Addison s disease is known as adrenal insufficiency or hypocortisolism. It is a hormonal disorder which occurs when adrenal glands which are located just above the kidneys do not produce enough of the hormone. The hormones produced by adrenal glands include cortisol and aldosterone, which are essential for a healthy life.

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and darkening of the skin also sometimes. Most cases of Addison's disease are caused by autoimmune disorders.
It is quite a rare condition. Only 1 in 1 lakh suffer from this condition. this condition can affect a person of any age group irrespective of sex. To live a normal life people, with this condition, a patient will be required to take their medication regularly.

Cortisol and Aldosterone - What do they do?
The most important function of the cortisol in the body is to respond to stress. It helps the body in using protein, carbohydrates, and fat. It maintains blood pressure, cardiovascular function; and controls inflammation. While as aldosterone helps kidneys in regulating the amount of salt and water in the body   which helps in regulating blood volume and keeping blood pressure under control.

Cause of Addison's Disease
Mostly Addison s disease occurs due to problems with adrenal glands themselves   which is known as primary adrenal insufficiency. While Autoimmune disease accounts for 70% of Addison s disease. In this condition, the body's immune system mistakenly attacks the adrenal glands. This attack destroys the outer layer of the glands.

Some long-term infections such as tuberculosis, HIV, and some fungal infections harm the adrenal glands. It is also caused by the cancer cells that spread from other parts of the body to the adrenal glands.
Less commonly, adrenal glands can also be affected by secondary adrenal insufficiency. It is caused by a problem with the pituitary gland or a problem with the hypothalamus, both located in the center of the brain.
These glands produce hormones that control the production of hormones in the rest of the body. A pituitary hormone called ACTH which turns on cortisol production in the adrenal gland. If ACTH levels are too low, the adrenal glands do not function.
One more cause of secondary adrenal insufficiency is also caused by the prolonged or abuse of steroid hormones such as prednisone.
Symptoms of Addison's disease
The symptoms of adrenal insufficiency grow gradually and the main characteristics are:

Chronic, worsening fatigue
Muscle weakness
Loss of appetite
Weight loss
About 50 percent of the time, one will notice:

Nausea
Vomiting
Diarrhea

A Quick Guide To Addison's Disease!

Diabetes is caused in your body due to an insulin imbalance or improper functioning of insulin, and it can affect multiple parts of your body within a short time. Therefore, regular check-ups of your body are very essential to know if you have diabetes.

Once you find out that you have tested positive for the disease, you need to become even more thorough in your testing to find out if your blood sugar levels are rapidly fluctuating. If they get out of hand, they may cause medical emergencies that may be impossible for you to tackle alone at home.

Hence, daily monitoring of blood sugar is of great importance, and can be done in the following ways-

  Monitoring with a meter - In this rather simple but effective way, you have to draw blood from a small puncture on your skin made with the help of a needle or small pricking device. The blood is placed on a strip and then introduced on a testing meter, which displays accurately your blood sugar levels.

  Meters that monitor blood from several body parts - There are meters that monitor glucose levels in blood from several parts of the body. These parts include the base of the thumb, and the forearm too. This method of diagnosis is particularly helpful for those whose blood sugar levels constantly fluctuate, as this device provides an average of blood sugar levels from different parts of the body, as a composite whole.

  Continuous glucose monitoring systems - Known as interstitial glucose measuring devices popularly, they give results not as accurate as the other two devices, but still a fairly accurate estimate.

How to keep your sugar levels in constant control?

If your blood sugar levels are too high or too low, you have to bring them to normal via treatment, and if they are at a harmless level, you have to maintain it at that mark. There are several ways to maintain your sugar levels at acceptable rates. They are-

  Daily regulated exercise - Daily exercise dramatically helps your health if you have diabetes because it increases your insulin sensitivity and promotes better utilization of it in your body. Exercise is also helpful to guard you against other illnesses related to high bad cholesterol, or a weak immune system.

  A balanced, healthy diet - A balanced diet helps you keep your sugar levels in check while providing you with the requisite nutrients for making your body even healthier. Make sure to include an abundance of fresh fruits and green leafy vegetables in your diet, and cut down intake of fast, processed and extremely sugary foods/beverages.

