Women are not really sure about frozen embryos  ability to result in pregnancy. Ironically, the success of Frozen Embryo Transfer has dramatically improved over the last few years. In the days gone by, the chance of women getting pregnant through the use of frozen embryos seemed to be on the lower side compared to that from the transfer of fresh embryos. Recent data related to this suggests that this is no longer the case.

Reasons behind the low success rate of frozen embryo transfer in the past
Previously during the frozen embryo transfer process, the embryos which had to get frozen were the ones that did not get chosen for the fresh embryo transfer initially. The reason being that the embryologist had gone ahead to choose the best possible embryos for getting them transferred initially. As far as the fresh embryo transfer is concerned, quality of embryo has got a major effect on the chance of a woman getting pregnant. On the other hand, if quality of embryos frozen is not good, the rate of survival after it gets thawed along with the rate of pregnancy would be on the lower side.

The second important reason is the amount of embryos that got transferred. Let us consider a couple who produce four very good quality embryos. Two of them are transferred during fresh In Vitro Fertilization Process and the remaining two are frozen. This leads to pregnancy and the woman gives birth to a baby. Later on, the couple once again decides to go for pregnancy by using the frozen embryos. Though only one embryo survives after getting thawed. The frozen embryo transfer is that of a single embryo. The success rate of a frozen embryo transfer through a single embryo is always going to be on the lower side than what it will be when multiple embryo transfer is involved.

Finally the method of freezing embryos has seen a sea change quite a number of years ago. Nowadays the freezing of embryos takes place by a fast method, known as vitrification. This process has got a much better survival rate when embryos get thawed along with good rates of pregnancy when those particular embryos are transferred in a much better manner.

Studies about high success rate of frozen embryo transfer
There have been studies performed in women, who have had quite a vigorous stimulation of their ovaries and were considered to be at high risk for Ovarian Hyperstimulation Syndrome. The physicians took the decision of skipping the process of embryo transfer and instead go ahead to freeze all the embryos for use at a later stage.

This tends to significantly decrease the risk of having serious Ovarian Hyperstimulation Syndrome along with decrease in complications. Other cases involved, physicians deciding to move on with a fresh embryo transfer depite the risk of Ovarian Hyperstimulation Syndrome. In both the scenarios the couples have quite a large number of embryos and the embryos selected for transfer were the best embryos.

The studies have shown no difference in the rates of pregnancy between fresh or frozen embryos or for that matter higher rate of pregnancy with frozen embryos.

How Successful Is Frozen Embryo Transfer?

In order to determine whether a person is having a drug problem, there are several signs, which can be interpreted to know about the exact drug abuse state of a person. Drug abuse requires immediate attention before it becomes more problematic. There are several patterns and stages of drug use that have been listed below:

1. Hard drug use: Heroin, cocaine and methamphetamine fall under the category of hard drugs and are the most dangerous drugs. There are severe effects on the health and behavior of a user of hard drugs. Some people use these kinds of drugs for recreational purposes, but some can get addicted just after using them once. Such people usually isolate themselves from society and possess a high-risk behavior.

2. Frequent drug use: Frequency alone cannot determine whether a person is addicted to a certain drug. Some people may take drugs only once and twice a week, but still suffer from acute addiction. Frequency of drug use may indicate tolerance and a person may require more with each day. Frequent drug users usually keep on continuing the habit and it is hard for them to quit.

3. Early drug use: Some people start taking drugs at an early age during adolescence, and they are likely to develop severe drug problems later in life. People who take drugs before the age of fifteen turn out to be addicts as they grow up. The earlier a person uses drugs, the earlier he becomes addicted. Early drug use is a common phenomenon in today's world.

4. Solitary drug use: Using drugs and addictive substances while a person is alone may result in fatal addiction and various problems in life. Teenagers using alcohol, marijuana and cigarettes are prone to serious drug problems during adulthood. Solitary drug users are usually poor in studies and have a violent or abusive behavior.

5. Escapist drug use: Many people use drugs for dealing with stress, several problems in life or for building self esteem. These are used as a substitute for escapism, which allows a person to escape from reality to a place where nothing bothers them and they can be at peace. Such people are likely to develop drug problems. Some people may experiment with drugs just for the sake of trying, but slowly they may like it and get addicted. This causes several problems in life, and a drug problem arises. Such drug problems may affect the health in many severe ways.

