What is Endometrium?

The uterus is where the fetus grows and develops. It has three linings- the outermost lining, the middle layer and the innermost lining. The innermost layer is called Endometrium. The endometrium is made of mucosal tissues.

How the endometrium changes and what is its function?

Before ovulation, when an egg is released, the functional layer of the endometrium undergoes a change. Vascularization takes place i.e. a buildup of blood vessels and tissues that thickens the endometrium in anticipation of implantation of a fertilized egg. If conception does not take place, the tissues and cells are shed from the endometrium lining. This is when a woman gets her period.

When conception does take place, the fertilized egg attaches itself to the endometrium. The endometrium also supports the placenta, which provides the fetus with oxygen and nutrition.

What is the ideal thickness of the endometrium?

In pre-menopausal women, the thickness of the endometrium should be-

  Between 2-4 millimetres during menstruation,
  5-7 millimetres at the onset of the early proliferative phase
  Around 11 millimetres during the late proliferative phase
  16 millimetres during the secretory phase



What is a poor/thin endometrium?

If the endometrium lining does not meet standard thickness and is not conducive to implantation, it is called a poor endometrium.

Causes behind thin endometrium

There could be many reasons that can lead to a poor endometrial layer-

  Inadequate secretion of estrogen
  Insufficient blood flow
  Prolonged use of birth control pills
  Substandard quality of endometrial tissues
  Presence of fibroids (small uterine tumours)
  Amenorrhea (unnatural periods/ excess bleeding or too little bleeding)
  Intrauterine adhesions (scar tissues form between the layers of the uterus and glue them together)
  Pelvic inflammatory disease
  Use of clomiphene

What are the symptoms of poor endometrium?

  Infertility (inability to conceive)
  miscarriage
  Irregular menstruation
  Painful periods
  Inadequate bleeding during menstruation

Treatment for poor endometrium

  Since the most common cause of poor endometrium is insufficient estrogen, doctors prescribe estrogen pills that can raise estrogen levels.
  If poor endometrium is the result of poor blood flow, an Ultrasonography Test will reveal that. Then doctors prescribe Vitamin E pills and L-arginine amino acid pills to thicken the endometrium layer.
  Regular exercising increases blood flow to the uterus
  Acupuncture is a very effective stress buster. Chronic stress could lead to a shrunk uterine wall. Acupuncture can allay the stress and promote the health of the uterus.
  Intrauterine adhesions can be extracted through surgery.
  Natural remedy (through natural therapy) includes asparagus, royal jelly, cover and they help in thickening the endometrium layer.
  Granulocyte Colony Stimulating Factor if injected into the body raises endometrial thickness and combats infertility.

Only an endometrium of normal thickness can support a pregnancy. If the lining is not thick enough medical intervention may be necessary.

Poor Endometrium - Can It Be Treated?

When endometrial tissue that usually grows inside the uterus, starts growing outside uterus, it is called Endometriosis. Pain during or before periods, pain during intercourse, pain while urinating or bowel movements, heavy bleeding, infertility are some of the symptoms of endometriosis.

Treatment of endometriosis usually depends on the following factors:

Age of female
Severity of symptoms
Duration of the symptoms
Future plans for children/ fertility
Associated pathologies
Accordingly the doctor might choose any of the treatment options like:

Medication for Pain: If the symptoms are mild, then the doctor will prescribe some pain  relieving medications like Nonsteroidal anti-inflammatory drugs (e.g. Diclofenac) or anti-spasmodics(e.g.drotaverine)
Hormone Therapy: Hormone therapy is effective, but once you stop them, your symptoms may recur. Some of the hormone therapies include: 
Hormonal Contraceptive pills: Useful in controlling the hormones that are responsible for endometrial tissue growing outside the uterine cavity.
Medroxyprogesterone: This helps to counter effect estrogen hormone which is responsible for endometrial tissue growth.
Gonadotropin-releasing hormone (GnRH) agonists: Gonadotropin hormones that stimulate ovaries are blocked by these. They bring down oestrogen levels and hence symptoms. It can cause absence of menstruation in some females which is reversible.
Danazol: It is synthetic androgen, suppresses growth of endometrial tissue temporarily.  However, Danazol may not be a favourable option because of its side effects. Females should avoid pregnancy while on this drug.
Dienogest: This newer progesterone molecule, which does not have major side effects and is apporved for use in endometriosis.
Other medications like selective progesterone receptor modulators, immunomodulators, anti angiogenic factors are being evaluated.
Conservative surgery: If you are trying to conceive, then surgical excision or ablation of endometrial tissue is one treatment option.Suboptimal surgery with conservation of maximum ovarian tissue is considered suitable in such cases.
Hysterectomy: In severe endometriosis cases where female has completed her family, hysterectomy is offered wherein the uterus, cervix & if required ovaries can be removed.

