Addison s disease is known as adrenal insufficiency or hypocortisolism. It is a hormonal disorder which occurs when adrenal glands which are located just above the kidneys do not produce enough of the hormone. The hormones produced by adrenal glands include cortisol and aldosterone, which are essential for a healthy life.

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and darkening of the skin also sometimes. Most cases of Addison's disease are caused by autoimmune disorders.
It is quite a rare condition. Only 1 in 1 lakh suffer from this condition. this condition can affect a person of any age group irrespective of sex. To live a normal life people, with this condition, a patient will be required to take their medication regularly.

Cortisol and Aldosterone - What do they do?
The most important function of the cortisol in the body is to respond to stress. It helps the body in using protein, carbohydrates, and fat. It maintains blood pressure, cardiovascular function; and controls inflammation. While as aldosterone helps kidneys in regulating the amount of salt and water in the body   which helps in regulating blood volume and keeping blood pressure under control.

Cause of Addison's Disease
Mostly Addison s disease occurs due to problems with adrenal glands themselves   which is known as primary adrenal insufficiency. While Autoimmune disease accounts for 70% of Addison s disease. In this condition, the body's immune system mistakenly attacks the adrenal glands. This attack destroys the outer layer of the glands.

Some long-term infections such as tuberculosis, HIV, and some fungal infections harm the adrenal glands. It is also caused by the cancer cells that spread from other parts of the body to the adrenal glands.
Less commonly, adrenal glands can also be affected by secondary adrenal insufficiency. It is caused by a problem with the pituitary gland or a problem with the hypothalamus, both located in the center of the brain.
These glands produce hormones that control the production of hormones in the rest of the body. A pituitary hormone called ACTH which turns on cortisol production in the adrenal gland. If ACTH levels are too low, the adrenal glands do not function.
One more cause of secondary adrenal insufficiency is also caused by the prolonged or abuse of steroid hormones such as prednisone.
Symptoms of Addison's disease
The symptoms of adrenal insufficiency grow gradually and the main characteristics are:

Chronic, worsening fatigue
Muscle weakness
Loss of appetite
Weight loss
About 50 percent of the time, one will notice:

Nausea
Vomiting
Diarrhea

A Quick Guide To Addison's Disease!


Many overweight and obese people have darkened and a rather flaky texture behind neck, darkening in armpits and other parts of body with creases and folds like elbows, knees or knuckles. This is commonly mistaken as smudge of dirt, uncleanliness or lack of hygiene. Some people think that it is due to repeated friction caused by necklace or chains etc. In fact it is a sign of'diabetes' which is already developed or might develop in future.

This darkening is due to excessive cell growth and differentiation of fibroblasts caused by excess of insulin in the body especially in obese individuals and type 2 diabetes patients.

In obese individuals and type 2 diabetes patients excess amount of fat especially abdominal fat (tummy fat) causes resistance to action of insulin secreted by pancreas and tends to hamper its action. In return, body produces more and more insulin from pancreas to keep blood sugar under control. This excess amount of insulin secreted by body promotes this skin cell growth leading to the visible condition called'acanthosis nigricans' in medical terms.

After producing excess amount of insulin pancreas start exhausting, this converts into diabetes. At this stage diabetes can be prevented by simple lifestyle modifications &amp; focussed weight loss.

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Are Dark Cracks Behind Neck A Sign Of Diabetes?

Diabetes is also known as diabetes mellitus, is a group of metabolic diseases, which raises the glucose level in the blood. If suffering from diabetes, parts of your body might get affected with other diseases as well, like bad eyesight, etc. 

Diabetes is of 3 types:

1. Type 1 Diabetes: where your body stops insulin production.

2. Type 2 Diabetes: where your body does not produce enough insulin to function on or where the cells of your body do not react toward the insulin produced

3. Gestational Diabetes: This is the diabetes you or your partner may suffer from during pregnancy.

Suffering from diabetes can make your lifestyle extremely difficult as you will have to go through a lot of restrictions. In order to avoid diabetes and its various outcomes, here are some tips you can follow:

1. Keep your weight in control: Make sure you are of the right weight according to your height. If you are more than what you should weigh, and you are creeping towards obesity, you have a high chance of succumbing to diabetes. If you are already obese, start working towards losing weight. Even if you lose 5% of your weight, you will slash the risk of having diabetes by 70%. 

