Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

World brain tumor day is observed on the 8th of june every year. The german brain tumor association initially took this initiative and it is celebrated worldwide to educate people about the brain tumor. 

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What is brain tumor? 

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When abnormal cells grow inside the brain and are in the form of a mass the condition is called a brain tumor. There are various types of brain tumors that exist. Some of the existing brain tumors are malignant or cancerous while others may be non-cancerous.

 

A brain tumor can begin in any part of the brain and spread to other parts of the body or vice-versa. The growth rate of brain tumors is different for each individual suffering from it.

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What are the symptoms of a brain tumor? 

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If a person is suffering from a brain tumor he/she may be exhibiting the following symptoms: 


	
	Headaches in the morning after waking up, while sleeping
	
	
	The headaches will get worse after coughing and sneezing
	
	
	Vomiting
	
	
	Change in the mental functioning
	
	
	Confusion
	
	
	Clumsiness
	
	
	Effect on the memory
	
	
	Loss of balance
	
	
	Numbness or tingling sensation on one side of the body
	
	
	Trouble in speaking
	
	
	Blurred vision
	
	
	A person might have seizures without any previous history of neurological disease
	


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Risk factors of a brain tumor 

There are some risk factors that increase the risk of brain tumors in individuals


	
	The risk of brain tumors increases with age.
	
	
	This condition can also be inherited from the family however, the chances are only 5 to 10 percent.
	
	
	The risk of brain tumors increases in people who have been exposed to ionizing radiation.
	
	
	If a person is exposed to certain chemicals then they have an increased risk of suffering from a brain tumor.
	



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Treatment of brain tumor

 

The treatment of brain tumors depends on the location, size, and type of the tumor. The general health of the patient is also taken into consideration. The treatment which is common for brain tumor is surgery. The objective of the surgery is to remove as much of the tumor as possible without damaging the other parts of the brain. For surgery to take place the tumors must be located within the area of limits of the surgery.

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Doctors may suggest the following treatments according to the type, grade, and position of tumor and the general health of the patient.

 


	
	Surgery
	
	
	Radiation therapy
	
	
	Chemotherapy
	
	
	Anti-seizure medicines
	
	
	Steroids
	
	
	Ventricular peritoneal shunt
	
	
	Combination of treatments
	


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World Brain Tumour Day: All About Brain Tumour- Risk Factors, Symptoms And Treatments

Hepatitis is a condition that affects the liver by causing inflammation which is a common outcome resulting from a viral infection. While different types of hepatitis diseases are caused by different causes, there are some reasons like medications, toxins, alcohol, and drugs that are typically known.

 

Types

The five common types of viral hepatitis are hepatitis a, b, c, d, and e.

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	Hepatitis a
	


Hepatitis a is the result of an infection caused by the hepatitis a virus. This type of hepatitis is an acute disease.

 


	
	Hepatitis b
	


The hepatitis b virus causes hepatitis b. This is often a chronic disease that lasts longer.

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	Hepatitis c
	


Hepatitis c comes from the hepatitis c virus. It is one of the most common bloodborne infections in the world. It is a long-lasting condition.

 


	
	Hepatitis d
	


This is a not so commonly found form of hepatitis that only occurs in hepatitis b infected people. This virus not only causes liver inflammation but also cannot be contracted without an existing hbv infection.

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	Hepatitis e
	


Hepatitis e is waterborne. Hepatitis e virus infection is responsible for it. It is generally acute but can be severely chronic for pregnant women.


 

Causes of viral hepatitis

It is true that different types of viral hepatitis infections are caused by distinct modes of transmission. Here are the causes of a hepatitis infection:

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	Hepatitis a- when a person is exposed to the hepatitis a virus through food or water.
	


 


	
	Hepatitis b- when an individual comes in contact with hepatitis b virus through the transmission of bodily fluids like blood, semen, etc.
	


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	Hepatitis c- when someone gets infected with the hepatitis c virus through the contamination of bodily fluids.
	


 


	
	Hepatitis d- when a person is exposed to hepatitis d virus-infected blood, it causes this disease.
	


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	Hepatitis e- when a person comes in contact with the hepatitis e virus through water or food.
	


 

Causes of non-viral hepatitis

Although hepatitis is commonly caused due to an infection, other factors can also be reasons to cause hepatitis.

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Alcohol

Excessive alcohol can lead to liver damage, causing inflammation. It can also be called alcoholic hepatitis. The alcohol impacts the liver cells directly. Moreover, it can also cause cirrhosis or even permanent liver failure.

