There are many types of cancer that may affect the human body. Bladder cancer is one such cancer that is caused when there is an abnormal growth and accumulation of the cells in the bladder. This kind of growth may cause mutations which can then manifest into tumours that may or may not be malignant. 

Let us find out more about the causes and risk factors of bladder cancer.

Transitional cell carcinoma: In this kind of bladder cancer, the transitional cells that line the inner region of the uterus and urethra will expand when the bladder is full. Further, these cells will end up contracting when the bladder is empty. This will lead to numerous complications which can cause the formation of tumours as an end result.
Squamous cell carcinoma: The squamous cells are those that are usually found in the bladder as a response to any kind of infection or even irritation in the area. These cells become cancerous over a certain period of time. This is also one of the most common types of bladder cancer in the US, as per various medical reports.
Adenocarcinoma: This kind of cancer usually starts in the cells that make mucus and form glands for the production of the same, in the bladder. This is a rather rare form of bladder cancer.
Risk factors: There are a number of risk factors that may affect the manifestation of the abnormal cell growth which can lead to any one of the above types of bladder cancer. Let us learn more about these risk factors.
Smoking: Smoking does not merely cause lung cancer, but it is also capable of causing chemicals from tobacco to accumulate in your urine and lead to several complications, including the increase of abnormal cell growth in the bladder. These chemicals may also cause widespread damage to the lining of your bladder.
Diabetes medication: One of the side effects of taking certain types of diabetes medication may be seen in the bladder and its cells. Pioglitazone is one such medicine which can cause these kinds of complications.
Chronic bladder inflammation: Repeated bladder infections may cause an unhealthy amount of persistent inflammation, which can lead to the growth of cells in an abnormal manner. This can lead to damage of the bladder s inner lining. In such a case, bladder cancer becomes a risk for the patient.
Family history: A family history of the condition also leaves the person susceptible to this disease. Colorectal cancer instances or Lynch syndrome cases in the family can increase the risk of contracting bladder cancer. This is due to the fact that the faulty gene can affect the various organs of the urinary area.

Bladder Cancer - Risk Factors Associated With it!

What are the functions of the kidney? 

The kidneys filter waste and excess fluid from the blood. As kidneys fail, the waste accumulates in the body. The two most important enzymes, which kidney makes are erythropoietin & renin. Erythropoietin are made by the kidneys if there is less oxygen in the blood. It tells the bone marrow to make more red blood cells. So this means there will be more oxygen carried in the blood.

Renin is made by the kidney if there is low blood pressure, low volume of blood, or too low salts in the blood Renin make the blood vessels smaller and tells the adrenal gland to make aldosterone. It also makes a person feel thirsty and all of this makes the blood pressure go up. Since Kidney plays a very important role in the overall functioning of the body, it s very important to take care of its health. 

Let s have a look on various kind of kidney disease including the one which are chronic:

Kidney stones
Kidney Infections
Glomerulonephritis
Congenital Kidney disease
Diabetic Nephropathy
Hypertensive Nephropathy
Cancer 

Now what is Chronic Kidney Disease?
Chronic kidney disease include conditions that damage your kidneys and decrease their ability to keep healthy by doing the jobs listed, if it gets worse, wastes can build to high levels in the blood and make person sick.
Chronic kidney disease is caused by diabetes, high blood pressure and other disorders.

What causes chronic kidney disease?
The two main causes of chronic kidney disease are diabetes & high blood pressure which are responsible for up to two third of the cases. Other conditions that affect the kidney are:
1. A group of diseases that cause inflammation and damage to the kidney s filtering unit.
2. Inherited disease such as poly cystic kidney disease.
3. Malformation that occur as a baby develop in mother s womb.
4. Lupus and other disease that affect the body s immune system.
5. Repeated urinary infections.

What are the symptoms of chronic kidney disease?
1. Feel more tired and have less energy
2. Have trouble concentrating
3. Poor appetite
4. Trouble sleeping
5. Muscle cramping at night
6. Swollen feet and ankles
7. Puffiness around the eyes especially in the morning
8. Dry itchy skin
9. Need to urinate more often, especially at night. 
In case of the similar symptoms one needs to get it diagnosed and connect with the physician for good care and treatment. Stay Healthy!

Chronic Kidney Disease - 9 Symptoms that Can Help You Detect it 

A lot of bad things can and do happen when the kidneys fail.  The kidneys are vital for proper bodily functioning because they filter liquid and solid waste products out of the blood and allow vital chemicals (which the body needs for functioning) to flow into the body through the bloodstream.  People can become very sick when the kidneys either fail to perform these functions or fail to perform them properly.  Many people will get chronic kidney disease, therefore, they need to know what the causes and symptoms are in order to treat, and even prevent these diseases from occurring.

