HIV: QUICK FACTSIntroductionThe human immunodeficiency virus (HIV) is a subgroup of retrovirus (lentivirus) that causes HIV infection. After a period of time, this infection leads to what is called acquired immunodeficiency syndrome (AIDS).

Epidemiology

According to the Centers for Disease Control and Prevention (CDC), from 2010-2015, the estimated rate of HIV infection in all 50 US states decreased from 14.2 per 100,000 population in 2010 to 12.3 per 100,000 population in 2015. In 2015, 39,513 individuals were diagnosed with HIV infection. From 2010 to 2014, the annual number of new HIV infections decreased by 9%.

Virology HIV-1 and HIV-2 are retroviruses in the Retroviridae family, Lentivirus genus. They are enveloped, diploid, single-stranded RNA viruses with a DNA intermediate.Upon entry into the target cell, the viral RNA genome is converted into double-stranded DNA by an enzyme, reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase. HIV contains three retroviral genes, namely gag, pol, and env.

Gag gene: Encodes group-specific antigen; the inner structural proteins
Pol gene: Encodes polymerase; it also contains integrase and protease
Env gene: Encodes the viral envelope, the outer structural proteins responsible for cell-type specificity. Glycoprotein 120, the viral envelope protein, binds to the host CD4+molecule
Pathophysiology

HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells and leads to cellular immune deficiency. This results in the development of opportunistic infections and neoplastic processes.

Mode of Transmission
Sexual intercourse: Unprotected sexual intercourse; especially receptive anal intercourse and different sexual partnersContact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids infected with the virus.Spread from an infected mother to her infant through breast milk. An HIV-positive mother can transmit HIV to her baby both during pregnancy and childbirth due to exposure to her blood or vaginal fluid.

Signs and Symptoms There are 3 categories of infection 

Category A: Asymptomatic HIV infection without a history of symptoms or AIDS-defining conditions
Category B: HIV infection with symptoms that are directly attributable to HIV infection
Category C: HIV infection with AIDS-defining opportunistic infections
Investigation

A high-sensitivity enzyme-linked immunosorbent assay (ELISA) should be used for screening.

Management

Start with antiretroviral therapy (ART) in all HIV-infected adults ready to start therapy. 
CD4 count is no longer a criterion for starting the therapy.
Use of nucleoside reverse transcriptase inhibitors and protease inhibitors.
For refractory cases, during the failing treatment regimen and before switching therapy, use rapid confirmation, perform resistance testing and reevaluate.

HIV - Quick Facts Need To Know!

Frequent headaches can be uncomfortable at best, and debilitating at worst. While a chronic migraine can come with a throbbing pain on one side of the head, headaches due to tension can cause mild to moderate pain on both sides. Also, daily headaches happen in at least 15 days, Hemicrania Continua is a condition that brings about constant pain, and usually happens on one side of the head. Read on to learn more about dealing with these different kinds of headaches.

1. Medical Treatment: Inflammation, infections like meningitis and brain injuries that have been proven to be traumatic should be treated with due medication after a proper consultation with a doctor. In certain cases, headaches can be caused due to brain tumours and they must be treated at once. Also, headaches that come with fever, stiff neck, confusion and constant vomiting must be treated by a doctor immediately.

2. Take an Over the Counter Drug: Taking an over the counter drug for instant pain relief can stop the pain and give temporary or long term relief, depending on the kind of headache you are experiencing. It is advisable to speak with a doctor before taking any kind of drug.

3. Find your Triggers: Find and limit your triggers like certain food types as well as stress and certain seasonal changes. Stepping out in the summer with an umbrella and avoiding caffeine or too much of chocolate and cheese can also help in alleviating the pain. Stress is also a major factor that contributes to headaches and should be avoided in order to prevent or stop the pain.

4. Drink Plenty of Water: Staying hydrated is a good way to treat headaches instantly. The consumption of water is known to soothe the pain effectively.

5. A Soothing Break: Find a quiet place with dim lighting to take a break that should ideally last at least half an hour to one hour, or even more. This will help in diminishing and removing the pain. You can also use a cold compress and get yourself a massage.

5 Ways To Deal With Headaches

Hives, also known as urticaria, is characterized by an outbreak of swollen red bumps on the skin. It may cause symptoms of itching, burning or stinging. The disorder can affect any part of the body including the tongue, throat and face. The size of the bumps can vary, they may join together to form plaques. The bumps or plaques appear and disappear until the disorder runs its course. In case of chronic hives, the bumps can last up to six weeks.