Endometriosis - Ways To Manage It Well!

Cancer that originates in the uterus is termed as Endometrial Cancers. The cancer is known to originate in the endometrium i.e. lining as well as the cells of the uterus. Abnormal vaginal bleeding causes the cancer to be detected early and a consultation with the doctor should be done immediately. When other cancers originating from the uterus are considered, endometrial cancer is found to be the most common.

Causes
The exact cause for endometrial cancer is not known clearly. The cells in the endometrium tend to become abnormal due to the occurrence of a genetic mutation, which causes rapid multiplication of cells that ultimately lead to the formation of a tumour like mass. They begin to spread to other parts and proceed to affect the tissues in the surrounding areas.

Symptoms
The typical symptoms of endometrial cancer include:
1. Irregular bleeding in between periods
2. A watery discharge from the vagina
3. Bleeding from the vagina postmenopausal
4. Pain in the pelvic floor muscles

Risk factors that might increase the chances of being affected by endometrial cancer include:
1. Aging increases the chances of this disease, especially post menopause.
2. Obesity can cause hormonal imbalance.
3. Certain drugs used in hormone therapy
4. Early onset of menstruation, especially before 12 years of age

Treatment for Endometrial Cancer Includes:
1. Radiation therapy: This treatment procedure involves using radiations, such as X-rays to target and destroy the cancer cells. The two forms of radiation therapy are external radiation therapy (external machine is used to direct radiation on the cancer cells) and internal radiation therapy (radioactive substance enclosed within small and consumable items is placed near to or directly at the spot of cancer).

2. Hormone therapy: Medications are administered to eliminate imbalances in hormone levels and prohibit the growth of cancer cells in the body. This remedy is preferred if the cancer progresses to an advanced stage.

3. Chemotherapy: This form of treatment uses oral administration or injection of chemicals into the veins so that the growth of cancerous cells is curbed, either by elimination of the cells or by prohibiting cell division.

4. Surgery: In this surgery, the areas affected by cancer are surgically removed; i.e. the uterus in this case. The surgical procedures that might be used include total hysterectomy (total removal of uterus), radical hysterectomy (removal of the cervix, uterus and part of the vagina) and Bilateral salpingo-oophorectomy (removal of both the ovaries and the fallopian tubes)

All About Endometrial Cancer

Endometriosis is a condition where the endometrial tissue lining the womb, grows outside the urethral lining. This can cause severe pelvic pain and a host of other complications, if it is not treated on time. 

Here is everything you need to know about this ailment.


- symptoms: owing to the location of this tissue and its painful protrusion through the lining or walls of the womb, one of the earliest and most painful symptoms experienced may include severe cramps and pain during the menstrual cycle. Also, the patient will experience pain in the lower abdomen region about a week before the onset of the cycle. Heavy bleeding as well as infertility may be experienced in such cases too. Sexual intercourse will also give rise to pain in the region, while discomfort will be felt during the bowel movements. Pain in the lower back will also be experienced throughout the menstruation period. 


- stages: there are several stages of this disease and its progression, each of which will require a different form of treatment. These four stages usually depend on the location, size, depth and number of the endometrial implants within the body of the patient.


- minimal stages: in this stage, usually there will be small wounds and lesions as well as shallow implants on the ovaries. Inflammation in the pelvic cavity can also be felt in this stage.


- mild stage: in this stage, there will also be light lesions and shallow implants which will spread over the ovaries as well as the pelvic lining.