Drugs are used in several patterns. All people do not use drugs in the same pattern and frequency. The pattern of drug use by a person lets the doctor determine the level of drug abuse he is on, or if he is addicted.

Patterns of Drug Abuse

There are glands inside the anus that secrete fluids. Sometimes these glands can get clogged. Pus builds up in the blocked clogs, which get infected. This is called an abscess. Unless the abscess is treated right away, it will keep growing. It eventually punches a hole through the skin near your anus to drain the infected tissues and pus. This tunnel that leads from the gland to the hole is called a fistula.

Usually, it is an abscess that causes a fistula. But sometimes a fistula can be caused by tuberculosis, a bowel illness or sexually transmitted diseases.

What are the symptoms of anal fistula?

The symptoms of anal fistula are-

  Pain while sitting down
  Soreness around the anus
  Swelling and redness
  Bleeding
  Painful defecation
  Fever
  Foul secretion from a hole near your anus

How is fistula diagnosed?

If you complain of any of the above symptoms, a doctor will perform a physical examination on you.

Sometimes a physical examination does not reveal a fistula because the fistula can close for a while and then open up again. So then your doctor might ask you to get the following tests done-

  A blue dye test
  Computerized tomography (CT Scan)
  Anorectal ultrasound
  Colonoscopy.

Treatment for anal fistula

Unfortunately, there are no medicines that can treat fistula. If you are diagnosed with fistula, you will require surgery. However, it is a minimally invasive surgery with no risks involved.

The surgery is performed under general anaesthesia. A fistula surgery can be done in the following ways-

  If the fistula is located beneath the sphincter muscles, the surgeon cuts the fistula open so that it can heal and new healthy tissues can develop there.
  If the fistula passes through the upper part of the sphincter muscles, then the surgeon runs a special stitch through the fistula (seton stitch) so that the fistula can drain properly and heal. It takes 6 weeks for the pus to drain and the wound to heal
  Sometimes, a doctor will simply plug the fistula so it does not seep pus.

General and specific complications of a fistula surgery

Though it is a safe surgery, some complications may arise, but rarely. These may be general or specific.

General complications-

  Bleeding and pain
  Scarring around the region of the surgery

Specific complications-

  Pain while urinating
  The involuntary passing of wind or lose faeces

An anal fistula is a painful condition that refuses to go away and the only way to cure it is surgery.

Can Medication Treat Anal Fistula? Find Out!

A cough is a sign that there is something wrong with the throat. Be it an infection or a sore throat or food stuck in the windpipe, a cough can start. While it may sometimes disappear, sometimes, it may just refuse to go. This not just is bothersome to you to allow to continue work, it also irritates the others in the surrounding and attracts attention. Everybody looks at you annoyed and gives a look which says  why don t you do something about it?  Well, they mean well, and there are definitely things that can help manage a nagging cough. Find out for yourself!

Salt water gargling: Mix about a teaspoon of water in a glass of warm water and gargle your mouth for about 1 minute. It helps soothe the throat and reduce the cough. It can also clear the bacteria along the throat, providing relief from the cough. If there is phlegm lodged in the throat, it gets easily expelled too.
Honey: This viscous liquid coats the inflamed and irritated mucous membranes along the throat and provides instant relief. It is also known for its antibacterial nature and has good enzymes from the bees, which are known for providing instant relief to both children and adults. The sweet taste makes it further appealing. Adding ground black pepper powder to it further improves the effect, as it clears congestion.
Steam: Cough is often the result of an irritated and inflamed throat mucosa. Inhaling steam is one of the best ways to soothe this mucosa and provide relief. It reduces mucosal inflammation and removes phlegm. Adding a few drops of essential oils like eucalyptus or tea tree oil further improves the effect. These have antibacterial and antiviral properties and so enhance the relief. With boiled water in a vessel, bend over it and cover your head to ensure the steam is inhaled. Be careful to avoid burns, as steam can burn. This can be repeated 4 to 5 times daily until you get sufficient relief.
Ginger and Mint: Another wonder substance is the ginger. To a cup of warm water, add honey, few slices of ginger, and some dried peppermint. This helps by acting as an expectorant and reduces irritation in the throat, which produces cough.
Cough drops or lozenges: If you are in a public space and cannot do the above, try cough drops. Sucking on them can soothe the throat and the constant swallowing of saliva helps relieve the irritation in the throat.
Nasal irrigation: This helps relieve the postnasal congestion and dripping, which often leads to nagging coughs.
These are some simple, effective ways to reduce constant coughing.