Symptoms
The symptoms of this disorder are formation of bumps on the body, severe itching and pain resulting from the bumps. The symptoms can get aggravated by stress, heat and exercise. You may also experience dizziness, chest pain and a swollen throat.

Causes
Chronic hives can be caused when specific cells in the body release histamine in the blood. The exact cause of this disorder is not known. This reaction of releasing histamine in the blood can be triggered by factors like: 
1. Insects
2. Medications to control pain
3. Scratching
4. Exposure to cold and heat
5. Excessive consumption of alcohol
6. Heavy exercise

Being a female and being young raises your risk of being affected by this disorder.


Ayurvedic Treatment
The first line of treatment for hives is the use of home remedies. The doctor will aim to treat any underlying condition, if any. Ayurvedic remedies for hives are holistic and free from side effects. They are based on natural ingredients that do not cause any adverse effects on the body.

The Ayurvedic treatment for this disorder are

Herbs: Certain herbs like turmeric are very effective to treat this condition. It is known for its anti-inflammatory properties that help relieve its symptoms. A mixture of rock salt and mustard oil can be applied on the affected part to foster speedy recovery.
Diet: You need to follow certain dietary guidelines so that the symptoms do not get aggravated. Avoid taking foods that are sour and salty. Include plenty of buttermilk as it has a cooling effect on the body.

Chronic Hives - How Ayurveda Remedies Helpful in Treating it?

When a condition is painful, it is common to hate it. And, when the condition is the piles, you will hate it more, because, along with the pain it might embarrass you as well. Characterized by the enlargement of blood vessels that surround the anus, when the veins tend to swell towards the lower-end of the rectum and anus, it is called piles. Swelling of the veins that are located within the rectum is called internal haemorrhoids. External piles is a condition where the veins towards the external part of the anal verge become swollen.

Symptoms that you may not fail to notice

Red blood spots on toilet paper, stools, or toilet bowl are a few symptoms of piles. This occurs when the pressure within the veins increases and causes them to tear and cause bleeding.
The patient also experiences pain during and after passing stools. This is due to inflammation of the veins that causes their swelling. The swollen veins apply strain on the muscles, cause spasms and is the reason for the discomfort that patients experience.
Persons suffering from piles may also face itching around the anal portion. The inflamed veins ooze mucous that gives rise to inflammation around the anus and causes itching.
Know the causes and how you can prevent it:

The primary cause for the piles is attributed to one factor which is heightened abdominal pressure. 
Consequently, there is a build-up of pressure in the veins around the anus that causes the piles disorder.
The various causes for an increase in abdominal pressure are flatulence, constipation, obesity, sedentary lifestyle, diarrhea, pregnancy and sitting for prolonged durations.
What is the approach? 
Homeopathy serves as an effective cure for piles because it adopts a holistic approach. The homeopathic medicines are prescribed after studying the medical history of the patient and present physical condition. The person s predisposition to illnesses is also scrutinized by the homeopaths.
Unhealthy lifestyle habits are recognized to be the reason for bloating of the anal veins and piles symptoms. Hence, homeopathy aims to correct the underlying conditions that are causing the discomfort.

Why homeopathy?
Homeopathy medications are considered effectual for alleviating the discomfort of the hemorrhoids by controlling the bleeding. Additionally, the treatment methods provide a permanent cure for the disorder because they address the underlying cause. The treatment is also focused on treating conditions that give rise to piles. And, there are no worries of side effects.

So, if you have been suffering from piles for a while now and seeking a definitive cure without side effects, you can very well opt for homeopathy under the able guidance of a homeopath practician.


Piles - Treating It The Right Way With Homeopathy!

People with spine problems face tough choices when considering treatment. Depending on the severity and scale of the disorder, you will have to decide which treatment works the best for you, and keep an eye out for its long-term impact. Owing to the numerous myths and misconceptions surrounding spine surgery, many patients are unreasonably reluctant to consider this as a treatment option.
Before you make your mind, learn the truth behind these myths about spine surgery. 

  Myth: Spine surgery invariably leads to paralysis

Fact: With the introduction of modern technology in the field of medical science, the efficacy and success rates of spine surgery has improved significantly. The chances of paralysis following surgery are less than 1%. Latest advancements in operating techniques have made the procedure safer and more effective than before.

  Myth: You might require multiple surgeries following spine surgery in the future

Fact: In over 90% of all cases, one successful spine surgery at the right time is all you need to treat the disorder. Majority of patients can do without a second surgery. However, it is essential that patients follow all the instructions and preventive measures to make the surgery successful. The post-treatment guidelines include simple things, such as   eating healthy, reducing and maintaining body weight, exercising regularly, quitting tobacco etc. In rare cases, failing to keep up with these instructions may lead to the need for a second surgery.