- moderate stage: in this stage, the implants will dig deeper into the ovaries and the pelvic lining, which will result in the growth of even more lesions.


- severe stage: as the name suggests, in this stage the patient will experience deep implants along with lesions in the bowels and the fallopian tubes.


- treatment: there are varied forms of this treatment including pain relief medication for minimal to mild stage patients. Also, hormonal therapy with the help of supplements may be prescribed. Hormonal contraceptives may also be used. In such cases, medication like danazol, medroxyprogesterone, 

Gonadotripin releasing hormone agonists, and other such elements may be prescribed. Conservative surgery and radical surgery may follow, depending on the severity of the condition. Laparoscopy is the preferred form of treatment in such cases. A hysterectomy can be conducted as a final resort where the surgeon will remove the cervix as well as the uterus of the patient. This will make pregnancy impossible for the patient, thereafter. To stem estrogen production, the ovaries will also be removed. 


One must discuss all risks and complications before going in for a certain form of treatment for this ailment.

Symptoms, Stages and Treatment of Endometriosis

One of the silent diseases in the female population, endometriosis can be symptomless for years and sometimes even decades, but can sometimes manifest itself quickly. The uterus is lined on the inner side by a tissue known as endometrium. When this tissue is found in other parts (fallopian tubes, abdomen, near the ovaries, etc., it is known as endometriosis.

Causes: The exact cause for endometriosis is not clear. There is a possibility that during the regular period, there could be spilling of the tissue back into the fallopian tube, from where it reaches the ovaries or other organs and gets implanted.

There are certain predisposing factors for a woman to develop this condition, including genetic correlation and non-menopausal women. The female hormone estrogen is essential for the development of endometriosis. There are also immunological reasons attributed to the development. It can range from minimal to mild to moderate to severe.

Symptoms: From being completely benign to causing severe pain, endometriosis can present itself in varying ways. The implanted tissue can be minimal like a small lump to large clumps. The symptoms are not dependent on the size of the implanted tissue, however, 

1. Painful menstruation: One of the most common causes of non-menstrual cramps, the pain is different from usual menstrual pain, starts a few days before the period and can last up to after the period.

2. Pelvic pain: One of the most common causes of pelvic pain, this can happen wherever the implanted tissue is. In severe cases, this tissue can also bind different organs, forming what are called adhesions. The bladder or the bowels may adhere to the uterus. These are more painful than individual lumps of tissue outside the uterus.

3. Intermenstrual bleeding: There could be spotting to severe bleeding between the regular cycles.

4. Painful sex: There is a deep pain within the pelvis and it can lead to losing interest in sex.

5. Infertility: The most severe symptom and complication is not being able to become pregnant.

Diagnosis: A detailed patient history, discussion on symptoms followed by ultrasound and laparoscopy can help in diagnosing endometriosis.

Treatment: If there is no symptom and fertility is not an issue, then it is possible that no treatment is required. However, depending on symptoms and complications, the following are done.
- If pain is the only main problem, painkillers are administered
- Surgical treatment may be required if there is severe bleeding and adhesions complicating the situation. 

This will also relieve other symptoms
1. Hormone therapy is also an option for treating endometriosis.
2. If you are having pelvic pain and irregular bleeding, bring it up with your doctor. Even if it is not endometriosis, a thorough check up will put your mind at rest.

Endometriosis and Complications Associated With It

Endometriosis is a painful disorder wherein, a tissue that normally belongs to the inside of a woman s uterus, starts to grow out of the uterus. It common involves a woman s ovaries, fallopian tubes and the tissue, which lines the pelvis. In case of endometriosis, the displaced endometrial tissue continues to act like normal, becomes thick, breaks down and leads to bleeding with each menstrual cycle. Endometriosis can lead to pain, which might be severe especially during a woman s period. 