People who suddenly experience the following symptoms should see a nephrologist as soon as possible for a medical examination:  blood or protein in the urine, kidney stones, acute kidney injury, kidney infections, and/or pain, and Hepatitis C and kidney disease.  

Blood in the urine can be a sign of kidney problems which can lead to kidney disease.  Additionally, people who urinate frothy or bubbly urine, or have swelling in the hands, face, and feet should see a doctor because this is a sign of protein in the urine.  Protein in the urine can be detected by a urine test.  Kidney stones can be very painful and are problematic.  They are caused by mineral buildup in the kidneys.  Men and white people tend to get kidney stones more, and they can cause blood in the urine, painful urination, sharp lower abdominal or back pain, and nausea and vomiting.

Acute kidney injury occurs when the kidneys stop functioning altogether in a short period of time.  Because this disease can be deadly, those with this disease should get immediate medical help.  Usually, the very sick patients in hospitals get this disease, but it can also be caused by certain medicines, injury, or infections.  This type of kidney disease is easily reversible.  

Symptoms include

Not passing enough urine when urinating
Leg, ankle, or feet swelling
Fatigue
Breathing problems
Confusion
Nausea, and chest pressure or pain. 
Kidney infections tend to be caused by bacteria that have spread from the urinary tract.  Women, because of their anatomy, tend to get kidney infections more than men. 

Symptoms include:

Fever
Vomiting
Back, side or groin pain
Chills
Nausea
Frequent urination
Frequent urges to urinate
Painful or burning urination
Pus or blood in the urine
Cloudy or foul-smelling urine
Kidney pain in the lower back or sides can signify more serious kidney problems.  They can be caused by urinary tract infections, polycystic kidney disease, kidney infections, blood clots, and/or bleeding in the kidneys.  
Hepatitis C is a disease that attacks the liver and can cause kidney disease.  

Symptoms include

Loss of appetite
Nausea
Fever
Fatigue
Vomiting
Dark colored urine
Grey colored stool
Joint pain
Yellow skin and eyes
While kidney diseases are at best unpleasant, and at worst, life-threatening, they can be avoided by drinking lots of water, eating a healthy low salt diet, and watching for any changes in health and urine over time.



What Happens When Kidneys Fail & Signs That Indicate It

Kidney stones can range from being the size of a grain to a pebble. These stones can be described as crystallized mineral deposits in the kidneys. Some kidney stones can be passed out of the body along with urine while others may require surgery. Symptoms of having a kidney stone vary from mild to severe. In the case of very small kidney stones, the patient may not experience any symptoms at all. The 5 most common kidney stone symptoms usually experienced are:

Pain: Pain in the lower abdomen and back is one of the most common symptoms of having a kidney stone. This may be felt just below the ribs, on the centre and sides of the abdomen, in the lower back and in the groin. The intensity of pain is not directly related to the size of the kidney stone. This pain can come and go and will vary in terms of intensity. In certain cases, the pain can be severe enough to warrant a trip to the hospital. This pain is usually a sign that the stone is moving.
Frequent Urination: People suffering from kidney stones may find themselves needing to go to the bathroom more often than normal. In some cases, patients may also wake up in the middle of the night with the urge to urinate. However, only a small amount of urine may be passed at a time. This is a sign that the kidney stone has moved into the lower urinary tract. Small stones may later be passed out of the body along with urine.
Bloody Urine: Urine should ideally be pale yellow. Patients suffering from kidney stones may notice that their urine is darker than normal and cloudy. There may also be blood in the urine. This is known as hematuria. The colour of blood in such cases can range from pink to brown. Cloudy urine is also considered a sign of a urinary infection. This is a sign that the urine also contains pus cells or pyuria.
Nausea: Vomiting and nausea are common symptoms of kidney stones. This is caused by the nerve connections shared by the kidneys and the gastrointestinal tract. The presence of kidney stones in the kidneys or urinary system can trigger an upset stomach. Some people also feel nauseous because of the pain caused by kidney stones.
Foul Smelling Urine: Under normal conditions, urine should not have a very strong smell. Urine that smells bad is a symptom of a urinary infection. Bacteria in the kidneys or urinary tract can be the cause of this smell. It may also be caused by the high concentration of urine. 

