Renal Tubular Acidosis is a medical condition. When the kidney is unable to acidify urine, it leads to the accumulation of acid in the body. Usually, when blood is filtered by the kidney, it passes through the tubules of the nephrons (the functional unit of the kidney).

Before it flows into the bladder from the kidney, the urine undergoes an exchange of salts, acids and other solutes. Renal tubular acidosis results in the formation of excessive amounts of acid because the kidneys cannot drain them. This may happen because the kidneys cannot reabsorb the alkaline bicarbonate ions from the urine in the early segment of the nephron or because of inadequate production of acidic hydrogen ions in the latter half of the nephron.

Renal Tubular Acidosis is simply associated with abnormal urinary acidification. Other functions of the kidneys remain unimpaired.
There are several different types of renal tubular acidosis-

  Distal Renal Tubular Acidosis (RTA)
This is the most fundamental form of RTA. It is characterized when the hydrogen ions are not secreted into the lumen of the nephron by the alpha-intercalated cells of the medullary collective duct of the distal nephron. When this happens the pH of urine cannot be brought down below 5.3. Renal excretion is inhibited and hydrogen ions are not eliminated which leads to academia. At the same time, Potassium ions cannot be absorbed by the cell which leads to hypokalemia. The end result is protein retention and potassium excretion. Distal RTA can lead to the urinary stone formation, calcium deposits in the kidney, rickets and osteomalacia and Sjogren s syndrome.

  Proximal RTA
When proximal tubular cells reabsorb 85% of filtered bicarbonates and 60% of filtered sodium from the urine, then this again leads to academia. The distal intercalated cells, however, function normally and so the academia is not as severe as in case of Distal RTA. The alpha-intercalated cells can acidify urine to a pH of 5.3 or less because they produce hydrogen ions. Proximal RTA is also associated with Fanconi Syndrome which is characterized by aminoaciduria, uricosuria, glucosuria, and tubular proteinuria.

  Combined distal and proximal RTA
Inherited carbonic anhydrase II deficit leads to combined distal and proximal RTA. This is accompanied by osteopetrosis, cerebral calcification, and renal tubular acidosis. Cases of combined distal and proximal RTA are very rare.

How is RTA understood?
The following steps are applied to analyze Renal Tubular Acidosis-
  Determining the anion gap in acidosis. The normal Anion Gap is 8-12 (4-6 mEq/L)
  Separating the renal from the extrarenal causes of normal anion gap acidosis
  Classifying the types of RTA
  If it is distal RTA, further tests will be necessary to support the diagnosis

How is RTA diagnosed?
Three types of tests can reveal if a person is affected by Renal Tubular Acidosis-
  Urine test
  Acid load test
  Physical examination

Treatment of RTA-
Doctors prescribe either or both of the following two types of therapies-

  Alkali therapy- The pH level of urine is restored and electrolytes are balanced
  Vitamin D supplements- If RTA leads to bone deformities or rickets, your doctor will prescribe vitamin supplements to strengthen your bones.

Timely diagnosis can prevent the effects of Renal tubular Acidosis from becoming compounded. With the right medication, a person can lead a healthy normal life.

What Should You Know About Renal Tubular Acidosis?

Cancer, in any form, is a deadly disease that requires immediate attention and treatment. Colon cancer is a common form of the disease, with over 10 lakh people reportedly affected in India each year.

In some cases, surgery is the only remedy for colon cancer. Depending on the progression of your cancer, if surgery becomes necessary, you should consider undergoing laparoscopic surgeries.

What is a laparoscopic surgery?

While most surgeries are open, where a large incision is made on the body to operate on the internal organs and tissues, it s not the same with laparoscopic surgery. Here very small incisions are made on a particular body part to carry out the surgery. The procedure gets its name from the equipment used in the operation. A laparoscope is a tube-like instrument that has a camera on one end. During the surgery, this laparoscope is inserted in the patient s body and the image relayed back by the camera is used to perform the surgery.

In case of laparoscopic colon cancer surgeries, the surgeon uses the same method to reach your the cancerous mass in your colon and remove it.

Why choose laparoscopic colon cancer surgeries?

As a person affected by cancer, you have already endured substantial pain and discomfort. You do not need additional discomfort from your surgery. This is why laparoscopic surgeries are so popular when it comes to colon cancer. Here are some benefits of the procedure over the standard surgery.

  Less pain after the surgery
  Limited stay at the hospital post surgery
  Allows you to return to a solid food diet sooner after the surgery
  Allows normal bowel function to resume quicker
  Less scaring from the procedure
  Faster return to a normal lifestyle

Not everyone is eligible for open surgery to treat colon cancer. For instance, open surgery on elderly people can be extremely dangerous. For them, laparoscopic surgeries are a better alternative.

Are you eligible for laparoscopic surgery?