Nagging Cough - 6 Quick Ways You Can Manage It!

Nephrotic syndrome is a type of kidney disorder wherein, the body passes out excess amount of proteins through urine, owing to the damage caused to the tiny clusters of blood vessels in the kidneys. The symptoms include putting on excessive weight as a result of fluid retention, foamy urine and severe swelling around the region of the feet, ankles and eyes.

Common causes behind it

Minimal change disease (also known as nil disease) leads to the abnormal functioning of the kidneys
Excess deposit of amyloid proteins in the organs, thus taking a toll on the filter mechanism of the kidneys.
Diabetes affecting the glomeruli (capillaries present in the nephrons of the kidneys).
Systemic lupus  erythematous causing chronic swelling of your kidney.
Membranous nephropathy wherein the membranes in your glomeruli thicken.
Infections such as malaria, hepatitis C, hepatitis B and HIV.
Medications to combat infections and nonsteroidal anti-inflammatory drugs.
Treatment Available

Kidney Biopsy is an essential part of disease assessment.
Angiotensin-converting enzyme inhibitors bring down blood pressure levels as well as the amount of protein discharged from the urine.
Water pills help control sweating, thus, increasing the fluid flushed from the kidneys.
Statins reduce cholesterol level.
Blood thinners such as anticoagulants lower the risk of blood clots.
Corticosteroids regulate the immune system and ease the inflammation that results from kidney disorders.
Incorporating certain lifestyle changes such as opting for lean proteins, cutting on the intake of fat in the diet and consuming lesser amounts of salt can treat inflammation and swelling.

Nephrotic Syndrome - 9 Surprising Causes Behind it

Epilepsy is a disorder of the central nervous system, thus it is basically a neurological disorder. In this the nerve cell activity of the brain is disrupted and causes seizures along with episodes of unusual behavior along with the loss of consciousness. The symptoms of the seizure can vary and some people with epilepsy just stare blankly for few seconds when a seizure takes place, while some twitch their arms and legs repeatedly.

Symptoms of Epilepsy:
As epilepsy is caused by the abnormal activities in the brain cells, seizures affect the processes with which the brain coordinates. Some signs and symptoms are:

Staring blankly
Confusion which is temporary
Uncontrolled jerking movements of the legs and arms
Loss of awareness and consciousness
Psychic symptoms
Mostly the symptoms vary depending on the type of the seizure. The seizures are further classified into focal and generalized depending on which part of the brain shows abnormal activity.
Focal seizures
When seizures are due to the abnormal activity of the cells in just one area then it is known as focal seizures. These seizures are of two types:

Simple partial seizures or the focal seizures without loss of consciousness. These seizures basically alter the emotions and the things like change in smell, look, sound and taste. These also result in the involuntary jerking of the body like the legs and arms, with spontaneous sensory symptoms like the tingling and flashing of the lights.
Complex partial seizures or the focal dyscognitive seizures. These seizures have a loss of awareness and consciousness. One might just stare blankly into space in this seizure and performs repetitive activities like swallowing, chewing, walking in circles and chewing.
Generalized seizures
There are six types of generalized seizures. These are:

Absence seizures, also known as petit mal seizures, are commonly seen in children and are characterized by subtle body movements like lip smacking and eye blinking and staring blankly into space. These also cause loss of consciousness.
Tonic seizures lead to stiffening of the muscles. These affect the muscles of the legs and arms and also cause to fall to the ground.
Atonic seizures are also called as drop seizures. These cause loss of control in the muscles, thereby leading to collapse or fall.
Clonic seizures are the rhythmic and jerking muscle movements. These affect the arms, face and neck.
Myoclonic seizures appear as twitches in the arms and legs.
Tonic-clonic seizures also known as grand mal seizures are very dramatic and lead to body stiffening, abrupt loss of consciousness, shaking and loss of bladder control and tongue biting.

Epilepsy - How Seizures Affect It?

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