Chromosomal abnormality happens when a cell has too many or too few chromosomes. The most common form of chromosomal anomaly is Down s syndrome. If a parent has a chromosomal anomaly, she/he will pass it on to the child. PGD or Pre-implantation Genetic Testing aims to select only the embryos with normal chromosomal count and only these embryos are implanted to achieve a healthy pregnancy and bring down the number of children affected with a chromosomal anomaly.

The risk of Aneuploid pregnancy:

The older a woman is when she tries to conceive (aged 35 or more), the higher the risk of Aneuploid pregnancy (carrying a baby with genetic or chromosomal abnormality). Most of these pregnancies end in miscarriages and the few that come to term produce babies with chromosomal abnormalities.

Causes of Chromosomal Abnormality:

Usually, chromosomal abnormalities occur due to an error in the cell division. Meiosis refers to the cell division, which the sperm and the egg undergo during the development procedure. Normally, meiosis breaks the chromosomal material into two equal halves, so that each of the parents contributes 23 chromosomes to the pregnancy. However, when the number of chromosomes in the cell goes up or down than the normal, it results in genetic/chromosomal anomalies.

PGD Procedure for a Chromosomal Anomaly:

If a couple elects to go for Pre-implantation Genetic Diagnosis, they have to undergo ICSI Cycle. ICSI cycle initiates a fertilization cycle to produce embryos. When the embryos reach upto day 5 and blastocyst are formed, they are biopsied and further sent to genetic lab for detecting the chromosomal abnormalities. The embryos are incubated for the entire duration of the genetic screening. Only the embryos that the genetic test clears are implanted. PGD never reveals the gender of the embryo.

PGD can help detect the single genetic disorders that may lead to the following ailments:

  Cystic fibrosis
  Muscular dystrophy
  Tay-Sachs
  Sickle cell anaemia
  Thalassemia
  Turner syndrome

PGD is a revolutionary science that can help root out incurable disorders linked to genetics. It ensures that pregnancy is sustained until term and a healthy baby is born.

Suffering From Genetic & Chromosomal Anomalies - Know About PGD!

Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

What is Bipolar Disorder?

Bipolar disorders are brain disorders that cause changes in a person s mood, energy and ability to function. Bipolar disorder is a category that includes three different conditions - bipolar I, bipolar II and cyclothymic disorder.

People with bipolar disorders have extreme and intense emotional states that occur at distinct times, called mood episodes. These mood episodes are categorized as manic, hypomanic or depressive. People with bipolar disorders generally have periods of normal mood as well. Bipolar disorders can be treated, and people with these illnesses can lead full and productive lives.

Types:

There are three main types of bipolar disorder: bipolar I, bipolar II, and cyclothymia.

-Bipolar I:
Bipolar I is defined by the appearance of at least one manic episode. You may experience hypomanic or major depressive episodes before and after the manic episode. This type of bipolar disorder affects men and women equally.

-Bipolar II:
People with this type of bipolar disorder experience one major depressive episode that lasts at least two weeks. They also have at least one hypomanic episode that lasts about four days. This type of bipolar disorder is thought to be more common in women.

-Cyclothymia:
People with cyclothymia have episodes of hypomania and depression. These symptoms are shorter and less severe than the mania and depression caused by bipolar I or bipolar II disorder. Most people with this condition only experience a month or two at a time where their moods are stable.

Symptoms:
Bipolar symptom in women:

Men and women are diagnosed with bipolar disorder in equal numbers. However, the main symptoms of the disorder may be different between the two genders. In many cases, a woman with bipolar disorder may:

be diagnosed later in life, in her 20s or 30s
have milder episodes of mania
experience more depressive episodes than manic episodes
have four or more episodes of mania and depression in a year, which is called rapid cycling
experience other conditions at the same time, including thyroid disease, obesity, anxiety disorders, and migraines
have a higher lifetime risk of alcohol use disorder
Women with bipolar disorder may also relapse more often. This is believed to be caused by hormonal changes related to menstruation, pregnancy, or menopause. If you re a woman and think you may have bipolar disorder, it s important for you to get the facts. Here s what you need to know about bipolar disorder in women.
Bipolar system in men:
Men and women both experience common symptoms of bipolar disorder. However, men may experience symptoms differently than women. Men with bipolar disorder may:

be diagnosed earlier in life
experience more severe episodes, especially manic episodes
have substance abuse issues
act out during manic episodes
Men with bipolar disorder are less likely than women to seek medical care on their own. They re also more likely to die by suicide.
Bipolar disorder in children:

Diagnosing bipolar disorder in children is controversial. This is largely because children don t always display the same bipolar symptoms as adults. Their moods and behaviors may also not follow the standards doctors use to diagnose the disorder in adults.