 

Autoimmune system response

In rare cases, the immune system of a person attacks the liver itself. It leads to inflammation that can be mild to severe according to the infection. Moreover, it s more common in females than in males.

How Is Hepatitis Caused And Some Common Types?

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

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	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

Type 1 diabetes occurs when your pancreas is unable to produce enough insulin to keep the blood sugar ;levels under control. The condition, if not managed properly, can lead to related health disorders and complications, both long-term and short-term.

Health problems arising from type 1 diabetes

Type 1 diabetes can have severe effects on your eyes, kidney, nervous system, and heart health. The most common ailments associated with type 1 diabetes may include the following-

1. Diabetic retinopathy

Diabetic retinopathy is a disease of the eyes, which occurs when the blood vessels in the retina (tissue present at the back of your eyes) are damaged. The walls of the retina gradually weaken from increasing blood pressure and blood sugar levels, and this leads to leakage of blood or fluid into the nearby tissues.

Early symptoms of diabetic retinopathy include-


	
	Blurred vision
	
	
	Floaters
	
	
	Difficulty perceiving colors
	


2. ;Diabetic neuropathy

Diabetic neuropathy unfolds when the nerves are damaged due to type 1 diabetes. The condition mostly affects your feet and legs. Reduced blood circulation due to high blood glucose impedes normal wound healing in the extremities, hence, even a minor bruise ;can develop into a permanent injury.

Symptoms of diabetic neuropathy are-


	
	Numbness
	
	
	Reduced sensation
	
	
	Severe, debilitating pain in the extremities
	


3. Diabetic nephropathy

Also known as ;diabetic kidney disease, the condition is a slow deterioration of the kidney and its ability to function properly. In severe cases, where the levels of blood glucose are extremely high due to type 1 diabetes, diabetic nephropathy can ultimately result in kidney failure ;or end-stage renal disease (esrd).

The following are the symptoms of diabetic nephropathy-


	
	Dark urine
	
	
	Swollen ankles, feet, eyes, or hands
	
	
	Shortness of breath
	


4. Cardiovascular diseases

Cardiovascular diseases refer to a range of heart conditions including blood clots and diseased blood vessels. High blood glucose levels resulting from type 1 diabetes can contribute to the deposition of fat in the walls of the blood vessel. Over time, this may restrict the flow of blood and put you at risk of cardiovascular disorders such as coronary artery disease, stroke, or even ;heart attack.

Symptoms of cardiovascular diseases widely vary, ranging from palpitations ;to chest pain. Sometimes, such a condition may not exhibit any symptoms at all.

Type 1 diabetes complications are related to poor management of blood glucose. The best way to monitor the condition and control the symptoms is to get in touch with your doctor. A specialist in this field can prescribe the correct treatment and help prevent the onset the related health disorders.

Complications Associated With Type 1 Diabetes

Hepatitis- related to an inflammatory condition of the liver. It occurs mainly due to infection caused by viruses but there are other possible causes as well. Hepatitis can be temporary or viral. Temporary hepatitis, which is acute in nature, gets resolved on its own. Viral hepatitis can be of five types, a, b, c, d, and e.

Symptoms of hepatitis

Hepatitis, in its initial phase, is called the acute phase. The following symptoms along with mild flu are visible:

Loss of appetite
Fatigue
Joint pains
Pain in the abdomen
Nausea
Weight loss
Jaundice
Though this phase is not really dangerous for some patients, it can result in liver failure leading to death.

How is hepatitis diagnosed?

Physical examination
Laboratory tests
Imaging tests


Treatment for hepatitis

Treatment options for different types of hepatitis are:

Hepatitis a: this doesn t require treatment as it is short-term in nature. In case the symptoms cause a lot of discomforts, then bed rest is recommended. The vaccine is available to prevent this infection.

Hepatitis b: acute hepatitis b doesn t require treatment either. Its chronic form can be treated with antiviral medications. This can be prevented with vaccination.

Hepatitis c: this type of hepatitis, both in its acute and chronic forms, is treated through antiviral medications.

Hepatitis d: according to a study in 2013, a drug known as alpha interferon is used to treat this type of hepatitis. Unfortunately, this only comes to the rescue of 25-30% of people.

Hepatitis e: this acute form of hepatitis gets resolved on its own. Adequate rest, drinking a sufficient amount of water, and taking enough nutrients in their food are some of the ways to get healed from this disease.


 

Hepatitis: Signs, Diagnosis, And Treatment

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