What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

The most common forms of diabetes ;are type 1 and type 2 diabetes. In type 1, your immune system damages the cells inside the pancreas that produce insulin. Therefore, the pancreas are unable to produce an adequate amount of insulin.

In type 2 diabetes, your body does not respond properly to the insulin produced by the pancreas. As a result, your body will have a difficult time removing sugar ;from the blood. The cells may stop insulin production over time that may lead to insulin deficiency. However, there are other forms of diabetes that are lesser-known but can affect you just as bad.

Types of diabetes beyond type 1 and type 2

Gestational diabetes

In gestation diabetes, a condition that affects pregnant women, the blood sugar levels increase to an extent that may hamper the health of the mother and the child.

Symptoms

Usually, there are no symptoms as such. If diabetes worsens, women may observe symptoms such as -


	
	A need to pee more frequently
	
	
	Excessive thirst and hunger
	
	
	Dryness in the mouth
	


Lada (latent autoimmune diabetes in adults)

It is sometimes referred to as type 1.5 diabetes. Here, your immune system kills the insulin-producing cells inside the pancreas. As this condition takes a longer period to develop, you may not need insulin for many months after you have been diagnosed.

Symptoms

You may observe the following symptoms  


	
	Dryness and itchiness
	
	
	Tingling sensation in feet or hands
	
	
	Blurry vision
	
	
	Frequent urination
	


Mody (maturity-onset diabetes of the young)

This condition is observed during adolescence. Here, genetic mutations limit the pancreas from making insulin. So, due to insufficient insulin, your blood sugar level goes up. If any of your parents have mody, you are likely to have the condition.

Symptoms

Symptoms may include  


	
	Yeast and ;skin infections
	
	
	Frequent urination
	
	
	An urge to pee more often
	


Treatment

Primary care for these other forms of diabetes follows the usual course of treatment as with type 1 and type 2.


	
	Diabetic medications
	
	
	Insulin shots or injections
	
	
	Dietary changes
	


The doctor may instruct you to monitor your blood sugar levels frequently to keep it under control. This will be accompanied by a diet ;consisting of adequate calories, but avoid fatty foods, excess sugar and carbohydrates. Mild exercise is also recommended.

The best way to prevent these conditions is to visit your doctor frequently and follow the treatment plan. Do not keep your diabetes untreated.

A Sneak Peek Beyond Type 1 And Type 2 Diabetes

People with sickle cell disease often experience myriad symptoms of the disease that can be controlled by the right nutrition. Reports suggest that nutrition is an increasingly significant factor to prevent symptoms such as slow growth, lower body mass, joint issues, infections, pain crises, and anemia.

There is a greater than the typical requirement for both calories and micronutrients.

The nutritional requirement of a sickle cell patient emphasizes more on vegetables, fruits, whole grains, and more similar food items. These can prevent any deficiencies in the body and also decrease any chances of disease exacerbation.

 


	
	High-calorie nutrient-dense diet
	


The usual energy intake in a sickle cell patient is normally lower than the average values. It is a case even when the condition is asymptomatic where the requirement drops to half the level. As a result, people with sickle cell diseases (especially kids) are at higher risk for impaired growth and considerably lesser fat and fat-free mass, with obesity also posing a risk. It is suggested to have adequate energy supplements in the diet to reach the minimum sufficient requirement of the body that can be done only by proper nutritional assessment.


	
	Adequate fluids
	


Avoiding dehydration is another significant factor to avoid any severe symptoms of sickle cell disease. Sickling of the erythrocytes aggravates in patients who perform hardcore physical work in the heat without drinking enough fluids. This leads to dehydration and can even result in constipation.


	
	Micronutrients
	


Micronutrient deficiencies can be found in sickle cell patients up to a great extent. Several vitamins and minerals like vitamin a, b6, c, e, carotenoids, zinc, and magnesium are often found in fewer numbers in scd patients. A significant drop in blood-antioxidant status may result in acute chest syndrome. The supplementation of these vitamins and minerals can reduce the number of sickled cells in the body. Plant phenols and flavonoids may also help in lowering oxidative stress.