Before you opt for laparoscopic surgery to treat your colon cancer, consult an expert. The surgeon will help you understand whether you meet the requirements for laparoscopic surgeries. Your doctor will evaluate your case and let you know which procedure will have the maximum impact on your long-term recovery from cancer.

Is laparoscopic surgery as effective in treating colon cancer as open surgery?

According to a study performed by a Canadian team of researchers, the laparoscopic procedure is just as useful in treating colon cancer as the standard surgery. However, each case of colon cancer is different and the outcome of surgery may vary from person to person.

Laparoscopic Colon Cancer Surgeries!

Potassium is an essential mineral which is known as an electrolyte. Electrolytes are responsible for maintaining the ionic balance of your body. Other electrolytes are sodium, calcium, magnesium, phosphate, chloride. These electrolytes bear an electric charge which manages the electrical activity of your health system. Potassium also helps the muscles of the body to function properly. In fact, it has its contribution in regulating blood pressure; a crucial role for a healthy heart.

Potassium deficiency is a kind of medical condition which is known as hypokalemia. The normal level of potassium in the human body should be in between 3.5-5.0 mmol/L. But the deficiency in potassium can cause severe problems including muscle weakness, nerve disorders, heart problems, etc. Kidney is the organ which is known to manage the potassium balance by removing the extra potassium through urine.

Causes of potassium deficiency:

Lack of potassium in diet
Dehydration
Diarrhoea
Too much sweating
Several medicines also cause potassium deficiency

Signs of potassium deficiency:

You are getting wiped out too often: Like it is discussed before that potassium is responsible for your muscles to work actively. Each and every cell needs the required amount of potassium to work effectively. So, a little deficiency of potassium can leave you exhausted throughout the day. If your normal working routine leaves you exhausted and if you are sweating too often, then there is a chance that you are suffering from hypokalemia.
High blood pressure: Potassium plays an important role in maintaining the blood pressure by helping in relaxing the blood vessels. Low potassium can cause the blood vessels to get constricted, due to which your blood pressure increases.
Muscle weakness: Potassium plays a significant role in building the strength of your muscles. Lack of potassium can easily cause muscle weakness, aches and spasms.
Irregular heartbeat: Anything regarding your heart problem can scare you badly; especially when you experience sudden skipped heart rate or when your heart rate doubles. Low potassium can cause such palpitations and skipped heartbeat.
Feeling dizzy: Lack of potassium in your body can slow down your heart rate and make you feel dizzy or you may feel that you are going to faint. Though many other medical conditions can be responsible for such symptoms but hypokalemia is one of them.
Constipation: Potassium deficiency can affect your overall health. You might encounter symptoms like bloating, abdominal cramping etc.
Numbness and tingling: Potassium is significant in keeping your nerves healthy. Potassium deficiency can make you experience numbness, needle sensations on your feet, wrist, etc.
These are the signs that people encounter when they suffer from hypokalemia. Hypokalemia can make you feel extremely sick and it causes several diseases which are discussed above. It is always advisable to visit a doctor when you encounter any of these above mentioned symptoms.

Potassium Deficiency - 7 Signs You Are Suffering From It!

Colon cancer is believed to be one of the common types of cancer affecting people. As the name suggests, here, the point of origin of the cancer is the colon or the large intestine. Though colon cancer can affect anyone, people with unhealthy lifestyle (sedentary) and habits (excess smoking and consumption of alcohol), obesity, certain medical conditions like diabetes, or exposed to radiations (radiation therapy) are at a greater risk of colon cancer. Colon cancer may also be hereditary.

Colon cancer usually proceeds through five stages, stage 0 (zero), stage I, II, III and IV.

In stage 0, cancer remains in situ, (it remains confined within the innermost layer of the colon).
In stage I, cancer slowly starts spreading to the other layers (second and third) of the inner walls of the colon.
In stage II, cancer spreads further to the muscular walls of the colon (the lymph nodes, are, however, still not affected by this condition).
In stage III, cancer spreads outside the colon, affecting one or more lymph nodes.
Stage IV is more severe and metastatic. Here cancer has spread to and affected vital organs like the liver and the lungs.
Many of the symptoms do not appear at the initial stages. As a result, colon cancer mostly gets detected at a later (often metastatic) stage. Thus, a person should be alert. The initial symptoms, no matter how trivial, should be taken seriously. There is no harm in seeking medical help. It will only help you in the long run. 

The following symptoms are often the initial or first signs of something as big as colon cancer.