Many bipolar symptoms that occur in children also overlap with symptoms from a range of other disorders that can occur in children, such as attention deficit hyperactivity disorder (ADHD).

However, in the last few decades, doctors and mental health professionals have come to recognize the condition in children. A diagnosis can help children get treatment, but reaching a diagnosis may take many weeks or months. Your child may need to seek special care from a professional trained to treat children with mental health issues.

Like adults, children with bipolar disorder experience episodes of elevated mood. They can appear very happy and show signs of excitable behavior. These periods are then followed by depression. While all children experience mood changes, changes caused by bipolar disorder are very pronounced. They re also usually more extreme than a child s typical mood swing.

Manic symptoms in children

Symptoms of a child s manic episode caused by bipolar disorder can include:

-acting very silly and feeling overly happy
-talking fast and rapidly changing subjects
-having trouble focusing or concentrating
-doing risky things or experimenting with risky behaviors
-having a very short temper that leads quickly to outbursts of anger
-having trouble sleeping and not feeling tired after sleep loss
-Depressive symptoms in children

Symptoms of a child s depressive episode caused by bipolar disorder can include:

-moping around or acting very sad
-sleeping too much or too little
-having little energy for normal activities or showing no signs of interest in anything
-complaining about not feeling well, including having frequent headaches or stomachaches
-experiencing feelings of worthlessness or guilt
-eating too little or too much
-thinking about death and possibly suicide
-Other possible diagnoses

Some of the behavior issues you may witness in your child could be the result of another condition. ADHD and other behavior disorders can occur in children with bipolar disorder. Work with your child s doctor to document your child s unusual behaviors, which will help lead to a diagnosis.

Bipolar disorder in teens:

Angst-filled behavior is nothing new to the average parent of a teenager. The shifts in hormones, plus the life changes that come with puberty, can make even the most well-behaved teen seem a little upset or overly emotional from time to time. However, some teenage mood swings may be the result of a more serious condition, such as bipolar disorder.

A bipolar disorder diagnosis is most common during the late teens and early adult years. For teenagers, the more common symptoms of a manic episode include:

-being very happy
- acting out  or misbehaving
-taking part in risky behaviors
-abusing substances
-thinking about sex more than usual
-becoming overly sexual or sexually active
-having trouble sleeping but not showing signs of fatigue or being tired
-having a very short temper
-having trouble staying focused, or being easily distracted
-For teenagers, the more common symptoms of a depressive episode include:
-sleeping a lot or too little
-eating too much or too little
-feeling very sad and showing little excitability
-withdrawing from activities and friends
-thinking about death and suicide
-Diagnosing and treating bipolar disorder can help teens live a healthy life. Learn more about bipolar disorder in teenagers and how to treat it.

Bipolar and depression:

Bipolar disorder can have two extremes: up and down. To be diagnosed with bipolar, you must experience a period of mania or hypomania. People generally feel  up  in this phase of the disorder. When you re experiencing an  up  mood swing, you may feel highly energized and be easily excitable.

Some people with bipolar disorder will also experience a major depressive episode, or a  down  mood. When you re experiencing a  down  mood swing, you may feel lethargic, unmotivated, and sad. However, not all people with bipolar disorder who have this symptom feel  down  enough to be labeled depressed. For instance, for some people, once their mania is treated, a normal mood may feel like depression because they enjoyed the  high  caused by the manic episode.

While bipolar disorder can cause you to feel depressed, it s not the same as the condition called depression. Bipolar disorder can cause highs and lows, but depression causes moods and emotions that are always  down.  Discover the differences between bipolar disorder and depression.

Causes:

Bipolar disorder is a common mental health disorder, but it s a bit of a mystery to doctors and researchers. It s not yet clear what causes some people to develop the condition and not others.