Causes of Endometriosis:

Embryonic Cells Getting Transformed: Hormones like estrogen might transform the cells, which are in the early stage of development, into implantation of endometrial cells at the time of puberty. 
Surgical Scar Implantation: After undergoing a surgery like a hysterectomy or C-section, the endometrial cells might get attached to the incisions done for conducting the surgery. 
Transport of Endometrial Cells: The tissue fluid system or the blood vessels might transport the endometrial cells to different parts of the body. 
Let us take a look at some of the symptoms of endometriosis: 

Periods which become painful 
Pain suffered during or after the intercourse. 
Feeling of pain during bowel movements 
Excess bleeding 
Infertility 
Possible location of endometriosis: 

Ovaries(the most common site) 
Fallopian tubes 
Back of the uterus 
Front of the uterus 
Uterine ligaments such as the broad or round ligament of the uterus 
Pelvic walls 
Intestines 
Urinary bladder and ureters 
Investigations Required in Endometriosis 
The investigations required in endometriosis are as follows: 

Pelvic Exam   In this exam, a doctor manually tends to feel certain areas in pelvis for any kind of abnormality like cysts or the reproductive organs or scars behind the uterus. 
Ultrasound   High-frequency sound waves are used to create certain images inside the body, through capturing them via a device known as transducer and getting it pressed against a woman s abdomen.
MRI   MRI by way of magnetic field and radio waves help to get detailed images of the tissues and organs in the body. 
Laparoscopy Endometriosis through the eyes of ayurveda: The signs and symptoms mentioned in endometriosis are described in ayurveda under the heading of vataja yonivyapadh and udavartha. 
Apana Vata is considered as the main functioning agent to maintain normal menstruation. 
This is vitiated due to sedentary life style, lack of exercise, sleep, irregular sleep, stressful professional atmosphere, mental tensions and unhealthy food habits. 
The deranged apana vata causes retrograde menstruation leading to endometriosis. Along with this, the other two doshas-pitta and kapha are vitiated leading to hormonal imbalance and abnormal growth of endometrium respectively. Hence, the first and foremost step is to restore the physiology of these doshas. 
What are shodhanas? 
Shodhanas are detoxifying procedures like snehana, svedana, vamana, virechana and basti. Benefits of shodhana in female reproductive system: 

Biological systems return to normalcy. 
Revitalizes body tissues 
Potentiates pharmacological actions of internal medicines 
Removes toxins 
Improves physiological functions and gut absorption. 
Also, improper metabolism is corrected 

Mental faculties, strength and vitality are enhanced 
Fine tunes the endocrine system (hormonal balance correcting hypothalamus-pituitary-ovarian axis). 
Promotive-promotes fertility, preventive-prevents recurrence and curative- cures from the root and rehabilitative too. 
Ayurvedic Treatment for Endometriosis 
Endometriosis s treatment in Ayurveda requires an anti-Pitta diet and regimen, where there would be complete avoidance of all spices, except coriander, turmeric and saffron. One must also refrain from having 

Salt 
Alcohol 
Refined sugar 
Good herbs might get included in the form of: 

Shatavari 
Kumari Saar 
Kanchanar 
Ashoka 
Lodhra 
Pradranta Churna 
As per Ayurveda, Endometriosis happens as a result of more Kapha due to increased growth of the uterine membrane. Anti-kapha, anti-tumor and general detoxification can be helpful along with some typical herbs like Guggul, Myrrh, Turmeric and Dandelion. 

How can Diet and Yoga help to improve Endometriosis? 
Modifications in diet by switching to the intake of healthy foods and Yoga can help to a great extent in improving Endometeriosis. Some of the diet tips include: 

Avoiding foods like cakes, donuts and fries that contain trans fats. 
Cut down on consumption of red meat. 
Have lots of fruit, vegetables and whole grains 
Put a check on consumption of caffeine and alcohol 
Reduce the intake of processed foods. 
Impact of Yoga 
Yoga s positive impact in treating endometriosis includes: 

Yoga, with its structured approach towards the body help reduce the symptoms of emdometriosis, while improving the general functioning of the body & oxygenation to the organs. 
Women, who have tried out Yoga in order to decrease pain, also observed that there has been an improvement in their condition through healing. 
Control in the breathing exercises decrease anxiety and a general sense of well-being is promoted. 
Yoga helps to ease out menstrual pain, improves fertility and helps in bringing about hormonal balance.

Endometriosis - A Possible Therapy In Ayruveda!

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