5 Symptoms Of Kidney Stones!

The bladder is a hollow storage organ that collects urine from the kidneys and stores it until it can be passed out of the body through the urethra during the process of micturition or urination. It has a thin inner lining of cells called urothelial cells and a thick muscular wall, which exerts pressure to push the urine out of the body.

Causes of Bladder Tumors

In most cases, the bladder tumor develops on the inner layer due to a combination of some of the following factors.

1. Hereditary: A strong family history of cancer predisposes a person to cancer.
2. Gender: Men are 3 times more prone for bladder cancer than women.
3. Ethnicity: White people are more prone for bladder cancer black people.
4. Smoking: Smokers develop bladder cancer 2-6 times more frequently than non-smokers. cigarettes contain toxic, carcinogenic substances which reach the kidney and are stored in the bladder, leading to their damage.
5. Occupational hazards: Some workplaces have a higher likelihood of causing bladder cancers, especially dye and rubber industries. The effects can be damaging, and the person may develop cancers years after the exposure has happened.
6. Recurrent bladder infections: In some people, this can also lead to bladder cancer in the long run.

Types of Bladder Tumor

Depending on the extent of the cancerous spread, it can be of two types:

1. Non-muscle-invasive bladder tumors: The tumor spread is limited to the inner part of the bladder (urothelial cells)
2. Muscle-invasive bladder tumor: The tumor has spread to the thick muscular outer layer. This is more advanced and prognosis is poor compared to the noninvasive type.

The most common and diagnostic symptom of bladder cancer is the presence of blood in the urine, known as hematuria. This will be intermittent and happens whenever the tumor bleeding happens. Other symptoms include pain in the lower abdomen and frequent urination.

Diagnosis

From the most noninvasive to the most invasive diagnostic test, these include:

1. Urine microscopy to detect cancer cells in the urine
2. Cystoscopy A tube inserted into the urethra to look into the inner wall of the bladder is highly diagnostic
3. Ultrasound, CT Scan, and biopsy can also be further used to identify severity of the tumor.

Treatment

Once the tumor is diagnosed, treatment would depend on the severity of the tumor. For both invasive and noninvasive tumors, definitive therapy is surgery, known as transurethral resection of the bladder tumor (TURBT). The cancerous bladder tissue is removed through a cystoscope as done for diagnosis. The bladder is then flushed with chemotherapy agent to kill any residual cancer cells in the bladder. This is then followed by BCG vaccine, which is again done 1 to 4 weeks for several months to avoid recurrence. In some cases, radiotherapy may also be included.

Bladder Tumor and Its Common Causes

Urinary incontinence is a common problem that afflicts many adults around the world. Stress related urinary incontinence is a fairly common problem that afflicts many as well. This form of incontinence is usually caused by physical activity, which exerts pressure on the bladder and may cause the leakage of small amounts of urine.

Triggers and Symptoms for stress urinary incontinence
In terms of urinary problems, stress is used to describe physical problems in particular and not mental stress. So the triggers or risk factors of it could be any of the following:
1. Exercise
2. Jumping
3. Sneezing
4. Coughing
5. Exercises
6. Sexual activity

This form of urinary incontinence is very common in women who are older or have already been through menopause. It may also be common for women who have recently given birth or are pregnant. The urethra or the bladder may become prone to external stress and then involuntarily leak out some urine.

Causes
The causes can be quite varied from patient to patient but are primarily attributed to the weakening of the pelvic muscles, bladder or the sphincter. If any of these muscles open involuntarily due to physical stress, it leads to urine leaking out. Some of the causes which may lead to this are:
1. Pregnancy and childbirth: Pregnancy or childbirth related problems may cause damage to the urethra or sphincter during childbirth; leading to stress urinary incontinence.
2. Surgery of the prostate: Another common problem, especially with men, is with surgical interventions to correct prostate problems.
3. Menopause: Many older women often complain about stress incontinence after menopause due to the weakening of the muscles.
4. Pelvic surgery: Any surgery to the pelvic area or illnesses which may cause the muscles to become relaxed or act involuntarily due to external stress, may cause incontinence.
5. Weakening of the pelvic muscles: Certain illnesses may cause the pelvic muscles to become weak and thus cause the sphincter as well as the bladder to react involuntarily. UTIs or urinary tract infections have also been known to cause incontinence due to the same reason.
6. Obesity: Obesity has been known to put stress on many of the bodily systems and it may affect the bladder and the urinary sphincters as well.

Causes and Symptoms of Stress Urinary Incontinence

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