Possible causes of bipolar disorder include:

-Genetics
If your parent or sibling has bipolar disorder, you re more likely than other people to develop the condition (see below). However, it s important to keep in mind that most people who have bipolar disorder in their family history don t develop it.

-Your brain
Your brain structure may impact your risk for the disease. Abnormalities in the structure or functions of your brain may increase your risk.

Diagnosis:

A diagnosis of bipolar disorder I involves either one or more manic episodes, or mixed (manic and depressive) episodes. It may also include a major depressive episode, but it may not. A diagnosis of bipolar II involves one or more major depressive episodes and at least one episode of hypomania.

To be diagnosed with a manic episode, you must experience symptoms that last for at least one week or that cause you to be hospitalized. You must experience symptoms almost all day every day during this time. Major depressive episodes, on the other hand, must last for at least two weeks.

Bipolar disorder can be difficult to diagnose because mood swings can vary. It s even harder to diagnose in children and adolescents. This age group often has greater changes in mood, behavior, and energy levels.

Bipolar disorder often gets worse if it s left untreated. Episodes may happen more often or become more extreme. But if you receive treatment for your bipolar disorder, it s possible for you to lead a healthy and productive life. Therefore, diagnosis is very important. See how bipolar disorder is diagnosed.

Role of Homeopathy in Bipolar Disorder:

The first step in our treatment method involves the use of homeopathy. Homeopathy is a system of medicine which stimulates the body to heal itself. When homeopathic medicines are prescribed properly, they work quickly to alleviate symptoms and improve overall health.

Natural remedies for bipolar disorder:

Some natural remedies may be helpful for bipolar disorder. However, it s important not to use these remedies without first talking with your doctor. These treatments could interfere with medications you re taking.

The following herbs and supplements may help stabilize your mood and relieve symptoms of bipolar disorder:

Fish oil. A 2013 study shows that people who consume a lot of fish and fish oil are less likely to develop bipolar disease. You can eat more fish to get the oil naturally, or you can take an over-the-counter (OTC) supplement.

Rhodiola rosea: This research also shows that this plant may be a helpful treatment for moderate depression. It may help treat depressive symptoms of bipolar disorder.
S-adenosylmethionine (SAMe): SAMe is an amino acid supplement. The research shows it can ease symptoms of major depression and other mood disorders.
Several other minerals and vitamins may also reduce symptoms of bipolar disorder. Here s 10 alternative treatments for bipolar disorder.

Bipolar Disorder - What Should You Know About It?

This post-traumatic stress disorder is a mental health condition, which gets triggered by a terrifying event. It can happen either through experiencing it or by witnessing it. The symptoms include flashbacks of the events, nightmares leading to severe anxiety and thoughts related to the events, which you are unable to control. Going through traumatic events is quite normal and each and every individual goes through phases, where they encounter events filled with trauma and those who have long-lasting effect on their minds. If the symptoms get worse and go on to last for months and sometimes stretch up to years, then that might be of clear indication a person suffering from Post-traumatic Stress Disorder. 

Let us discuss about the symptoms in detail

The symptoms related to the Post-traumatic Stress Disorder might start within a month after coming across a traumatic sequence.
All these symptoms pose major problems in society, work situations and also in relationships. One s ability to go about doing any normal daily task might also get hampered.
Post-traumatic Stress Disorder symptoms are usually grouped into four types. Different symptoms of each type are:
Intrusive Memories: The symptoms are included under intrusive memories are

Utterly disturbing memories of any particular traumatic event on a recurring basis.
Feel as if you are reliving the traumatic sequence
Dreams which might upset or nightmares related to the horrifying incident.
Avoidance: Symptoms related to avoidance include, trying to avoid thinking or talking about a traumatic event and also avoid going to places or interacting with people, who might remind a person of a particular traumatic event.

Thinking pattern might turn negative: Symptoms of negative thinking patterns may include:You start thinking about yourself and the world in general negatively.There is a sense of hopelessness about the future.You start to get aloof from family and friends.