2. Walk: No exercise is better and easier than walking. Try walking as much as you can. Walking will help you reduce the risk of getting affected with diabetes. If you walk for around 35 minutes every day, you are cutting down the risk of diabetes by almost 30%. Walking, being an exercise, helps your body use the insulin produced in your body more efficiently. 

3. Drink coffee: Coffee, unlike common belief of being harmful, is actually very beneficial when it comes to keeping diabetes at bay. Coffee contains caffeine, which is believed to improve metabolism. Coffee also has potassium, magnesium and various antioxidants which enable the cells to absorb glucose. Drinking coffee regularly might lower the risk of diabetes by 29%.

4. Get proper rest at night: If you sleep for less than 6 hours every night, then the risk of you suffering from diabetes is doubled. But that doesn't mean you are supposed to oversleep. If you sleep more than 8 hours, the risk of being affected with it rises to almost 75%. Hence sleep at least for 6 to 8 hours each night for a healthy life sans diabetes.

4 Tips to Keep Diabetes at Bay

10 symptoms that signal hypothyroidism

When your thyroid malfunctions, you may face difficult health issues. Hypothyroidism leads to excessive weight gain and a lot of other medical ailments. It can be identified by a bunch of symptoms which if present, should not be taken lightly.

1) weight gain - if there is sudden and unexpected weight gain, this is the earliest and definite sign of an underactive thyroid gland. This means that there are strong chances of lowered levels of t3 and t4 hormones in the body, leading to slow metabolism in the body. People suffering from hypothyroidism face increased body weight which becomes difficult to lose despite maintaining healthy diet and exercising rigorously.

2) constant fatigue - if you have slept well the night before, yet you are tired and if this is a regular feature, then chances are that your thyroid gland is underactive. Being low in energy, it gets difficult to complete daily chores or exercise.

3) swelling in the neck - another telltale sign would be goiter - an abnormal swelling in the neck. The thyroid gland mainly concentrates iodine from the blood to create both the thyroid hormones. If there is iodine deficiency in the body, this process gets disrupted resulting in hypothyroidism.

4) hair loss - hypothyroidism causes hormonal imbalance which in turn causes hair loss. If there is sudden, unexplainable hair loss, chances of hypothyroidism are high.

5) imbalance in body temperature - if you are suddenly feeling too cold, it is advised to get your thyroid tests done.

6) brittle nails - if your nails have become brittle, get chipped very easily and look weak, this could be an indication of hypothyroidism.

7) mood changes - the weight gained and the excessive fatigue, both trigger massive mood swings which at times, the person has no control over.

8) constipation - the contractions of the digestive tract get weakened due to low levels of thyroid hormones resulting in constipation. Chronic constipation without any apparent reason could be an indicator of hypothyroidism.

9) irregular menses - if your periods are irregular, do not take it lightly. This could be most likely because of hormonal imbalances which are caused by hypothyroidism.

10) slower heart rate - if your heart beats at less than 60 times per minute, it could be because of the interference by thyroid hormones.

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10 Symptoms That Signal Hypothyroidism. Do You Have Any Of These?

Female infertility is considered as the inability of conceiving. As per WHO it is described as the inability to be pregnant, maintain and carry forward a pregnancy to its full term. It is often of two types:

    Primary Infertility: This is the inability to give birth to a baby either due to the inability to become pregnant or maintain a pregnancy, which includes stillborn and miscarriage.
    Secondary Infertility: This refers to the inability to give birth when there is already a live birth or the woman was pregnant.

The causes of infertility can vary from being acquired or genetic. However, following factors are largely responsible for infertility:

    Genetic: Some genes can lead to mutation leading to infertility like, in case of BMP15 gene there is a hypergonadotrophic ovarian failure which causes infertility.
    Acquired: This is caused by factors like age, smoking, sexually transmitted diseases, obesity, body weight, eating disorders, diseases like diabetes, thrombophilia and also radiation and chemotherapy.

The treatment for infertility usually depends on the cause, age, duration of time for which a person has been infertile and preference of the patient. Infertility is believed to be a complex disorder and the treatment involves a huge amount of physical, financial and psychological commitments. All this also requires a lot of time. Some women might need just a minimum of two therapies to attain fertility while others might require different treatment before they can conceive.

Treatment is largely aimed to restore the fertility either by means of medication and surgery or help in reproduction with the help of some procedures.