  Drinking plenty of water - Drinking adequate water hydrates your body, and contributes to a healthy diet. It also reduces your risk of diabetes and guards you against diseases like gallbladder stones which are caused due to a lack of water in your body.

  Stay mentally sound and stress-free - Controlling your stress and anxiety levels can work wonders for your diabetes. If you make it a goal to stay stress-free about factors that are beyond your control, and be optimistic about life in general, it could work wonders for control of your diabetes.

Diabetes is a potentially life-threatening disease with a host of secondary complications. To avoid the worst of it, make sure you go for regular medical checks. If you do happen to be diagnosed with it, perform regular tests to check your levels, and take adequate measures to keep it under firm control.

Ways To Monitor Blood Sugar And Followup Care!


Many overweight and obese people have darkened and a rather flaky texture behind neck, darkening in armpits and other parts of body with creases and folds like elbows, knees or knuckles. This is commonly mistaken as smudge of dirt, uncleanliness or lack of hygiene. Some people think that it is due to repeated friction caused by necklace or chains etc. In fact it is a sign of'diabetes' which is already developed or might develop in future.

This darkening is due to excessive cell growth and differentiation of fibroblasts caused by excess of insulin in the body especially in obese individuals and type 2 diabetes patients.

In obese individuals and type 2 diabetes patients excess amount of fat especially abdominal fat (tummy fat) causes resistance to action of insulin secreted by pancreas and tends to hamper its action. In return, body produces more and more insulin from pancreas to keep blood sugar under control. This excess amount of insulin secreted by body promotes this skin cell growth leading to the visible condition called'acanthosis nigricans' in medical terms.

After producing excess amount of insulin pancreas start exhausting, this converts into diabetes. At this stage diabetes can be prevented by simple lifestyle modifications &amp; focussed weight loss.

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Are Dark Cracks Behind Neck A Sign Of Diabetes?

Insulin is the most common treatment prescribed for people affected with diabetes. Diabetes is condition where high amounts of glucose prevail in the blood for an extended period of time. However, there are some drugs that offer an alternative to insulin in treating diabetes, which are:

1. Liraglutide: Liraglutide is a glucagon-like peptide-1 (GLP-1) drug that causes the body to release greater amounts of insulin so as to facilitate the movement of glucose from the blood to the cells. People with type 2 diabetes generally use this treatment. It slows the digestion process and can cause symptoms of headache and nausea. 

2. Pramlintide: It's an artificially produced version of amylin. It is taken by both type 1 and type 2 diabetic patients, facilitates slower digestion of food and therefore, controls release of sugar in the blood. It can cause tiredness and nausea.

3. Dulaglutide:This treatment is for people affected with type 2 diabetes and it is administered once a week. It causes more insulin to be released and pass the glucose to the cells. It can cause loss of appetite, nausea and abdominal cramps as side effects.

4. Albiglutide: This treatment facilitates pancreas to release insulin and limits the glucagon hormone production. It is used by type 2 diabetes patients who have not taken well to other treatments. The side effects are skin reaction, respiratory tract infection and nausea.

5. Exenatide: It is a drug that causes pancreas to release insulin that facilitates movement of glucose to cells. It is a treatment for type 2 diabetes and it restricts release of glucagon in the body. The possible side effects are acidity, constipation and vomiting.

Common Insulin Alternatives

10 symptoms that signal hypothyroidism

When your thyroid malfunctions, you may face difficult health issues. Hypothyroidism leads to excessive weight gain and a lot of other medical ailments. It can be identified by a bunch of symptoms which if present, should not be taken lightly.

1) weight gain - if there is sudden and unexpected weight gain, this is the earliest and definite sign of an underactive thyroid gland. This means that there are strong chances of lowered levels of t3 and t4 hormones in the body, leading to slow metabolism in the body. People suffering from hypothyroidism face increased body weight which becomes difficult to lose despite maintaining healthy diet and exercising rigorously.

2) constant fatigue - if you have slept well the night before, yet you are tired and if this is a regular feature, then chances are that your thyroid gland is underactive. Being low in energy, it gets difficult to complete daily chores or exercise.