Physical and emotional reactions change: Symptoms of changes in physical and emotional reactions include

You tend to get scared easily
Unable to sleep peacefully
You cannot concentrate on a particular job
Sense of guilt and shame eats you from inside
Causes

Doctors are not really sure why people suffer from Post-traumatic Stress Disorder. Like most of the health problems, this disorder is in all probability caused by a mix of:

Stressful experiences which a person has to go through while bearing any severe trauma.
Mental health risks inherited, if any of the family members suffered from anxiety and depression.
A person s temperament.
Treatment

The treatment for this Post-traumatic Stress Disorder can help people to take control of their lives once again. Psychotherapy is the primary mode of treatment followed for getting rid off this problem. Along with this, medication can also take an active part in the healing process.  A combination of these treatments can help in improving the symptoms by:

Showing the skills on how to address the symptoms
Counselling, through which people would be made to think better about themselves and others.
Different ways to help cope up, in case the symptoms arise in future.

Post Traumatic Stress Disorder - Know The Detailed Symptoms Of The Problem!


A new relationship involves a lot of weighing from both the sides. Learn what really matters to win people over in this post. When you want to build a new relationship, whether it is for work, business, personal, marriage, friendship etc there are several factors that help take off and bloom the relationship. These factors are broadly the same in different age groups as far as psychological impact matters. Some of the most important influential factors from a psychological point of view have been highlighted here. 

1. Presentation- When you want to draw someone into relationship with you for any reason, it is important that you present yourself at you best levels be it physical or mental. Like they say that the first impression is the best impression, your display of you strengths creates an impression that helps people decide what they want to do with you. This doesn't mean you should hide all your weaknesses but highlighting your strengths is as important as making your weaknesses clear. Always learn to put your best foot forward as sometimes that itself may not be enough. You can't really send your neighbour for your job interview!! There are many instances when people send different photographs in their applications and different ones appear for the exams. This is mere cheating and not winning.

2. Plan – Let people know what you want to do with them and what they can they can do with you. No one can say they don’t have a plan. There is always some plan. Knowing it strengthens why you want to have that relationship in the first place. Otherwise it's like something which is there but you can never want to do anything with! When you are honest with your plans and they workout as you described it, it creates confidence in relationship or else it is destroyed forever. You can cheat a person with your plans once, not forever.

3. Possibilities- Will this relationship bring me trouble? Obviously nobody wants to get into a relationship with anybody that brings them trouble be it physical or mental. Next question is whether it will benefit me? Small or big depends on person's needs. Some relationships neither bring us trouble nor benefits us, such relationships are better than the ones which can cause harm.

4. Potential – Question. Does this relationship you are trying to develop have any possibilities of growth a few or many years down the line. Obviously we have a lot of friends who wither by passing of time. Does this relationship have an expiry date irrespective of how well or bad it goes? Like when we join college we know for sure that the friends will be with us till the duration of the course and that's it. We will know that if we study together it will help us achieve great grades in college and hence a great life later. These kind of growth possibilities or possibilities of deterioration are important to be well aware of and will naturally decide the course of relationships.

5. Progress – No matter what our initial assessments are, how the relationships helps us fare in the outside world will ultimately decide the future of any relationship. Loss, sorrow, tragedy, degradation in any aspect of life, insults, injury, loss of health etc will never help any relationship continue or last.

6. Partnerships – When we want to build a relationship with someone, the best way to do it is to obviously partner with that person in as many activities as possible. The more interested a person is the more activities that person will involve you in and try to do it with you. This type of partnership activities, be it spending a few hours in the evening, or a few minutes on phone, or an association of months or years are a foolproof way to show you are interested. Conversely a person who doesn't partner with you in anything is extremely unlikely to ever have any sort of relationship with you. Partnership in activities is the only way to show and know that you are interested or the other person is interested respectively. After all chasing the moon, stars and rainbow are activities of people who don’t realize its out of their reach. Sensible people are busy with what their eyes see, hands feel, ears listen, tongue tastes and thinking perceives as appropriate.

7. Positioning attitudes- As a tree bends with the winds to prevent from cracking, we all have to be flexible with our attitudes towards each other. Being too rigid about our protocol on how relationships should run irrespective of the reality and circumstances of the person we are having a relationship with is naturally going to break relationships. After all a doctor who heals and prevents all illnesses is better than a doctor who abuses his patients for falling ill but never does anything for them. Eg: You get bed and good food in a hotel as well as at your home. A hotel will provide food only on payment of money, but family will provide it whenever your hungry. Hence hotels can never expect the same emotions as family can, and this is as natural as it should be. Hence be careful what you want from a relationship. Whether you want to be treated as a hotel or family is entirely how you play yourself with others. After all only families can expect loyalty not hotels.