	
	Calcium-rich food
	


Getting plenty of calcium-rich food like dairy products, leafy vegetables, cereals, and fruit juices aids the child's growth and development. This may lead to a stronger physical structure and a greater resistance to the disease.


	
	Omega-3 fatty acid
	


There are reduced proportions of omega-3 polyunsaturated fatty acids in sickle cell patients. These acids aid the fluidity of red blood cell membranes. As a result, they prevent sickle cell crises. Supplemental docosahexaenoic (dha) and eicosapentaenoic (epa) have shown numerous therapeutic benefits in scd patients.


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Role Of Nutrition In Sickle Cell Disease

World environment day is celebrated annually on 5th june. This day encourages awareness and action for the protection of our environment. It raises the problems facing our environment such as plastic pollution, air pollution, illegal wildlife trade, sea-level increase, sustainable consumption, and food security, among others. 

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World environment day is a reminder for us to pause and reflect on our actions and their subsequent consequences on the planet. 

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When was the world environment first celebrated?

The day was first observed in 1974 in the city of spokane in the usa.

 

History of world environment day (wed)

1972- the un general assembly established world environment day on the 1st day of the stockholm conference on the human environment. ;

1974- the first" world environment day" was held with the theme" only one earth. 

1987- the idea for rotating the center of these activities by selecting different host countries began. ;

 

Why is world environment day celebrated? ;

For a healthy life, the environment plays an important role. It provides us with air, food, etc. The environment is like our neighborhood, its surrounding conditions affect us and also modify development. It is really necessary to address the environmental issues like deforestation, increasing global warming, pollution, wastage and losses of food, etc. Currently, our earth is experiencing a triple planetary emergency: 


	
	Pollution is poisoning our air, land and water. ;
	
	
	Climate is heating up too quickly
	
	
	Habitat loss
	


The deteriorating environmental conditions worldwide had already raised alarms in academic circles, among scholars studying its conditions. However, general masses seemed oblivious to changes that were not directly affecting them.

The world environment day is structured in a manner that allows one country to take up the responsibility of selecting the theme and hosting the key celebrations each year. 

Let's all come together and ensure this unique and beautiful planet remains a comfortable home for humanity. 

 ;

 

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World Environment Day: What Is World Environment Day And Why It Is Celebrated? 

Potassium is one of the seven essential macrominerals found in a variety of foods, including legumes, fish, and leafy vegetables. The mineral plays a vital role in various body functions, such as regulating water balance, heart functioning, and muscle contractions.

Potassium deficiency can lead to weakness, ;fatigue, and constipation. It is therefore important that you include potassium-rich foods in your daily ;diet.

However, keep in mind that taking in more than the required amount of potassium can do more harm than good to your body.

How much should you take in and why?

As per the world health organization, the recommended daily intake of potassium for adults is between 3500mg and 4700mg, as it is safe to consume. When taken in recommended measures, a potassium-rich diet can have some impressive benefits on your overall health. It may reduce or prevent a host of health problems.


	
	Lower high blood pressure
	
	
	Helps eliminate salt insensitivity
	
	
	Reduces your chances of getting a ;stroke by 7%
	
	
	Helps prevent osteoporosis and minimizes the risk of bone fractures
	
	
	Alleviates the risk of ;kidney stones
	


Natural foods are the best source of this mineral. However, you may also turn to supplements, as per your healthcare provider s recommendation.

How much is too much?

Despite its health benefits, potassium should be consumed within the prescribed limit. Going overboard can cause excess potassium to be stored in your blood, and your kidneys may not be able to filter the excess amount   this condition could possibly lead to hyperkalemia. If your potassium levels are between 5.1mmol/l and 6.0mmol/l, you might be at risk of hyperkalemia. Higher than 6.0mmol/l level is considered dangerous   you will need to monitor and manage the condition in order to avoid the risk.

Potassium is essential for bodily functions. A healthy diet and overall eating patterns are important for maintaining good health and keeping illnesses at bay. Be sure to meet your recommended daily intake and avoid exceeding 4700mg of potassium daily. If you are looking to include supplements, talk to your doctor and make sure you stick to the prescribed dosage.

How Safe Is Potassium For Your Health?

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

 ;


	
	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

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