Unexplained poor appetite followed by sudden and rapid weight loss. Losing weight at an alarming rate without sweating it out needs thorough investigation. More than often, colon cancer interferes with the digestion process in a person. A person is not able to eat well. There is a feeling of being full (irrespective of how much you eat) all the time.
Constipation, gas or (and) diarrhea. Often overlooked and mistaken for common bowel disorder, these are some of the initial symptoms of colon cancer. The symptoms may be an outcome of polyps (abnormal tissue growths that can take place in any organs. These polyps are mostly benign in nature) or malignant tumors in the colon. Seek medical help if the conditions persist for more than a week. It is better to be safe than to be sorry.
A person feels exhausted, sleepy and weak all the time. The symptom may be an outcome of iron deficiency and anemia. Colon cancer can cause injury to the digestive tract. There may be bleeding followed by blood loss and hence the associated symptoms.
Mild to severe abdominal pain. The abdomen also appears tender than usual (in the case of metastatic tumor).
Stomach upset accompanied by pain, nausea, vomiting, cramps and at times, indigestion (an outcome of intestinal obstruction and inflammation).
There may be blood while passing stool.

Colon Cancer - What Signs You Must Watch Out For?

An anorectal abscess is a painful swelling near the anus or in the buttock. The swelling contains pus. 60% anorectal abscesses are superficial and resulting from infection in small anal glands present in between internal and external anal sphincters (intersphincteric space). They are known as a perianal abscess. 30% of anorectal abscesses are deep-seated and results in systemic infection. They are call Ischiorectal abscess. Submucous abscess, pelvirectal abscess and pilonidal abscess developed from versatile cause are comparatively less common. Inadequate and improper management of anorectal abscess may potentially cause complication like fistula formation.


Fast facts on Anorectal abscess-

* Anorectal abscess should be drained at the earliest.
* Conservative medical management almost invariably invites complication like fistula formation.
* Surgical drainage of pus reduces the chance of fistula formation by 50%.


What causes Anorectal abscess?

* Blocked and infected anal glands (cryptoglandular infection).
* Untreated anal fissure that becomes infected.
* Sexually transmitted infections.
* Penetrating injury of the perianal or buttock region.
* Crohn s disease.
* Colon cancer.
* Tuberculosis.



What are the symptoms of Anorectal abscess?

Superficial abscess-

* Constant and throbbing pain that worsens on sitting down.
* Swelling, redness and tenderness of the skin around the anus.
* Discharge of pus.
* Pain is often associated with bowel movement.

Deep abscess-

* All or some of the symptoms of a superficial abscess.
* Fever with chill and rigor.
* General weakness.
* Sometimes fever is the only symptom of the deep abscess.

The anorectal abscess should preferably be explored under general or spinal anesthesia. Medical management often fails and subsequently fistula is formed.

Anorectal Abscess - Know In Detail About It!

Colon cancer is a medical condition where malignant cancerous growths mainly originate in the colon or the large intestine. Believed to be the sixth most common type of cancer prevalent in India (As per the Rajiv Gandhi Cancer Institute & Research Centre), the colon cancer can metastasize and affect the other healthy body parts and organs.

The symptoms that may be indicative of colon cancer include:

Irritable Bowel Syndrome.
A person may suffer from anemia (triggered by iron deficiency).
Rapid and unexplained loss of body weight.
There may be rectal bleeding (blood may also appear in the stool). There may also be pain and discomfort during the bowel movement.
A person may experience extreme weakness and fatigue.
Frequent diarrhea or constipation.
A person may complain of abdominal pain and cramps.
There may be a change in the consistency of the stool.
Unfortunately, in most cases, the symptoms associated with colon cancer may not appear in the initial stages, thus complicating the situation.

Prevention and management of Colon Cancer
A little alertness on your part can help to prevent colon cancer.

Regular health checkups and screening: Whether the symptoms appear or not, health check-ups at regular intervals are a must. In addition to preventing colon cancer, regular health check-ups can also help to avert a host of other health complications. The screening tests for colon cancer are necessary for people who have a family history of colon cancer and also those who are above 50 years of age. The various screening tests for colon cancer include:
Colonoscopy (used to examine the inside of the colon for any abnormalities).
Fecal Occult Blood Test (FOBT)/Fecal Immunochemical Test (FIT) (These tests are carried out to detect the presence of blood in the feces).
The screening may also be done using Virtual Colonoscopy or Flexible Sigmoidoscopy.
Forget the unhealthy lifestyle habits: Smoking and drinking (excessive) can be the chief contributors triggering colon cancer. Limiting your alcohol intake and quitting smoking will not only keep you healthy but also keep colon cancer at bay.
Shed the extra pounds: The harmful effects of obesity are known to all. Obesity is considered to be one of the underlying factors that can trigger a colon cancer. A healthy body weight can go a long way in preventing colon cancer and keep you fit and active. Minimum 30 minutes exercise daily is all that you need to stay fit and healthy.
Make healthy changes in the diet: If you want to prevent colon cancer, make your diet as healthy as you can. Enrich it with fruits, vegetables and food items that are rich in fibers, minerals, vitamins, and antioxidants. Dietary fats (red meat or any other processed meats) are a strict no. Choose whole grain products over refined ones.

Colon Cancer - How To Prevent It?

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