8. Politeness- In any relationship, many years down the line, what our long term memory retains is how comfortable we were in that relationship. Even if we profit from a particular relationship, the fact that it shook us mentally and emotionally will never allow us to go back or retain that relationship. Life is short and the only thing that matters is to spend it comfortably. Not destroy our peace for some benefit that destroys our peace of mind.

9. Personation- While sending a representative of your organization for a client meeting may work in business, you cant really send a representative to meet you wife or kids at home. In personal relationship, lack of your physical presence obviously means that you don’t have time for them. In any relationship, individuality matters a lot. Just imagine, if all actors acted exactly the same in movies, why would you prefer any particular one over the other as your favourite? The nuances and differences in our personalities are what makes us all unique. We are not robots from a particular brand to behave exactly the same way. If a person in a relationship doesn't sense your individuality you are wasting their time by trying to have a relationship with them, especially a personal one.

10. Positive reinforcement- When we get into a relationship, it is important that we feel good about ourselves and what we are doing. If you feel like a shoplifter entering a shop, you will not feel good about that relationship. When a shopkeeper welcomes us, shows us his products, tells us their details and provides all the explanations on how we will be well off with the product, provides his guarantee for it, confirms its essence, many people buy it even if they don’t compulsively need it. It’s the same in relationships. On the same side if a shopkeeper is arrogant, avoidant, abusive, insulting etc you are very unlikely to buy anything in that shop because you are not sure that the shopkeeper means any good and will be happy with the shopkeeper s product. The experience of buying is as important as the product we buy. Nobody is happy about something they got when they weren't treated the right way or is interested in retaining it when they don’t get good service for it.

11. Persistence on all Ps – Obviously when we want relationships to last, we need to be persistent on all the above P's. Otherwise it wont take long for a relationship to be counted in “once upon a time”!! A simple conversation even if for a few minutes every now and then when you need it may make it seem that you are still there for a person. Without even that people may even find it hard to remember that they even had something to do with you sometime before keeping in mind the the numerous activities we involve daily to maintain our lifestyles.

“KNOWING IS DOING AND NOT KNOWING IS UNDOING EVEN IF DOING!”

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How To Win Over New Relationships

Sadly, millions of people around the world attempt to commit suicide every day. This can be defined as the act of purposefully taking one s life. There can be many causes for a person to take this extreme step but in most cases, the person gives out warning signs before committing suicide. It is important for us as family and friends to look out for these signs and protect our loved ones.

Social withdrawal: When a person loses interest in things he or she likes to do normally or starts keeping a distance from others, it may be cause for concern. Social withdrawal is one of the most common symptoms of depression. Depression could in many cases trigger suicidal thoughts.
Focus on death: People having suicidal thoughts may talk openly about death and wanting to die. Do not take this lightly. In other cases, they may be fixated on death and begin researching various ways to take their life. This could also take the form of buying a gun, sleeping pills or a sharp knife.
Despair: Nobody likes listening to others crib but in many cases, this may be a way for a depressed person to seek help. Many people commit suicide not to end their lives but to end the physical or emotional pain they are suffering from.
Making Plans: People thinking of committing suicide may begin drafting suicide notes or start making plans to get rid of their belongings. This could be in the form of a sudden garage sale or drawing up a will.
Reckless behavior: People who are depressed and contemplating suicide may show signs of reckless behavior as they think they have nothing to lose. They could start drinking excessively or doing drugs or even have unprotected sexual intercourse. Drugs and alcohol could also be a way for them to lessen their pain. Driving under the influence or driving too fast could also be a sign to look out for.
How can you help?
If you do notice something strange, do not ignore it. Try talking to the person and help them express their frustration in words. Find ways for them to meet more people and do something different. You should also encourage the person to talk to a professional mental health care expert. If you are in a situation where someone threatens suicide, do not leave them alone. Try to calm them down and call for help immediately.

How To Identify Suicidal Behaviour?

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