3) swelling in the neck - another telltale sign would be goiter - an abnormal swelling in the neck. The thyroid gland mainly concentrates iodine from the blood to create both the thyroid hormones. If there is iodine deficiency in the body, this process gets disrupted resulting in hypothyroidism.

4) hair loss - hypothyroidism causes hormonal imbalance which in turn causes hair loss. If there is sudden, unexplainable hair loss, chances of hypothyroidism are high.

5) imbalance in body temperature - if you are suddenly feeling too cold, it is advised to get your thyroid tests done.

6) brittle nails - if your nails have become brittle, get chipped very easily and look weak, this could be an indication of hypothyroidism.

7) mood changes - the weight gained and the excessive fatigue, both trigger massive mood swings which at times, the person has no control over.

8) constipation - the contractions of the digestive tract get weakened due to low levels of thyroid hormones resulting in constipation. Chronic constipation without any apparent reason could be an indicator of hypothyroidism.

9) irregular menses - if your periods are irregular, do not take it lightly. This could be most likely because of hormonal imbalances which are caused by hypothyroidism.

10) slower heart rate - if your heart beats at less than 60 times per minute, it could be because of the interference by thyroid hormones.

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10 Symptoms That Signal Hypothyroidism. Do You Have Any Of These?

To understand about hypothyroidism, it is essential to first understand the thyroid gland. Thyroid is an endocrine gland situated in the neck and produces the thyroid hormone. This hormone is then carried through the blood to different cells of the body. It helps the organs to function properly maintain the temperature of the body. The two thyroid hormones are Triiodothyronine (T3) and Thyroxine (T4). They regulate protein, fat, carbohydrates and vitamins in the body along with the metabolism. They are also responsible for the proper differentiation and development of cells.

Hypothyroidism or underactive thyroid or low thyroid
This is a condition where the thyroid gland is underactive and produces a low amount of the thyroid hormone. To help the thyroid gland produce the required amount of T3 and T4 hormones, the pituitary gland will make additional thyroid stimulating hormone called TSH. Due to this additional secretion of TSH, one also develops chance of thyroid gland enlargement and in some cases, it can form a goiter. 

The major cause of the low level of thyroid hormones is considered to be iodine deficiency. Hence the addition of iodine to the common salt has always been considered to be a safe method to prevent goiter. There can be several other causes of hypothyroidism such as weak immune system, radiation, surgery, Hashimoto s disease, hormonal changes etc. It can be caused due to pregnancy and is called postpartum thyroiditis.

Symptoms of Hypothyroidism
Whatever be the cause of hypothyroidism, it can show the following mild symptoms:

Increased sense of fatigue or tiredness
Sudden increase in weight with puffiness on the face
Hoarse voice
Muscle weakness with aches, tenderness and stiffness
Joint pain or stiffness
Increased sensitivity towards cold thus causing dry skin
Constipation due to slow metabolism
Decreased heart rate
Elevated blood cholesterol level
Irregular menstrual periods
Decreased concentration and depression too
However, it is important to understand that you may show no symptoms or show some mild symptoms that can be easily confused with some other condition. Hence, a proper diagnosis is a must to confirm hypothyroidism.

Diagnosis of hypothyroidism
The most common tests to determine if you have hypothyroidism are TSH Testing and T4 Testing. In case the low level of TSH is due to a defect in the pituitary gland, your doctor may request for another test called TRH. Also, Anti-thyroid Microsomal Antibodies Testing or thyroid peroxidase test (TPO) helps in identifying if the thyroid gland is damaged.

Treatment of hypothyroidism
Hormone replacement therapy is the best form of treatment available today. It involves the use of synthetic Levothyroxine (T4) or liothyronine (synthetic T3). Before these synthetic hormones were used for several years, however, prescribing thyroxine tablets is the most common mode of treatment and they are generally given for a really long period of time, although the dosage may vary. It is only in rare cases of severe decompensated hypothyroidism that one requires hospitalization.

Apart from the above treatment options, it is best advised to avoid soy products, sugary processed foods and alcohol to keep a check on hypothyroidism. In case you have a concern or query you can always consult an expert & get answers to your questions!

Hypothyroidism - Signs Your Kid Is Suffering From It!

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