Fertility Restoration through medication

This is the main treatment for women who are infertile because of ovulation disorders. These drugs include:

    Gonadotropins: These are injected to stimulate the ovaries. Drugs like Menopur, Repronex, Follistim AQ, Gonal-F, Bravelle restore the production of eggs, while Ovidrel and Pregnyl are used for maturing the eggs and for their release.
    Clomiphene citrate: This is taken orally and stimulates ovulation by releasing more Follicle Stimulating Hormone and Luteinizing Hormone from the pituitary gland.
    Metformin: This is used in females who have PCOS and also when insulin resistance plays a major role in infertility.
    Bromocriptine: Used when the infertility is caused due to excess prolactin production.
    Letrozole: This also induces ovulation

Fertility Restoration through surgery

Surgical procedures can amend the problem of infertility. However, these treatments are very rare these days owing to the success of other fertility treatments. These include:

    Tubal ligation reversal surgery: In case a tubal ligation has been performed it can be reversed by reconnecting the tubes again through surgery.
    Hysteroscopic surgery: This corrects or removes the abnormalities that cause infertility. This surgery can correct the shape of the uterus, remove endometrial polyps and improve chance of getting pregnant.
    Tubal surgeries: In case of blocked fallopian tubes laproscopic surgery can be performed to dilate the tubes, removed blockages or create a new opening.

Assistance in Reproduction through techniques

The most common used techniques for reproduction assistance are:

    Intrauterine insemination or IUI: In this about million healthy sperms are put in the uterus at the time of ovulation.
    Assisted reproductive technology: In this mature eggs are retrieved from a woman and this is then fertilized with sperms in a dish in the lab. Once the fertilization is done the embryo is placed in the uterus for further development. IVF is the most common and effective assisted reproductive technology. This procedure takes place over weeks with several blood tests and hormone injections.

Dealing with infertility is not easy and can be emotionally and physically draining. To cope with the various tests and treatments of infertility one should be fully prepared, eat a healthy diet, exercise reach out for help and support of family and friends and look for other options like a donor egg, adoption or no children.

Treatments of Infertility

Gestational diabetes is a kind of diabetes that happens during pregnancy. Diabetes is referred to a condition where your blood glucose or blood sugar is very high. Although, glucose is good as it used by your body for energy, but excessive glucose in your blood can be harmful for both you and your child. Gestational diabetes is mostly diagnosed in the later stages of pregnancy. If gestational diabetes is diagnosed in the early stages of pregnancy, then it is quite possible that you may have had diabetes before you became pregnant. Treating gestational diabetes can help both you and your baby stay fit and healthy. You can protect both, yourself and your baby by controlling your blood glucose levels.

Here are 7 things that you need to know about Gestational diabetes:

Every three to eight out of 100 ladies tend to develop diabetes during pregnancy, a condition known as gestational diabetes. Fortunately, it can be dealt with and even kept away by maintaining healthy lifestyle choices. Eating leafy foods and avoiding sugar-rich things, is a vital step for both control and counteractive action. Exercise, after consulting your doctor can guarantee that you have a healthy pregnancy.
In diabetes, when your body's glucose or sugar levels get so high that the carbohydrates and sugars cannot be converted into energy, the excess starts accumulating in your body. This additional glucose can harm the vessels in your kidneys and all through your body, particularly in organs like eyes.
Two or three factors might cause danger for creating gestational diabetes, both inside and outside of your control. If you are overweight before you get pregnant or while you are pregnant or your family history shows that you are hereditarily inclined to the sickness, you will probably build up the condition.
One will have to stay on the right path as far as medication and insulin goes. Your specialist may prescribe that you require diabetic pills or insulin to help you control your glucose levels.
Your weight can bring about complexities during the delivery in case of gestational diabetes. So it is best to keep your weight in check in order to have a smooth sailing pregnancy and delivery.
Gestational diabetes can likewise put ladies at risk of contracting preeclampsia, which can bring about a number of side effects and complexities. Side effects brought on may start from swollen feet, legs, fingers, and hands to hypertension and even seizures or strokes.
Apart from the risks of having gestational diabetes during your pregnancy, it might affect the child later on. Your baby may have a higher danger of obesity as it develops, both in the teenage years and youth. Youngsters who are overweight may suffer from type 2 diabetes in the long run.

Gestational Diabetes - 7 Things You Must Know About it 

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