to an imbalance of hormones within the female body. When this happens, the female body faces anumber of problems as far as her periods or menstrual cycles goes, besides finding it difficult to conceive naturally and easily. Let us find out more about this condition.

PCOS and hormones
To begin with, let us understand what hormones are. These are chemical impulses that send messages to various parts of the brain and rest of the body to signal the release of other kinds of hormones that may be vital for various functions. In PCOS, it is normally seen that the sex hormones are thrown out of balance, due to which the ovaries start producing a small dose of some male hormones. This creates problems as far as ovulation is concerned and also, it gives rise to the growth of facial hair, acne and changes in the overall appearance of the patient. Insulin resistance is another cause that may also trigger PCOS. It is also an inherited issue in many cases.

Symptoms
From irregular periods to an increase in acne and facial hair, there are many symptoms that may point at the existence of this condition. Fertility problems and issues related to normal ovulation are also often seen in women who are suffering from this condition due to the irregular periods. Additionally, depression may be seen in many patients who are suffering from this condition on a chronic basis. Thinning of hair and excess weight gain with difficulty in losing extra pounds may also be indicative of PCOS.

Diagnosis
The diagnosis of PCOS is usually done with the help of a physical examination as well as a blood test that will primarily help in determining the sugar levels and insulin. The doctor will also conduct other hormone tests so as to understand which hormones are not in balance and which ones may be triggering changes in the body. Apart from all this, the doctor will also study the body mass index (BMI) of the patient to find out if there has been a sudden and drastic change on the weight of the patient. During the lab tests, where the blood and urine are examined, the doctor will also seek to rule out any anomalies in the thyroid gland. An ultrasound of the ovaries will also be conducted.

Treatment
Weight loss programs as well as diet tweaks that remove excess dairy and meat may be recommended by the doctor. Further, the doctor may also put the patient on birth control pills so as to bring better balance of hormones. Moreover, moderate exercise will be required for the patient so that the normal production of hormones may be resumed eventually. 

PCOS - How It Can Be Diagnosed?

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