  Myth: Spine surgeries are painful

Fact: This was once true when open spine surgeries requiring long incisions were performed   but not anymore. Spine surgeries are now relatively painless as compared to earlier times   all thanks to technological advancements. The modern-day minimally invasive procedure has made spine surgery less painful with no or minimal complications, as you need not go under the knife, literally. In fact, patients do not require anaesthesia before opting for the procedure.

  Myth: You will be bed-ridden for life after the surgery

Fact: The common belief among people is that they will never be able to walk again after spine surgery. But that is not true. With minimally invasive techniques and keyhole surgery, the patient is able to walk the very same day of the surgery. In most cases, they are discharged in a few hours following the procedure. Moreover, pain management techniques and physiotherapy have made it easier for patients to move about without much difficulty.

  Myth: The complication rates are very high in the case of surgery

Fact: With advancements in technology, the overall rates of complications have reduced drastically   less than 3% precisely. The state-of-the-art neuro-monitoring system monitors every nerve during the surgery and allows no scope for error. Surgeons have reportedly been able to avoid all nerve-related complications and offer a 100% success rate using this technique.
The decision to undergo spine surgery can be difficult and the misconceptions floating around do not make it easier. Nevertheless, distinguishing the facts from myths is important. Be sure to discuss any concerns or questions you may have with your physician. They can clear your doubts and help you find out if surgery is the appropriate approach to treat your condition.

Myths About Spine Surgery - Debunked!

What is anemia?

Anemia is due to lack of haemoglobin in the blood which is below the normal level or due to less than normal levels of red blood cells in blood.

The haemoglobin helps carry oxygen in blood. Lack of haemoglobin thus causes deficiency of life giving oxygen to vital organs. (1-4)

Types of anemia

There are various causes of anemia. It could be due to:

Decreased production of RBCs in blood
Increased blood loss OR
Excessive destruction of RBCs
Causes of anemia
Anemia most commonly occurs due to nutritional problems. This includes lack of iron in the diet.
Iron deficiency is the commonest form of anemia.
In the United States 7% of toddlers ages 1 to 2 years old and 9-16% of menstruating women suffer from iron deficiency.
The poorer nations 30-70% of the people have iron deficiency anemia.
Iron and anemia

Since iron is needed for the manufacture of haemoglobin in the body its deficiency can lead to anemia.
Iron is found in meat, dried fruit and some vegetables.
Lack of iron may be caused due to bleeding especially in stomach ulcers or within the intestines.
Women before menopause commonly suffer from iron deficiency anemia due to heavy periods and increased demands during pregnancy.
Vitamins and anemia

Certain vitamins like vitamin B12 and folic acid or folate are also essential in the normal production of RBCs in blood. Their lack in diet may lead to anemia.
Both vitamin B12 deficiency and folate deficiency are more common in older people, affecting around 1 in 10 people above the age of 75.
There is an inherited condition called Pernicious anemia where patients find it difficult to use the vitamin B 12 in diet for production of healthy RBCs. This is a rare condition and affects 1 in 10,000 people in northern Europe.
Other causes of anemia

Increased blood loss due to surgery or major trauma may lead to anemia.
Excessive destruction of RBCs may occur due to certain conditions called haemolytic anemias. These are often inherited and include Sickle cell anemia, Thalassemia etc. Anemia can also occur in severe infections, cancers and due to exposure to a drug or toxin.
For example, the RBCs are made in bone marrow. If there is cancer in the marrows a shortage of good red blood cells results. This is called aplastic anaemia and may also occur with blood cancers like leukaemia.
Symptoms

Anemia signs and symptoms vary depending on the cause of your anemia. They may include:

Fatigue
Weakness
Pale or yellowish skin
Irregular heartbeats
Shortness of breath
Dizziness or lightheadedness
Chest pain
Cold hands and feet
Headache
At first anemia can be so mild that it goes unnoticed. But symptoms worsen as anemia worsens.

Treatment of anemia

Treatment depends on the cause of the anaemia. If the anaemia is due to a lack of iron, eating iron-rich food or iron supplements may be given. If, however, the cause of anemia is deeper like internal bleeding or cancers, the cause should be explored before treatment. When the anaemia is more severe, a blood transfusion may be prescribed.

Anemia - Causes, Symptoms & Treatment Of It!

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